Mitochondrial Medicine for Aging and Neurodegenerative Diseases

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864

Sequence and organization of the human mitochondrial genome

Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,740

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,889

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease

Misrani, A., Tabassum, S., & Yang, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.617588 · Cited by 654

Basic mechanisms of neurodegeneration: a critical update

Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 640

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease

McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0552-11.2011 · Cited by 432

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer’s disease: Implications to mitochondria-targeted antioxidant therapeutics

Reddy, P. H., Tripathi, R., Troung, Q., Tirumala, K., Reddy, T. P., Anekonda, V., Shirendeb, U. P., Calkins, M. J., Reddy, A. P., Mao, P., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.011 · Cited by 394

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

Gouras, G. K., Tampellini, D., Takahashi, R. H., & Capetillo-Zarate, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0679-9 · Cited by 372

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

Reddy, P. H., Reddy, T. P., Mańczak, M., Calkins, M. J., Shirendeb, U. P., & Mao, P. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.11.004 · Cited by 372

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

Kim, J., Moody, J. P., Edgerly, C. K., Bordiuk, O. L., Cormier, K., Smith, K., Beal, M. F., & Ferrante, R. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq306 · Cited by 364

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361

Are circulating microRNAs peripheral biomarkers for Alzheimer's disease?

Kumar, S., & Reddy, P. H. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.06.001 · Cited by 292

Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer’s Disease

Cai, Q., & Tammineni, P. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160726 · Cited by 281

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

Reddy, P. H. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.042 · Cited by 266

Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies

Onyango, I. G., Dennis, J., & Khan, S. M. (2016) · Aging and Disease · doi:10.14336/ad.2015.1007 · Cited by 260

Mitochondrial Dysfunction as a Driver of Cognitive Impairment in Alzheimer’s Disease

Sharma, C., Kim, S., Nam, Y., Jung, U. J., & Kim, S. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094850 · Cited by 253

Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline

Reddy, P. H., Mańczak, M., Mao, P., Calkins, M. J., Reddy, A. P., & Shirendeb, U. P. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100504 · Cited by 247

Is multiple sclerosis a mitochondrial disease?

Mao, P., & Reddy, P. H. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.002 · Cited by 246

Brain region‐specific deficit in mitochondrial electron transport chain complexes in children with autism

Chauhan, A., Gu, F., Essa, M. M., Wegiel, J., Kaur, K., Brown, W. T., & Chauhan, V. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07189.x · Cited by 243

Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements.

Nicolson, G. L. (2014) · PubMed Central · Cited by 235

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases

Reddy, P. H., & Reddy, T. P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745401 · Cited by 233

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

Guo, L., Tian, J., & Du, H. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160702 · Cited by 211

Creatine as an antioxidant

Sestili, P., Martinelli, C., Colombo, E., Barbieri, E., Potenza, L., Sartini, S., & Fimognari, C. (2011) · Amino Acids · doi:10.1007/s00726-011-0875-5 · Cited by 212

Role of Mitochondria in Neurodegenerative Diseases: Mitochondria as a Therapeutic Target in Alzheimer's Disease

Reddy, P. H. (2009) · CNS Spectrums · doi:10.1017/s1092852900024901 · Cited by 192

Mitochondria as a target in treatment

Frantz, M., & Wipf, P. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20554 · Cited by 183

Dynamics of Dynamin-Related Protein 1 in Alzheimer’s Disease and Other Neurodegenerative Diseases

Oliver, D., & Reddy, P. H. (2019) · Cells · doi:10.3390/cells8090961 · Cited by 172

Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

Morton, H., Kshirsagar, S., Orlov, E., Bunquin, L. E., Sawant, N. A., Boleng, L., George, M., Basu, T., Ramasubramanian, B., Pradeepkiran, J. A., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.013 · Cited by 172

Amyotrophic lateral sclerosis: a long preclinical period?

