Cited by 1,026SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesImmune responses and vaccinations

A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

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Huang, Angkana T., Garcia-Carreras, Bernardo, Hitchings, Matt D. T., Yang, Bingyi, Katzelnick, Leah C., Rattigan, Susan M., Borgert, Brooke A., Moreno, Carlos A. +9 more·2020·Nature Communications

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Abstract

Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.

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  1. [6]Baker, R. E., Yang, W., Vecchi, G. A., Metcalf, C. J. E. & Grenfell, B. T. Susceptible supply limits the role of climate in the COVID-19 pandemic. 10.1101/2020.04.03.20052787 (2020). PMC7243362 32423996 · DOI
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Authors
Huang, A. T., Garcia-Carreras, B., Hitchings, M. D. T., Yang, B., Katzelnick, L. C., Rattigan, S. M., Borgert, B. A., Moreno, C. A., Solomon, B. D., Trimmer-Smith, L., Etienne, V., Rodriguez-Barraquer, I., Lessler, J., Salje, H., Burke, D. S., Wesolowski, A., & Cummings, D. A. T.
Affiliations
  • University of Florida (US)
  • National Institutes of Health (US)
  • Johns Hopkins University (US)
  • Institut Pasteur (FR)
  • University of Pittsburgh (US)
Corresponding author
Cummings, Derek A. T.
Venue
Nature Communications
Published
2020-09-17
Volume
11
Issue
1
Pages
4704-4704
ISSN
2041-1723 (ISSN-L)
OpenAlex
W3087128437
Cited by
1,026
References
149
Citations by year
2026: 10 · 2025: 28 · 2024: 57 · 2023: 92 · 2022: 227 · 2021: 412 · 2020: 199 · 2018: 1
FWCI
11.02
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • medRxiv (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion, cc-by)
  • PubMed Central (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Apollo (cc-by)
  • Apollo
Funders
  • John A Watson Faculty Scholar fellowship
  • U.S. Department of Health & Human Services | National Institutes of Health (DP2LM013102)
  • Burroughs Wellcome Fund (Career Award at the Scientific Interface)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
humoral immunity, SARS-CoV-2, COVID-19 pandemic, SARS-CoV, MERS-CoV, antibody kinetics, correlates of protection, immunopathogenesis, antigenic diversity, cross-reactivity, seroprevalence, disease severity, protective immunity

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