Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation
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Establishment of oligodendrocyte identity is crucial for subsequent events of myelination in the CNS. Here, we demonstrate that activation of ATP-dependent SWI/SNF chromatin-remodeling enzyme Smarca4/Brg1 at the differentiation onset is necessary and sufficient to initiate and promote oligodendrocyte lineage progression and maturation. Genome-wide multistage studies by ChIP-seq reveal that oligodendrocyte-lineage determination factor Olig2 functions as a prepatterning factor to direct Smarca4/Brg1 to oligodendrocyte-specific enhancers. Recruitment of Smarca4/Brg1 to distinct subsets of myelination regulatory genes is developmentally regulated. Functional analyses of Smarca4/Brg1 and Olig2 co-occupancy relative to chromatin epigenetic marking uncover stage-specific cis-regulatory elements that predict sets of transcriptional regulators controlling oligodendrocyte differentiation. Together, our results demonstrate that regulation of the functional specificity and activity of a Smarca4/Brg1-dependent chromatin-remodeling complex by Olig2, coupled with transcriptionally linked chromatin modifications, is critical to precisely initiate and establish the transcriptional program that promotes oligodendrocyte differentiation and subsequent myelination of the CNS.
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Several motifs were enriched in Olig2 single-cell CUT&Tag, including CAGMTG similar to the previously identified Olig2 motif.
“We found several motifs enriched in the Olig2 scCUT&Tag, including motif CAGMTG, similar to the previously identified CAGMTG/CAGCTG motif specific for Olig2 (Figure 5h) in mouse33 and rat34 respectively.”
From Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues (2021) · cites this paper as [33]
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Cites
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679 · see citing works
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302 · see citing works
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029 · see citing works
Haberland, M., Montgomery, R. L., & Olson, E. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2485 · Cited by 2,541 · see citing works
Widespread transcription at neuronal activity-regulated enhancers
Kim, T.-K., Hemberg, M., Gray, J. M., Costa, A. M., Bear, D. M., Wu, J., Harmin, D. A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., et al. (2010) · Nature · doi:10.1038/nature09033 · Cited by 2,450 · see citing works
Self-citationA unique chromatin signature uncovers early developmental enhancers in humans
Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233 · see citing works
The diverse functions of histone lysine methylation
Martin, C., & Zhang, Y. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1761 · Cited by 2,066 · see citing works
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544 · see citing works
Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
Adelman, K., & Lis, J. T. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3293 · Cited by 1,186 · see citing works
Lu, Q. R., Sun, T., Zhu, Z.-M., Ma, N., García, M., Stiles, C., & Rowitch, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,064 · see citing works
Self-citationThe bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Zhou, Q., & Anderson, D. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00677-3 · Cited by 1,059 · see citing works
Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
Chang, A., Tourtellotte, W. W., Rudick, R., & Trapp, B. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010994 · Cited by 991 · see citing works
The oligodendrocyte and its many cellular processes
Pfeiffer, S. E., Warrington, A. E., & Bansal, R. (1993) · Trends in Cell Biology · doi:10.1016/0962-8924(93)90213-k · Cited by 852 · see citing works
ATP-Dependent Nucleosome Remodeling
Becker, P. B., & Hörz, W. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135400 · Cited by 790 · see citing works
Lessard, J., Wu, J. I., Ranish, J. A., Wan, M., Winslow, M. M., Staahl, B. T., Wu, H., Aebersold, R., Graef, I. A., & Crabtree, G. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.019 · Cited by 735 · see citing works
Self-citationRegulation of oligodendrocyte differentiation and myelination
Emery, B. (2010) · Science · doi:10.1126/science.1190927 · Cited by 653 · see citing works
Zhou, D., Lambert, S., Malen, P. L., Carpenter, S., Boland, L. M., & Bennett, V. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1295 · Cited by 568 · see citing works
Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination
Emery, B., Agalliu, D., Cahoy, J. D., Watkins, T. A., Dugas, J. C., Mulinyawe, S. B., Ibrahim, A., Ligon, K. L., Rowitch, D. H., & Barres, B. A. (2009) · Cell · doi:10.1016/j.cell.2009.04.031 · Cited by 559 · see citing works
