Cited by 146Gut microbiota and healthInfant Nutrition and HealthProbiotics and Fermented Foods

The DOI matches its Crossref record; 254 of the 255 references it cites were found in a registry or an index.

Factors influencing the gut microbiome in children: from infancy to childhood

Kumbhare, Shreyas V, Patangia, Dhrati V, Patil, Ravindra H, Shouche, Yogesh S, Patil, Nitinkumar P·2019·Journal of Biosciences

DOI 10.1007/s12038-019-9860-z

Open this paper in CoChat — free account

Abstract

The human microbiota plays a crucial role in educating the immune system and influencing host health right since birth. Various maternal factors along with the vertical microbial transfer from the mother, as well as the horizontal environmental transmission and internal factors relating to the infant, play a crucial role in modulating the gut microbiota. The early life microflora is highly unstable and undergoes dynamic changes during the first few years, converging towards a more stabilized adult microbiota by co-evolving with the host by the age of 3-4 years. Microbiota studies have underlined the role of dysbiosis in developing several metabolic disorders like obesity, diabetes and immune-related disorders like asthma, to name a few. Thus, understanding early life microbial composition and various factors affecting the microbial community will provide a platform for developing strategies/techniques to maintain host health by restoring gut microbial flora. This review focuses on the factors that affect the microbial composition of the foetus in utero, during birth, infancy through childhood.

Integrity signals

Registry

Crossref · 10.1007/s12038-019-9860-z

Cites

254 of 254 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Nishita, M., Park, S.-Y., Nishio, T., Kamizaki, K., Wang, Z., Tamada, K., Takumi, T., Hashimoto, R., Otani, H., Pazour, G. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-016-0028-x · Cited by 15,947
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054
Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164
Atopic Dermatitis: Global Epidemiology and Risk Factors
Nutten, S. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000370220 · Cited by 3,124

Show all 255 references

Research works printed but not linked: 3

Kaphingst KA, Persky S and Lachance C 2008 Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta 29 274–281 · DOI · Paper page
Leta D, Aragaw K and Yared M 2016 Antibiotics susceptibility pattern of hospital indoor airborne bacteria in Hawassa University teaching and referral hospital, South Ethiopia. Int. J. Mod. Chem. Appl. Sci. 3 287–292
Sharma M and Solanki A 2014 Original research article prevalence of Candida infection in pregnant women with and without diabetes. Int. J. Curr. Microbiol. App. Sci. 3 605–610

