Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry
Open accessAbstract
Background The biological mechanisms that link the development of depression to metabolic disorders such as obesity and diabetes remain obscure. Dopamine- and plasticity-related signalling in mesolimbic reward circuitry is implicated in the pathophysiology and aetiology of depression.Objective To determine the impact of a palatable high-fat diet (HFD) on depressive-like behaviour and biochemical alterations in brain reward circuitry in order to understand the neural processes that may contribute to the development of depression in the context of diet-induced obesity (DIO).Methods Adult male C57Bl6 mice were placed on a HFD or ingredient-matched, low-fat diet for 12 weeks. At the end of the diet regimen, we assessed anxiety and depressive-like behaviour, corticosterone levels and biochemical changes in the midbrain and limbic brain regions. Nucleus accumbens (NAc), dorsolateral striatum (DLS) and ventral tegmental area dissections were subjected to SDS-PAGE and immunoblotting using antibodies against D1A receptor, D2 receptor, brain-derived neurotrophic factor (BDNF), phospho-DARPP-32(thr75), phospho-CREB and ΔFosB.Results HFD mice showed significant decreases in open arm time and centre time activity in elevated plus maze and open field tasks, respectively, and increased immobility (behavioural despair) in the forced swim test. Corticosterone levels following acute restraint stress were substantially elevated in HFD mice. HFD mice had significantly higher D2R, BDNF and ΔFosB, but reduced D1R, protein expression in the NAc. Notably, the expression of BDNF in both the NAc and DLS and phospho-CREB in the DLS was positively correlated with behavioural despair.Conclusions Our results demonstrate that chronic consumption of high-fat food and obesity induce plasticity-related changes in reward circuitry that are associated with a depressive-like phenotype. As increases in striatal BDNF and CREB activity are well implicated in depressive behaviour and reward, we suggest these signalling molecules may mediate the effects of high-fat feeding and DIO to promote negative emotional states and depressive-like symptomology.
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Prolonged high-fat diet elicits metabolic dysfunction and increases anxiety- and depressive-like behaviors in rodents.
“To this end, rodent research has revealed that prolonged high-fat diet (HFD) elicits metabolic dysfunction and increases anxiety-and depressive-like behaviors [28][29][30][31][32][33][34][35][36], heightens stress and hypothalamic-pituitary-adrenal (HPA) responses [37,38], and triggers neurobehavioral deficits associated with blunted mesolimbic dopamine function [39][40][41].”
From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [28]
BDNF affects the regulation of feeding and energy metabolism.
“BDNF is known to affect the regulation of feeding and energy metabolism [218–221].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [221]
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Cites
Behavioral despair in mice: a primary screening test for antidepressants.
Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,275 · see citing works
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864 · see citing works
New approaches to antidepressant drug discovery: beyond monoamines
Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589 · see citing works
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561 · see citing works
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Association between obesity and psychiatric disorders in the US adult population
Simon, G. E., Von Korff, M., Saunders, K., Miglioretti, D. L., Crane, P. K., van Belle, G., & Kessler, R. C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.7.824 · Cited by 1,338 · see citing works
Molecular mechanisms of drug addiction
Nestler, E. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.031 · Cited by 1,108 · see citing works
Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000 · see citing works
Mouse and rat <i>BDNF</i> gene structure and expression revisited
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943 · see citing works
Lyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., & Tessarollo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15239 · Cited by 862 · see citing works
BDNF regulates eating behavior and locomotor activity in mice
Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1290 · Cited by 806 · see citing works
Lucki, I. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00010 · Cited by 803 · see citing works
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767 · see citing works
Prospective association between obesity and depression: evidence from the Alameda County Study
Roberts, R. E., Deleger, S., Strawbridge, W. J., & Kaplan, G. A. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802204 · Cited by 674 · see citing works
