Cited by 613Child Abuse and TraumaPsychoanalysis and Psychopathology ResearchStress Responses and Cortisol

Neurobiological and psychiatric consequences of child abuse and neglect

Heim, Christine, Shugart, Margaret, Craighead, W. Edward, Nemeroff, Charles B.·2010·Developmental Psychobiology

Abstract

The effects of early-life trauma and its consequences for the treatment of depression are reviewed. The prevalence and clinical sequelae of early sexual and physical abuse, neglect and parental loss are described. An overview of preclinical studies that help guide clinical research and practice is presented. Human clinical studies on the neurobiological consequences of early trauma are summarized. Moderating factors, such as genetic variation and sex differences, are discussed. The few current treatment outcome studies relevant to this research area are described. Guidance for the management of patients with depression and a history of child abuse and neglect are provided. Most patients who have experienced early traumatic experiences are likely best treated with a combination of psychotherapy and pharmacotherapy. This review is dedicated to the memory of Seymour Levine who pioneered the field of early experience research and to a considerable extent inspired the clinical studies described in this review.

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Crossref · 10.1002/dev.20494

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185 of 185 references verified0 citation errors · 0 not checkable

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Authors
Heim, C., Shugart, M., Craighead, W. E., & Nemeroff, C. B.
Affiliations
  • Emory University (US)
  • University of Miami (US)
Corresponding author
Nemeroff, Charles B.
Venue
Developmental Psychobiology
Publisher
Wiley
Published
2010-09-29
Volume
52
Issue
7
Pages
671-690
ISSN
  • 0012-1630 (ISSN-L)
  • 1098-2302
OpenAlex
W2158678922
Cited by
613
References
185
Citations by year
2026: 18 · 2025: 24 · 2024: 16 · 2023: 28 · 2022: 39 · 2021: 39 · 2020: 36 · 2019: 42 · 2018: 57 · 2017: 50 · 2016: 58 · 2015: 52 · 2014: 50 · 2013: 47 · 2012: 34
FWCI
4.75
Type
journal article
Language
en
Open access
closed
Locations
  • Developmental Psychobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
child abuse, child neglect, early trauma, depression, neurobiology of trauma, psychiatric consequences, sexual abuse, physical abuse, parental loss, genetic variation, sex differences, psychotherapy, pharmacotherapy, treatment outcomes
MeSH terms
Child, Child Abuse, Child Abuse, Sexual, Combined Modality Therapy, Depression, Humans, Life Change Events, Neurobiology, Psychotherapy, Stress, Psychological

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