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Cited by 33Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental DisordersMultiple Sclerosis Research Studies

Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice

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Chen, Xianjun, Wang, Fei, Gan, Jingli, Zhang, Zhonghua, Liang, Xuejun, Li, Tao, Huang, Nanxin, Zhao, Xiaofeng +2 more·2020·Neuroscience Bulletin
DOI 10.1007/s12264-019-00449-7PMC PMC7142181
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Abstract

Oligodendrocyte (OL) and myelin development are crucial for network integration and are associated with higher brain functions. Accumulating evidence has demonstrated structural and functional impairment of OLs and myelin in serious mental illnesses. However, whether these deficits contribute to the brain dysfunction or pathogenesis of such diseases still lacks direct evidence. In this study, we conditionally deleted Olig2 in oligodendroglial lineage cells (Olig2 cKO) and screened the behavioral changes in adult mice. We found that Olig2 ablation impaired myelin development, which further resulted in severe hypomyelination in the anterior cingulate cortex. Strikingly, Olig2 cKO mice exhibited an anxious phenotype, aberrant responses to stress, and cognitive deficits. Moreover, Olig2 cKO mice showed increased vulnerability to social avoidance under the mild stress of social isolation. Together, these results indicate that developmental deficits in OL and myelin lead to cognitive impairment and increase the risk of phenotypes reminiscent of mental illnesses.

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  • This result is consistent with the previous observation that deficiency in PRRC2A reduces the oligodendroglia population in the brain and induces hypomyelination, which leads to impaired locomotive and cognitive functions.

    “This result is consistent with the previous observation that deficiency in PRRC2A reduces the oligodendroglia population in the brain and induces hypomyelination, which leads to an impaired locomotive and cognitive functions [74–76].”

    From Distinct sex-specific DNA methylation differences in Alzheimer’s disease (2022) · cites this paper as [75]

    The Discussion and Results report that Olig2 deletion in oligodendroglial cells caused hypomyelination and cognitive deficits in young adult mice. They do not establish those effects for PRRC2A deficiency or a reduced oligodendroglia population. The Results also report normal locomotor activity in the Olig2 knockout mice, rather than impaired locomotion (page numbers unavailable). (LLM, conf=0.90)

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Cited by

Sorted by citations

Authors
Chen, X., Wang, F., Gan, J., Zhang, Z., Liang, X., Li, T., Huang, N., Zhao, X., Mei, F., & Xiao, L.
Affiliations
  • Army Medical University (CN)
  • Chinese People's Liberation Army (CN)
  • Hangzhou Normal University (CN)
Corresponding author
Xiao, Lan
ORCID
Venue
Neuroscience Bulletin
Publisher
Springer Science and Business Media LLC
Published
2019-11-22
Volume
36
Issue
4
Pages
419-426
ISSN
  • 1995-8218 (ISSN-L)
  • 1673-7067
DOI
10.1007/s12264-019-00449-7
PMC
PMC7142181
OpenAlex
W3034238192
Cited by
33
References
9
Citations by year
2026: 2 · 2025: 7 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 2
FWCI
1.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuroscience Bulletin (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Keywords
Olig2, oligodendrocytes, myelination, hypomyelination, anterior cingulate cortex, cognitive impairment, anxiety, stress response, social withdrawal, social isolation, mental illness, conditional knockout mice
MeSH terms
Oligodendrocyte Transcription Factor 2, Animals, Cell Differentiation, Myelin Sheath, Oligodendroglia, Social Isolation, Mice, Cognitive Dysfunction

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