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Cited by 66Stress Responses and CortisolNeuroscience and Neuropharmacology ResearchTreatment of Major Depression

Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats

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Arcego, Danusa Mar, Toniazzo, Ana Paula, Krolow, Rachel, Lampert, Carine, Berlitz, Carolina, dos Santos Garcia, Emily, do Couto Nicola, Fabrício, Hoppe, Juliana Bender +4 more·2018·Molecular Neurobiology
DOI 10.1007/s12035-017-0538-y
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Abstract

During development, the brain goes through fundamental processes, including organization of neural networks and plasticity. Environmental interventions may change initial brain programming, leading to long-lasting effects and altering the susceptibility to psychopathologies, including depression disorder. It is known that depression is a psychiatric disorder with a high prevalence worldwide, including high rates among adolescents. In this study, we evaluated whether social isolation in the prepubertal period and chronic use of high-fat diet (HFD) may induce depressive-like behavior in male adult rats. We also investigated hippocampal plasticity markers and neurotransmitter systems. We found both social isolation and HFD induced a depressive-like behavior in the forced swimming task. Moreover, chronic HFD reduced synaptic markers in hippocampus, demonstrated by reductions in βIII-tubulin (neuronal marker), PSD-95, SNAP-25, and neurotrophin-3. The HFD group also presented decreased glutamatergic and GABAergic receptors subunits. On the other hand, stress affected hippocampal brain-derived neurotrophic factor (BDNF) signaling pathways, and increased expression of subunit of the NMDA receptor (NR2A). Both factors (stress and diet) decreased GR in the hippocampus without affecting plasma corticosterone at basal levels. Interactions between early stress and HFD access were observed only in the BNDF receptor (tropomyosin receptor kinase B; TrkB) and synaptophysin. In summary, these findings showed that a brief social isolation and chronic HFD, during a sensitive developmental period, cause depressive-like behavior in adulthood. The mechanisms underlying these behavioral effects may involve changes in the levels of synaptic proteins in hippocampus: HFD consumption appears to affect synaptic markers, while social isolation affected BDNF signaling more significantly.

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  • Dietary aspects and diet components (e.g., vitamin D, folate, selenium intake, iron, vitamin B12, vitamin K, fiber intake, zinc) as well as diet-related inflammatory potential have been linked to depression outcomes.

    “dietary aspects and diet components (ex. vitamin D, folate, selenium intake, iron, vitamin B12, vitamin K, fiber intake, zinc) as well as diet-related inflammatory potential have been linked to depression outcomes [161,208,236,312,396,402,403,404,405,406,407,408,409,410,411,412,413,414,415,416,417,418,419,420,421,422,423,424,425,426,427,428].”

    From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [208]

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Authors
Arcego, D. M., Toniazzo, A. P., Krolow, R., Lampert, C., Berlitz, C., dos Santos Garcia, E., do Couto Nicola, F., Hoppe, J. B., Gaelzer, M. M., Klein, C. P., Lazzaretti, C., & Dalmaz, C.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
Corresponding author
Arcego, Danusa Mar
ORCID
Venue
Molecular Neurobiology
Publisher
Springer Science and Business Media LLC
Published
2017-04-27
Volume
55
Issue
4
Pages
2740-2753
ISSN
  • 0893-7648 (ISSN-L)
  • 1559-1182
DOI
10.1007/s12035-017-0538-y
OpenAlex
W2609163510
Cited by
66
References
72
Citations by year
2026: 5 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 14 · 2020: 6 · 2019: 9 · 2018: 3 · 2017: 5
FWCI
3.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Lume (Universidade Federal do Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
Funders
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
high-fat diet, early life stress, social isolation, depression-like behavior, hippocampal plasticity, synaptic proteins, BDNF signaling, TrkB, glucocorticoid receptor, glutamate receptors, GABA receptors, neurotrophin-3, synaptophysin, forced swim test, developmental programming, depression vulnerability
MeSH terms
Animals, Behavior, Animal, Depression, gamma-Aminobutyric Acid, Hippocampus, Male, Models, Biological, Neuronal Plasticity, Receptors, Glucocorticoid, Sexual Maturation, Social Isolation, Stress, Psychological, Sucrose, Biomarkers, Rats, Wistar, Glutamic Acid, Diet, High-Fat

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