Intestinal absorption and buccal absorption of liquid levothyroxine
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Some patients may squeeze the liquid LT4 ampoule directly into their mouth for convenience, which may cause buccal absorption and poor efficacy.
“Some patients may simply squeeze the liquid LT4 ampoule directly into their mouth for convenience, which may cause buccal absorption and poor efficacy (217).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [217]
Benvenga and Di Bari observed abnormally high TSH levels in patients with inappropriate (undiluted) oral administration of liquid LT4.
“However, Benvenga and Di Bari observed abnormally high TSH levels in patients with inappropriate (undiluted) oral administration of liquid LT4—showing that use of a liquid formulation is not a panacea [ 46 ].”
From Factors influencing the levothyroxine dose in the hormone replacement therapy of primary hypothyroidism in adults (2022) · cites this paper as [46]
Cites
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A review of the pharmacokinetics of levothyroxine for the treatment of hypothyroidism
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Self-citationVita, R., Saraceno, G., Trimarchi, F., & Benvenga, S. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2684 · Cited by 99 · see citing works
Self-citationThe administration of l -thyroxine as soft gel capsule or liquid solution
Vita, R., Fallahi, P., Antonelli, A., & Benvenga, S. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.918101 · Cited by 93 · see citing works
Self-citationVita, R., Saraceno, G., Trimarchi, F., & Benvenga, S. (2013) · Endocrine · doi:10.1007/s12020-012-9772-2 · Cited by 91 · see citing works
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When thyroid hormone replacement is ineffective?
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Self-citationLiquid and softgel levothyroxine use in clinical practice: state of the art
Virili, C., Trimboli, P., Romanelli, F., & Centanni, M. (2016) · Endocrine · doi:10.1007/s12020-016-1035-1 · Cited by 71 · see citing works
Understanding the Oral Mucosal Absorption and Resulting Clinical Pharmacokinetics of Asenapine
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Self-citationLevothyroxine absorption in health and disease, and new therapeutic perspectives.
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Levothyroxine: conventional and novel drug delivery formulations.
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Novel thyroxine formulations: a further step toward precision medicine
Virili, C., Trimboli, P., & Centanni, M. (2019) · Endocrine · doi:10.1007/s12020-019-02049-x · Cited by 41 · see citing works
Levothyroxine sodium pentahydrate tablets – formulation considerations
Kaur, N., & Suryanarayanan, R. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.08.006 · Cited by 19 · see citing works
Peirce, C., Ippolito, S., Lanas, A., Pesce, M., Pontieri, G., Arpaia, D., Sarnelli, G., & Biondi, B. (2018) · Endocrine · doi:10.1007/s12020-017-1367-5 · Cited by 16 · see citing works
- Authors
- Benvenga, S., & Di Bari, F.
- Affiliations
- University of Messina (IT)
- ORCID
- Benvenga, Salvatore
- Venue
- Endocrine
- Published
- 2017-03-07
- Volume
- 58
- Issue
- 3
- Pages
- 591-594
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2593396652
- Cited by
- 8
- References
- 20
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2017: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- levothyroxine, buccal absorption, intestinal absorption, oral drug absorption, liquid formulation, thyroid hormones
- MeSH terms
- Administration, Oral, Adult, Aged, Drug Compounding, Female, Humans, Hypothyroidism, Intestinal Absorption, Male, Middle Aged, Thyrotropin, Thyroxine, Oral Mucosal Absorption
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