Tuberoinfundibular peptide of 39 residues is activated during lactation and participates in the suckling-induced prolactin release in rat
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Tuberoinfundibular peptide of 39 residues (TIP39) and the PTH-2 receptor (PTH2R) constitute a peptide-receptor neuromodulator system. Based on the abundance of TIP39 fibers and axonal terminals as well as PTH2R-containing neurons and their processes in the hypothalamic para- and periventricular and arcuate nuclei TIP39 has been suggested to play a role in neuroendocrine regulation. We showed previously that TIP39 expression decreased dramatically by adulthood. In the present study, using in situ hybridization histochemistry, real-time RT-PCR, and immunohistochemistry, we found that TIP39 mRNA and peptide expression levels are markedly elevated in the posterior intralaminar complex of the thalamus (PIL) of lactating dams, one of the three locations of TIP39-containing cell bodies in the brain. In addition, in mother rats, these TIP39 neurons showed Fos expression in response to pup exposure. Transection of TIP39 fibers originating in the PIL resulted in an ipsilateral disappearance of TIP39 immunoreactivity throughout the mediobasal hypothalamus of mother rats, suggesting that TIP39 fibers there arise from the PIL. To elucidate the function of TIP39 activation in dams, mothers separated from their pups for 4 h on postpartum d 9 received injection of a PTH2R antagonist into the lateral ventricle 5 min before returning the pups. Blood samples were taken seven times during the experimental period through jugular cannulae. The PTH2R antagonist administered in two different concentrations markedly inhibited suckling-induced elevation of plasma prolactin levels in a dose-dependent manner. These results suggest that TIP39 neurons in the PIL may regulate suckling-induced prolactin release in rat dams.
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The PIL is considered a relay center by which sensory information is conveyed to other brain regions for the generation of relevant social behaviors.
“The posterior intralaminar complex of the thalamus (PIL) is considered a relay center by which sensory information is conveyed to other brain regions for the generation of relevant social behaviors (1-6).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [2]
In maternal female rats, a subpopulation of PIL neurons expressing TIP39 is activated in response to pup exposure and suckling.
“In maternal female rats, a subpopulation of PIL neurons that expresses tuberoinfundibular peptide 39 (TIP39) were shown to be activated in response to pup exposure and suckling (2-4).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [2]
No statistical power estimation analyses were used to predetermine sample sizes; sample sizes were chosen to match previous publications.
“No statistical power estimation analyses were used to predetermine sample sizes, which instead were chosen to match previous publications (2, 11, 26-28).”
From Social Interaction Elicits Activity in Glutamatergic Neurons in the Posterior Intralaminar Complex of the Thalamus (2024) · cites this paper as [2]
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Puska, G., Szendi, V., & Dobolyi, Á. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105683 · Cited by 9 · see citing works
Suckling induced insulin-like growth factor-1 (IGF-1) release in mother rats
Lékó, A. H., Cservenák, M., & Dobolyi, Á. (2017) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2017.10.003 · Cited by 8 · see citing works
Proteomic Analysis of the Maternal Preoptic Area in Rats
Udvari, E. B., Völgyi, K., Kékesi, K. A., Simon, D., Hunyadi‐Gulyás, É., & Dobolyi, Á. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02755-y · Cited by 6 · see citing works
Microglia depletion prevents lactation by inhibition of prolactin secretion
Csikós, V., Oláh, S., Dóra, F., Arrasz, N., Cservenák, M., & Dobolyi, Á. (2023) · iScience · doi:10.1016/j.isci.2023.106264 · Cited by 5 · see citing works
Arakawa, H., & Tokashiki, M. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16520 · Cited by 4 · see citing works
Absence epileptic activity in Wistar Albino Glaxo Rijswijk rat mothers
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Neural circuits for mammalian parental behaviour
Jamieson, B. B., & Kohl, J. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01073-x · Cited by 2 · see citing works
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0008 · Cited by 2 · see citing works
Hormonal Control of Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0003 · Cited by 2 · see citing works
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0002 · Cited by 1 · see citing works
Puska, G., Szendi, V., Egyed, M., Dimén, D., Cservenák, M., & Dobolyi, Á. (2025) · Brain Structure and Function · doi:10.1007/s00429-024-02870-9 · Cited by 1 · see citing works
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Social behavior: Closing the gap for close encounters
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Mood, Food, and Fertility: Adaptations of the Maternal Brain
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Central Neural Circuits Regulating Maternal Behavior in Nonhuman Mammals
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Alloparental Behavior and Paternal Behavior in Nonhuman Mammals
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Neuroanatomy of Tuberoinfundibular Peptide 39 Related to Neuroendocrine and Behavioral Regulations
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A Novel Parathyroid Protein in Chicken: Origin, Expression and Function
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Who Are You and Where Am I? New Insights Into How Animals Determine Their Social Context
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Evolutionary Perspectives on the Parental Brain
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0011
Anxiety Reduction and Maternal Aggression in Postpartum Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0006
Development of the Parental Brain in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0009
Development of the Parental Brain in Humans
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0010
Brain Mechanisms Regulating Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0004
Parathyroid hormone receptors in GtoPdb v.2021.2
Bisello, A., Chorev, M., Friedman, P. A., Gardella, T., Hills, R., Jueppner, H. W., Martin, T. J., Nissenson, R. A., Potts, J. T. J., Silve, C., et al. (2021) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f53/2021.2
Parathyroid hormone receptors in GtoPdb v.2021.3
Bisello, A., Chorev, M., Friedman, P. A., Gardella, T., Hills, R., Jueppner, H. W., Martin, T. J., Nissenson, R. A., Potts, J. T. J., Silve, C., et al. (2021) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f53/2021.3
The neurogenetic background of parental care
Fazekas, E. A. (2021) · Eötvös Loránd Tudományegyetem · doi:10.15476/elte.2020.149
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0006
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0003
Abbreviations Used for Major Brain Regions
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0007
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0004
- Authors
- Cservenák, M., Bodnár, I., Usdin, T. B., Palkovits, M., Nagy, G. M., & Dobolyi, A.
- Affiliations
- Neuromorphological and Neuroendocrine Research Laboratory, Departments of Anatomy, Histology, and Embryology (M.C., M.P., A.D.), Hungarian Academy of Sciences and Semmelweis University, H-1094 Budapest, Hungary
- Human Morphology and Developmental Biology (I.B., G.M.N.), Hungarian Academy of Sciences and Semmelweis University, H-1094 Budapest, Hungary
- National Institutes of Health (US)
- ORCID
- Usdin, Ted B.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2010-09-22
- Volume
- 151
- Issue
- 12
- Pages
- 5830-5840
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC2999487
- OpenAlex
- W2095450885
- Cited by
- 82
- References
- 47
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 19 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Semmelweis University Repository (Semmelweis University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- lactation, hypothalamic neurons, maternal behavior, neuroendocrine regulation, prolactin secretion
- MeSH terms
- Amino Acid Sequence, Animals, Animals, Suckling, Dose-Response Relationship, Drug, Female, Gene Expression Regulation, Immunohistochemistry, Lactation, Neuropeptides, Prolactin, RNA, Messenger, Thalamus, Rats, Wistar, Reverse Transcriptase Polymerase Chain Reaction, Receptor, Parathyroid Hormone, Type 2, Rats
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