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Cited by 473D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis ApplicationsTissue Engineering and Regenerative Medicine

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Sensors-integrated organ-on-a-chip for biomedical applications

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Chen, Hanxu, Luo, Zhiqiang, Lin, Xiang, Zhu, Yujuan, Zhao, Yuanjin·2023·Nano Research
DOI 10.1007/s12274-023-5651-9PMC PMC10130312
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Abstract

As a promising new micro-physiological system, organ-on-a-chip has been widely utilized for in vitro pharmaceutical study and tissues engineering based on the three-dimensional constructions of tissues/organs and delicate replication of in vivo -like microenvironment. To better observe the biological processes, a variety of sensors have been integrated to realize in-situ , real-time, and sensitive monitoring of critical signals for organs development and disease modeling. Herein, we discuss the recent research advances made with respect to sensors-integrated organ-on-a-chip in this overall review. Firstly, we briefly explore the underlying fabrication procedures of sensors within microfluidic platforms and several classifications of sensory principles. Then, emphasis is put on the highlighted applications of different types of organ-on-a-chip incorporated with various sensors. Last but not least, perspective on the remaining challenges and future development of sensors-integrated organ-on-a-chip are presented.

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Metadata

Authors
Chen, H., Luo, Z., Lin, X., Zhu, Y., & Zhao, Y.
Affiliations
Nanjing Drum Tower Hospital (CN)
Corresponding author
Zhao, Yuanjin
ORCID
Venue
Nano Research
Publisher
Tsinghua University Press
Published
2023-04-26
Volume
16
Issue
7
Pages
10072-10099
ISSN
  • 1998-0000 (ISSN-L)
  • 1998-0124
DOI
10.1007/s12274-023-5651-9
PMC
PMC10130312
OpenAlex
W4367054425
Cited by
47
References
7
Citations by year
2026: 11 · 2025: 18 · 2024: 14 · 2023: 4
FWCI
1.05
Type
journal article
Language
en
Open access
Licence
Locations
  • Nano Research (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (ZKX21019, 52073060, JCYJ20190813152616459, 2020YFA0908200, 61927805, T2225003)
  • Shenzhen Fundamental Research Program (61927805, 2020YFA0908200, JCYJ20190813152616459, 52073060, T2225003)
  • Nanjing Medical Science and Technique Development Foundation (ZKX21019)
  • National Key Research and Development Program of China (JCYJ20190813152616459, 2020YFA0908200, 61927805, 52073060)
  • Basic and Applied Basic Research Foundation of Guangdong Province (2021B1515120054)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
organ-on-a-chip, integrated sensors, microfluidic platform, in situ monitoring, real-time signal monitoring, disease modeling, organogenesis, sensor fabrication, microphysiological systems, tissue engineering

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