Leptin Regulation of the Mesoaccumbens Dopamine Pathway
Fulton, S., Pissios, P., Manchon, R. P., Stiles, L., Frank, L., Pothos, E. N., Maratos-Flier, E., & Flier, J. S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.006 · Cited by 644 · see citing works
Self-citationVolkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Thanos, P. K., Logan, J., Alexoff, D., Ding, Y.-S., Wong, C., Ma, Y., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.002 · Cited by 573 · see citing works
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
Bibb, J. A., Snyder, G. L., Nishi, A., Yan, Z., Meijer, L., Fienberg, A. A., Tsai, L., Kwon, Y. T., Girault, J., Czernik, A. J., et al. (1999) · Nature · doi:10.1038/45251 · Cited by 553 · see citing works
Gray, J. A., Yeo, G. S. H., Cox, J. J., Morton, J., Adlam, A., Keogh, J. M., Yanovski, J. A., Gharbawy, A. E., Han, J. C., Tung, Y. C. L., et al. (2006) · Diabetes · doi:10.2337/db06-0550 · Cited by 515 · see citing works
Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509 · see citing works
Barrot, M., Olivier, J. D. A., Perrotti, L. I., DiLeone, R. J., Berton, O., Eisch, A. J., Impey, S., Storm, D. R., Neve, R. L., Yin, J. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172091899 · Cited by 508 · see citing works
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
Bibb, J. A., Chen, J., Taylor, J. R., Svenningsson, P., Nishi, A., Snyder, G. L., Yan, Z., Sagawa, Z. K., Ouimet, C. C., Nairn, A. C., et al. (2001) · Nature · doi:10.1038/35066591 · Cited by 480 · see citing works
ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, D. L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2551 · Cited by 479 · see citing works
Depression and anxiety among US adults: associations with body mass index
Zhao, G., Ford, E. S., Dhingra, S., Li, C., Strine, T. W., & Mokdad, A. H. (2009) · International Journal of Obesity · doi:10.1038/ijo.2008.268 · Cited by 423 · see citing works
Molecular Neurobiology of Addiction
Nestler, E. J. (2001) · American Journal on Addictions · doi:10.1080/105504901750532094 · Cited by 412 · see citing works
Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity
Geiger, B. M., Haburcak, M., Avena, N. M., Moyer, M. C., Hoebel, B. G., & Pothos, E. N. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.02.007 · Cited by 403 · see citing works
ΔFosB: a molecular switch for long-term adaptation in the brain
McClung, C. A., Ulery, P. G., Perrotti, L. I., Zachariou, V., Berton, O., & Nestler, E. J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.05.014 · Cited by 398 · see citing works
Common Molecular and Cellular Substrates of Addiction and Memory
Nestler, E. J. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4084 · Cited by 354 · see citing works
Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome
Han, J. C., Liu, Q., Jones, M. S., Levinn, R. L., Menzie, C. M., Jefferson‐George, K., Adler‐Wailes, D. C., Sanford, E. L., Lacbawan, F. L., Uhl, G. R., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801119 · Cited by 352 · see citing works
Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works
Conti, A. C., Cryan, J. F., Dalvi, A., Lucki, I., & Blendy, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03262.2002 · Cited by 328 · see citing works
Davis, J. F., Tracy, A. L., Schurdak, J. D., Tschöp, M. H., Lipton, J. W., Clegg, D. J., & Benoit, S. C. (2008) · Behavioral Neuroscience · doi:10.1037/a0013111 · Cited by 307 · see citing works
Tannenbaum, B. M., Brindley, D. N., Tannenbaum, G. S., Dallman, M. F., McArthur, M. D., & Meaney, M. J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1168 · Cited by 289 · see citing works
Impaired CNS Leptin Action Is Implicated in Depression Associated with Obesity
Yamada, N., Katsuura, G., Ochi, Y., Ebihara, K., Kusakabe, T., Hosoda, K., & Nakao, K. (2011) · Endocrinology · doi:10.1210/en.2011-0004 · Cited by 247 · see citing works
Nestler, E. J., Kelz, M. B., & Chen, J. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01191-3 · Cited by 246 · see citing works
McClean, P. L., Irwin, N., Cassidy, R. S., Holst, J. J., Gault, V. A., & Flatt, P. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00460.2007 · Cited by 237 · see citing works
Relationship of obesity to depression: a family-based study
Dong, C., Sanchez, L. E., & Price, R. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802626 · Cited by 234 · see citing works
IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
Russo, S. J., Bolaños, C. A., Theobald, D. E. H., DeCarolis, N. A., Renthal, W. R., Kumar, A., Winstanley, C. A., Renthal, N. E., Wiley, M. D., Self, D. W., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1812 · Cited by 215 · see citing works
Ca2+-sensing receptors in intestinal epithelium
Gama, L., Baxendale‐Cox, L. M., & Breitwieser, G. E. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.4.c1168 · Cited by 214 · see citing works