Sorted by citations

Items 101–146 of 146

A microbial symphony: a literature review of the factors that orchestrate the colonization dynamics of the human colonic microbiome during infancy and implications for future health
Horwell, E., Bearn, P. E., & Cutting, S. M. (2024) · Microbiome Research Reports · doi:10.20517/mrr.2024.32 · Cited by 3
Microbiome-Targeted Therapies: Enhancing Resilience in Metabolic Disorders
Janiad, S., & Rehman, K. (2024) · Springer eBooks · doi:10.1007/978-981-97-3790-1_13 · Cited by 1
Introducing blueberry powder as one of the first complementary foods changes the gut microbiota composition and diversity in U.S. human milk-fed infants: a double-blind, randomized controlled trial
Glime, G. N. E., Matzeller, K. L., Frank, D. N., Kotter, C. V., Kofonow, J. M., Robertson, C. E., Venter, C., Campbell, W. W., Krebs, N. F., & Tang, M. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1623521 · Cited by 1
The gut microbiota of Labrador retriever puppies: a longitudinal cohort study
Woolley, C. S. C., Muwonge, A., Bronsvoort, M., Schoenebeck, J. J., Handel, I. G., Chamberlain, K., Rose, E., & Clements, D. N. (2025) · Animal Microbiome · doi:10.1186/s42523-025-00464-2 · Cited by 2
Determinants of the Gut Microbiota
Muthaiyan, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-47384-6_2 · Cited by 1
Short term antibiotic effects on gut microbiome in Indian preschoolers: A 16S rRNA analysis
Neha, N., Bavdekar, A., Kawade, A. S., Veligandla, K. C., Joshi, D. K., Rathod, R., & Kotak, B. (2023) · Journal of Laboratory Physicians · doi:10.25259/jlp_6_2023 · Cited by 1
Nutritional Epigenetics and Gut Microbiome
Mohanan, A., Harilal, S. L., Plakkot, B., Pottakkat, B., & Kanakkaparambil, R. (2024) · Epigenetics and human health · doi:10.1007/978-3-031-54215-2_7 · Cited by 1
The Gut Microbiota, Nutrition, and Long-Term Disease Risk: A Mother and Child Perspective
Montoya‐Uribe, V., Glibetić, N., Aan, F. J., & Matter, M. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00068-1 · Cited by 1
Diet Potentially Drives the Differentiation of Eating Behaviours via Alterations to the Gut Microbiome in InfantsPreprint
Yan, C., Zhao, H., Nayar, N., Rhee, K. E., & Lumeng, J. C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.24.438478 · Cited by 1
Interaction Between Diet and Dominant Fecal Microbiota Along the First Year of LifePreprint
Gómez‐Martín, M., Saturio, S., Arboleya, S., Herrero-Morín, D., Calzón, M., López, T., González, S., & Gueimonde, M. (2021) · Research Square · doi:10.21203/rs.3.rs-1028299/v1 · Cited by 1
Abstracts of XVII International Scientific and Practical Conference
(2021) · doi:10.46299/isg.2021.i.xvii · Cited by 1
How Gut Microbiota Supports Immunity, Growth and Development of Preterm Infants: A Narrative Review
Widodo, A. D. (2021) · Amerta Nutrition · doi:10.20473/amnt.v5i1sp.2021.14-20
References
(2021) · Elsevier eBooks · doi:10.1016/b978-0-323-68013-4.00080-8
Oral and gut microbiome biomarkers of susceptibility to respiratory tract infection in adults: a longitudinal cohort feasibility studyPreprint
Woodall, C. A., Hammond, A., Cleary, D. W., Preston, A., Muir, P., Pascoe, B., Sheppard, S. K., & Hay, A. D. (2021) · medRxiv · doi:10.1101/2021.12.21.21268189
Gut microbial ecology and exposome of a healthy Pakistani cohortPreprint
Gul, F., Herrema, H., Davids, M., Keating, C., Nasir, A., Ijaz, U. Z., & Javed, S. (2023) · Research Square · doi:10.21203/rs.3.rs-3395306/v1
Gut-Brain Interplay and Cognitive Degeneration
Krishnamoorthy, K., Rajagopal, P., & Jayaraman, S. (2024) · Springer eBooks · doi:10.1007/978-981-99-8803-7_4
Study of Factors Influencing the Intestinal Microbiota in Children from 0 to 3 Months at the Mother and Child Hospital of Bingerville, Ivory Coast during 2023
Miedjim, G. K., Gbonon, V., Evelyne, A.-G. A., Assal, N. N. N., Mathias, N. K., Guédé, C. M., ASSOHOUN, E. S., MONEY, M. E., Gnahoré, F. D., Kintossou, A. K., et al. (2024) · Journal of Applied Life Sciences International · doi:10.9734/jalsi/2024/v27i3649
The Effect of Dadih Functional Bread for Nutritional Intake, Maternal Weight Gain During Pregnancy, and Outcomes: A Prospective Randomized Double-Blind Controlled Trial
Helmizar, H., Ariyasra, U., Sakinah, R., Ferry, F., & Lipoeto, N. I. (2025) · F1000Research · doi:10.12688/f1000research.160927.1
Dynamic Alternations in Mother–Infant Dyad’s Gut Microbiota over the Period of Six Months
Yang, L., Sakandar, H. A., Zhihong, S., & Zhang, H. (2025) · Applied Sciences · doi:10.3390/app15063239
The Role of Gut Microbiota in Ocular Diseases
Roy, T. K., Roy, A., Bairagya, S., & De, S. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815324549125010009
Prenatal and postnatal factors of childhood obesity
Jiménez-Ortega, A. I., García, R. M. M., Cuadrado‐Soto, E., & Salas‐González, M. D. (2025) · Nutrición Hospitalaria · doi:10.20960/nh.06094
Early-Life Demographic Factors Shape Gut Microbiome Patterns Associated with Rotavirus Gastroenteritis Severity
Abdelbary, E. R., Ramadan, M., Amin, I. A., Abd-Elsamea, F. S., Elsaghier, A. M., Abd-Alrahman, E., Ozbak, H. A., Hemeg, H. A., Almutawif, Y. A., Zakai, S. A., et al. (2025) · Viruses · doi:10.3390/v17121542 · Cited by 1
Additional file 4 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435887
Additional file 5 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435890
Additional file 9 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435902
Additional file 12 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435875
Additional file 11 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435872
Additional file 6 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435893
Additional file 1 of Prenatal and postnatal determinants in shaping offspring’s microbiome in the first 1000 days: study protocol and preliminary results at one month of life
Raspini, B., Porri, D., Giuseppe, R. D., Chieppa, M., Liso, M., Cerbo, R. M., Civardi, E., Garofoli, F., Monti, M. C., Vacca, M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12134154
Additional file 2 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435881
Additional file 3 of Gut microbial ecology and exposome of a healthy Pakistani cohort
Gul, F., Herrema, H., Davids, M., Keating, C., Nasir, A., Ijaz, U. Z., & Javed, S. (2024) · Figshare · doi:10.6084/m9.figshare.26670867
Additional file 8 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435899
Additional file 2 of Effects of age, seasonality, and reproductive status on the gut microbiome of Southern White Rhinoceros (Ceratotherium simum simum) at the North Carolina zoo
Burnham, C. M., McKenney, E. A., Heugten, K. A., Minter, L. J., & Trivedi, S. (2023) · Figshare · doi:10.6084/m9.figshare.22774208
Additional file 1 of Gut microbial ecology and exposome of a healthy Pakistani cohort
Gul, F., Herrema, H., Davids, M., Keating, C., Nasir, A., Ijaz, U. Z., & Javed, S. (2024) · Figshare · doi:10.6084/m9.figshare.26670861
Additional file 1 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435878
Additional file 3 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435884
Additional file 2 of Gut microbial ecology and exposome of a healthy Pakistani cohort
Gul, F., Herrema, H., Davids, M., Keating, C., Nasir, A., Ijaz, U. Z., & Javed, S. (2024) · Figshare · doi:10.6084/m9.figshare.26670864
Additional file 7 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435896
Additional file 10 of The Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
Phillips, S., Watt, R., Atkinson, T., Savva, G. M., Hayhoe, A., & Hall, L. J. (2021) · Figshare · doi:10.6084/m9.figshare.16435869
Foundations of the gut microbiome: understanding microbial ecology
Kalia, P., Angelis, M., Rani, A., & Qavi, D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40483-2.00019-4
Research Progress on Gut Microbiota in Pediatric Allergic Rhinitis
王, 敏. (2026) · Journal of Clinical Personalized Medicine · doi:10.12677/jcpm.2026.52119
Polluants organiques persistants : impact sur la composition du lait maternel et l'installation du microbiote intestinal du nouveau-né
Dzon, B. E. (2023) · theses.fr (ABES) · doi:10.70675/3c1e3055z816cz48a2za02dze8962bba8ed7
Exposition aux produits de peroxydation lipidique induits par l'apport nutritionnel de fer héminique des viandes : conséquences sur l'homéostasie intestinale et la susceptibilité aux maladies chroniques chez l'adulte et sa descendance
Mazenc, A. (2022) · theses.fr (ABES) · doi:10.70675/993fac83z1efdz4dd2z8639z1373d18cf659
Facteurs de variation précoce du microbiote intestinal des enfants de 3 ans et relations avec l'évolution de la corpulence : données des cohortes EPIPAGE 2 et ELFE
Toubon, G. (2023) · theses.fr (ABES) · doi:10.70675/638acae3z4651z4ecfz9b2bzbbd1859ef6f8
Human milk oligosaccharides as a factor in the formation of differentiated microbiological profiles of the gut microbiota in infants during the first months of life
Orobinskaya, Y. V., Sugian, N. G., Игоревич, К. С., Odintsova, V. Y., Zakharova, I. N., & Макаркин, Д. В. (2026) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2026-270
Грудное вскармливание и питание детей раннего возраста: первый год жизни. Ладодо О.Б., Макарова С.Г., Олина А.А. и соавт.
Ladodo, O. B., Makarova, S. G., Olina, A. A., Хухрева, Д. А., & Мошкина, Н. А. (2021) · Medical Opponent · doi:10.64831/2619-0001.2021.4.167175