Eisen, A., Kiernan, M. C., Mitsumoto, H., & Swash, M. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-307135 · Cited by 167

Defective Autophagy and Mitophagy in Aging and Alzheimer’s Disease

Tran, M., & Reddy, P. H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.612757 · Cited by 167

Mitochondrial structural and functional dynamics in Huntington's disease

Reddy, P. H., Mao, P., & Mańczak, M. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.04.001 · Cited by 164

Small molecules as therapeutic drugs for Alzheimer's disease

Oliver, D., & Reddy, P. H. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.03.001 · Cited by 159

The Influence of Fluorine on the Disturbances of Homeostasis in the Central Nervous System

Dec, K., Łukomska, A., Maciejewska, D., Jakubczyk, K., Baranowska‐Bosiacka, I., Chlubek, D., Wąsik, A., & Gutowska, I. (2016) · Biological Trace Element Research · doi:10.1007/s12011-016-0871-4 · Cited by 154

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

Demetrius, L., Magistretti, P. J., & Pellerin, L. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2014.00522 · Cited by 151

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

Kandimalla, R. J. L., & Reddy, P. H. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.018 · Cited by 148

Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease

Bhatti, G. K., Reddy, A. P., Reddy, P. H., & Bhatti, J. S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00369 · Cited by 145

Creatine Supplementation, Physical Exercise and Oxidative Stress Markers: A Review of the Mechanisms and Effectiveness

Arazi, H., Eghbali, E., & Suzuki, K. (2021) · Nutrients · doi:10.3390/nu13030869 · Cited by 145

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease

Yin, X., Mańczak, M., & Reddy, P. H. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw045 · Cited by 144

Mitochondrial Dysfunction and Oxidative Stress in Asthma: Implications for Mitochondria-Targeted Antioxidant Therapeutics

Reddy, P. H. (2011) · Pharmaceuticals · doi:10.3390/ph4030429 · Cited by 144

Inhibitors of Mitochondrial Fission as a Therapeutic Strategy for Diseases with Oxidative Stress and Mitochondrial Dysfunction

Reddy, P. H. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132060 · Cited by 138

Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients☆

Liu, J., Shen, W., Zhao, B., Wang, Y., Wertz, K., Weber, P., & Zhang, P. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.06.007 · Cited by 133

Mitochondrial dynamics, a key executioner in neurodegenerative diseases

Panchal, K., & Tiwari, A. K. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.11.002 · Cited by 128

Molecular Basis of Alzheimer’s Disease: Focus on Mitochondria

Oliver, D. M. A., & Reddy, P. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190048 · Cited by 120

Analysis of the mitochondrial proteome in multiple sclerosis cortex

Broadwater, L., Pandit, A., Clements, R. J., Azzam, S., Vadnal, J., Sulak, M. A., Yong, V. W., Freeman, E. J., Gregory, R. B., & McDonough, J. A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.01.012 · Cited by 119

Reactive Oxygen Species and Their Impact in Neurodegenerative Diseases: Literature Landscape Analysis

Yeung, A. W. K., Tzvetkov, N. T., Georgieva, M. G., Ognyanov, I., Kordos, K., Jóźwik, A., Kühl, T., Perry, G. L., Petralia, M. C., Mazzon, E., et al. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7952 · Cited by 112

Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases

Bartman, S., Coppotelli, G., & Ross, J. M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46030130 · Cited by 110

Disentangling Mitochondria in Alzheimer’s Disease

Johri, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111520 · Cited by 103

Glaucoma: Focus on mitochondria in relation to pathogenesis and neuroprotection

Osborne, N. N., Núñez-Álvarez, C., Joglar, B., & del Olmo-Aguado, S. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.04.032 · Cited by 101

Mitochondrial DNA and inflammatory diseases

Escames, G., López, L. C., García, J. A., García‐Corzo, L., Ortiz, F., & Acuña-Castroviejo, D. (2011) · Human Genetics · doi:10.1007/s00439-011-1057-y · Cited by 97

Glutamate and Mitochondria: Two Prominent Players in the Oxidative Stress-Induced Neurodegeneration

Cassano, T., Pace, L., Bedse, G., Lavecchia, A. M., Marco, F. D., Gaetani, S., & Serviddio, G. (2015) · Current Alzheimer Research · doi:10.2174/1567205013666151218132725 · Cited by 96

Behavioral changes and mitochondrial dysfunction in a rat model of schizophrenia induced by ketamine

de Oliveira, L., Fraga, D. B., Luca, R. D. D., Canever, L., Ghedim, F. V., Matos, M. P. P., STRECK, E. L., Quevedo, J., & Zugno, A. I. (2011) · Metabolic Brain Disease · doi:10.1007/s11011-011-9234-1 · Cited by 90

