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Cognitive changes with omega-3 polyunsaturated fatty acids in non-demented older adults with low omega-3 index

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Hooper, Claudie, de Souto Barreto, P., Coley, N., Cantet, C., Cesari, M., Andrieu, S., Vellas, B.·2017·The Journal of nutrition, health and aging
DOI 10.1007/s12603-017-0957-5PMC PMC12879888
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Abstract

OBJECTIVES: To investigate the changes in specific domains of cognitive function in older adults reporting subjective memory complaints with a low omega-3 index receiving omega 3 polyunsaturated fatty acid (n-3 PUFA) supplementation or placebo. DESIGN: This is a secondary exploratory analysis of the Multidomain Alzheimer Preventive Trial (MAPT) using subjects randomized to the n-3 PUFA supplementation or placebo group. SETTING: French community dwellers aged 70 or over reporting subjective memory complaints, but free from clinical dementia. PARTICIPANTS: A subgroup of MAPT subjects in the lowest quartile of omega-3 index distribution with baseline values ≤ 4.83 % (n = 183). INTERVENTION: The n-3 PUFA supplementation group consumed a daily dose of DHA (800 mg) and EPA (a maximum amount of 225 mg) for 3 years. The placebo group received identical capsules comprising liquid paraffin oil. MEASUREMENTS: Linear mixed-model repeated-measures analyses were used including baseline, 6, 12, 24 and 36-month follow-up data to assess between-group differences in the change in eight cognitive tests over 36 months. RESULTS: There was less decline on the Controlled Oral Word Association Test (COWAT) in the n-3 PUFA supplementation group compared to placebo (p = 0.009; between group mean difference over 36 months, 2.3; 95% CI, 0.6,4.0). No significant differences for any of the other cognitive tests were found, including other tests of executive functioning, although, numerically all results were in favour of the n-3 PUFA supplementation. CONCLUSIONS: We found some evidence that n-3 PUFAs might be beneficial for the maintenance of executive functioning in older adults at risk of dementia with low omega-3 index, but this exploratory finding requires further confirmation. A larger specifically designed randomised controlled trial could be merited.

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  • Epidemiological studies revealed that increased uptake of ω-3 PUFAs reduced risk of dementia.

    “Epidemiological studies revealed that increased uptake ω-3 of PUFAs reduced the risk of dementia.548”

    From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [548]

    The Introduction discusses mixed findings from intervention trials on cognitive function, and the Discussion reports only preliminary evidence concerning executive functioning in older adults at risk of dementia. Neither section reports epidemiological findings that increased omega-3 intake reduced dementia risk; searches for epidemiological studies, dietary intake, and dementia incidence found no such passage. (LLM, conf=0.74)

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Research works printed but not linked: 26

