miR‐155 modulates microglia‐mediated immune response by down‐regulating SOCS‐1 and promoting cytokine and nitric oxide production
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Innate immunity constitutes the first line of defence against both external and endogenous threats in the brain, and microglia cells are considered key mediators of this process. Recent studies have shown that microRNAs (miRNAs) may play a determinant role in the regulation of gene expression during innate immune responses. The major goal of this work was to investigate the contribution of a specific miRNA - miR-155 - to the modulation of the microglia-mediated immune response. For this purpose, in vitro studies were performed in N9 microglia cells to evaluate changes in the levels of this miRNA following microglia activation. A strong up-regulation of miR-155 expression was observed following microglia exposure to lipopolysaccharide, which was consistent with a decrease in the levels of the suppressor of cytokine signalling 1 (SOCS-1) protein, a key inhibitor of the inflammatory process and a predicted target of miR-155. The miR-155 knockdown by anti-miRNA oligonucleotides up-regulated SOCS-1 mRNA and protein levels and significantly decreased the production of nitric oxide and the expression of inflammatory cytokines and inducible nitric oxide synthase. Finally, treatment of neuronal primary cultures with conditioned medium obtained from microglia cells, in which miR-155 was inhibited before cell activation, decreased inflammatory-mediated neuronal cell death. Overall, our results show that miR-155 has a pro-inflammatory role in microglia and is necessary for the progression of the immune response through the modulation of SOCS-1, suggesting that, in a chronic inflammatory context, miR-155 inhibition can have a neuroprotective effect.
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miR-155 is induced by LPS in mouse N9 microglia cell line and primary cultures, and miR-155 targets SOCS1.
“Cardoso et al., based on findings in other myeloid-derived cells, demonstrated that miR-155 is induced by LPS in a mouse N9 microglia cell line and in primary cultures. Similar to other authors [244], they confirmed targeting of the suppressor of the cytokine signaling 1 gene (SOCS1) by miR-155.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [237]
Neuron-derived EVs enriched in miR-132-3p or miR-124-3p can reprogram glial states, while glial EV cargo such as miR-155, miR-21-5p, and miR-146a feeds back onto neurons and other glia to propagate inflammatory or compensatory signals.
“For example, neuron-derived EVs enriched in miR-132-3p or miR-124-3p can reprogram glial states, while glial EV cargo such as miR-155, miR-21-5p, and miR-146a feeds back onto neurons and other glia to propagate inflammatory or compensatory signals (Aloi et al., 2023; Cardoso et al., 2011; Fan et al., 2020; Gaudet et al., 2017; Guedes et al., 2014; Han et al., 2020; Lukiw et al., 2008; Saba et al.,”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Cardoso et al., 2011
MiR-155 is one of the strongest determinants of microglial pathogenicity; its upregulation in AD microglia enhances NF-κB signaling, increases production of pro-inflammatory cytokines, and reduces phagocytic Aβ clearance, thereby worsening plaque burden and neuronal injury.
“MiR-155 is one of the strongest determinants of microglial pathogenicity. Its upregulation in AD microglia enhances NF-κB signaling, increases production of pro-inflammatory cytokines, and reduces phagocytic Aβ clearance, thereby worsening plaque burden and neuronal injury (Cardoso et al., 2011; Guedes et al., 2014).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Cardoso et al., 2011
MiR-155 is induced in reactive astrocytes and is associated with pro-inflammatory glial reprogramming.
“MiR-155 is also induced in reactive astrocytes and is associated with pro-inflammatory glial reprogramming.”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Cardoso et al., 2011
Astrocytic and microglial miRNAs, including miR-21-5p, miR-155, miR-33, miR-146a, and miR-181c-5p, govern processes such as NF-κB-dependent inflammatory activation, ApoE/ABCA1 lipid pathways, and microglial plaque-associated phenotypes.
