Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

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Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

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Alzheimer’s disease

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Alzheimer's Disease Is a Synaptic Failure

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

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Interplay between Cortical Spreading Depolarization and Seizures

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An Energy Budget for Signaling in the Grey Matter of the Brain

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Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

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Alzheimer’s disease

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THE SYNAPTIC VESICLE CYCLE

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

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The cholinergic hypothesis of Alzheimer’s disease: A review of progress

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Tyrosine Hydroxylase

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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Calcium Signaling in Neurons: Molecular Mechanisms and Cellular Consequences

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Mitochondrial abnormalities in Alzheimer's disease

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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

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Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

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Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

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S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

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Tyrosine hydroxylase and regulation of dopamine synthesis

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The cholinergic system in aging and neuronal degeneration

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Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

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Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer’s disease

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Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

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The ageing cortical synapse: hallmarks and implications for cognitive decline

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Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

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Dimers of mitochondrial ATP synthase form the permeability transition pore

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Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

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Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease

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The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives

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Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

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Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

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Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

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Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

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A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

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Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications

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Calcium- and activity-dependent synaptic plasticity

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Brain fuel metabolism, aging, and Alzheimer’s disease

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An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore

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Energetic basis of brain activity: implications for neuroimaging

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Mitochondria as all‐round players of the calcium game

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Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

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Quasi‐synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

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Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

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Calcium Stores in Hippocampal Synaptic Boutons Mediate Short-Term Plasticity, Store-Operated Ca2+ Entry, and Spontaneous Transmitter Release

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Disease‐specific patterns of locus coeruleus cell loss

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Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

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Electron transport chain defects in Alzheimer's disease brain

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Mitochondria-targeted antioxidants protect against amyloid-β toxicity in Alzheimer's disease neurons

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Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

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Synapses and Alzheimer's Disease

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Presynaptic Mitochondrial Calcium Sequestration Influences Transmission at Mammalian Central Synapses

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Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer’s disease

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Abnormalities of mitochondrial enzymes in Alzheimer disease

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Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases

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Alterations in Expression of Glutamatergic Transporters and Receptors in Sporadic Alzheimer's Disease

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Brain aging, Alzheimer's disease, and mitochondria

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Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment

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Alzheimer's disease: synapses gone cold

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Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

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Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.

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Calcium Secretion Coupling at Calyx of Held Governed by Nonuniform Channel–Vesicle Topography

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Are mitochondria critical in the pathogenesis of Alzheimer's disease?

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Mitochondria: A therapeutic target in neurodegeneration

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Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease

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Oxidative Stress in Diabetes and Alzheimer's Disease

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“Is dopamine involved in Alzheimer's disease?”

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The Glutamatergic System and Alzheimer???s Disease

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The cholinergic hypothesis of Alzheimer's disease: a review of progress

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Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

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Does Donepezil Treatment Slow the Progression of Hippocampal Atrophy in Patients With Alzheimer’s Disease?

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Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline

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PKC ε Activation Prevents Synaptic Loss, Aβ Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice

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Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

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Mitochondrial Medicine for Aging and Neurodegenerative Diseases

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Release of Adenosine and ATP During Ischemia and Epilepsy

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Apolipoprotein E in Alzheimer’s Disease: Focus on Synaptic Function and Therapeutic Strategy

Qu, L., Xu, S., Lan, Z., Fang, S., Xu, Y., & Zhu, X. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04449-1 · Cited by 22 · see citing works

Codonopsis pilosula Polysaccharides Alleviate Aβ1-40-Induced PC12 Cells Energy Dysmetabolism via CD38/NAD+ Signaling Pathway

Hu, Y. R., Xing, S. L., Chen, C., Shen, D. Z., & Chen, J. L. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666210608103831 · Cited by 21 · see citing works

Hydroxytyrosol–Donepezil Hybrids Play a Protective Role in an In Vitro Induced Alzheimer’s Disease Model and in Neuronal Differentiated Human SH-SY5Y Neuroblastoma Cells

Maiuolo, J., Costanzo, P., Masullo, M., D'Errico, A. A., Nasso, R., Bonacci, S., Mollace, V., Oliverio, M., & Arcone, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713461 · Cited by 21 · see citing works

Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome

Day, S. M., Yang, W., Wang, X., Stern, J. E., Zhou, X., Macauley, S. L., & Ma, T. (2019) · eNeuro · doi:10.1523/eneuro.0031-19.2019 · Cited by 21 · see citing works

Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice

Li, Q., Wang, X., Wang, Z. H., Lin, Z., Yang, J., Chen, J., Wang, R., Ye, W., Li, Y., Wu, Y., et al. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2121568 · Cited by 19 · see citing works

Protective effect of resveratrol on mitochondrial biogenesis during hyperoxia-induced brain injury in neonatal pups

Yang, M., Shen, Y., Zhao, S., Zhang, R., Dong, W., & Lei, X. (2023) · BMC Neuroscience · doi:10.1186/s12868-023-00797-1 · Cited by 19 · see citing works

The mTOR Inhibitor Rapamycin Prevents General Anesthesia-Induced Changes in Synaptic Transmission and Mitochondrial Respiration in Late Postnatal Mice

Ju, X., Ryu, M. J., Cui, J., Lee, Y., Park, S., Hong, B., Yoo, S., Lee, W. H., Shin, Y. S., Yoon, S.-H., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00004 · Cited by 19 · see citing works

Shenqi Yizhi granules protect hippocampus of AD transgenic mice by modulating on multiple pathological processes

Ren, J., Wei, D., An, H., Zhang, J., & Zhang, Z. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112869 · Cited by 19 · see citing works

