Effects of polydopamine coating on the bioactivity of titanium for dental implants
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Deposition of a nanoscale PDA coating on titanium or zirconia implants markedly enhances their surface bioactivity and overall biological performance.
“Numerous studies have demonstrated that the deposition of a nanoscale PDA coating on titanium or zirconia implants markedly enhances their surface bioactivity and overall biological performance.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [8]
PDA-modified surfaces provide a supportive microenvironment that facilitates cell adhesion, proliferation, and differentiation while eliciting minimal inflammatory responses or adverse biological effects.
“Moreover, PDA-modified surfaces can provide a supportive microenvironment that facilitates cell adhesion, proliferation, and differentiation, while eliciting minimal inflammatory responses or adverse biological effects.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [8]
PDA has consistently been reported to exhibit biological inertness toward primary oral-derived cells.
“From a cytotoxicity standpoint, PDA has consistently been reported to exhibit biological inertness toward primary oral-derived cells.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [8]
In ISO 10993-5 extract testing, co-culture of human gingival fibroblasts with PDA nanoparticles at 0.5 mg mL−1 for 72 h resulted in cell viabilities exceeding 92% by MTT assays.
“According to standard ISO 10993–5 extract testing, co-culture of human gingival fibroblasts with PDA nanoparticles at a concentration of 0.5 mg mL−1 for 72 h resulted in cell viabilities exceeding 92% as determined by MTT assays.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [8]
In periodontal ligament stem cells, PDA surface coatings were associated with a 1.8-fold increase in focal adhesion kinase phosphorylation.
“Notably, in periodontal ligament stem cells, PDA surface coatings were associated with a 1.8-fold increase in focal adhesion kinase phosphorylation, suggesting that PDA is not only non-cytotoxic but may actively promote cell adhesion and spreading.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [8]
The proportion of cells positive for the early apoptosis marker Annexin V remained below 3%, with no statistically significant difference relative to the negative control.
“In parallel, the proportion of cells positive for the early apoptosis marker Annexin V remained below 3%, with no statistically significant difference relative to the negative control.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [8]
Live/Dead fluorescence confocal imaging revealed intact cell membranes and normal nuclear morphology, with no evidence of membrane disruption or nuclear condensation.
“Live/Dead fluorescence confocal imaging further revealed intact cell membranes and normal nuclear morphology, with no evidence of membrane disruption or nuclear condensation.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [8]
Cites
Surface treatments of titanium dental implants for rapid osseointegration
Le Guéhennec, L., Soueidan, A., Layrolle, P., & Amouriq, Y. (2007) · Dental Materials · doi:10.1016/j.dental.2006.06.025 · Cited by 2,406 · see citing works
A reversible wet/dry adhesive inspired by mussels and geckos
Lee, H., Lee, B. P., & Messersmith, P. B. (2007) · Nature · doi:10.1038/nature05968 · Cited by 2,043 · see citing works
Intra-Osseous Anchorage of Dental Prostheses: I. Experimental Studies
Brånemark, P., Breine, U., Adell, R., Hansson, B. O., Lindström, J., & Ohlsson, A. (1969) · Scandinavian Journal of Plastic and Reconstructive Surgery · doi:10.3109/02844316909036699 · Cited by 1,827 · see citing works
Buser, D., Martin, W. C., & Belser, U. C. (2004) · PubMed · Cited by 1,030 · see citing works
Mussel‐Inspired Polydopamine Coating as a Universal Route to Hydroxyapatite Crystallization
Ryu, J., Ku, S. H., Lee, H., & Park, C. B. (2010) · Advanced Functional Materials · doi:10.1002/adfm.200902347 · Cited by 778 · see citing works
