Cited by 146Gut microbiota and healthInfant Nutrition and HealthProbiotics and Fermented Foods

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Factors influencing the gut microbiome in children: from infancy to childhood

Kumbhare, Shreyas V, Patangia, Dhrati V, Patil, Ravindra H, Shouche, Yogesh S, Patil, Nitinkumar P·2019·Journal of Biosciences

DOI 10.1007/s12038-019-9860-z

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Abstract

The human microbiota plays a crucial role in educating the immune system and influencing host health right since birth. Various maternal factors along with the vertical microbial transfer from the mother, as well as the horizontal environmental transmission and internal factors relating to the infant, play a crucial role in modulating the gut microbiota. The early life microflora is highly unstable and undergoes dynamic changes during the first few years, converging towards a more stabilized adult microbiota by co-evolving with the host by the age of 3-4 years. Microbiota studies have underlined the role of dysbiosis in developing several metabolic disorders like obesity, diabetes and immune-related disorders like asthma, to name a few. Thus, understanding early life microbial composition and various factors affecting the microbial community will provide a platform for developing strategies/techniques to maintain host health by restoring gut microbial flora. This review focuses on the factors that affect the microbial composition of the foetus in utero, during birth, infancy through childhood.

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Retracted
Pre- and Postnatal Determinants Shaping the Microbiome of the Newborn in the Opinion of Pregnant Women from Silesia (Poland)
Krupa-Kotara, K. H., Grajek, M. K., Grot, M., Czarnota, M., Wypych-Ślusarska, A., Oleksiuk, K., Głogowska‐Ligus, J., & Slowinski, J. L. (2023) · Life · doi:10.3390/life13061383 · Cited by 2

Authors: Kumbhare, S. V., Patangia, D. V., Patil, R. H., Shouche, Y. S., & Patil, N. P.
Affiliations: National Centre for Cell Science (IN)
Corresponding author: Patil, Nitinkumar P
ORCID: Kumbhare, Shreyas V
Patangia, Dhrati V
Patil, Ravindra H
Shouche, Yogesh S
Patil, Nitinkumar P
Venue: Journal of Biosciences
Publisher: Springer Science and Business Media LLC
Published: 2019-04-11
Volume: 44
Issue: 2
ISSN: 0250-5991 (ISSN-L)
0973-7138
DOI: 10.1007/s12038-019-9860-z
OpenAlex: W2939636141
Cited by: 143
References: 255
Citations by year: 2026: 5 · 2025: 17 · 2024: 20 · 2023: 34 · 2022: 24 · 2021: 31 · 2020: 12
FWCI: 5.54
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Biosciences (publishedVersion)
PubMed (publishedVersion)
Funders: Indian Council of Medical Research (3/1/2/27/15-RCH)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, early-life microbiota, infant microbiome, maternal factors, dysbiosis, obesity, diabetes mellitus, asthma, immune system development, microbial colonization, host-microbe coevolution
MeSH terms: Gastrointestinal Microbiome, Adult, Anti-Bacterial Agents, Asthma, Child, Child, Preschool, Diabetes Mellitus, Diet, Female, Fetus, Humans, Immunity, Innate, Infant, Male, Obesity, Pregnancy, Risk Factors, Dysbiosis

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Factors influencing the gut microbiome in children: from infancy to childhood

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