A cerebellar framework for predictive coding and homeostatic regulation in depressive disorder
Open accessAbstract
Depressive disorder is associated with abnormalities in the processing of reward and punishment signals and disturbances in homeostatic regulation. These abnormalities are proposed to impair error minimization routines for reducing uncertainty. Several lines of research point towards a role of the cerebellum in reward- and punishment-related predictive coding and homeostatic regulatory function in depressive disorder. Available functional and anatomical evidence suggests that in addition to the cortico-limbic networks, the cerebellum is part of the dysfunctional brain circuit in depressive disorder as well. It is proposed that impaired cerebellar function contributes to abnormalities in predictive coding and homeostatic dysregulation in depressive disorder. Further research on the role of the cerebellum in depressive disorder may further extend our knowledge on the functional and neural mechanisms of depressive disorder and development of novel antidepressant treatments strategies targeting the cerebellum.
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The cerebellum plays an abnormal role in the pathophysiology of mood disorders, psychiatric disorders, and predictive impairments.
“The cerebellum was found to play an abnormal role in the patho physiology of mood disorders (Schutter, 2016; Olivito et al., 2022), psychiatric disorders (Escelsior et al., 2019), and predictive impairments (Friston and Herreros, 2016).”
From Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review. (2025) · cites this paper as Schutter, 2016
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Predictive coding in neuropsychiatric disorders: a systematic transdiagnostic review.
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“The cerebellum was found to play an abnormal role in the pathophysiology of mood disorders (Schutter, 2016; Olivito et al., 2022), psychiatric disorders (Escelsior et al., 2019), and predictive impairments (Friston and Herreros, 2016).”
- Authors
- Schutter, D. J. L. G.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Schutter, Dennis J. L. G.
- Venue
- The Cerebellum
- Published
- 2015-08-07
- Volume
- 15
- Issue
- 1
- Pages
- 30-33
- ISSN
- 1473-4222 (ISSN-L)
- 1473-4230
- PMC
- PMC4726720
- OpenAlex
- W2218799125
- Cited by
- 42
- References
- 25
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 11 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The Cerebellum (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institute of Mental Health (R15MH106957)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- cerebellum, depressive disorders, predictive coding, homeostatic regulation, reward processing, punishment processing, error reduction, cortico-limbic network, antidepressant treatment, neurobiology of depression
- MeSH terms
- Cerebellum, Depressive Disorder, Homeostasis, Humans, Nerve Net, Predictive Value of Tests
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