Cited by 724Gut microbiota and healthProbiotics and Fermented FoodsInfant Nutrition and Health

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Intestinal microbiota in human health and disease: the impact of probiotics

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Gerritsen, Jacoline, Smidt, Hauke, Rijkers, Ger T., de Vos, Willem M.·2011·Genes & Nutrition

DOI 10.1007/s12263-011-0229-7PMC PMC3145058

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Abstract

The complex communities of microorganisms that colonise the human gastrointestinal tract play an important role in human health. The development of culture-independent molecular techniques has provided new insights in the composition and diversity of the intestinal microbiota. Here, we summarise the present state of the art on the intestinal microbiota with specific attention for the application of high-throughput functional microbiomic approaches to determine the contribution of the intestinal microbiota to human health. Moreover, we review the association between dysbiosis of the microbiota and both intestinal and extra-intestinal diseases. Finally, we discuss the potential of probiotic microorganism to modulate the intestinal microbiota and thereby contribute to health and well-being. The effects of probiotic consumption on the intestinal microbiota are addressed, as well as the development of tailor-made probiotics designed for specific aberrations that are associated with microbial dysbiosis.

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Authors: Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M.
Affiliations: Wageningen University & Research (NL)
Radboud University Medical Center (NL)
Corresponding author: Gerritsen, Jacoline
ORCID: Gerritsen, Jacoline
Smidt, Hauke
Rijkers, Ger T.
Venue: Genes & Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2011-05-27
Volume: 6
Issue: 3
Pages: 209-240
ISSN: 1555-8932 (ISSN-L)
1865-3499
DOI: 10.1007/s12263-011-0229-7
PMC: PMC3145058
OpenAlex: W2116844657
Cited by: 724
References: 266
Citations by year: 2026: 13 · 2025: 40 · 2024: 60 · 2023: 35 · 2022: 50 · 2021: 54 · 2020: 69 · 2019: 63 · 2018: 70 · 2017: 75 · 2016: 63 · 2015: 49 · 2014: 32 · 2013: 32 · 2012: 15
FWCI: 10.77
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Genes & Nutrition (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Agentschap NL
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: gut microbiota, probiotics, dysbiosis, gut microbiota composition, gut microbiota diversity, gastrointestinal diseases, probiotic consumption

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Intestinal microbiota in human health and disease: the impact of probiotics

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