Natural Bioactive Products and Alzheimer’s Disease Pathology: Lessons from Caenorhabditis elegans Transgenic Models

Navarro‐Hortal, M. D., Romero‐Márquez, J. M., Osta, S., Jiménez-Trigo, V., Muñoz-Ollero, P., & Varela‐López, A. (2022) · Diseases · doi:10.3390/diseases10020028 · Cited by 18 · see citing works

Mitochondrial and Cellular Function in Fibroblasts, Induced Neurons, and Astrocytes Derived from Case Study Patients: Insights into Major Depression as a Mitochondria-Associated Disease

Cardon, I., Grobecker, S., Kücükoktay, S., Bader, S., Jahner, T., Nothdurfter, C., Koschitzki, K., Berneburg, M., Weber, B. H. F., Stöhr, H., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020963 · Cited by 18 · see citing works

NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model

Magi, S., Piccirillo, S., Maiolino, M., Lariccia, V., & Amoroso, S. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102268 · Cited by 18 · see citing works

Impaired Synaptic Plasticity Mechanisms in Alzheimer’s Disease

Ebrahimi, R., Golzari, Z., Heidari‐Foroozan, M., Khosravi, A., Sharghi, S. G., Saleh, M., Salarvandian, S., & Esmaeilpour, K. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01712-9 · Cited by 19 · see citing works

Adiponectin Modulation by Genotype and Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer’s Disease

Alldred, M. J., Lee, S. H., & Ginsberg, S. D. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132994 · Cited by 17 · see citing works

A molecular framework for autistic experiences: Mitochondrial allostatic load as a mediator between autism and psychopathology

Mahony, C., & O’Ryan, C. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.985713 · Cited by 16 · see citing works

Mitochondrial Interaction with Serotonin in Neurobiology and Its Implication in Alzheimer’s Disease

Tian, J., Du, E. Y., & Guo, L. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230070 · Cited by 17 · see citing works

Involvement of mitochondria in Alzheimer’s disease pathogenesis and their potential as targets for phytotherapeutics

Maruthiyodan, S., Mumbrekar, K. D., & Guruprasad, K. P. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101868 · Cited by 17 · see citing works

Intrinsic aerobic capacity modulates Alzheimer’s disease pathological hallmarks, brain mitochondrial function and proteome during aging

Kugler, B. A., Lysaker, C. R., Franczak, E., Hauger, B. M., Csikós, V., Stopperan, J. A., Allen, J., Stanford, J. A., Koch, L. G., Britton, S. L., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01248-3 · Cited by 17 · see citing works

Hippocampal transcriptome-wide association study and pathway analysis of mitochondrial solute carriers in Alzheimer’s disease

Tian, J., Jia, K., Wang, T.-J., Guo, L., Xuan, Z.-Y., Michaelis, E. K., Swerdlow, R., & Du, H. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02958-0 · Cited by 13 · see citing works

Influence of Tau on Neurotoxicity and Cerebral Vasculature Impairment Associated with Alzheimer’s Disease

Rather, M. A., Khan, A., Jahan, S., Siddiqui, A. J., & Wang, L. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.042 · Cited by 16 · see citing works

Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons

Zhao, Y.-J., Tian, J., Sui, S.-M., Yuan, X.-D., Chen, H., Qu, C.-Q., Du, Y.-F., Guo, L., & Du, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-05168-5 · Cited by 13 · see citing works

Unveiling the multifaceted pathogenesis and therapeutic drugs of Alzheimer's disease: A comprehensive review

Peng, L., Zhang, Z., Li, Q., Song, Z., Yan, C., & Ling, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39217 · Cited by 16 · see citing works

Idebenone protects mitochondrial function against amyloid beta toxicity in primary cultured cortical neurons

Wang, H., Li, L., Jia, K., Wang, Q., Sui, S., Lin, Y., & He, Y. (2020) · Neuroreport · doi:10.1097/wnr.0000000000001526 · Cited by 14 · see citing works

Modulation of OSCP mitigates mitochondrial and synaptic deficits in a mouse model of Alzheimer's pathology

Gauba, E., Sui, S., Tian, J., Driskill, C. M., Jia, K., Yu, C., Rughwani, T., Wang, Q., Kroener, S., Guo, L., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.09.018 · Cited by 15 · see citing works

Emerging two-dimensional materials-enabled diagnosis and treatments of Alzheimer's disease: Status and future challenges

Song, S., Wu, J., Cheng, Y., Ma, L., Liu, T., Liu, J., Liu, J., Sotor, J. Z., & Luan, P. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.101028 · Cited by 14 · see citing works

Mitochondria and its epigenetic dynamics: Insight into synaptic regulation and synaptopathies

Gupta, S., Kishore, A., Rishi, V., & Aggarwal, A. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01530-3 · Cited by 13 · see citing works

Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer’s Disease

Cai, Q., & Tammineni, P. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160726 · Cited by 274 · see citing works

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

Du, H., Guo, L., Yan, S., Sosunov, A. A., McKhann, G. M., & ShiDu Yan, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006586107 · Cited by 704 · see citing works

Key Role of Mitochondria in Alzheimer’s Disease Synaptic Dysfunction

Cavallucci, V., Ferraina, C., & D’Amelio, M. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319360005 · Cited by 47 · see citing works

Synaptic Mitochondrial Pathology in Alzheimer's Disease

Du, H., Guo, L., & Yan, S. S. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4277 · Cited by 150 · see citing works

Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease

Tang, J. J., Oliveros, A., & Jang, M. (2019) · International Neurourology Journal · doi:10.5213/inj.1938036.018 · Cited by 56 · see citing works