Cited by 101Liver Disease Diagnosis and TreatmentVitamin D Research StudiesAdipokines, Inflammation, and Metabolic Diseases

Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease.

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Cimini, Flavia A, Barchetta, Ilaria, Carotti, Simone, Bertoccini, Laura, Baroni, Marco G, Vespasiani-Gentilucci, Umberto, Cavallo, Maria-Gisella, Morini, Sergio·2017·World Journal of Gastroenterology

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood. Over the years many studies have proposed various pathophysiological hypotheses, among which the currently most widely accepted is the "multiple parallel hits" theory. According to this model, lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury, inflammation and fibrosis. Among these factors, adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role. Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue, and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD. Furthermore, given the strong association between these conditions, current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD. The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction, and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity, together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD.

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Authors
Cimini, F. A., Barchetta, I., Carotti, S., Bertoccini, L., Baroni, M. G., Vespasiani-Gentilucci, U., Cavallo, M.-G., & Morini, S.
Affiliations
Università Campus Bio-Medico (IT)
Corresponding author
Morini, Sergio
Venue
World Journal of Gastroenterology
Published
2017
Volume
23
Issue
19
Pages
3407
ISSN
1007-9327 (ISSN-L)
OpenAlex
W2616329440
Cited by
101
References
166
Citations by year
2026: 4 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 9 · 2021: 13 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 4
FWCI
1.34
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
  • Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
non-alcoholic fatty liver disease, adipose tissue dysfunction, vitamin D deficiency, insulin resistance, low-grade inflammation, obesity, hepatic lipid accumulation, vitamin D supplementation, liver fibrosis
MeSH terms
Adipose Tissue, Animals, Fibrosis, Humans, Inflammation, Lipids, Liver, Obesity, Vitamin D, Vitamin D Deficiency, Hepatocytes, Adiposity, Mice, Adipokines, Non-alcoholic Fatty Liver Disease

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