The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae
Open accessAbstract
Ergosterol, an important component of the fungal cell membrane, is not only essential for fungal growth and development but also very important for adaptation to stress in fungi. Ergosterol is also a direct precursor for steroid drugs. The biosynthesis of ergosterol can be divided into three modules: mevalonate, farnesyl pyrophosphate (farnesyl-PP) and ergosterol biosynthesis. The regulation of ergosterol content is mainly achieved by feedback regulation of ergosterol synthase activity through transcription, translation and posttranslational modification. The synthesis of HMG-CoA, catalyzed by HMGR, is a major metabolic check point in ergosterol biosynthesis. Excessive sterols can be subsequently stored in lipid droplets or secreted into the extracellular milieu by esterification or acetylation to avoid toxic effects. As sterols are insoluble, the intracellular transport of ergosterol in cells requires transporters. In recent years, great progress has been made in understanding ergosterol biosynthesis and its regulation in Saccharomyces cerevisiae. However, few reviews have focused on these studies, especially the regulation of biosynthesis and intracellular transport. Therefore, this review summarizes recent research progress on the physiological functions, biosynthesis, regulation of biosynthesis and intracellular transportation of ergosterol in S. cerevisiae.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Conversely, hyperosmotic stress adaptation (such as salt or sorbitol treatment) leads to the decrease in ergosterol abundance [6,7].”
From Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae (2020) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Regulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593
Enzymes of the mevalonate pathway of isoprenoid biosynthesis
Miziorko, H. M. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.09.028 · Cited by 529
Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites
Stefan, C. J., Manford, A. G., Baird, D., Yamada-Hanff, J., Mao, Y., & Emr, S. D. (2011) · Cell · doi:10.1016/j.cell.2010.12.034 · Cited by 499
Puig, S., Askeland, E., & Thiele, D. J. (2005) · Cell · doi:10.1016/j.cell.2004.11.032 · Cited by 382
Yeast lipid metabolism at a glance
Klug, L., & Daum, G. (2014) · FEMS Yeast Research · doi:10.1111/1567-1364.12141 · Cited by 349
Regulation of HMG-CoA reductase in mammals and yeast
Burg, J. S., & Espenshade, P. J. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.07.002 · Cited by 303
The Red Seaweed Gracilaria gracilis as a Multi Products Source
Francavilla, M., Franchi, M., Monteleone, M., & Caroppo, C. (2013) · Marine Drugs · doi:10.3390/md11103754 · Cited by 264
Aguilera, F. S., Peinado, R. A., Millán, C., Ortega, J. M., & Mauricio, J. C. (2006) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2006.02.002 · Cited by 253
ERGOSTEROL BIOSYNTHESIS: A FUNGAL PATHWAY FOR LIFE ON LAND?
Dupont, S., Lemetais, G., Ferreira, T., Cayot, P., Gervais, P., & Beney, L. (2012) · Evolution · doi:10.1111/j.1558-5646.2012.01667.x · Cited by 246
Perry, R. J., & Ridgway, N. D. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-01-0060 · Cited by 234
Research works printed but not linked: 1
- Kodedova M, Sychrova H (2015) Changes in the sterol composition of the plasma membrane affect membrane potential, salt tolerance and the activity of multidrug resistance pumps in Saccharomyces cerevisiae. PLoS ONE 10:e0139306. doi: 10.1371/journal.pone.0139306 · DOI
Cited by
Sorted by citations
Items 201–228 of 228
Additional file 2 of Divergent patterns of selection on metabolite levels and gene expression
Kern, A., Yang, G. X., Khosla, N. M., Ang, R. M. L., Snyder, M. P., & Fraser, H. B. (2021) · Figshare · doi:10.6084/m9.figshare.16702984
Naftoquinonas: Potencial biológico e perspectivas como antifúngicos
de Almeida, J. D. R., de Sousa, C. D. S., Silva, I. B., da Silva, R. D. C. S., da Silva, S. R. S., de Souza, J. V. B., & de Souza, É. S. (2026) · Research Society and Development · doi:10.33448/rsd-v15i1.50492
Wang, Y.-H., Xie, L.-L., Zhang, C.-N., Sheng, R., Li, H., & Chen, F. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6469741
Synthetic Biology Approaches for Representative Bioactive Metabolites of Medicinal Mushrooms
Li, Y., Wang, X. S., Cheng, M., Zhao, X., & Han, C. (2026) · International journal of medicinal mushrooms · doi:10.1615/intjmedmushrooms.2026064068
Huo, Z., Zhong, C., Wang, F., Gao, J., Su, Z., Dong, R., He, Y., Feng, S., Kang, J., Zhang, Y., et al. (2026) · Microbial Cell Factories · doi:10.1186/s12934-026-02983-2
Discovery of tRNA-dependent ergosterol aminoacylation in fungi