Mitochondria-Targeting Particles

Wongrakpanich, A., Geary, S. M., Joiner, M.-L. A., Anderson, M. E., & Salem, A. K. (2014) · Nanomedicine · doi:10.2217/nnm.14.161 · Cited by 90

Mitochondrial Abnormalities in Alzheimer’s Disease

Silva, D. F., Selfridge, J. E., Lu, J., E, L., Cardoso, S. M., & Swerdlow, R. H. (2012) · Advances in Pharmacology · doi:10.1016/b978-0-12-394816-8.00003-9 · Cited by 86

Mitochondrial MicroRNAs in Aging and Neurodegenerative Diseases

John, A. A., Kubosumi, A., & Reddy, P. H. (2020) · Cells · doi:10.3390/cells9061345 · Cited by 84

Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology

Nesci, S., Trombetti, F., Pagliarani, A., Ventrella, V., Algieri, C., Tioli, G., & Lenaz, G. (2021) · Life · doi:10.3390/life11030242 · Cited by 84

Mitochondrial medicine for neurodegenerative diseases

Du, H., & Yan, S. S. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.01.004 · Cited by 82

Quantification of mitochondrial DNA copy number in suspected cancer patients by a well optimized ddPCR method

Memon, A. A., Zöller, B., Hedelius, A., Wang, X., Stenman, E., Sundquist, J., & Sundquist, K. (2017) · Biomolecular Detection and Quantification · doi:10.1016/j.bdq.2017.08.001 · Cited by 81

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

Siedlak, S. L., Casadesús, G., Webber, K. M., Pappolla, M. A., Atwood, C., Smith, M. A., & Perry, G. L. (2009) · Free Radical Research · doi:10.1080/10715760802644694 · Cited by 79

Behavioral Effects Induced by Mitochondria-Targeted Antioxidant SkQ1 in Wistar and Senescence-Accelerated OXYS Rats

Stefanova, N. A., Фурсова, А. Ж., & Kolosova, N. G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091675 · Cited by 78

Photobiomodulation and Coenzyme Q10 Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice

Salehpour, F., Farajdokht, F., Mahmoudi, J., Erfani, M., Farhoudi, M., Karimi, P., Rasta, S. H., Sadigh‐Eteghad, S., Hamblin, M. R., & GJEDDE, A. H. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00074 · Cited by 78

Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease

Ding, X.-W., Robinson, M., Li, R., Aldhowayan, H., Geetha, T., & Babu, J. R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105783 · Cited by 73

Mitochondrial dysfunction in psychiatric and neurological diseases: Cause(s), consequence(s), and implications of antioxidant therapy

Kasote, D. M., Hegde, M. V., & Katyare, S. S. (2013) · BioFactors · doi:10.1002/biof.1093 · Cited by 73

Swimming attenuates d -galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics

Kou, X., Li, J., Liu, X., Chang, J., Zhao, Q., Jia, S., Fan, J., & Chen, N. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00018.2017 · Cited by 73

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

Cardoso, S., Carvalho, C., Correia, S. C., Seiça, R. M. F., & Moreira, P. I. (2016) · Brain Pathology · doi:10.1111/bpa.12402 · Cited by 69

Excitotoxins, Mitochondrial and Redox Disturbances in Multiple Sclerosis

Rajda, C., Pukoli, D., Bende, Z., Majláth, Z., & Vécsei, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020353 · Cited by 69

Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease

Bhatti, J. S., Kaur, S., Mishra, J., HariKrishnaReddy, D., Singh, A., Reddy, A. P., Bhatti, G. K., & Reddy, P. H. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166798 · Cited by 69

The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules

Kunde, S., Musante, L., Grimme, A., Fischer, U., Müller, E., Wanker, E. E., & Kalscheuer, V. M. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr430 · Cited by 68

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

Nicolson, G. L., Ferreira, G., Settineri, R. A., Costa, C., Ellithorpe, R. R., Rosenblatt, S., LaValle, J. B., Jimenez, A., & Ohta, S. (2016) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2016.71005 · Cited by 68

The Roles of Mitochondrial Dysfunction and Reactive Oxygen Species in Aging and Senescence