General functionalization route for cell adhesion on non-wetting surfaces
Ku, S. H., Ryu, J., Hong, S. K., Lee, H., & Park, C. B. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.020 · Cited by 687 · see citing works
Nature's underwater adhesive specialist
Waite, J. H. (1987) · International Journal of Adhesion and Adhesives · doi:10.1016/0143-7496(87)90048-0 · Cited by 588 · see citing works
Coating carbon nanotubes by spontaneous oxidative polymerization of dopamine
Fei, B., Qian, B., Yang, Z., Wang, R., Liu, W. C., Mak, C. L., & Xin, J. H. (2008) · Carbon · doi:10.1016/j.carbon.2008.06.049 · Cited by 469 · see citing works
In vitro evaluation of cell/biomaterial interaction by MTT assay
Ciapetti, G., Cenni, E., Pratelli, L., & Pizzoferrato, A. (1993) · Biomaterials · doi:10.1016/0142-9612(93)90055-7 · Cited by 465 · see citing works
Elias, C. N., Oshida, Y., Lima, J. L. F. C., & Muller, C. A. (2008) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2007.12.002 · Cited by 463 · see citing works
Berglundh, T., & Lindhe, J. (1997) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.1997.080206.x · Cited by 417 · see citing works
Formation and characterization of anodic titanium oxide films containing Ca and P
Ishizawa, H., & Ogino, M. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820290110 · Cited by 368 · see citing works
ADHESION IN BYSSALLY ATTACHED BIVALVES
Waite, J. H. (1983) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1983.tb00387.x · Cited by 192 · see citing works
Development of bioadhesives from marine mussels
Chi, H. J., Hwang, D. S., & Lim, S. (2008) · Biotechnology Journal · doi:10.1002/biot.200700258 · Cited by 165 · see citing works
Effects of calcium ion incorporation on bone healing of Ti6Al4V alloy implants in rabbit tibiae
Park, J., Park, K.-B., & Suh, J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.04.007 · Cited by 139 · see citing works
Hayashi, K., Inadome, T., Mashima, T., & Sugioka, Y. (1993) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820270502 · Cited by 98 · see citing works
Gottlander, M., & Albrektsson, T. O. (1991) · PubMed · Cited by 96 · see citing works
Factors Associated With Dental Implant Survival: A 4‐Year Retrospective Analysis
Zupnik, J., Kim, S., Ravens, D., Karimbux, N. Y., & Guze, K. A. (2011) · Journal of Periodontology · doi:10.1902/jop.2011.100685 · Cited by 94 · see citing works
In vitro cytotoxicity of solid epoxy-based dental resins and their components
Kostoryz, E. L., Tong, P. Y., CHAPPELOW, C. C. J., Eick, J. D., Glaros, A. G., & Yourtee, D. M. (1999) · Dental Materials · doi:10.1016/s0109-5641(99)00058-5 · Cited by 81 · see citing works
Levine, R. A., Clem, D. S., Beagle, J. R., Ganeles, J., Johnson, P., Solnit, G. S., & Gw, K. (2002) · PubMed · Cited by 78 · see citing works
Coelho, P. G., Granato, R., Marin, C., Teixeira, H. S., Suzuki, M., Valverde, G. B., Janal, M. N., Lilin, T., & Bonfante, E. A. (2011) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2011.06.016 · Cited by 65 · see citing works
Rabiei, A., Thomas, B., Jin, C., Narayan, R. J., Cuomo, J. J., Yang, Y., & Ong, J. L. (2005) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2005.09.027 · Cited by 64 · see citing works
Microdissolution of calcium ions from calciumion-implanted titanium
Hanawa, T., Asami, K., & Asaoka, K. (1996) · Corrosion Science · doi:10.1016/0010-938x(96)00053-4 · Cited by 53 · see citing works
Bai, Y., Park, I. S., Park, H. H., Bae, T., & Lee, M. (2010) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31724 · Cited by 30 · see citing works
Self-citationPredicting Clustered Dental Implant Survival Using Frailty Methods
Chuang, S.-K., & Cai, T. (2006) · Journal of Dental Research · doi:10.1177/154405910608501216 · Cited by 29 · see citing works
Evaluation of in vitro and in vivo tests for surface-modified titanium by H2SO4 and H2O2 treatment
