History of Major Depressive Disorder Prospectively Predicts Worse Quality of Life in Women with Breast Cancer
Open accessAbstract
BACKGROUND: Data are scarce about whether past history of major depressive disorder in the absence of current depression places breast cancer patients at risk for worse quality of life. PURPOSE: The current study prospectively examined quality of life during chemotherapy in breast cancer patients with a history of resolved major depressive disorder (n = 29) and no history of depression (n = 144). METHODS: Women with Stages 0-II breast cancer were assessed prior to and at the completion of chemotherapy. Major depressive disorder was assessed via structured interview and quality of life with the SF-36. RESULTS: Patients with past major depressive disorder displayed greater declines in physical functioning relative to patients with no history of depression (p ≤ 0.01). CONCLUSIONS: Findings suggest that breast cancer patients with a history of resolved major depressive disorder are at increased risk for declines in physical functioning during chemotherapy relative to patients with no history of depression.
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- Authors
- Jim, H. S. L., Small, B. J., Minton, S., Andrykowski, M., & Jacobsen, P. B.
- Affiliations
- Moffitt Cancer Center (US)
- University of South Florida (US)
- University of Kentucky (US)
- Corresponding author
- Jim, Heather S. L.
- Venue
- Annals of Behavioral Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-12-14
- Volume
- 43
- Issue
- 3
- Pages
- 402-408
- ISSN
- 0742-5554 (ISSN-L)
- 0883-6612
- 1532-4796
- PMC
- PMC3424106
- OpenAlex
- W2007280301
- Cited by
- 32
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (K07CA138499, R01CA082822)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- major depressive disorder, breast cancer, quality of life, physical function, chemotherapy, history of depression, women, SF-36
- MeSH terms
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Major Depressive Disorder, Female, Humans, Middle Aged, Predictive Value of Tests, Quality of Life, Surveys and Questionnaires
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