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction
Ye, F., Chen, Y., Hoang, T., Montgomery, R. L., Zhao, X.-H., Bu, H., Hu, T., Taketo, M. M., van Es, J. H., Clevers, H., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2333 · Cited by 559 · see citing works
Self-citationDicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
Dugas, J. C., Cuellar, T. L., Scholze, A., Ason, B., Ibrahim, A., Emery, B., Zamanian, J. L., Foo, L. C., McManus, M. T., & Barres, B. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.027 · Cited by 527 · see citing works
Hah, N., Danko, C. G., Core, L. J., Waterfall, J. J., Siepel, A. C., Lis, J. T., & Kraus, W. L. (2011) · Cell · doi:10.1016/j.cell.2011.03.042 · Cited by 488 · see citing works
MicroRNA-Mediated Control of Oligodendrocyte Differentiation
Zhao, X., He, X., Han, X., Yu, Y., Ye, F., Chen, Y., Hoang, T., Xu, X., Mi, Q.-S., Xin, M., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.018 · Cited by 443 · see citing works
Self-citationFlavell, S. W., Kim, T.-K., Gray, J. M., Harmin, D. A., Hemberg, M., Hong, E. J., Markenscoff-Papadimitriou, E., Bear, D. M., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.029 · Cited by 440 · see citing works
Ho, L., Jothi, R., Ronan, J. L., Cui, K., Zhao, K., & Crabtree, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812888106 · Cited by 427 · see citing works
Peterson, C. L., Dingwall, A. K., & Scott, M. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.2905 · Cited by 410 · see citing works
Isolation and culture of rat and mouse oligodendrocyte precursor cells
Chen, Y., Balasubramaniyan, V., Peng, J., Hurlock, E. C., Tallquist, M. D., Li, J., & Lu, Q. R. (2007) · Nature Protocols · doi:10.1038/nprot.2007.149 · Cited by 409 · see citing works
Self-citationRegulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes
Wu, J. I., Lessard, J. A., Olave, I. A., Qiu, Z., Ghosh, A., Graef, I. A., & Crabtree, G. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.021 · Cited by 387 · see citing works
Self-citationUnderstanding the Words of Chromatin Regulation
Wu, J. I., Lessard, J. A., & Crabtree, G. R. (2009) · Cell · doi:10.1016/j.cell.2009.01.009 · Cited by 364 · see citing works
Self-citationNGF Controls Axonal Receptivity to Myelination by Schwann Cells or Oligodendrocytes
Chan, J. R., Watkins, T. A., Cosgaya, J. M., Zhang, C., Chen, L., Reichardt, L. F., Shooter, E. M., & Barres, B. A. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.024 · Cited by 326 · see citing works
Self-citationFunctional Genomic Analysis of Oligodendrocyte Differentiation
Dugas, J. C., Tai, Y. C., Speed, T. P., Ngai, J., & Barres, B. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2572-06.2006 · Cited by 324 · see citing works
Regulating RNA polymerase pausing and transcription elongation in embryonic stem cellsPreprint
Min, I. M., Waterfall, J. J., Core, L. J., Munroe, R. J., Schimenti, J. C., & Lis, J. T. (2011) · Genes & Development · doi:10.1101/gad.2005511 · Cited by 297 · see citing works
Myelinogenesis and Axonal Recognition by Oligodendrocytes in Brain Are Uncoupled in Olig1-Null Mice
Xin, M., Yue, T., Ma, Z.-Y., Wu, F.-F., Gow, A., & Lu, Q. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3034-04.2005 · Cited by 253 · see citing works
Self-citationEuskirchen, G. M., Auerbach, R. K., Davidov, E., Gianoulis, T. A., Zhong, G., Rozowsky, J. S., Bhardwaj, N., Gerstein, M., & Snyder, M. P. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002008 · Cited by 219 · see citing works
Liu, Z., Hu, X.-M., Cai, J., Liu, B., Peng, X.-Z., Wegner, M., & Qiu, M.-S. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.007 · Cited by 200 · see citing works
SNF2β-BRG1 is Essential for the Viability of F9 Murine Embryonal Carcinoma Cells
Sumi‐Ichinose, C., Ichinose, H., METZGER, D., & Chambon, P. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.5976 · Cited by 165 · see citing works
Weng, Q.-J., Chen, Y., Wang, H.-B., Xu, X., Yang, B., He, Q., Shou, W., Chen, Y., Higashi, Y., van den Berghe, V., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.021 · Cited by 165 · see citing works
Self-citationATP-dependent chromatin remodeling in neural development
Yoo, A. S. J., & Crabtree, G. R. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.04.006 · Cited by 150 · see citing works
Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K.-A., Franklin, R. J. M., Brakebusch, C., Suter, U., & Relvas, J. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2158-06.2006 · Cited by 142 · see citing works
Küspert, M., Hammer, A., Bösl, M., & Wegner, M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq951 · Cited by 136 · see citing works
Olig2-dependent developmental fate switch of NG2 cells
Zhu, X., Zuo, H., Maher, B., Serwanski, D., Loturco, J., Lu, Q. R., & Nishiyama, A. (2012) · Development · doi:10.1242/dev.078873 · Cited by 134 · see citing works
Self-citationPhosphorylation Regulates OLIG2 Cofactor Choice and the Motor Neuron-Oligodendrocyte Fate Switch
Li, H., de Faria, J. P., Andrew, P., Nitarska, J., & Richardson, W. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.030 · Cited by 127 · see citing works
Chromatin-Remodeling Factor Brg1 Is Required for Schwann Cell Differentiation and Myelination
Weider, M., Küspert, M., Bischof, M., Vogl, M. R., Hornig, J., Loy, K., Kosian, T., Müller, J. T., Hillgärtner, S., Tamm, E. R., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.05.017 · Cited by 124 · see citing works
Two-tier transcriptional control of oligodendrocyte differentiation
Li, H., He, Y., Richardson, W., & Casaccia, P. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.08.004 · Cited by 98 · see citing works
A Critical Role for Dorsal Progenitors in Cortical Myelination
Yue, T., Xian, K., Hurlock, E., Xin, M., Kernie, S., Parada, L., & Lu, Q. R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4717-05.2006 · Cited by 91 · see citing works
Self-citationNuclear organization in differentiating oligodendrocytes
Nielsen, J. A., Hudson, L. D., & Armstrong, R. C. (2002) · Journal of Cell Science · doi:10.1242/jcs.00103 · Cited by 83 · see citing works
Embryonic stem cell-based system for mapping developmental transcriptional programs
Mazzoni, E. O., Mahony, S., Iacovino, M., Morrison, C. A., Mountoufaris, G., Closser, M., Whyte, W. A., Young, R. A., Kyba, M., Gifford, D. K., et al. (2011) · Europe PMC (PubMed Central) · doi:10.1038/nmeth.1775 · Cited by 79 · see citing works
Takano, K., Toyooka, K., & Suetsugu, S. (2008) · EMBO Journal · doi:10.1038/emboj.2008.216 · Cited by 75 · see citing works
Leukodystrophies: recent developments in genetics, molecular biology, pathogenesis and treatment*
Berger, J., Moser, H. W., & Forss‐Petter, S. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200106000-00007 · Cited by 64 · see citing works
Flagged first, then by citations
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Regulation of prefrontal cortex myelination by the microbiota
Hoban, A. E., Stilling, R. M., Ryan, F. J., Shanahan, F., Dinan, T. G., Claesson, M. J., Clarke, G., & Cryan, J. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.42 · Cited by 635 · see citing works
Wang, Y., He, L., Du, Y., Zhu, P., Huang, G., Luo, J., Yan, X., Ye, B., Li, C., Xia, P., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.03.003 · Cited by 634 · see citing works
Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues
Bartosovic, M., Kabbe, M., & Castelo-Branco, G. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00869-9 · Cited by 483 · see citing works
The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers
Alver, B. H., Kim, K. H., Lu, P., Wang, X., Manchester, H. E., Wang, W., Haswell, J. R., Park, P. J., & Roberts, C. W. M. (2017) · Nature Communications · doi:10.1038/ncomms14648 · Cited by 427 · see citing works
SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation
Wang, X., Lee, R. S., Alver, B., Haswell, J. R., Wang, S., Mieczkowski, J., Drier, Y., Gillespie, S. M., Archer, T. C., Wu, J. N., et al. (2016) · Nature Genetics · doi:10.1038/ng.3746 · Cited by 370 · see citing works
Self-citationA novel m6A reader Prrc2a controls oligodendroglial specification and myelination
Wu, R., Li, A., Sun, B., Sun, J.-G., Zhang, J., Zhang, T., Chen, Y., Xiao, Y., Gao, Y., Zhang, Q., et al. (2019) · Cell Research · doi:10.1038/s41422-018-0113-8 · Cited by 366 · see citing works
Self-citationMyelin plasticity: sculpting circuits in learning and memory
Xin, W., & Chan, J. R. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00379-8 · Cited by 329 · see citing works
Self-citationVulnerabilities of mutant SWI/SNF complexes in cancer
Helming, K., Wang, X.-F., & Roberts, C. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.07.018 · Cited by 278 · see citing works
Emery, B., & Lu, Q. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020461 · Cited by 293 · see citing works
Self-citationMolecular Control of Oligodendrocyte Development
Elbaz, B., & Popko, B. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.01.002 · Cited by 286 · see citing works
Single-cell brain organoid screening identifies developmental defects in autism
Li, C., Fleck, J. S., Martins-Costa, C., Burkard, T. R., Themann, J., Stuempflen, M., Peer, A. M., Vertesy, Á., Littleboy, J. B., Esk, C., et al. (2023) · Nature · doi:10.1038/s41586-023-06473-y · Cited by 283 · see citing works
Bujalka, H., Koenning, M., Jackson, S., Perreau, V. M., Pope, B., Hay, C. M., Mitew, S., Hill, A. F., Lu, Q. R., Wegner, M., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001625 · Cited by 271 · see citing works
“and Olig2 [3] in differentiating oligodendrocytes and Sox10 in the spinal cord.”
BackgroundMethodInfluentialGriveau, A., Seano, G., Shelton, S. J., Kupp, R., Jahangiri, A., Obernier, K., Krishnan, S., Lindberg, O. R., Yuen, T. J., Tien, A., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.020 · Cited by 261 · see citing works
Mechanisms regulating the development of oligodendrocytes and central nervous system myelin.
Mitew, S., Hay, C., Peckham, H., Xiao, J., Koenning, M., & Emery, B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.029 · Cited by 259 · see citing works
ATP-dependent chromatin remodeling during mammalian development
Hota, S. K., & Bruneau, B. G. (2016) · Development · doi:10.1242/dev.128892 · Cited by 239 · see citing works
Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders
Sokpor, G., Xie, Y., Rosenbusch, J., & Tuoc, T. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00243 · Cited by 221 · see citing works
How to make an oligodendrocyte
Goldman, S. A., & Kuypers, N. J. (2015) · Development · doi:10.1242/dev.126409 · Cited by 226 · see citing works
Wang, X., Haswell, J. R., & Roberts, C. W. M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0280 · Cited by 222 · see citing works
Ninkovic, J., Steiner-Mezzadri, A., Jawerka, M., Akinci, U., Masserdotti, G., Petricca, S., Fischer, J., von Holst, A., Beckers, J., Lie, D. C., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.07.002 · Cited by 208 · see citing works
Self-citationLaurette, P., Strub, T., Koludrović, D., Keime, C., Gras, S. L., Seberg, H., Otterloo, E. V., Imrichová, H., Siddaway, R., Aerts, S., et al. (2015) · eLife · doi:10.7554/elife.06857 · Cited by 189 · see citing works
Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination
He, D., Marie, C., Zhao, C., Kim, B., Wang, J., Deng, Y., Clavairoly, A., Frah, M., Wang, H., He, X., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4258 · Cited by 183 · see citing works
Self-citationGain of Olig2 function in oligodendrocyte progenitors promotes remyelination
Wegener, A., Deboux, C., Bachelin, C., Frah, M., Kerninon, C., Seilhean, D., Weider, M., Wegner, M., & Nait‐Oumesmar, B. (2014) · Brain · doi:10.1093/brain/awu375 · Cited by 169 · see citing works
A latent lineage potential in resident neural stem cells enables spinal cord repair
Llorens-Bobadilla, E., Chell, J. M., Merre, P. L., Wu, Y.-C., Zamboni, M., Bergenstråhle, J., Stenudd, M., Sopova, E., Lundeberg, J., Shupliakov, O., et al. (2020) · Science · doi:10.1126/science.abb8795 · Cited by 143 · see citing works
Zhao, C., Deng, Y., Liu, L., Yu, K., Zhang, L., Wang, H., He, X., Wang, J., Lu, C., Wu, L. N., et al. (2016) · Nature Communications · doi:10.1038/ncomms10883 · Cited by 154 · see citing works
Self-citationRoles and activities of chromatin remodeling ATP ases in plants
Han, S., Wu, M., Cui, S., & Wagner, D. (2015) · The Plant Journal · doi:10.1111/tpj.12877 · Cited by 158 · see citing works
Zhao, C., Dong, C., Frah, M., Deng, Y., Marie, C., Zhang, F., Xu, L., Ma, Z., Dong, X., Lin, Y., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.05.022 · Cited by 146 · see citing works
Self-citationIntrinsic and extrinsic control of oligodendrocyte development
Zuchero, J. B., & Barres, B. A. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.06.005 · Cited by 155 · see citing works
The role of BAF (mSWI/SNF) complexes in mammalian neural development
Son, E., & Crabtree, G. R. (2014) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31416 · Cited by 151 · see citing works
Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets
van Tilborg, E., Heijnen, C. J., Benders, M. J. N. L., van Bel, F., Fleiss, B., Gressèns, P., & Nijboer, C. H. A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.11.002 · Cited by 148 · see citing works
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune functionPreprint
Akay, L. A., Effenberger, A. H., & Tsai, L. (2021) · Genes & Development · doi:10.1101/gad.344218.120 · Cited by 142 · see citing works
Balakrishnan, A., Belfiore, L., Chu, T., Fleming, T., Midha, R., Biernaskie, J. A., & Schuurmans, C. J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.608442 · Cited by 139 · see citing works
Zeb2 recruits HDAC–NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination
Wu, L. M. N., Wang, J., Conidi, A., Zhao, C., Wang, H., Ford, Z. K., Zhang, L., Zweier, C., Ayee, B., Maurel, P., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4322 · Cited by 138 · see citing works
Self-citationNG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis
Zhang, S.-Z., Wang, Q., Yang, Q., Gu, H., Yin, Y., Li, Y., Hou, J., Chen, R., Sun, Q., Sun, Y., et al. (2019) · BMC Medicine · doi:10.1186/s12916-019-1439-x · Cited by 138 · see citing works
He, D., Wang, J., Lu, Y., Deng, Y., Zhao, C., Xu, L., Chen, Y., Hu, Y., Zhou, W., & Lu, Q. R. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.044 · Cited by 135 · see citing works
Self-citationMack, S. C., Singh, I., Wang, X., Hirsch, R. A., Wu, Q., Villagomez, R., Bernatchez, J. A., Zhu, Z., Gimple, R. C., Kim, L. J. Y., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190196 · Cited by 125 · see citing works
Myelin plasticity in the central nervous system
Purger, D. A., Gibson, E. M., & Monje, M. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.001 · Cited by 126 · see citing works
Wolf, B. K., Zhao, Y., McCray, A. D., Hawk, W. H., Deary, L. T., Sugiarto, N. W., LaCroix, I. S., Gerber, S. A., Cheng, C., & Wang, X. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00880-x · Cited by 124 · see citing works
Chromatin Landscape Defined by Repressive Histone Methylation during Oligodendrocyte Differentiation
Liu, J., Magri, L., Zhang, F., Marsh, N. O., Albrecht, S., Huynh, J. L., Kaur, J., Kuhlmann, T., Zhang, W., Slesinger, P. A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2606-14.2015 · Cited by 123 · see citing works
Narayanan, R., Pirouz, M., Kerimoglu, C., Pham, L., Wagener, R. J., Kiszka, K. A., Rosenbusch, J., Seong, R. H., Kessel, M., Fischer, A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.046 · Cited by 119 · see citing works
Zhang, L., He, X.-L., Liu, L., Jiang, M.-Q., Zhao, C.-T., Wang, H.-B., He, D.-Y., Zheng, T., Zhou, X., Hassan, A., et al. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.002 · Cited by 121 · see citing works
Self-citationFrom OPC to Oligodendrocyte: An Epigenetic Journey
Tiane, A., Schepers, M., Rombaut, B., Hupperts, R., Prickaerts, J., Hellings, N., van den Hove, D., & Vanmierlo, T. (2019) · Cells · doi:10.3390/cells8101236 · Cited by 121 · see citing works
Lu, F., Chen, Y., Zhao, C., Wang, H., He, D., Xu, L., Wang, J., He, X., Deng, Y., Lu, E. E., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.03.027 · Cited by 120 · see citing works
Self-citationDecoding Cortical Glial Cell Development
Li, X., Liu, G., Yang, L., Li, Z., Zhang, Z., Xu, Z., Cai, Y., Du, H., Su, Z., Wang, Z., et al. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00640-9 · Cited by 114 · see citing works
Life-long oligodendrocyte development and plasticity
Nishiyama, A., Shimizu, T., Sherafat, A., & Richardson, W. D. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.02.004 · Cited by 114 · see citing works
Diversity Matters: A Revised Guide to Myelination
Tomassy, G. S., Dershowitz, L. B., & Arlotta, P. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.09.002 · Cited by 115 · see citing works
The role of SOX10 during enteric nervous system development
Bondurand, N., & Sham, M. H. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.04.024 · Cited by 115 · see citing works
From trans to cis: transcriptional regulatory networks in neocortical development
Shibata, M., Gulden, F. O., & Sestan, N. (2015) · Trends in Genetics · doi:10.1016/j.tig.2014.12.004 · Cited by 109 · see citing works
Marie, C., Clavairoly, A., Frah, M., Hmidan, H., Yan, J., Zhao, C., Van Steenwinckel, J., Daveau, R., Zalc, B., Hassan, B., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802620115 · Cited by 103 · see citing works
Self-citationZic2 Is an Enhancer-Binding Factor Required for Embryonic Stem Cell Specification
Luo, Z., Gao, X., Lin, C., Smith, E. R., Marshall, S. A., Swanson, S. K., Florens, L. A., Washburn, M. P., & Shilatifard, A. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.01.007 · Cited by 105 · see citing works
Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution
Ramos, A. I., & Barolo, S. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0018 · Cited by 116 · see citing works
SoxE factors: Transcriptional regulators of neural differentiation and nervous system development
Weider, M., & Wegner, M. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.08.013 · Cited by 107 · see citing works
All Wrapped Up: Environmental Effects on Myelination
Forbes, T. A., & Gallo, V. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.06.009 · Cited by 102 · see citing works
Transcriptional control of myelination and remyelination
Sock, E., & Wegner, M. (2019) · Glia · doi:10.1002/glia.23636 · Cited by 109 · see citing works
Cheng, Y.-J., Wang, F., Feng, J., Yu, B., Wang, B., Gao, Q. C., Wang, T.-Y., Hu, B., Gao, X., Chen, J., et al. (2024) · Brain · doi:10.1093/brain/awae029 · Cited by 102 · see citing works
Self-citationDifferential Sox10 genomic occupancy in myelinating glia
Lopez‐Anido, C., Sun, G., Koenning, M., Srinivasan, R., Hung, H. A., Emery, B., Keleş, S., & Svaren, J. P. (2015) · Glia · doi:10.1002/glia.22855 · Cited by 100 · see citing works
Sock, E., & Wegner, M. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22849 · Cited by 85 · see citing works
Brg1 modulates enhancer activation in mesoderm lineage commitment
Alexander, J. M., Hota, S. K., He, D. X., Thomas, S., Ho, L., Pennacchio, L. A., & Bruneau, B. G. (2015) · Development · doi:10.1242/dev.109496 · Cited by 95 · see citing works
Weng, X., Yu, L., Liang, P., Li, L., Dai, X. J., Zhou, B., Wu, X., Xu, H., Fang, M., Chen, Q., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.02.010 · Cited by 93 · see citing works
Current Understanding of the Neural Stem Cell Niches
Llorente, V., Velarde, P., Desco, M., & Gómez‐Gaviro, M. V. (2022) · Cells · doi:10.3390/cells11193002 · Cited by 94 · see citing works
Ou, Z., Sun, Y., Li, L., You, N., Liu, X., Li, H., Ma, Y., Cao, L., Han, Y., Liu, M., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0898-16.2016 · Cited by 91 · see citing works
Self-citationZhao, L., Wang, W., Huang, S., Yang, Z., Xu, L., Yang, Q., Zhou, X., Wang, J., Shen, Q., Wang, C., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1412-6 · Cited by 90 · see citing works
Liu, Z.-X., Yan, M., Liang, Y.-J., Liu, M., Zhang, K., Shao, D.-D., Jiang, R., Li, L., Wang, C.-M., Nussenzveig, D., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.018 · Cited by 80 · see citing works
Deng, Y., Wu, L. M. N., Bai, S., Zhao, C., Wang, H., Wang, J., Xu, L., Sakabe, M., Zhou, W., Xin, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15161 · Cited by 86 · see citing works
Self-citationSMARCB1-Deficient Cancers: Novel Molecular Insights and Therapeutic Vulnerabilities
Cooper, G. W., & Hong, A. L. (2022) · Cancers · doi:10.3390/cancers14153645 · Cited by 85 · see citing works
Weider, M., Starost, L. J., Groll, K., Küspert, M., Sock, E., Wedel, M., Fröb, F., Schmitt, C., Baroti, T., Hartwig, A. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03336-3 · Cited by 86 · see citing works
Lim, R. G., Al-Dalahmah, O., Wu, J., Gold, M. P., Reidling, J. C., Tang, G., Adam, M., Dansu, D. K., Park, H.-J., Casaccia, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35388-x · Cited by 84 · see citing works
Self-citationCoordinated control of oligodendrocyte development by extrinsic and intrinsic signaling cues
He, L., & Lu, Q. R. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1318-y · Cited by 82 · see citing works
Self-citationDevelopment of myelinating glia: an overview
Cristobal, C. D. D., & Lee, H. K. (2022) · Glia · doi:10.1002/glia.24238 · Cited by 71 · see citing works
Alvarez-Saavedra, M., Repentigny, Y. D., Lagali, P. S., Edupuganti, R. R., Yan, K., Hashem, L. E., Ivanochko, D., Huh, M. S., Yang, D., Mears, A. J., et al. (2014) · Nature Communications · doi:10.1038/ncomms5181 · Cited by 81 · see citing works
Voronova, A., Yuzwa, S. A., Wang, B. S., Zahr, S. K., Syal, C., Wang, J., Kaplan, D. R., & Miller, F. D. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.018 · Cited by 78 · see citing works
Archacki, R., Yatusevich, R., Buszewicz, D., Krzyczmonik, K., Patryn, J., Iwanicka‐Nowicka, R., Biecek, P., Wilczyński, B., Koblowska, M., Jerzmanowski, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1273 · Cited by 75 · see citing works
TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice
Moyon, S., Frawley, R., Maréchal, D., Huang, D., Marshall-Phelps, K. L., Kegel, L., Bøstrand, S. M. K., Sadowski, B., Jiang, Y., Lyons, D. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23735-3 · Cited by 84 · see citing works
From CNS stem cells to neurons and glia: Sox for everyone
Reiprich, S., & Wegner, M. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1909-6 · Cited by 83 · see citing works
Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation
Starossom, S. C., Garcia, J. C., Woelfle, T., Romero‐Suárez, S., Olah, M., Watanabe, F., Cao, L., Yeste, A., Tukker, J. J., Quintana, F. J., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08140-7 · Cited by 75 · see citing works
Liu, X., Xin, D. E., Zhong, X., Zhao, C., Li, Z., Zhang, L., Dourson, A. J., Lee, L., Mishra, S. V., Bayat, A. E., et al. (2024) · Cell · doi:10.1016/j.cell.2024.04.005 · Cited by 76 · see citing works
Self-citationZhang, K.-K., Chen, S., Yang, Q., Guo, S., Chen, Q., Liu, Z.-X., Li, L., Jiang, M., Li, H.-D., Hu, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29068-z · Cited by 74 · see citing works
Castelo‐Branco, G., Lilja, T., Wallenborg, K., Falcão, A. M., Marques, S., Gracias, A., Solum, D., Paap, R. H., Walfridsson, J., Teixeira, A. I., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.07.008 · Cited by 70 · see citing works
Ho, P. J., Lloyd, S. M., & Bao, X. (2019) · Development · doi:10.1242/dev.178780 · Cited by 66 · see citing works
Wedel, M., Fröb, F., Elsesser, O., Wittmann, M., Lie, D., Reis, A., & Wegner, M. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa218 · Cited by 60 · see citing works
Duncan, I. D., Bugiani, M., Radcliff, A., Moran, J. J., Lopez-Anido, C., Duong, P. C., August, B. K., Wolf, N. I., van der Knaap, M. S., & Svaren, J. (2017) · Annals of Neurology · doi:10.1002/ana.24930 · Cited by 57 · see citing works
Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration
López‐Juárez, A., He, D., & Lu, Q. R. (2015) · Brain Research · doi:10.1016/j.brainres.2015.10.051 · Cited by 63 · see citing works
Self-citationBischof, M., Weider, M., Küspert, M., Nave, K., & Wegner, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1468-14.2015 · Cited by 63 · see citing works
Epigenetic control of oligodendrocyte development: adding new players to old keepers
Liu, J., Moyon, S., Hernandez, M., & Casaccia, P. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.06.002 · Cited by 62 · see citing works
Ferrer, I. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.07.004 · Cited by 62 · see citing works
Sen, M., Wang, X., Hamdan, F. H., Rapp, J., Eggert, J., Kosinsky, R. L., Wegwitz, F., Kutschat, A. P., Younesi, F. S., Gaedcke, J., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0690-5 · Cited by 61 · see citing works
Tissue-specific SMARCA4 binding at active and repressed regulatory elements during embryogenesisPreprint
Attanasio, C., Nord, A. S., Zhu, Y., Blow, M. J., Biddie, S. C., Mendenhall, E. M., Dixon, J. R., Wright, C., Hosseini, R., Akiyama, J. A., et al. (2014) · Genome Research · doi:10.1101/gr.168930.113 · Cited by 59 · see citing works
Jiang, M., Liu, L., He, X., Wang, H., Lin, W., Wang, H., Yoon, S. O., Wood, T. L., & Lu, Q. R. (2016) · Nature Communications · doi:10.1038/ncomms12185 · Cited by 59 · see citing works
Self-citationDewari, P. S., Southgate, B., McCarten, K., Monogarov, G., O’Duibhir, E., Quinn, N., Tyrer, A., Leitner, M.-C., Plumb, C., Kalantzaki, M., et al. (2018) · eLife · doi:10.7554/elife.35069 · Cited by 58 · see citing works
ATP-Dependent Chromatin Remodeling During Cortical Neurogenesis
Sokpor, G., Castro-Hernández, R., Rosenbusch, J., Staiger, J. F., & Tuoc, T. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00226 · Cited by 60 · see citing works
Katsel, P., Roussos, P., Fam, P. S., Khan, S., Tan, W., Hirose, T., Nakagawa, S., Pletnikov, M., & Haroutunian, V. (2019) · npj Schizophrenia · doi:10.1038/s41537-019-0071-2 · Cited by 74 · see citing works
Zhang, M., Wang, J., Zhang, K., Lu, G., Liu, Y., Ren, K., Wang, W., Xin, D. E., Xu, L., Mao, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25353-5 · Cited by 58 · see citing works
Self-citationMSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells
Hornbachner, R., Lackner, A., Papúchová, H., Haider, S., Knöfler, M., Mechtler, K., & Latos, P. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2105130118 · Cited by 58 · see citing works
Zhao, L., Wang, W., Xu, L., Yi, T., Zhao, X., Wei, Y., Vermeulen, L., Goel, A., Zhou, S., & Wang, X. (2018) · Oncogene · doi:10.1038/s41388-018-0577-5 · Cited by 57 · see citing works
Lu, C., Dong, L., Zhou, H., Li, Q., Huang, G., Bai, S. J., & Liao, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-22452-0 · Cited by 57 · see citing works
Srivastava, T., Diba, P., Dean, J. M., Banine, F., Shaver, D. C., Hagen, M. W., Gong, X., Su, W., Emery, B., Marks, D. L., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci94158 · Cited by 58 · see citing works
EEF1A1 deacetylation enables transcriptional activation of remyelination
Duman, M., Vaquie, A. M., Nocera, G., Heller, M., Stumpe, M., Sankar, D. S., Dengjel, J., Meijer, D., Yamaguchi, T., Matthias, P., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17243-z · Cited by 56 · see citing works
Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
Allan, K. C., Hu, L. R., Scavuzzo, M. A., Morton, A. R., Gevorgyan, A. S., Cohn, E. F., Clayton, B. L. L., Bederman, I. R., Hung, S., Bartels, C. F., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.09.019 · Cited by 62 · see citing works
de Monasterio‐Schrader, P., Patzig, J., Möbius, W., Barrette, B., Wagner, T. L., Kusch, K., Edgar, J. M., Brophy, P., & Werner, H. B. (2013) · Glia · doi:10.1002/glia.22561 · Cited by 56 · see citing works
Epigenetic modifications—insight into oligodendrocyte lineage progression, regeneration, and disease
Gregath, A., & Lu, Q. R. (2018) · FEBS Letters · doi:10.1002/1873-3468.12999 · Cited by 56 · see citing works
Self-citationOligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice
Kawamura, A., Katayama, Y., Nishiyama, M., Shoji, H., Tokuoka, K., Ueta, Y., Miyata, M., Isa, T., Miyakawa, T., Hayashi‐Takagi, A., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa036 · Cited by 56 · see citing works
- Authors
- Yu, Y., Chen, Y., Kim, B., Wang, H., Zhao, C., He, X., Liu, L., Liu, W., Wu, L. M. N., Mao, M., Chan, J. R., Wu, J., & Lu, Q. R.
- Affiliations
- Sichuan University (CN)
- The University of Texas Southwestern Medical Center (US)
- Konkuk University (KR)
- University of California, San Francisco (US)
- Corresponding author
- Lu, Q. Richard
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 152
- Issue
- 1-2
- Pages
- 248-261
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3553550
- OpenAlex
- W2021548599
- Cited by
- 375
- References
- 49
- Citations by year
- 2026: 12 · 2025: 20 · 2024: 31 · 2023: 31 · 2022: 31 · 2021: 33 · 2020: 34 · 2019: 33 · 2018: 25 · 2017: 28 · 2016: 26 · 2015: 31 · 2014: 23 · 2013: 17
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS075243, R01NS072427, R01NS078092)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- Olig2, SWI/SNF chromatin remodeling, oligodendrocyte differentiation, myelination, enhancers, cis-regulatory elements, transcriptional regulation, central nervous system development
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Brain, Cell Differentiation, Cells, Cultured, DNA Helicases, Enhancer Elements, Genetic, Gene Expression Regulation, Nerve Tissue Proteins, Nuclear Proteins, Oligodendroglia, Spinal Cord, Transcription Factors, Mice, Knockout, Chromatin Assembly and Disassembly, Mice, Rats, Basic Helix-Loop-Helix Proteins
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