A direct neuronal connection between the subparafascicular and ventrolateral arcuate nuclei in non-lactating female rats. Could this pathway play a role in the suckling-induced prolactin release?
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The neuronal pathways, through which prolactin secretion is regulated during lactation, have still not been fully explored. Studies indicate that the suckling stimulus travels through the spinal cord, the brain stem, and then reaches the hypothalamus. The focus of this present experiment is to further explore the neuronal connections between the brain stem and the arcuate nucleus that may be involved in suckling-induced prolactin release. Ante- and retrograde tracing techniques were used. To chemically characterize the explored neurons neuropeptide immunohistochemistry was applied. Previous studies have indicated that the peripeduncular nucleus is a relay of the suckling stimulus in the midbrain, conveying the information to the hypothalamus. In our experiments, we have found an additional cell group in the subparafascicular parvocellular nucleus located just behind the posterior thalamus that projects to the arcuate neurons. The injection of the retrograde tracer into the ventrolateral part of the arcuate nucleus labeled cells in the lateral subdivision of the subparafascicular parvocellular nucleus. Anterograde tracing from the subparafascicular parvocellular nucleus resulted in fiber labeling in the arcuate nucleus in close apposition with dynorphin immunopositive neurons. Double labeling revealed that a subpopulations of the subparafascicular parvocellular neurons projecting to the arcuate nucleus contained tuberoinfundibular peptide of 39 residues or calcitonin gene-related peptide. The presented findings suggest that the ascending fibers from the subparafascicular parvocellular nucleus might be in the pathway involved in the suckling-induced prolactin release.
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Neuroanatomical studies in lactating rats show that TIP39+ neurons project to the MPOA and the PVH.
“Based on neuroanatomical studies in lactating rats showing that TIP39 + neurons project to the MPOA (4, 30) and the PVH (3)”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [30]
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Self-citation
- Authors
- Szabo, F. K., Snyder, N., Usdin, T. B., & Hoffman, G. E.
- Affiliations
- University of Maryland, Baltimore (US)
- National Institute of Mental Health (US)
- Morgan State University (US)
- Corresponding author
- Hoffman, Gloria E.
- ORCID
- Usdin, Ted B.
- Venue
- Endocrine
- Published
- 2009-11-05
- Volume
- 37
- Issue
- 1
- Pages
- 62-70
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- PMC
- PMC3255077
- OpenAlex
- W2123932049
- Cited by
- 32
- References
- 38
- Citations by year
- 2024: 3 · 2023: 3 · 2021: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (ZIAMH002685)
- National Institute of Neurological Disorders and Stroke (NS 43788, R01NS043788)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- prolactin secretion regulation, dynorphin, calcitonin gene-related peptide, lactation, retrograde tracing, anterograde tracing, neuropeptides
- MeSH terms
- Animals, Arcuate Nucleus of Hypothalamus, Biotin, Dextrans, Dynorphins, Female, Hypothalamus, Posterior, Immunohistochemistry, Neural Pathways, Neurons, Neuropeptides, Prolactin, Protein Precursors, Stilbamidines, Tyrosine 3-Monooxygenase, Calcitonin Gene-Related Peptide, Rats, Sprague-Dawley, Galanin, Rats, Neuronal Tract-Tracers, Neuroanatomical Tract-Tracing Techniques
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