Evidence for defective mesolimbic dopamine exocytosis in obesity‐prone rats
Geiger, B. M., Behr, G. G., Frank, L. E., Caldera-Siu, A. D., Beinfeld, M. C., Kokkotou, E. G., & Pothos, E. N. (2008) · The FASEB Journal · doi:10.1096/fj.08-110759 · Cited by 194 · see citing works
Alsiö, J., Olszewski, P. K., Norbäck, A. H., Gunnarsson, Z. E., Levine, A. S., Pickering, C., & Schiöth, H. B. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.046 · Cited by 189 · see citing works
Olson, V. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0345-05.2005 · Cited by 186 · see citing works
Pandey, S. C., Zhang, H., Roy, A., & Misra, K. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4988-05.2006 · Cited by 174 · see citing works
Maniam, J., & Morris, M. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.10.013 · Cited by 173 · see citing works
Fulton, S. (2010) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2009.10.003 · Cited by 164 · see citing works
Self-citationRegulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens
Barrot, M., Wallace, D. L., Bolaños, C. A., Graham, D. L., Perrotti, L. I., Neve, R. L., Chambliss, H., Yin, J. C. P., & Nestler, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500587102 · Cited by 162 · see citing works
High-fat diet selectively protects against the effects of chronic social stress in the mouse
Finger, B. C., Dinan, T. G., & Cryan, J. F. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.072 · Cited by 161 · see citing works
Cordeira, J., Frank, L., Sena‐Esteves, M., Pothos, E. N., & Rios, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5768-09.2010 · Cited by 142 · see citing works
Maniam, J., & Morris, M. J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.05.012 · Cited by 140 · see citing works
Molecular and genetic substrates linking stress and addiction
Briand, L. A., & Blendy, J. A. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.002 · Cited by 125 · see citing works
BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events
Gooney, M., Messaoudi, E., Maher, F. O., Bramham, C. R., & Lynch, M. A. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.01.003 · Cited by 124 · see citing works
ΔFosB-Mediated Alterations in Dopamine Signaling Are Normalized by a Palatable High-Fat Diet
Teegarden, S. L., Nestler, E. J., & Bale, T. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.007 · Cited by 68 · see citing works
Role of Cdk5 in Drug Abuse and Plasticity
Benavides, D. R., & Bibb, J. A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.041 · Cited by 64 · see citing works
CREB Gene Transcription Factors: Role in Molecular Mechanisms of Alcohol and Drug Addiction
Pandey, S. C., Chartoff, E. H., Carlezon, W. A., Zou, J., Zhang, H., Kreibich, A. S., Blendy, J. A., & Crews, F. T. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000153550.31168.1d · Cited by 58 · see citing works
The Nuclear Transcription Factor CREB: Involvement in Addiction, Deletion Models and Looking Forward
McPherson, C. S., & Lawrence, A. J. (2007) · Current Neuropharmacology · doi:10.2174/157015907781695937 · Cited by 45 · see citing works
Rauggi, R., Scheggi, S., Cassanelli, A., Montis, M. G. D., Tagliamonte, A., & Gambarana, C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02920.x · Cited by 31 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Dong C, Sanchez LE, Price RA. Relationship of obesity to depression: a family- based study. Int J Obes Relat Metab Disord 2004; 28: 790 --795.
- Russo SJ, Bolanos CA, Theobald DE, DeCarolis NA, Renthal W, Kumar A et al. IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nat Neurosci 2007; 10: 93--99.
- Nestler EJ, Kelz MB, Chen J. [Delta]FosB: a molecular mediator of long-term neural and behavioral plasticity. Brain Res 1999; 835: 10 --17.
- Teegarden SL, Nestler EJ, Bale TL. Delta]FosB-mediated alterations in dopamine signaling are normalized by a palatable high-fat diet. Biol Psychiatry 2008; 64: 941 --950.
- Maniam J, Morris MJ. Palatable cafeteria diet ameliorates anxiety and depression- like symptoms following an adverse early environment. Psychoneuroendocrinology 2010; 35: 717 --728.
Cited by
Sorted by citations
Stress & the gut-brain axis: Regulation by the microbiome
Foster, J. A., Rinaman, L., & Cryan, J. F. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.03.001 · Cited by 1,150 · see citing works
The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857 · see citing works
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
The menace of obesity to depression and anxiety prevalence
Fulton, S., Décarie-Spain, L., Fioramonti, X., Guiard, B., & Nakajima, S. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.10.005 · Cited by 441 · see citing works
“The effects of DIO on the hippocampus have received considerable attention because of the well-reported effects of HFD to elicit cognitive and emotional impairments [102].”
