Impact of single nucleotide polymorphisms of base excision repair genes on DNA damage and efficiency of DNA repair in recurrent depression disorder
Open accessAbstract
Elevated level of DNA damage was observed in patients with depression. Furthermore, single nucleotide polymorphisms (SNPs) of base excision repair (BER) genes may modulate the risk of this disease. Therefore, the aim of this study was to delineate the association between DNA damage, DNA repair, the presence of polymorphic variants of BER genes, and occurrence of depression. The study was conducted on peripheral blood mononuclear cells of 43 patients diagnosed with depression and 59 controls without mental disorders. Comet assay was used to assess endogenous (oxidative) DNA damage and efficiency of DNA damage repair (DRE). TaqMan probes were employed to genotype 12 SNPs of BER genes. Endogenous DNA damage was higher in the patients than in the controls, but none of the SNPs affected its levels. DRE was significantly higher in the controls and was modulated by BER SNPs, particularly by c.977C>G-hOGG1, c.972G>C-MUTYH, c.2285T>C-PARP1, c.580C>T-XRCC1, c.1196A>G-XRCC1, c.444T>G-APEX1, c.-468T>G-APEX1, or c.*50C>T-LIG3. Our study suggests that both oxidative stress and disorders in DNA damage repair mechanisms contribute to elevated levels of DNA lesions observed in depression. Lower DRE can be partly attributed to the presence of specific SNP variants.
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Higher oxidative stress, lower antioxidants, and more oxidative stress-related DNA/RNA damage are linked to clinical markers of major depressive disorder progression such as greater chronicity, more episodes, and treatment resistance.
“greater oxidative stress, lower antioxidant, and greater oxidative stress-related DNA/RNA damage have been linked to clinical markers of MDD illness progression, including greater chronicity, more MDEs, and treatment resistance (98,108–113).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [110]
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- Authors
- Czarny, P., Kwiatkowski, D., Toma, M., Kubiak, J., Sliwinska, A., Talarowska, M., Szemraj, J., Maes, M., Galecki, P., & Sliwinski, T.
- Affiliations
- University of Łódź (PL)
- Medical University of Lodz (PL)
- Universidade Estadual de Londrina (BR)
- Venue
- Molecular Neurobiology
- Published
- 2016-06-21
- Volume
- 54
- Issue
- 6
- Pages
- 4150-4159
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- PMC
- PMC5509815
- OpenAlex
- W2462592384
- Cited by
- 43
- References
- 34
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 4
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Molecular Neurobiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Polish National Science Centre (DEC-2014/13/N/NZ7/00232)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- recurrent depression, base excision repair, single nucleotide polymorphisms, DNA damage, DNA repair efficiency, oxidative DNA damage, oxidative stress, OGG1, MUTYH, PARP1, XRCC1, APEX1, LIG3, genetic susceptibility, peripheral blood mononuclear cells
- MeSH terms
- Alleles, Depression, DNA Damage, DNA Repair, Humans, Middle Aged, Oxidation-Reduction, Risk Factors, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, DNA Glycosylases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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