“Astrocytic and microglial miRNAs, including miR-21-5p, miR-155, miR-33, miR-146a, and miR-181c-5p, govern processes such as NF-κB–dependent inflammatory activation, ApoE/ABCA1 lipid pathways, and microglial plaque-associated phenotypes (Aloi et al., 2023; Cardoso et al., 2011; Fan et al., 2020; Garcia et al., 2022; Hansen et al., 2017; Hutchison et al., 2013; Li et al., 2024; Lukiw et al., 2008; O”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Cardoso et al., 2011
Cites
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works
MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866 · see citing works
Requirement of <i>bic/microRNA-155</i> for Normal Immune Function
Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science · doi:10.1126/science.1139253 · Cited by 1,833 · see citing works
Inflammation in neurodegenerative diseases
Amor, S., Puentes, F., Baker, D., & Van Der Valk, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03225.x · Cited by 1,355 · see citing works
Tili, E., Michaille, J.-J., Cimino, A., Costinean, S., Dumitru, C. D., Adair, B., Fabbri, M., Alder, H., Liu, C. G., Calin, G. A., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5082 · Cited by 1,304 · see citing works
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
Stańczyk, J., Pedrioli, D. M. L., Brentano, F., Sánchez‐Pernaute, O., Kolling, C., Gay, R. E., Detmar, M. J., Gay, S., & Kyburz, D. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23386 · Cited by 905 · see citing works
MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?
Sonkoly, E., Wei, T., Janson, P. C. J., Sääf, A., Lundeberg, L., Tengvall-Linder, M., Norstedt, G., Alenius, H., Homey, B., Scheynius, A., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000610 · Cited by 754 · see citing works
Jiang, S., Zhang, H.-W., Lu, M.-H., He, X.-H., Li, Y., Gu, H., Liu, M.-F., & Wang, E.-D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4250 · Cited by 679 · see citing works
Kluiver, J. L., Poppema, S., de Jong, D., Blokzijl, T., Harms, G., Jacobs, S. C., Kroesen, B., & van den Berg, A. (2005) · The Journal of Pathology · doi:10.1002/path.1825 · Cited by 672 · see citing works
Lehnardt, S. (2009) · Glia · doi:10.1002/glia.20928 · Cited by 596 · see citing works
Gironella, M., Seux, M., Xie, M.-J., Cano, C. E., Tomasini, R., Gommeaux, J., Garcia, S., Nowak, J., Yeung, M. L., Jeang, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703942104 · Cited by 548 · see citing works
Qin, L., Liu, Y., Cooper, C. L., Liu, B., Wilson, B. C., & Hong, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01210.x · Cited by 290 · see citing works
SOCS1 and SOCS3 in the control of CNS immunity
Baker, B. J., Akhtar, L. N., & Benveniste, E. N. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.001 · Cited by 276 · see citing works
Lu, C., Huang, X., Zhang, X., Roensch, K., Cao, Q., Nakayama, K. I., Blazar, B. R., Zeng, Y., & Zhou, X. (2011) · Blood · doi:10.1182/blood-2010-12-322503 · Cited by 269 · see citing works
Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration
Purisai, M. G., McCormack, A. L., Cumine, S., Li, J., Isla, M. Z., & Monte, D. A. D. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.10.008 · Cited by 255 · see citing works
Up-regulation of Microglial CD11b Expression by Nitric Oxide
Roy, A., Fung, Y. K., Liu, X., & Pahan, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600236200 · Cited by 214 · see citing works
Macrophages and microglia in central nervous system injury: are they helpful or harmful?
Schwartz, M. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200304000-00001 · Cited by 207 · see citing works
Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis
Masaki, S., Ohtsuka, R., Abe, Y., Muta, K., & Umemura, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.077 · Cited by 205 · see citing works
Dramatic Shifts in Circulating CD4 but not CD8 T Cell Subsets in Mild Alzheimer's Disease
Larbi, A., Pawelec, G., Witkowski, J., Schipper, H., Derhovanessian, E., Goldeck, D., & Fulop, T. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1015 · Cited by 198 · see citing works
Imaging individual microRNAs in single mammalian cells in situ
Lü, J., & Tsourkas, A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp482 · Cited by 158 · see citing works
Lipofection reagents prepared by a simple ethanol injection technique.
Campbell, M. J. (1995) · PubMed · Cited by 144 · see citing works
Neuropeptide Y Modulation of Interleukin-1β (IL-1β)-induced Nitric Oxide Production in Microglia
Ferreira, R., Xapelli, S., Santos, T., Silva, A. P., Cristóvão, A. J., Cortes, L., & Malva, J. O. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.164020 · Cited by 122 · see citing works
Kutty, R. K., Nagineni, C. N., Samuel, W., Vijayasarathy, C., Hooks, J. J., & Redmond, T. M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.042 · Cited by 121 · see citing works
Inflammation and gliosis in neurological diseases – clinical implications
Członkowska, A., & Kurkowska‐Jastrzębska, I. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.09.020 · Cited by 89 · see citing works
Takeuchi, H., Wang, J., Kawanokuchi, J., Mitsuma, N., Mizuno, T., & Suzumura, A. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.09.014 · Cited by 63 · see citing works
The role of CD8+ T-cells in lesion formation and axonal dysfunction in multiple sclerosis
Mcdole, J. R., Johnson, A. J., & Pirko, I. (2006) · Neurological Research · doi:10.1179/016164106x98125 · Cited by 53 · see citing works
Means, T. K., & Luster, A. D. (2010) · Nature Immunology · doi:10.1038/ni0810-691 · Cited by 28 · see citing works
Interleukin 4 induces the apoptosis of mouse microglial cells by a caspase-dependent mechanism
Soria, J. A., Arroyo, D. S., Gaviglio, E. A., Rodriguez‐Galán, M. C., Wang, J. M., & Iribarren, P. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.010 · Cited by 26 · see citing works
Lavigne, C., & Thierry, A. R. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7191 · Cited by 26 · see citing works
Bid regulates the immunological profile of murine microglia and macrophages
Mayo, L., Levy, A., Jacob‐Hirsch, J., Amariglio, N., Rechavi, G., & Stein, R. (2010) · Glia · doi:10.1002/glia.21109 · Cited by 10 · see citing works
miR-155 gene: A typical multifunctional microRNA
Faraoni, I., Antonetti, F. R., Cardone, J., & Bonmassar, E. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.02.013
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Ma, Y., Wang, J., Wang, Y., & Yang, G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.005 · Cited by 724 · see citing works
Alternatively activated microglia and macrophages in the central nervous system
Franco, R., & Fernández‐Suárez, D. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.003 · Cited by 650 · see citing works
Roles of microglia in brain development, tissue maintenance and repair
Michell‐Robinson, M. A., Touil, H., Healy, L. M., Owen, D. R., Durafourt, B. A., Bar‐Or, A., Antel, J. P., & Moore, C. S. (2015) · Brain · doi:10.1093/brain/awv066 · Cited by 421 · see citing works
Microglia: Agents of the CNS Pro-Inflammatory Response
Rodríguez-Gómez, J. A., Kavanagh, E., Engskog-Vlachos, P., Engskog, M. K. R., Herrera, A. J., Espinosa-Oliva, A. M., Joseph, B., Hajji, N., Venero, J. L., & Burguillos, M. A. (2020) · Cells · doi:10.3390/cells9071717 · Cited by 365 · see citing works
Kempuraj, D., Thangavel, R., Selvakumar, G. P., Zaheer, S. A., Ahmed, M. E., Raikwar, S. P., Zahoor, H., Saeed, D., Natteru, P., Iyer, S. S., et al. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00216 · Cited by 365 · see citing works
Inflammatory mediators in human epilepsy: A systematic review and meta-analysis
de Vries, E. E., van den Munckhof, B., Braun, K. P. J., van Royen‐Kerkhof, A., de Jager, W., & Jansen, F. E. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.007 · Cited by 271 · see citing works
MicroRNAs: Roles in Regulating Neuroinflammation
Gaudet, A. D., Fonken, L. K., Watkins, L. R., Nelson, R. J., & Popovich, P. G. (2017) · The Neuroscientist · doi:10.1177/1073858417721150 · Cited by 270 · see citing works
Slota, J. A., & Booth, S. A. (2019) · Non-Coding RNA · doi:10.3390/ncrna5020035 · Cited by 233 · see citing works
Brain-immune interactions in perinatal hypoxic-ischemic brain injury
Li, B., Concepcion, K. R., Meng, X., & Zhang, L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.006 · Cited by 230 · see citing works
Glial Cells Shape Pathology and Repair After Spinal Cord Injury
Gaudet, A. D., & Fonken, L. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0630-7 · Cited by 232 · see citing works
miR‐155 as a multiple sclerosis–relevant regulator of myeloid cell polarization
Moore, C. S., Rao, V. T. S., Durafourt, B. A., Bedell, B. J., Ludwin, S. K., Bar‐Or, A., & Antel, J. P. (2013) · Annals of Neurology · doi:10.1002/ana.23967 · Cited by 219 · see citing works
Microglia centered pathogenesis in ALS: insights in cell interconnectivity
Brites, D. M. T. O., & Vaz, A. R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00117 · Cited by 201 · see citing works
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Amici, S. A., Dong, J., & Guerau‐de‐Arellano, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01520 · Cited by 192 · see citing works
Manu, D. R., SLEVIN, M. A., Bărcuţean, L., Forró, T., Boghițoiu, T., & Bălașa, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417146 · Cited by 195 · see citing works
Matias, D., Balça-Silva, J., da Graça, G. C., Muriithi, W., Macharia, L. W., Nascimento, C. P., Roque, N. R., Coelho‐Aguiar, J. M., Pereira, C. M., DosSantos, M. F. H., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00235 · Cited by 179 · see citing works
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Seddiki, N., Brezar, V., Ruffin, N., Lévy, Y., & Swaminathan, S. (2013) · Immunology · doi:10.1111/imm.12227 · Cited by 173 · see citing works
miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF
Varendi, K., Kumar, A., Härma, M.-A., & Andressoo, J.-O. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1628-x · Cited by 144 · see citing works
MicroRNAs as regulators of brain function and targets for treatment of epilepsy
Brennan, G. P., & Henshall, D. C. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0369-8 · Cited by 168 · see citing works
Guedes (2014) · doi:10.1093/hmg/ddu348
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Zingale, V. D., Gugliandolo, A., & Mazzon, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010090 · Cited by 163 · see citing works
Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia
Freilich, R. W., Woodbury, M. E., & Ikezu, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079416 · Cited by 160 · see citing works
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Gao, X., Li, S., Ding, F., Liu, X., Wu, Y., Li, J., Feng, J. C., Zhu, X., & Zhang, C. (2021) · Advanced Materials · doi:10.1002/adma.202006116 · Cited by 160 · see citing works
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Caldeira, C., Oliveira, A. F., Cunha, C., Vaz, A. R., Falcão, A. S., Fernandes, A., & Brites, D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00152 · Cited by 156 · see citing works
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Yao, H., Ma, R., Yang, L., Hu, G., Chen, X., Duan, M., Kook, Y., Niu, F., Liao, K., Fu, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms5386 · Cited by 146 · see citing works
Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents
Khoshnam, S. E., Winlow, W., Farbood, Y., Moghaddam, H. F., & Farzaneh, M. (2017) · Journal of Stroke · doi:10.5853/jos.2016.01368 · Cited by 156 · see citing works
Kaminska, B., Mota, M., & Pizzi, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.026 · Cited by 153 · see citing works
Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization
Cunha, C., Gomes, C., Vaz, A. R., & Brites, D. (2016) · Mediators of Inflammation · doi:10.1155/2016/6986175 · Cited by 153 · see citing works
Epigenetics Control Microglia Plasticity
Cheray, M., & Joseph, B. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00243 · Cited by 151 · see citing works
Guo, Y.-W., Hong, W., Wang, X., Zhang, P., Körner, H., Tu, J., & Wei, W. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00125 · Cited by 151 · see citing works
Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 146 · see citing works
Lippai, D., Bala, S., Csák, T., Kurt‐Jones, E. A., & Szabó, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070945 · Cited by 141 · see citing works
Thounaojam, M. C., Kundu, K., Kaushik, D. K., Swaroop, S., Mahadevan, A., Shankar, S. K., & Basu, A. (2014) · Journal of Virology · doi:10.1128/jvi.02979-13 · Cited by 137 · see citing works
MicroRNAs mediating CNS inflammation: Small regulators with powerful potential
Su, W., Aloi, M. S., & Garden, G. A. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.003 · Cited by 139 · see citing works
Quero, L., Tiaden, A. N., Hanser, E., Roux, J., Łaski, A., Hall, J., & Kyburz, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03087 · Cited by 137 · see citing works
Pinto, S., Cunha, C., Barbosa, M., Vaz, A. R., & Brites, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00273 · Cited by 135 · see citing works
The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives
Walgrave, H., Zhou, L., Strooper, B. D., & Salta, E. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00496-7 · Cited by 132 · see citing works
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Zhu, J., Chen, T., Yang, L., Li, Z., Wong, M. M., Zheng, X., Pan, X., Zhang, L., & Yan, H. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046551 · Cited by 128 · see citing works
Karkeni, E., Astier, J., Tourniaire, F., Abed, M. E., Romier, B., Gouranton, E., Wan, L., Borel, P., Salles, J., Walrand, S., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3410 · Cited by 127 · see citing works
Pathak, S., Grillo, A. R., Scarpa, M., Brun, P., Renata D'Incà, Nai, L., Banerjee, A., Cavallo, D., Barzon, L., Palù, G., et al. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.21 · Cited by 124 · see citing works
Pareek, S., Roy, S., Kumari, B., Jain, P., Banerjee, A., & Vrati, S. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-97 · Cited by 121 · see citing works
Differential expression of miRNA 155 and miRNA 146a in Parkinson's disease patients
Caggiu, E., Paulus, K. S., Mameli, G., Arru, G., Sechi, G., & Sechi, L. A. (2018) · eNeurologicalSci · doi:10.1016/j.ensci.2018.09.002 · Cited by 118 · see citing works
MicroRNAs and HIV-1 Infection: Antiviral Activities and Beyond
Swaminathan, G., Navas, S., & Martín‐García, J. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.12.017 · Cited by 115 · see citing works
Emerging Roles of miRNAs in Brain Development and Perinatal Brain Injury
Cho, K. H. T., Xu, B., Blenkiron, C., & Fraser, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00227 · Cited by 114 · see citing works
Protective Microglia and Their Regulation in Parkinson’s Disease
Le, W., Wu, J., & Tang, Y. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00089 · Cited by 112 · see citing works
In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response
Pena-Philippides, J. C., Caballero-Garrido, E., Lordkipanidze, T., & Roitbak, T. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0753-x · Cited by 112 · see citing works
Microglia and inflammation: conspiracy, controversy or control?
Fernandes, A. M. A., Miller‐Fleming, L., & Pais, T. F. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1670-8 · Cited by 110 · see citing works
Berríos‐Cárcamo, P., Quezada, M., Quintanilla, M. E., Morales, P., Ezquer, M., Herrera‐Marschitz, M., Israel, Y., & Ezquer, F. E. (2020) · Antioxidants · doi:10.3390/antiox9090830 · Cited by 108 · see citing works
MicroRNA based theranostics for brain cancer: basic principles
Petrescu, G. E. D., Sabo, A. A., Torsin, L. I., Călin, G. A., & Dragomir, M. P. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1180-5 · Cited by 109 · see citing works
Thounaojam, M. C., Kaushik, D. K., Kundu, K., & Basu, A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12609 · Cited by 104 · see citing works
Su, W., Hopkins, S., Nesser, N. K., Sopher, B., Silvestroni, A., Ammanuel, S., Jayadev, S., Möller, T., Weinstein, J., & Garden, G. A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301397 · Cited by 103 · see citing works
Cannella, D., Brenier‐Pinchart, M., Braun, L., van Rooyen, J. M., Bougdour, A., Bastien, O., Behnke, M. S., Curt, R.-L., Curt, A., Saeij, J. P. J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.002 · Cited by 102 · see citing works
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Lippai, D., Bala, S., Catalano, D. E., Kodys, K., & Szabó, G. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12483 · Cited by 100 · see citing works
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Szabó, G., & Lippai, D. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00011-7 · Cited by 95 · see citing works
miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction
Woodbury, M. E., Freilich, R. W., Cheng, C. J., Asai, H., Ikezu, S., Boucher, J. D., Slack, F. J., & Ikezu, T. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4790-14.2015 · Cited by 94 · see citing works
Suppression of MicroRNA-155 Attenuates Neuropathic Pain by Regulating SOCS1 Signalling Pathway
Tan, Y., Yang, J. H., Xiang, K., Tan, Q., & Guo, Q. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1500-2 · Cited by 94 · see citing works
Fernandes, A., Ribeiro, A. R., Monteiro, M., Garcia, G., Vaz, A. R., & Brites, D. (2018) · Biochimie · doi:10.1016/j.biochi.2018.05.015 · Cited by 93 · see citing works
Ye, Y., He, X., Lu, F., Mao, H., Zhu, Z., Yao, L., Luo, W., Sun, X., Wang, B., Qian, C., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0821-5 · Cited by 93 · see citing works
Epigenetic Regulation of Neuroinflammation in Parkinson’s Disease
Rasheed, M., Liang, J., Wang, C., Deng, Y., & Chen, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094956 · Cited by 94 · see citing works
miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling
Collins, A. S., McCoy, C. E., Lloyd, A. T., O’Farrelly, C., & Stevenson, N. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069090 · Cited by 89 · see citing works
miR-155 as an Important Regulator of Multiple Sclerosis Pathogenesis. A Review
Maciak, K., Dziedzic, A., Miller, E. D., & Saluk, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094332 · Cited by 87 · see citing works
Gaudet, A. D., Mandrekar-Colucci, S., Hall, J. C. E., Sweet, D. R., Schmitt, P., Xu, X., Guan, Z., Mo, X. M., Guerau‐de‐Arellano, M., & Popovich, P. G. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0735-16.2016 · Cited by 87 · see citing works
Cunha, C., Santos, C., Gomes, C., Fernandes, A. M. A., Correia, A. M., Sebastião, A. M., Vaz, A. R., & Brites, D. M. T. O. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0631-2 · Cited by 85 · see citing works
Epigenetic reprogramming of immune cells in injury, repair, and resolution
Placek, K., Schultze, J. L., & Aschenbrenner, A. C. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124619 · Cited by 83 · see citing works
The old guard: Age-related changes in microglia and their consequences
Costa, J., Martins, S., Ferreira, P. A., Cardoso, A. M., Guedes, J. R., Peça, J., & Cardoso, A. L. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111512 · Cited by 84 · see citing works
Self-citationNeuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia
Lian, L., Zhang, Y., Liu, L., Yang, L., Cai, Y., Zhang, J., & Xu, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.612439 · Cited by 83 · see citing works
Rao, R., Nagarkatti, P. S., & Nagarkatti, M. (2014) · Infection and Immunity · doi:10.1128/iai.01666-14 · Cited by 83 · see citing works
Qiu, S., Feng, Y., LeSage, G., Zhang, Y., Stuart, C. A., He, L., Li, Y., Caudle, Y., Peng, Y., & Yin, D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400106 · Cited by 82 · see citing works
Henry, R. J., Doran, S. J., Barrett, J. P., Meadows, V. E., Sabirzhanov, B. E., Stoica, B. A., Loane, D. J., & Faden, A. I. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0665-9 · Cited by 82 · see citing works
Eren, E., Tüfekçi, K. U., Isci, K. B., Tastan, B., Genç, K., & Genç, Ş. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00036 · Cited by 84 · see citing works
The Roles of MicroRNAs in Stroke: Possible Therapeutic Targets
Xu, W., Gao, L., Zheng, J., Li, T., Shao, A., Reis, C., Chen, S., & Zhang, J. (2018) · Cell Transplantation · doi:10.1177/0963689718773361 · Cited by 83 · see citing works
Costa, P. M., Cardoso, A. L., Nóbrega, C., Pereira de Almeida, L. F., Bruce, J. N., Canoll, P., & Pedroso de Lima, M. C. (2013) · Human Molecular Genetics · doi:10.1093/hmg/dds496 · Cited by 80 · see citing works
Self-citationEpigenetics: The third pillar of nitric oxide signaling
Socco, S., Bovee, R. C., Palczewski, M. B., Hickok, J. R., & Thomas, D. D. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.04.011 · Cited by 80 · see citing works
Gomes, C., Cunha, C., Nascimento, F., Ribeiro, J. A., Vaz, A. R., & Brites, D. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1220-8 · Cited by 79 · see citing works
Involvement of MicroRNA in Microglia-Mediated Immune Response
Guedes, J. R., Cardoso, A. L., & de Lima, M. C. P. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/186872 · Cited by 79 · see citing works
Self-citationTong, L., Shao, A., Ou, Y., Guo, Z., Manaenko, A., Dixon, B. J., Tang, J., Lou, M., & Zhang, J. H. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16658490 · Cited by 78 · see citing works
Post-insult valproic acid-regulated microRNAs: potential targets for cerebral ischemia.
Hunsberger, J. G., Fessler, E. B., Wang, Z., ELKAHLOUN, A. G., & Chuang, D. (2012) · Europe PMC (PubMed Central) · Cited by 77 · see citing works
MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease
Guedes, J. R., Santana, I. J., Cunha, C., Duro, D., Almeida, M. R., Cardoso, A. M., de Lima, M. C. P., & Cardoso, A. L. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.11.004 · Cited by 76 · see citing works
Self-citationMiR-221 accentuates IFN׳s anti-HCV effect by downregulating SOCS1 and SOCS3
Xu, G., Yang, F., Ding, C., Wang, J., Zhao, P., Wang, W., & Ren, H. (2014) · Virology · doi:10.1016/j.virol.2014.06.024 · Cited by 75 · see citing works
Macrophage micro-RNA-155 promotes lipopolysaccharide-induced acute lung injury in mice and rats
Wang, W., Liu, Z., Su, J., Chen, W., Wang, X.-W., Bai, S.-X., Zhang, J., & Yu, S. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00001.2016 · Cited by 74 · see citing works
Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation
Matt, S. M., & Johnson, R. W. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.10.009 · Cited by 73 · see citing works
Critical Role of MicroRNA-155 in Herpes Simplex Encephalitis
Bhela, S., Mulik, S., Reddy, P. B. J., Richardson, R. L., Giménez, F., Rajasagi, N. K., Veiga‐Parga, T., Osmand, A. P., & Rouse, B. T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302326 · Cited by 72 · see citing works
Epigenetics and the Modulation of Neuroinflammation
Garden, G. A. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0207-4 · Cited by 70 · see citing works
Liu, X., Ma, J., Ding, G., Gong, Q., Wang, Y., Yu, H., & Cheng, X. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5753452 · Cited by 71 · see citing works
Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions
Cardoso, A. L., Guedes, J. R., & de Lima, M. C. P. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.001 · Cited by 70 · see citing works
Self-citationThe Interplay of MicroRNAs in the Inflammatory Mechanisms Following Ischemic Stroke
Khoshnam, S. E., Winlow, W., & Farzaneh, M. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx036 · Cited by 69 · see citing works
Hong, P., Jiang, M. H., & Li, H. (2014) · Glia · doi:10.1002/glia.22725 · Cited by 69 · see citing works
Danka Mohammed, C. P., Park, J. S., Nam, H. G., & Kim, K. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.01.007 · Cited by 68 · see citing works
Gypenoside AttenuatesβAmyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling
Cai, H., Liang, Q., & Ge, G. (2016) · Neural Plasticity · doi:10.1155/2016/6362707 · Cited by 68 · see citing works
LaRocca, D., Barns, S., Hicks, S. D., Brindle, A., Williams, J. R., Uhlig, R., Johnson, P. R., Neville, C., & Middleton, F. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0207785 · Cited by 67 · see citing works
Gong, T., Liu, Y.-T., & Fan, J. (2024) · Military Medical Research · doi:10.1186/s40779-024-00527-6 · Cited by 67 · see citing works
MicroRNA-155 induction by Mycobacterium bovis BCG enhances ROS production through targeting SHIP1
Wang, J., Wu, M., Wen, J., Yang, K., Li, M., Zhan, X., Feng, L., Li, M., & Huang, X. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.05.012 · Cited by 67 · see citing works
Guo, J., Liao, M., & Wang, J. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00771-6 · Cited by 66 · see citing works
microRNA‐200b modulates microglia‐mediated neuroinflammation via the cJun/MAPK pathway
Jadhav, S. P., Kamath, S. P., Choolani, M. A., Lu, J., & Dheen, S. T. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12731 · Cited by 66 · see citing works
Gupta, N., Shyamasundar, S., Patnala, R., Karthikeyan, A., Arumugam, T. V., Ling, E., & Dheen, S. T. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1515917 · Cited by 66 · see citing works
Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases
Gentile, G., Morello, G., Cognata, V. L., Guarnaccia, M., Conforti, F. L., & Cavallaro, S. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12050770 · Cited by 69 · see citing works
Rastegar-Moghaddam, S. H., Ebrahimzadeh-Bideskan, A., Shahba, S., Malvandi, A. M., & Mohammadipour, A. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01200-z · Cited by 64 · see citing works
Ma, C., Wang, Y., Shen, A., & Cai, W. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2802 · Cited by 64 · see citing works
Caplan, I. F., & Maguire‐Zeiss, K. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00417 · Cited by 65 · see citing works
Hu, J., Huang, C., Rao, P., Zhou, J., Wang, X., Tang, L., Liu, M., & Zhang, G. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.02.001 · Cited by 63 · see citing works
- Authors
- Cardoso, A. L., Guedes, J. R., Pereira de Almeida, L., & Pedroso de Lima, M. C.
- Affiliations
- Centro de Neurociências e Biologia Celular (PT)
- University of Coimbra (PT)
- Corresponding author
- Cardoso, Ana L.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2011-12-07
- Volume
- 135
- Issue
- 1
- Pages
- 73-88
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- PMC
- PMC3246654
- OpenAlex
- W2095876795
- Cited by
- 336
- References
- 32
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 17 · 2023: 26 · 2022: 21 · 2021: 29 · 2020: 34 · 2019: 24 · 2018: 25 · 2017: 26 · 2016: 25 · 2015: 20 · 2014: 29 · 2013: 15 · 2012: 5
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- miR-155, microglia, SOCS1, innate immunity, neuroinflammation, lipopolysaccharide, nitric oxide, inducible nitric oxide synthase, inflammatory cytokines, microglial activation, neuronal cell death, neuroprotection, antagomir
- MeSH terms
- Suppressor of Cytokine Signaling 1 Protein, Animals, Cells, Cultured, Lipopolysaccharides, Nitric Oxide, Down-Regulation, Up-Regulation, Cytokines, Microglia, MicroRNAs, Suppressor of Cytokine Signaling Proteins, Mice
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