Yakobov, N. (2020) · theses.fr (ABES) · doi:10.70675/54f07229z7a9bz4a0fz8263z43817d7f7c3c
Etude des besoins en stérols des souches de levures œnologiques (Saccharomyces Cerevisiae)
Piva, G. G. (2022) · theses.fr (ABES) · doi:10.70675/8a3d39d9z1c93z47b6z900fz2213d379468e
Urbina-Salazar, A. D. R., Inca-Torres, A. R., Paredes-Páliz, K. I., Mosquera, J. A. N., Llaguno, S. N. S., Morejon, J. P. A., & Escobar, K. Y. R. (2026) · Current Research in Nutrition and Food Science Journal · doi:10.12944/crnfsj.14.1.21
Nair, A. M., Rao, B. E., Kondaveeti, S. S., Kumar, A. V. A., Jayasinghe, R. D., Ramshankar, V., & Venugopal, D. C. (2026) · Journal of International Society of Preventive and Community Dentistry · doi:10.4103/jispcd.jispcd_187_25
Zhao, X., Zhang, T., Qi, Y., Liu, X., Ren, X., Chen, S., Meng, Z., Lin, W., Yang, S., Wang, L., et al. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-24738-5.00078-1
Nagdalian, A., & Govindarajan, R. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-12-819533-8.00013-0
He, X., Shen, C., Cheng, Q., Zhang, H., Liu, X., & Wang, W. (2026) · Plant Cell & Environment · doi:10.1111/pce.70582
Morphological and molecular changes in Botrytis cinerea occurring after cold plasma treatment
Miao, J., Zhai, S., Zhang, W., Guo, M., Cao, J., Chen, G., Yang, W., & Cheng, S. (2026) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2026.114420
Song, H. Y., Lee, G. W., Jung, Y. H., & Lee, J. W. (2026) · Frontiers in Chemical Engineering · doi:10.3389/fceng.2026.1833599
Wang, Y.-H. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6850545
Cheng, X., Huang, Q.-Y., Li, Y., Wu, Q., Gong, W., & Xie, L. (2026) · Scientific Reports · doi:10.1038/s41598-026-56305-y
Yin, L., Liu, X. D., Chen, J. K., Ding, N., Chen, H., Lin, H., Ma, Z., Shao, Q., Wang, D., & Zhang, P. (2026) · Molecules · doi:10.3390/molecules31132367
Han, Y., Luo, Y., Wang, K., Lin, L., Gao, J., Sun, M.-L., & Ji, X. (2026) · Bioresources and Bioprocessing · doi:10.1186/s40643-026-01094-5
High-level amyrin production in Yarrowia lipolytica via metabolic and enzyme engineering
Elsharawy, H., Abdullah, C. N., Yin, X., & Zhou, J. (2026) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2026.04.021
Antifungal effects of carvacrol on Penicillium verrucosum growth in refrigerated wet noodles
Li, H., Wang, Y.-Y., Lv, Y., Zhai, H.-C., Hu, Y., Wang, F.-Z., Huang, L., & Zhang, S.-B. (2026) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2026.111978
Chen, Z., Jiang, Z., Li, X., Yang, C., Han, F., Yang, H., & Xu, C. (2026) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2026.116968
Wang, H., Yang, Y., Wu, Z., Zhao, H., Ba, Y., Zhang, C., Sun, C., Yu, Z. H., Qiu, B., Liu, X., et al. (2026) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.6c06083
Oliveira, R. S., Gordijo, M. C., Segura, W. D., Manfio, P. H. C., de Moraes, L. B., Lima, S. F., Serrano, S. M. T., Chaves, A. F. A., & Batista, W. L. (2026) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6c00370
Ayala, M., Jakamartana, A., Costa, R. M. D. S., Cheung, E. C.-K., Bednarek, J. M., Moreau, C. T., & Brown, J. C. S. (2026) · mSphere · doi:10.1128/msphere.00432-26
Ahmed, T., Juhász, A., Bose, U., Terefe, N. S., Chan, L. Y., Craik, D. J., & Colgrave, M. L. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c09785
Makrofungal Sekonder Metabolitler: Biyolojik Aktiviteleri ve Biyoteknolojik Uygulamalar
Canpolat, Ş. (2026) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1508.c6073
Metadata
- Authors
- Hu, Z., He, B., Ma, L., Sun, Y., Niu, Y., & Zeng, B.
- Affiliations
- Jiangxi Science and Technology Normal University (CN)
- Corresponding author
- Zeng, Bin
- Venue
- Indian Journal of Microbiology
- Published
- 2017-07-04
- Volume
- 57
- Issue
- 3
- Pages
- 270-277
- ISSN
- 0046-8991 (ISSN-L)
- 0973-7715
- PMC
- PMC5574775
- OpenAlex
- W2733705455
- Cited by
- 225
- References
- 64
- Citations by year
- 2026: 30 · 2025: 37 · 2024: 42 · 2023: 25 · 2022: 26 · 2021: 28 · 2020: 15 · 2019: 17 · 2018: 5
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Indian Journal of Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31171731, 31460447)
- International S&T Cooperation Project of Jiangxi Provincial (20142BDH80003)
- General Science and Technology Project of Nanchang City (3000035402)
- “555 Talent Project” of Jiangxi Province
- Science and Technology Research Project of Jiangxi Provincial Department of Education (GJJ160765, GJJ160794)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- ergosterol biosynthesis, Saccharomyces cerevisiae, feedback regulation, mevalonate pathway, HMGR, lipid droplets, sterol esterification, sterol transporters, fungal cell membrane, stress adaptation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