Zia, A., Farkhondeh, T., Pourbagher‐Shahri, A. M., & Samarghandian, S. (2021) · Current Molecular Medicine · doi:10.2174/1566524021666210218112616 · Cited by 70

Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases

Bhatti, G. K., Gupta, A., Pahwa, P., Khullar, N., Singh, S., Navik, U., Kumar, S., Mastana, S. S., Reddy, A. P., Reddy, P. H., et al. (2022) · Biomedical Journal · doi:10.1016/j.bj.2022.05.002 · Cited by 66

NOX activity in brain aging: Exacerbation by high fat diet

Bruce‐Keller, A. J., White, C. L., Gupta, S., Knight, A. G., Pistell, P. J., Ingram, D. K., Morrison, C. D., & Keller, J. N. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.006 · Cited by 66

Neurotrophic function of phytochemicals for neuroprotection in aging and neurodegenerative disorders: modulation of intracellular signaling and gene expression

Naoi, M., Inaba-Hasegawa, K., Shamoto‐Nagai, M., & Maruyama, W. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1797-5 · Cited by 66

Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome

Yang, J., Suo, H., & Song, J. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1809344 · Cited by 65

Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage

Calkins, M. J., & Reddy, P. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.04.006 · Cited by 65

Targeting mitochondrial dysfunction as in aging and glaucoma

Osborne, N. N., Núñez‐Álvarez, C., & del Olmo‐Aguado, S. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.05.010 · Cited by 64

Drp1/Mff signaling pathway is involved in fluoride-induced abnormal fission of hepatocyte mitochondria in mice

Zhou, B.-H., Wei, S.-S., Jia, L.-S., Zhang, Y., Miao, C.-Y., & Wang, H. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138192 · Cited by 62

Therapeutic Strategies for Mitochondrial Dysfunction and Oxidative Stress in Age-Related Metabolic Disorders

Bhatti, J. S., Kumar, S., Vijayan, M., Bhatti, G. K., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.012 · Cited by 61

Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease

Onyango, I. G. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.224362 · Cited by 61

CART Peptide Is a Potential Endogenous Antioxidant and Preferentially Localized in Mitochondria

Mao, P., Meshul, C. K., Thuillier, P., Goldberg, N. R. S., & Reddy, P. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029343 · Cited by 59

Melatonin attenuates methamphetamine‐induced disturbances in mitochondrial dynamics and degeneration in neuroblastoma SH ‐ SY 5 Y cells

Parameyong, A., Charngkaew, K., Govitrapong, P., & Chetsawang, B. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12078 · Cited by 59

Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension

Soo, S. K., Rudich, Z. D., Ko, B., Moldakozhayev, A., AlOkda, A., & Raamsdonk, J. M. V. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101941 · Cited by 58

Analyzing Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis: Potential Role of L-carnitine.

Modanloo, M., & Shokrzadeh, M. (2019) · Iranian Journal of Kidney Diseases · Cited by 57

Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential

Wu, N., Zheng, W., Zhou, Y., Tian, Y., Tang, M., Feng, X., Ashrafizadeh, M., Wang, Y. Z., Niu, X., Tambuwala, M. M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102428 · Cited by 59

Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease

Manczak, M., Mao, P., Nakamura, K., Bebbington, C., Park, B., & Reddy, P. H. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp331 · Cited by 56

Mitochondria, motor neurons and aging

García, M. L., Fernández, A., & Solas, M. T. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.03.019 · Cited by 54

Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer’s disease

Reddy, A. P., Yin, X., Sawant, N. A., & Reddy, P. H. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab054 · Cited by 54

The mitochondrial brain: From mitochondrial genome to neurodegeneration

Turnbull, H. E., Lax, N. Z., Diodato, D., Ansorge, O., & Turnbull, D. M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.010 · Cited by 52

Therapeutic Approach to Neurodegenerative Diseases by Medical Gases: Focusing on Redox Signaling and Related Antioxidant Enzymes

Fujita, K., Yamafuji, M., Nakabeppu, Y., & Noda, M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/324256 · Cited by 51

Role of mitochondrial DNA copy number in incident cardiovascular diseases and the association between cardiovascular disease and type 2 diabetes: A follow-up study on middle-aged women

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