The DOI matches its Crossref record; 254 of the 255 references it cites were found in a registry or an index.
Factors influencing the gut microbiome in children: from infancy to childhood
Abstract
The human microbiota plays a crucial role in educating the immune system and influencing host health right since birth. Various maternal factors along with the vertical microbial transfer from the mother, as well as the horizontal environmental transmission and internal factors relating to the infant, play a crucial role in modulating the gut microbiota. The early life microflora is highly unstable and undergoes dynamic changes during the first few years, converging towards a more stabilized adult microbiota by co-evolving with the host by the age of 3-4 years. Microbiota studies have underlined the role of dysbiosis in developing several metabolic disorders like obesity, diabetes and immune-related disorders like asthma, to name a few. Thus, understanding early life microbial composition and various factors affecting the microbial community will provide a platform for developing strategies/techniques to maintain host health by restoring gut microbial flora. This review focuses on the factors that affect the microbial composition of the foetus in utero, during birth, infancy through childhood.
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“Several factors are known to influence microbial composition at different stages of life, including genetic factors, mode of delivery [vaginal birth or Caesarean section (C-section)], gestational age, exercise, medication use, living environment, and diet (237-240).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [239]
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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
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The Association between Early-Life Gut Microbiota and Long-Term Health and Diseases
Sarkar, A., Yoo, J. Y., Dutra, S. V. O., Morgan, K. H., & Groer, M. E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030459 · Cited by 371
Metadata
- Authors
- Kumbhare, S. V., Patangia, D. V., Patil, R. H., Shouche, Y. S., & Patil, N. P.
- Affiliations
- National Centre for Cell Science (IN)
- Corresponding author
- Patil, Nitinkumar P
- Venue
- Journal of Biosciences
- Published
- 2019-04-11
- Volume
- 44
- Issue
- 2
- ISSN
- 0250-5991 (ISSN-L)
- 0973-7138
- OpenAlex
- W2939636141
- Cited by
- 143
- References
- 255
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 20 · 2023: 34 · 2022: 24 · 2021: 31 · 2020: 12
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Biosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Indian Council of Medical Research (3/1/2/27/15-RCH)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, early-life microbiota, infant microbiome, maternal factors, dysbiosis, obesity, diabetes mellitus, asthma, immune system development, microbial colonization, host-microbe coevolution
- MeSH terms
- Gastrointestinal Microbiome, Adult, Anti-Bacterial Agents, Asthma, Child, Child, Preschool, Diabetes Mellitus, Diet, Female, Fetus, Humans, Immunity, Innate, Infant, Male, Obesity, Pregnancy, Risk Factors, Dysbiosis
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