Authors: Kumbhare, S. V., Patangia, D. V., Patil, R. H., Shouche, Y. S., & Patil, N. P.
Affiliations: National Centre for Cell Science (IN)
Corresponding author: Patil, Nitinkumar P
ORCID: Kumbhare, Shreyas V
Patangia, Dhrati V
Patil, Ravindra H
Shouche, Yogesh S
Patil, Nitinkumar P
Venue: Journal of Biosciences
Publisher: Springer Science and Business Media LLC
Published: 2019-04-11
Volume: 44
Issue: 2
ISSN: 0250-5991 (ISSN-L)
0973-7138
DOI: 10.1007/s12038-019-9860-z
OpenAlex: W2939636141
Cited by: 143
References: 255
Citations by year: 2026: 5 · 2025: 17 · 2024: 20 · 2023: 34 · 2022: 24 · 2021: 31 · 2020: 12
FWCI: 5.54
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Biosciences (publishedVersion)
PubMed (publishedVersion)
Funders: Indian Council of Medical Research (3/1/2/27/15-RCH)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, early-life microbiota, infant microbiome, maternal factors, dysbiosis, obesity, diabetes mellitus, asthma, immune system development, microbial colonization, host-microbe coevolution
MeSH terms: Gastrointestinal Microbiome, Adult, Anti-Bacterial Agents, Asthma, Child, Child, Preschool, Diabetes Mellitus, Diet, Female, Fetus, Humans, Immunity, Innate, Infant, Male, Obesity, Pregnancy, Risk Factors, Dysbiosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Factors influencing the gut microbiome in children: from infancy to childhood

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks