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Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models

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Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontitis treatment

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The Role of Reactive Oxygen Species and Autophagy in Periodontitis and Their Potential Linkage

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Enhanced Activity of the Macrophage M1/M2 Phenotypes and Phenotypic Switch to M1 in Periodontal Infection.

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Nanofibrous Spongy Microspheres To Distinctly Release miRNA and Growth Factors To Enrich Regulatory T Cells and Rescue Periodontal Bone Loss

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Novel nanoparticles of cerium-doped zeolitic imidazolate frameworks with dual benefits of antibacterial and anti-inflammatory functions against periodontitis

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Novel antioxidative nanotherapeutics in a rat periodontitis model: Reactive oxygen species scavenging by redox injectable gel suppresses alveolar bone resorption

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Local delivery of minocycline-loaded PEG-PLA nanoparticles for the enhanced treatment of periodontitis in dogs

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Light-Activable On-Demand Release of Nano-Antibiotic Platforms for Precise Synergy of Thermochemotherapy on Periodontitis

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Human β-defensin 3 inhibits periodontitis development by suppressing inflammatory responses in macrophages

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M2 Macrophages Enhance the Cementoblastic Differentiation of Periodontal Ligament Stem Cells via the Akt and JNK Pathways

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Functionalization of silica nanoparticles for nucleic acid delivery

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Understanding intracellular trafficking and anti-inflammatory effects of minocycline chitosan-nanoparticles in human gingival fibroblasts for periodontal disease treatment

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Periodontitis and Redox Status: A Review

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An enzyme-responsive membrane for antibiotic drug release and local periodontal treatment

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Multifunctional nanocarriers for the treatment of periodontitis: Immunomodulatory, antimicrobial, and regenerative strategies

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Minocycline hydrochloride nanoliposomes inhibit the production of TNF-α in LPS-stimulated macrophages

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RGD functionalized polymeric nanoparticles targeting periodontitis epithelial cells for the enhanced treatment of periodontitis in dogs

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Towards the nano‐control of periodontal inflammation?

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Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives

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Epigallocatechin gallate-based nanoparticles with reactive oxygen species scavenging property for effective chronic periodontitis treatment

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Functional biomaterials for comprehensive periodontitis therapy

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A Biomimetic Se‐nHA/PC Composite Microsphere with Synergistic Immunomodulatory and Osteogenic Ability to Activate Bone Regeneration in Periodontitis

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Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy

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Multifunctional PDA/ZIF8 based hydrogel dressing modulates the microenvironment to accelerate chronic wound healing by ROS scavenging and macrophage polarization

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ROS-Scavenging Electroactive Polyphosphazene-Based Core–Shell Nanofibers for Bone Regeneration

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Versatile hybrid nanoplatforms for treating periodontitis with chemical/photothermal therapy and reactive oxygen species scavenging

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Innovative Bio‐based Hydrogel Microspheres Micro‐Cage for Neutrophil Extracellular Traps Scavenging in Diabetic Wound Healing

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Revolutionizing oral care: Reactive oxygen species (ROS)-Regulating biomaterials for combating infection and inflammation

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Nanoparticles in Periodontitis Therapy: A Review of the Current Situation

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Multifunctional sericin-based biomineralized nanoplatforms with immunomodulatory and angio/osteo-genic activity for accelerated bone regeneration in periodontitis

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A review of magnetic ordered materials in biomedical field: Constructions, applications and prospects

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Insight into the role of macrophages in periodontitis restoration and development

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Functionalized Prussian Blue Nanozyme as Dual-Responsive Drug Therapeutic Nanoplatform Against Maxillofacial Infection via Macrophage Polarization

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Are Local Drug Delivery Systems a Challenge in Clinical Periodontology?

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New Advances in Periodontal Functional Materials Based on Antibacterial, Anti‐Inflammatory, and Tissue Regeneration Strategies

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Novel multifunctional dexamethasone carbon dots synthesized using the one-pot green method for anti-inflammatory, osteogenesis, and osteoimmunomodulatory in bone regeneration

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Detection and treatment of biofilm-induced periodontitis by histidine-doped FeSN nanozyme with ultra-high peroxidase-like activity

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Ros-responsive and scavenging bifunctional hydrogel enables co-delivery of anti-inflammatory agent and osteogenetic nanoparticle for periodontitis treatment

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Carvacrol combined with NIR light-responsive nano-drug delivery system with specific anti-bacteria, anti-inflammation, and immunomodulation for periodontitis

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Nanoparticle based periodontal drug delivery – A review on current trends and future perspectives

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Therapeutic potential of gelatine methacrylate hydrogels loaded with macrophage-derived exosomes for accelerating angiogenesis and cutaneous wound healing

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Nanotherapies Based on ROS Regulation in Oral Diseases

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Mesoporous polydopamine delivering 8-gingerol for the target and synergistic treatment to the spinal cord injury

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Polydopamine-coated thalidomide nanocrystals promote DSS-induced murine colitis recovery through Macrophage M2 polarization together with the synergistic anti-inflammatory and anti-angiogenic effects

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Pathogen infection-responsive nanoplatform targeting macrophage endoplasmic reticulum for treating life-threatening systemic infection

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Polydopamine-armored zeolitic imidazolate framework-8-incorporated zwitterionic hydrogel with multifunctional properties for infected wound healing

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An injectable MB/BG@LG sustained release lipid gel with antibacterial and osteogenic properties for efficient treatment of chronic periodontitis in rats

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Advancing Polyphenol-Based Nanomedicine for Inflammatory Bowel Disease: Challenges and Opportunities

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Polyphenols-based intelligent oral barrier membranes for periodontal bone defect reconstruction

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Nanotherapeutics for microenvironment modulation and immune homeostasis in periodontitis treatment

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Near-infrared light-driven multifunctional metal ion (Cu2+)-loaded polydopamine nanomotors for therapeutic angiogenesis in critical limb ischemia

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Emerging nanozyme therapy incorporated into dental materials for diverse oral pathologies

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Nanoparticle-based drug delivery systems for non-surgical periodontal therapy: innovations and clinical applications

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Drug molecules bridge with small gatekeeper to co-block mesoporous silica nanoparticles for drug delivery

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Mechanically Compliant Hydrogel Bioelectronics Promote Diabetic Skeletal Muscle Regeneration Through Immunomodulatory and Electrocoupling Effects

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A Multitarget Synergistic Core‐Shell Nanogel for Experimental Periodontitis Treatment

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3D-printed functionalized strontium-silk fibroin-hydroxyapatite scaffolds facilitate bone regeneration via immunomodulatory and sequential angiogenic-osteogenic coupling

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Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

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Advances in Polydopamine-Based Nanoplatforms: Antioxidant Mechanisms and Applications in Oxidative Stress-Mediated Diseases

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An Overview of Nanotechnology in Dental Medicine

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SrCO3@PCL/PDA composite scaffold promote osteoporotic bone regeneration through immune regulation

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Mesoporous Silica Modified with Polydopamine and Zinc Ions as a Potential Carrier in the Controlled Release of Mercaptopurine

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A cationic hydrogel for visual diagnosis and treatment of bacterial-infected wounds via mild, on-demand dual-phototherapy

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Immune regulated fibrous membrane loaded FK506 enhances peripheral nerve regeneration

Xing, D., Xu, M., Shuang, X., Li, J. J., Sun, D., Wang, Y., Li, M., Feng, S., & Ning, G. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.159075 · Cited by 8 · see citing works

Identifying genes for regulating osteogenic differentiation of human periodontal ligament stem cells in inflammatory environments by bioinformatics analysis

Wang, Q., Yang, X., Wang, X., Wang, X., Zhang, J., Gao, Y., Pan, J., & Wang, S. (2023) · Journal of Periodontal Research · doi:10.1111/jre.13215 · Cited by 7 · see citing works

A promising strategy for combating bacterial infections through the use of light-triggered ROS in Ce6-immobilized hydrogels

Hong, S. H., Lee, M. H., Go, E. J., & Park, J. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae101 · Cited by 7 · see citing works

NIR light-propelled Janus Polydopamine@Mesoporous silica gene delivery nanomotor for the enhanced gene treatment of critical limb ischemia

Gui, L., Wang, S., Miao, S., Qiao, M., Jiao, Y., Chen, H., Li, W., Zou, J., & Du, X. C. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101950 · Cited by 6 · see citing works

Ferrocene-functionalized polydopamine film timely mediates M1-to-M2 macrophage polarization through adaptive wettability

Shu, Y., Li, K., Li, J., Ding, Y., Yang, G., & Zheng, X. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113825 · Cited by 6 · see citing works

Design and application of antimicrobial nanomaterials in the treatment of periodontitis

Wang, C., Yang, Y., Wang, N., Luan, A., Wang, H., & Hu, C. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2469492 · Cited by 5 · see citing works

Pathologically catalyzed physical coating restores the intestinal barrier for inflammatory bowel disease therapy

Zhao, Y., He, R., Zang, J., Yin, W., Su, R., Xiong, W., Xu, W., Zhang, J., Liu, Y., Ren, T., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02227-0 · Cited by 5 · see citing works

Inhalable nanoaerosols target the activation of HSP70 to regulate macrophage reprogramming for the treatment of bacterial pneumonia

Hu, M., Ding, X., Cai, S., Feng, Z.-W., Li, X., Huang, X., Yu, Q., & Hu, Y.-J. (2025) · Nano Research · doi:10.26599/nr.2025.94908286 · Cited by 4 · see citing works

Poly-T-Modified Gold Nanorods Suppress Macrophage-Mediated Inflammation for Periodontitis Therapy

He, W., Wei, W., Zhao, Y., Wang, Y., Liu, C., Wei, Y., Lu, X., Жао, Л., Wang, C., Chen, J., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c00470 · Cited by 4 · see citing works

Stimuli‐Responsive Nanosystems for Theranostic Applications in Oral Diseases

Gong, M., Wang, Y., Dai, J., Fu, Q., & Yuan, C. (2025) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.70018 · Cited by 3 · see citing works

Persistent and Enhanced Elimination of Bacteria‐Induced Periodontitis Using a Local Drug Delivery Nanoreactor

Xu, L., Chen, S., Feng, Y., Chen, M., Liu, Y., Ma, X., Jing, J., Meng, S., Yao, Y., Sun, W., et al. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202200230 · Cited by 3 · see citing works

Association between blood lead and periodontitis among American adults: a cross-sectional study of the national health and nutrition examination survey

Liu, Y., Wu, Y., Shi, X., Tian, Y., Zhai, S., Yang, Z., & Chu, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1420613 · Cited by 2 · see citing works

Engineering a placenta-inspired biomimicking fibrous patch for chondrogenesis through immunomodulation

Xu, T., Wang, P., Yu, Y., Shen, Y., Li, D., Xiao, Q., Liu, M., Zhang, C., Duan, L., Dai, W., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114120 · Cited by 2 · see citing works

Advances of natural polyphenol based anti-oxidant nanomaterials for efficient treatment of inflammatory bowel diseasePreprint

Wang, L., Yang, Y., Xu, C., Zhu, L., Chen, G., Yang, H., & Yu, M. (2023) · doi:10.22541/au.169956081.14133273/v1 · Cited by 2 · see citing works

Metronidazole-Loaded Polydopamine Nanomedicine With Antioxidant and Antibacterial Bioactivity for Periodontitis

Yan, M., Liang, W., Du, L., Guo, R., Cao, Y., Ni, S., Zhong, Y., Zhang, K., Qu, K., Qin, X., et al. (2023) · Nanomedicine · doi:10.2217/nnm-2023-0245 · Cited by 1 · see citing works

Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges

Yang, Z., Song, W., Lv, L., Zhai, S., Liu, Y., Cui, H., Li, X., Gao, F., & Chu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s611922

Surface-Engineered Aligned Fibers Patch with Ph-Responsive Drug Releasefor Chondrogenesis Through ImmunomodulationPreprint

Xu, T., Wang, P., Shen, Y., Li, D., Xiao, Q., Liu, M., Duan, L., Yi, B., & Zhang, Y. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4870713

Eco-Friendly Dopamine Phenolic Resin with Water Solubility and Biodegradability: Enabling Flame-Retardant, High-Strength Tocnf Composites Via Pda@Msns and Borax SynergyPreprint

Wang, Q., Hui, L., Guo, W., Zhu, C., Zhu, R., Zhou, Q., Zhao, Z., & Duong, T. C. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5258465

Additional file 1 of Mesoporous polydopamine delivering 8-gingerol for the target and synergistic treatment to the spinal cord injury

Yang, J., Wang, M., Zheng, S., Huang, R., Wen, G., Zhou, P., Wang, W., Zhou, S., Jiang, X., Liu, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26597216

Additional file 1 of Pathologically catalyzed physical coating restores the intestinal barrier for inflammatory bowel disease therapy

Zhao, Y., He, R., Zang, J., Yin, W., Su, R., Xiong, W., Xu, W., Zhang, J., Liu, Y., Ren, T., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24630288

Additional file 1 of Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy

Shi, J., Zhang, Y., Zhang, X., Chen, R., Wei, J., Hou, J., Wang, B., Lai, H., & Huang, Y. (2021) · Figshare · doi:10.6084/m9.figshare.17305302

Methacrylated hyaluronic acid hydrogel enables CD44-mediated local berberine delivery to reprogram macrophage immunometabolism and promote alveolar bone repair in periodontitis

Lv, X., Zhang, Y., Zhang, X., Shi, J., Ding, X., Wei, J., Jiang, X., Yang, Y., Wei, X., Cen, L., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.154314

Surface-engineered resveratrol-loaded therapeutic nanoparticles for remodeling MRSA-infected wound microenvironment

Che, X., Chen, Z., Shen, Q., Huang, Z., Wang, Y., Pu, Y., Shi, J., Zhang, Z., Yang, N., & Yu, C. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.116192

Polymeric Nanoparticles for Modulating Reactive Oxygen Species in the Periodontitis Microenvironment

Mohammad, S. I., Vasudevan, A., Oriquat, G., & Qian, C. (2026) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70900

Hierarchically Targeting and ROS-Responsive Platform for Diabetic Periodontitis Treatment through Mitochondrial Repair in M1 Macrophages

Xie, W., Wang, Y., Wu, J., Wang, X., Wu, J., Cheng, B., Feng, H., Huang, X., Cheng, X., Chen, J., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c20136 · Cited by 2 · see citing works

Facile engineering of resveratrol nanoparticles loaded with 20(S)-protopanaxadiol for the treatment of periodontitis by regulating the macrophage phenotype

Huangfu, H., Du, S., Zhang, H., Wang, H., Zhang, Y., Yang, Z., Zhang, X., Ren, S., Chen, S., Wang, C., et al. (2023) · Nanoscale · doi:10.1039/d2nr06452a · Cited by 24 · see citing works

Remodeling periodontal osteoimmune microenvironment through MAPK/NFκB phosphorylation pathway of macrophage via intelligent ROS scavenging

Qiu, X., Peng, H., Zhao, Y., Yu, Y., Yang, J., Liu, C., Ren, S., & Miao, L. (2023) · Human Cell · doi:10.1007/s13577-023-00979-3 · Cited by 16 · see citing works

Polydopamine nanoparticles reprogram macrophage polarization via SERCA2-associated calcium remodeling to support osteogenic differentiation under inflammatory conditions

Yang, H., Ran, G., Chen, D., Li, X., Zhang, L., Guo, Z., & Zeng, S. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116711