Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease.
Open accessAbstract
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Its pathogenesis is complex and not yet fully understood. Over the years many studies have proposed various pathophysiological hypotheses, among which the currently most widely accepted is the "multiple parallel hits" theory. According to this model, lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury, inflammation and fibrosis. Among these factors, adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role. Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue, and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD. Furthermore, given the strong association between these conditions, current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD. The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction, and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity, together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD.
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NAFLD development is associated with the insulin receptor, low-grade inflammation, and ectopic lipid deposition.
“its development is associated with the insulin receptor, low-grade inflammation, and ectopic lipid deposition”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Cimini et al., 2017
The Abstract links chronic low-grade inflammation to NAFLD development, and the Introduction’s “Pathogenesis of NAFLD” section describes ectopic fat distribution and hepatic lipid accumulation. That section discusses insulin resistance and impaired phosphorylation of insulin receptor substrate-2, but does not identify the insulin receptor itself as an associated factor. Page numbers were not supplied for these passages. (LLM, conf=0.87)
Experimental — accuracy not yet measuredNAFLD is exacerbated with AT dysfunction.
“Consequently, NAFLD is exacerbated with AT dysfunction”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Cimini et al., 2017
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- Authors
- Cimini, F. A., Barchetta, I., Carotti, S., Bertoccini, L., Baroni, M. G., Vespasiani-Gentilucci, U., Cavallo, M.-G., & Morini, S.
- Affiliations
- Università Campus Bio-Medico (IT)
- Corresponding author
- Morini, Sergio
- ORCID
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2017
- Volume
- 23
- Issue
- 19
- Pages
- 3407
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC5442077
- OpenAlex
- W2616329440
- Cited by
- 101
- References
- 166
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 9 · 2021: 13 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 4
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- non-alcoholic fatty liver disease, adipose tissue dysfunction, vitamin D deficiency, insulin resistance, low-grade inflammation, obesity, hepatic lipid accumulation, vitamin D supplementation, liver fibrosis
- MeSH terms
- Adipose Tissue, Animals, Fibrosis, Humans, Inflammation, Lipids, Liver, Obesity, Vitamin D, Vitamin D Deficiency, Hepatocytes, Adiposity, Mice, Adipokines, Non-alcoholic Fatty Liver Disease
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