Lee, M., Park, I., Min, K.-S., Ahn, S., Park, J., Song, K., & Park, C.-W. (2007) · Metals and Materials International · doi:10.1007/bf03027560 · Cited by 22 · see citing works
Self-citationBiocompatibility of surface treated pure titanium and titanium alloy byin vivo andin vitro test
Lee, M., Yoon, D. J., Won, D. H., Bae, T., & Watari, F. (2003) · Metals and Materials International · doi:10.1007/bf03027227 · Cited by 18 · see citing works
Self-citationThe effect of fluoride treatment on titanium treated with anodic spark oxidation
Park, I. S., Kim, J. J., Ahn, S. G., Lee, M., Seol, K.-W., & Bae, T. (2007) · Metals and Materials International · doi:10.1007/bf03027561 · Cited by 7 · see citing works
Self-citationLee, I. G., Kim, Y., Park, I. S., Park, J., Lee, M., Bae, T., & Park, C. W. (2008) · Surface and Interface Analysis · doi:10.1002/sia.2930 · Cited by 5 · see citing works
Self-citationAgrawal (1997) · doi:10.1002/(sici)1097-4636(199722)38:2
Flagged first, then by citations
Cited by
Sorted by citations
Polydopamine Coating Enhances Mucopenetration and Cell Uptake of Nanoparticles
Poinard, B., Kamaluddin, S., Tan, A. Q. Q., Neoh, K. G., & Kah, J. C. Y. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b18107 · Cited by 128 · see citing works
Lin, B., Zhong, M., Zheng, C., Cao, L., Wang, D., Wang, L., Liang, J., & Cao, B. (2015) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2015.09.033 · Cited by 106 · see citing works
Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation
Mallinson, D., Mullen, A. B., & Lamprou, D. A. (2017) · Journal of Materials Science · doi:10.1007/s10853-017-1806-y · Cited by 86 · see citing works
Kaushik, N., Nhat Nguyen, L., Kim, J. H., Choi, E. H., & Kumar Kaushik, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186544 · Cited by 76 · see citing works
“It has been believed so far that the use of PDA is an easy and efficient method to regulate interfacial biological events in tissue engineering applications as a bioactive coating for direct signaling to cells [38,39].”
MethodChoi, S.-H., Jang, Y., Jang, J., Bae, T., Lee, S.-J., & Lee, M. (2019) · Journal of Applied Biomaterials & Functional Materials · doi:10.1177/2280800019847067 · Cited by 75 · see citing works
Self-citationHighly wear-resistant and biocompatible carbon nanocomposite coatings for dental implants
Penkov, O. V., Пуха, В. Е., Starikova, S. L., Khadem, M., Стариков, В. В., Maleev, M. V., & Kim, D. E. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.029 · Cited by 58 · see citing works
Steeves, A. J., Atwal, A., Schock, S., & Variola, F. (2016) · Journal of Materials Chemistry B · doi:10.1039/c5tb02510a · Cited by 56 · see citing works
Microbe-material hybrids for therapeutic applications
Chen, M., Xia, L., Wu, C., Wang, Z., Ding, L. S., Xie, Y., Feng, W., & Chen, Y. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00655g · Cited by 55 · see citing works
Zhang, L., Mohammed, E. A. A., & Adriaens, A. G. (2016) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2016.08.021 · Cited by 54 · see citing works
Ghorbani, F., Zamanian, A., & Aidun, A. (2019) · Journal of Applied Polymer Science · doi:10.1002/app.47656 · Cited by 45 · see citing works
Rezaei, H., Shahrezaee, M., Monfared, M. J., Ghorbani, F., Zamanian, A., & Sahebalzamani, M. (2020) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1911 · Cited by 40 · see citing works
Carbon Nanomaterials Modified Biomimetic Dental Implants for Diabetic Patients
Vijay, R., Mendhi, J., Prasad, K., Xiao, Y., Macleod, J. M., Ostrikov, K., & Zhou, Y. (2021) · Nanomaterials · doi:10.3390/nano11112977 · Cited by 38 · see citing works
Ghodrati, H., Goodarzi, A., Golrokhian, M., Fattahi, F., Anzabi, R. M., Mohammadikhah, M., Sadeghi, S., & Mirhadi, S. (2025) · Bone Reports · doi:10.1016/j.bonr.2025.101846 · Cited by 32 · see citing works
Soylu, H. M., Chevallier, P., Copes, F., Ponti, F., Candiani, G., Yurt, F., & Mantovani, D. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.678081 · Cited by 30 · see citing works
Polydopamine Nanomembranes as Adhesion Layers for Improved Corrosion Resistance in Low Carbon Steel