BackgroundInfluentialSelf-citationHigh-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation
Dutheil, S., Ota, K. T., Wohleb, E. S., Rasmussen, K., & Duman, R. S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.357 · Cited by 355 · see citing works
Luna, R. A., & Foster, J. A. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.10.007 · Cited by 325 · see citing works
Metabolic disturbances connecting obesity and depression
Hryhorczuk, C., Sharma, S., & Fulton, S. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00177 · Cited by 322 · see citing works
Self-citationDe Luca, M., Angrisani, L., Himpens, J., Busetto, L., Scopinaro, N., Weiner, R., Sartori, A., Stier, C., Lakdawala, M., Bhasker, A. G., et al. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2271-4 · Cited by 296 · see citing works
Association between Systemic Immune-Inflammation Index and Diabetic Depression
Wang, J., Zhou, D., Dai, Z., & Li, X. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s285000 · Cited by 238 · see citing works
André, C., Dinel, A.-L., Ferreira, G., Layé, S., & Castanon, N. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.012 · Cited by 241 · see citing works
Sharma, S., Fernandes, M. F., & Fulton, S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.197 · Cited by 231 · see citing works
The role of the gut microbiota in dietary interventions for depression and anxiety
Bear, T. L. K., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa016 · Cited by 229 · see citing works
Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism
Soto, M., Herzog, C., Pacheco, J. A., Fujisaka, S., Bullock, K., Clish, C. B., & Kahn, C. R. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0086-5 · Cited by 216 · see citing works
The role of reward circuitry and food addiction in the obesity epidemic: An update
Leigh, S.-J., & Morris, M. J. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2016.12.013 · Cited by 191 · see citing works
Crosstalk between the microbiota-gut-brain axis and depression
Du, Y., Gao, X.-R., Peng, L., & Ge, J.-F. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04097 · Cited by 191 · see citing works
Role of Adiposity-Driven Inflammation in Depressive Morbidity
Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works
High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice
Zemdegs, J., Quesseveur, G., Jarriault, D., Pénicaud, L., Fioramonti, X., & Guiard, B. P. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13343 · Cited by 180 · see citing works
Hassan, A. M., Mancano, G., Kashofer, K., Fröhlich, E. E., Matak, A., Mayerhofer, R., Reichmann, F., Olivares, M., Neyrinck, A. M., Delzenne, N. M., et al. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1465713 · Cited by 166 · see citing works
Park, S., Lee, Y., & Lee, J. H. (2016) · Nutrition Journal · doi:10.1186/s12937-016-0204-7 · Cited by 127 · see citing works
Hryhorczuk, C., Florea, M., Rodaros, D., Poirier, I., Daneault, C., Des Rosiers, C., Arvanitogiannis, A., Alquier, T., & Fulton, S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.207 · Cited by 119 · see citing works
Self-citationBeilharz, J. E., Kaakoush, N. O., Maniam, J., & Morris, M. J. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.38 · Cited by 116 · see citing works
Davis, D. J., Hecht, P. M., Jasarevic, E., Beversdorf, D. Q., Will, M. J., Fritsche, K., & Gillespie, C. H. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.09.003 · Cited by 112 · see citing works
Micanti, F., Iasevoli, F., Cucciniello, C., Costabile, R., Loiarro, G., Pecoraro, G., Pasanisi, F., Rossetti, G., & Galletta, D. (2017) · Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity · doi:10.1007/s40519-016-0275-7 · Cited by 107 · see citing works
McAllan, L., Skuse, P., Cotter, P. D., Connor, P. O., Cryan, J. F., Ross, R. P., Fitzgerald, G., Roche, H. M., & Nilaweera, K. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088904 · Cited by 106 · see citing works
Décarie-Spain, L., Sharma, S., Hryhorczuk, C., Issa-Garcia, V., Barker, P. A., Arbour, N., Alquier, T., & Fulton, S. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.018 · Cited by 107 · see citing works
Self-citationAgusti, A., Moya-Pérez, A., Campillo, I., Montserrat-de la Paz, S., Cerrudo, V., Perez-Villalba, A., & Sanz, Y. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0768-z · Cited by 85 · see citing works
Arcego, D. M., Toniazzo, A. P., Krolow, R., Lampert, C., Berlitz, C., dos Santos Garcia, E., do Couto Nicola, F., Hoppe, J. B., Gaelzer, M. M., Klein, C. P., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0538-y · Cited by 66 · see citing works
Liu, C., Carvalho, A., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130204031 · Cited by 61 · see citing works
Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats
Rebolledo-Solleiro, D., Roldán-Roldán, G., Díaz, D., Velasco, M., Larqué, C., Rico-Rosillo, G., Vega-Robledo, G. B., Zambrano, E., Hiriart, M., & Pérez de la Mora, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176554 · Cited by 64 · see citing works
Auguste, S., Fisette, A., Fernandes, M. F., Hryhorczuk, C., Poitout, V., Alquier, T., & Fulton, S. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw014 · Cited by 59 · see citing works
Self-citationWu, H., Lv, W., Pan, Q., Kalavagunta, P. K., Liu, Q., Qin, G., Cai, M., Zhou, L., Wang, T., Xia, Z., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.022 · Cited by 54 · see citing works
Prendergast, K. B., Schofield, G. M., & Mackay, L. M. (2015) · BMC Public Health · doi:10.1186/s12889-016-2755-0 · Cited by 54 · see citing works
Insulin modulates emotional behavior through a serotonin-dependent mechanism
Martin, H., Bullich, S., Martinat, M., Chataigner, M., Di Miceli, M., Simon, V., Clark, S., Butler, J., Schell, M., Chopra, S., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-022-01812-3 · Cited by 50 · see citing works
Hryhorczuk, C., Décarie-Spain, L., Sharma, S., Daneault, C., Rosiers, C. D., Alquier, T., & Fulton, S. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.06.002 · Cited by 51 · see citing works
Demers, G., Roy, J., Machuca-Parra, A. I., Dashtehei pour, Z., Bairamian, D., Daneault, C., Rosiers, C. D., Ferreira, G., Alquier, T., Fulton, S., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0623-6 · Cited by 53 · see citing works
Lin, M.-H., Cheng, P.-C., Hsiao, P.-J., Chen, S.-C., Hung, C.-H., Kuo, C.-H., Huang, S.-K., & Clair Chiou, H.-Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109653 · Cited by 42 · see citing works
Dopamine signalling adaptations by prolonged high-fat feeding
Décarie-Spain, L., Hryhorczuk, C., & Fulton, S. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.03.010 · Cited by 39 · see citing works
Self-citationGLP-1/dexamethasone inhibits food reward without inducing mood and memory deficits in mice
Décarie-Spain, L., Fisette, A., Zhu, Z., Yang, B., DiMarchi, R. D., Tschöp, M. H., Finan, B., Fulton, S., & Clemmensen, C. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.035 · Cited by 27 · see citing works
Self-citationNeuronal nitric oxide synthase regulates depression-like behaviors in shortening-induced obese mice
Wang, P., Kong, F.-Z., Hong, X.-H., Zhang, L., Zhao, W.-H., Yang, J.-C., & Zhang, H. (2022) · Nutrients · doi:10.3390/nu14204302 · Cited by 11 · see citing works
- Authors
- Sharma, S., & Fulton, S.
- Affiliations
- Université de Montréal (CA)
- Corresponding author
- Fulton, S
- Venue
- International Journal of Obesity
- Published
- 2012-04-17
- Volume
- 37
- Issue
- 3
- Pages
- 382-389
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2004415631
- Cited by
- 424
- References
- 59
- Citations by year
- 2026: 24 · 2025: 18 · 2024: 38 · 2023: 25 · 2022: 34 · 2021: 36 · 2020: 37 · 2019: 33 · 2018: 32 · 2017: 31 · 2016: 42 · 2015: 27 · 2014: 26 · 2013: 18 · 2012: 3
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Diabetes Association
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- diet-induced obesity, high-fat diet, depression-like behavior, reward systems, mesolimbic dopamine system, nucleus accumbens, dorsolateral striatum, ventral tegmental area, brain-derived neurotrophic factor, CREB, ΔFosB, dopamine D1 receptor, dopamine D2 receptor, corticosterone, anxiety, depression, metabolic disorders
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Corticosterone, Depression, Disease Models, Animal, Hippocampus, Male, Mice, Inbred C57BL, Motor Activity, Neuronal Plasticity, Obesity, Promoter Regions, Genetic, Reward, Stress, Psychological, Swimming, Receptors, Dopamine D2, Mice, Diet, High-Fat
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