The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
Brain Photobiomodulation Therapy: a Narrative Review
Open accessAbstract
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological conditions. Red/NIR light is able to stimulate complex IV of the mitochondrial respiratory chain (cytochrome c oxidase) and increase ATP synthesis. Moreover, light absorption by ion channels results in release of Ca2+ and leads to activation of transcription factors and gene expression. Brain PBM therapy enhances the metabolic capacity of neurons and stimulates anti-inflammatory, anti-apoptotic, and antioxidant responses, as well as neurogenesis and synaptogenesis. Its therapeutic role in disorders such as dementia and Parkinson’s disease, as well as to treat stroke, brain trauma, and depression has gained increasing interest. In the transcranial PBM approach, delivering a sufficient dose to achieve optimal stimulation is challenging due to exponential attenuation of light penetration in tissue. Alternative approaches such as intracranial and intranasal light delivery methods have been suggested to overcome this limitation. This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of brain PBM therapy.
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Cited by
Zhang, J., He, Y., Liang, S., Liao, X., Li, T., Qiao, Z., Chang, C., Jia, H., & Chen, X. (2021) · Nature Communications · doi:10.1038/s41467-021-23025-y · Cited by 371
Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances
Deng, Q., Wu, C., Parker, E., Liu, T. C.-Y., Duan, R., & Yang, L. (2023) · Aging and disease · doi:10.14336/ad.2023.0907 · Cited by 102
Metadata
- Authors
- Salehpour, F., Mahmoudi, J., Kamari, F., Sadigh-Eteghad, S., Rasta, S. H., & Hamblin, M. R.
- Venue
- Molecular Neurobiology
- Published
- 2018-01-11
- Volume
- 55
- Issue
- 8
- Pages
- 6601-6636
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2783026431
- Cited by
- 517
- References
- 204
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- green
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