Ding, Z., Fatollahi‐Fard, F., Kwon, I. S., Pistorius, P. C., & Bettinger, C. J. (2018) · Advanced Engineering Materials · doi:10.1002/adem.201800621 · Cited by 25 · see citing works
Steeves, A. J., & Variola, F. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb02188d · Cited by 20 · see citing works
Effect of polydopamine and fluoride ion coating on dental enamel remineralization: an in vitro study
Choi, S.-M., Jung, H.-W., Ryu, J. H., & You, H. (2023) · BMC Oral Health · doi:10.1186/s12903-023-03221-6 · Cited by 17 · see citing works
Zhong, X., & Guo, Z. (2022) · Journal of Bionic Engineering · doi:10.1007/s42235-022-00312-y · Cited by 14 · see citing works
Bok, W.-M., Kim, S.-Y., Lee, S.-J., Shin, G.-S., Park, J., & Lee, M. (2015) · International Journal of Precision Engineering and Manufacturing · doi:10.1007/s12541-015-0281-0 · Cited by 14 · see citing works
Self-citationWang, X., He, X., Liu, X., Chen, M., Wang, Y., Guo, C., Wang, J., Zhang, H., Hao, Y., Wei, Y., et al. (2024) · Composites Part B Engineering · doi:10.1016/j.compositesb.2024.112044 · Cited by 13 · see citing works
Yi, Y., Cui, M., Lin, T., Liu, C., Jin, X., Chen, H., Zheng, R., Huang, S., & Ma, J. (2021) · European Journal Of Oral Sciences · doi:10.1111/eos.12797 · Cited by 11 · see citing works
Huang, Z., Chen, S., Lin, Q., & Shen, B. (2022) · Progress in Organic Coatings · doi:10.1016/j.porgcoat.2022.107142 · Cited by 8 · see citing works
Xia, Z., Sun, X., Mu, C., Wang, K., Ma, W., Yang, W., & Xu, K. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202404940 · Cited by 4 · see citing works
Pak, S.-H., Park, J. H., & Park, C.-G. (2022) · Korean Journal of Chemical Engineering · doi:10.1007/s11814-022-1122-3 · Cited by 3 · see citing works
Zhai, C., Wang, C., Zhang, M., & Mi, G. (2023) · Materials Today Communications · doi:10.1016/j.mtcomm.2023.107363 · Cited by 2 · see citing works
Effect of MoS2/polydopamine coating on surface properties and biocompatibility of Ti implants
Yu, M., Song, Y. H., & Han, M. (2024) · 대한치과재료학회지 · doi:10.14815/kjdm.2024.51.3.129 · Cited by 2 · see citing works
Efficacy of polydopamine-coated titanium in order to improve bond strengths for dental resin cement
Kim, H., & Kwon, T. (2017) · 대한치과재료학회지 · doi:10.14815/kjdm.2017.44.2.179 · Cited by 2 · see citing works
Study on Preparation and Performance of Arg-Glu-Asp-Val Modified Silk Fibroin Tube
李, 文. (2021) · Bioprocess · doi:10.12677/bp.2021.114014 · Cited by 1 · see citing works
Yang, Z., Song, W., Lv, L., Zhai, S., Liu, Y., Cui, H., Li, X., Gao, F., & Chu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s611922
“4,5,8 From a surface chemistry perspective, PDA modification converts the inherently hydrophobic implant surface into a hydrophilic one, thereby facilitating plasma protein adsorption and promoting the early attachment of osteoblasts.”
Zhang, S., Li, M., & Zhang, C. (2026) · Anti-Corrosion Methods and Materials · doi:10.1108/acmm-02-2026-3532
Safshekan, A., Shahrabi, T., Ramezanzadeh, B., & Bagheri, F. (2026) · Progress in Organic Coatings · doi:10.1016/j.porgcoat.2026.110390
- Authors
- Lee, J.-J., Park, I.-S., Shin, G.-S., Lyu, S.-K., Ahn, S.-G., Bae, T.-S., & Lee, M.-H.
- Affiliations
- Jeonbuk National University (KR)
- Gyeongsang National University (KR)
- Corresponding author
- Lee, Min-Ho
- Venue
- International Journal of Precision Engineering and Manufacturing
- Published
- 2014-08
- Volume
- 15
- Issue
- 8
- Pages
- 1647-1655
- ISSN
- 1229-8557 (ISSN-L)
- 2234-7593
- 2005-4602
- OpenAlex
- W2011137120
- Cited by
- 30
- References
- 31
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Precision Engineering and Manufacturing (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Keywords
- polydopamine coating, titanium, dental implants, surface modification, surface roughness, wettability, contact angle, corrosion resistance, cytotoxicity, cell growth, potentiodynamic polarization
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