The DOI matches its Crossref record; 25 of the 28 references it cites were found in a registry or an index.
Childhood Abuse and Inflammatory Responses to Daily Stressors
Open accessAbstract
BACKGROUND: Childhood abuse leads to greater morbidity and mortality in adulthood. Dysregulated physiological stress responses may underlie the greater health risk among abused individuals. PURPOSE: This study evaluated the impact of childhood abuse on inflammatory responses to naturalistically occurring daily stressors. METHODS: In this cross-sectional study of 130 older adults, recent daily stressors and childhood abuse history were evaluated using the Daily Inventory of Stressful Events and the Childhood Trauma Questionnaire. Blood samples provided data on circulating interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP). RESULTS: Childhood abuse history moderated IL-6 levels but not TNF-α and CRP responses to daily stressors. Individuals with a childhood abuse history who experienced multiple stressors in the past 24 h had IL-6 levels 2.35 times greater than those of participants who reported multiple daily stressors but no early abuse history. CONCLUSION: Childhood abuse substantially enhances IL-6 responses to daily stressors in adulthood.
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“Concentrations of IL-6, IL-1β, and TNF-α are elevated with childhood maltreatment (Gouin et al, 2012;Hartwell et al, 2013;Kiecolt-Glaser et al, 2011;Smith et al, 2011;Tietjen et al, 2012).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Gouin et al, 2012
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“greater IL-6 responses to daily life stressors in a crosssectional study of older adults”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Gouin, Glaser, Malarkey, Beversdorf, & Kiecolt-Glaser, 2012
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“there is also evidence that ELS enhances inflammatory responses to minor daily life stressors in adulthood (67).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [67]
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Inflammation: Depression Fans the Flames and Feasts on the Heat
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Self-citationInflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
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Metadata
- Authors
- Gouin, J.-P., Glaser, R., Malarkey, W. B., Beversdorf, D., & Kiecolt-Glaser, J. K.
- Affiliations
- Concordia University (CA)
- The Ohio State University (US)
- University of Missouri (US)
- Corresponding author
- Gouin, Jean-Philippe
- Venue
- Annals of Behavioral Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-06-20
- Volume
- 44
- Issue
- 2
- Pages
- 287-292
- ISSN
- 0742-5554 (ISSN-L)
- 0883-6612
- 1532-4796
- PMC
- PMC3699690
- OpenAlex
- W2077730504
- Cited by
- 130
- References
- 28
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 19 · 2019: 8 · 2018: 12 · 2017: 11 · 2016: 8 · 2015: 13 · 2014: 9 · 2013: 6 · 2012: 2
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ohio State University (CA16058, UL1RR025755)
- National Institutes of Health (CA‐16058)
- National Institute on Aging (AG025732, R21AG025732)
- National Cancer Institute (CA16058, P30CA016058)
- National Center for Research Resources (UL1RR025755)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Health › Intimate Partner and Family Violence
- Keywords
- childhood abuse, childhood trauma, daily hassles, inflammation, interleukin-6, TNF-α, C-reactive protein, physiological stress response, older adults
- MeSH terms
- Aged, Aged, 80 and over, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Stress, Psychological, Tumor Necrosis Factor-alpha, Interleukin-6, Adult Survivors of Child Abuse
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