  1. [1]Quinn JF Raman R Thomas RG Yurko-Mauro K Nelson EB Van Dyck C Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial JAMA. 3 304 2010 1903 1911 10.1001/jama.2010.1510 PMC3259852 21045096 · DOI · Paper page
  2. [2]Vakhapova V Cohen T Richter Y Herzog Y Korczyn AD Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial Dement Geriatr Cogn Disord. 29 5 2010 467 474 PubMed PMID: 20523044 10.1159/000310330 20523044 · DOI
  3. [3]van de Rest O Geleijnse JM Kok FJ van Staveren WA Dullemeijer C Olderikkert MGM Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial Neurology. 5 71 2008 430 438 10.1212/01.wnl.0000324268.45138.86 18678826 · DOI
  4. [4]Sinn N Milte CM Street SJ Buckley JD Coates AM Petkov J Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial Br J Nutr. 107 11 2012 1682 1693 PubMed PMID: 21929835 10.1017/S0007114511004788 21929835 · DOI · Paper page
  5. [5]Iolascon G Gimigliano R Bianco M De Sire A Moretti A Giusti A Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review J Nutr Health Aging 21 5 2017 527 538 PubMed PMID: 28448083 10.1007/s12603-016-0823-x 28448083 · DOI
  6. [6]Boespflug EL, McNamara RK, Eliassen JC, Schidler MD, Krikorian R. Fish Oil Supplementation Increases Event-Related Posterior Cingulate Activation in Older Adults with Subjective Memory Impairment. J Nutr Health Aging. 2016 Feb;20(2):161–9. 26812512
  7. [7]Hooper C De Souto Barreto P Pahor M Weiner M Vellas B The relationship of omega 3 polyunsaturated fatty acids in red blood cell membranes with cognitive function and brain structure: A review focussed on Alzheimer's disease Journal of prevention of Alzheimer's disease 2017 PMC12280728 29405237
  8. [8]Mazereeuw G Lanctôt KL Chau SA Swardfager W Herrmann N Effects of ω-3 fatty acids on cognitive performance: a meta-analysis Neurobiol Aging. 33 7 2012 1482 PubMed PMID: 22305186 10.1016/j.neurobiolaging.2011.12.014 22305186 · DOI · Paper page
  9. [9]Andrieu S Guyonnet S Coley N Cantet C Bonnefoy M Bordes S Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial Lancet Neurol. 16 5 2017 377 PubMed PMID: 28359749 10.1016/S1474-4422(17)30040-6 28359749 · DOI · Paper page
  10. [10]Vellas B Carrie I Gillette-Guyonnet S Touchon J Dantoine T Dartigues J 2 MAPT Study: A Multidomain approach for preventing alzheimer's diesease: Design and baseline data J Prev Alzheimers Dis. 1 1 2014 13 22 PubMed PMID: 26594639; PMCID 4652787 26594639 PMC4652787
  11. [11]Legrand P Schmitt B Mourot J Catheline D Chesneau G Mireaux M The consumption of food products from linseed-fed animals maintains erythrocyte omega-3 fatty acids in obese humans Lipids. 45 1 2010 11 19 PubMed PMID: 20012223 10.1007/s11745-009-3376-5 20012223 · DOI
  12. [12]Grober E Buschke H Crystal H Bang S Dresner R Screening for dementia by memory testing Neurology. 38 6 1988 900 903 PubMed PMID: 3368071 10.1212/WNL.38.6.900 3368071 · DOI
  13. [13]Hughes CP Berg L Danziger WL Coben LA Martin RL A new clinical scale for the staging of dementia Br J Psychiatry J Ment Sci. 140 1982 566 572 10.1192/bjp.140.6.566 7104545 · DOI · Paper page
  14. [14]Cardebat D Doyon B Puel M Goulet P Joanette Y [Formal and semantic lexical evocation in normal subjects. Performance and dynamics of production as a function of sex, age and educational level] Acta Neurol Belg. 90 4 1990 207 217 PubMed PMID: 2124031 2124031
  15. [15]Guerrero-Berroa E Luo X Schmeidler J Rapp MA Dahlman K Grossman HT The MMSE orientation for time domain is a strong predictor of subsequent cognitive decline in the elderly Int J Geriatr Psychiatry. 24 12 2009 1429 1437 PubMed PMID: 19382130; PMCID 2919210 10.1002/gps.2282 19382130 PMC2919210 · DOI
  16. [16]Folstein MF Folstein SE McHugh PR “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res. 12 3 1975 189 198 PubMed PMID: 1202204 10.1016/0022-3956(75)90026-6 1202204 · DOI · Paper page
  17. [17]Reitan R Validity of the Trail Making Test as an indicator of brain damage Percept Mot Skills. 8 1958 271 276 10.2466/pms.1958.8.3.271 · DOI
  18. [19]Freund-Levi Y Eriksdotter-Jönhagen M Cederholm T Basun H Faxén-Irving G Garlind A Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial Arch Neurol. 63 10 2006 1402 1408 PubMed PMID: 17030655 10.1001/archneur.63.10.1402 17030655 · DOI · Paper page
  19. [20]Yurko-Mauro K McCarthy D Rom D Nelson EB Ryan AS Blackwell A Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline Alzheimers Dement J Alzheimers Assoc. 6 6 2010 456 464 10.1016/j.jalz.2010.01.013 20434961 · DOI
  20. [22]Jiao J Li Q Chu J Zeng W Yang M Zhu S Effect of n-3 PUFA supplementation on cognitive function throughout the life span from infancy to old age: a systematic review and meta-analysis of randomized controlled trials Am J Clin Nutr. 201 100 2014 1422 1436 10.3945/ajcn.114.095315 25411277 · DOI
  21. [23]Kyle DJ Schaefer E Patton G Beiser A Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia Lipids 34 1999 S245 PubMed PMID: 10419166 10.1007/BF02562306 10419166 · DOI
  22. [24]Guixà-González R Javanainen M Gómez-Soler M Cordobilla B Domingo JC Sanz F Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors Sci Rep. 6 2016 19839 PubMed PMID: 26796668; PMCID 4726318 10.1038/srep19839 26796668 PMC4726318 · DOI
  23. [25]McGahon BM Martin DS Horrobin DF Lynch MA Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids Neuroscience. 94 1 1999 305 314 PubMed PMID: 10613520 10.1016/S0306-4522(99)00219-5 10613520 · DOI
  24. [26]Lin Q Ruuska SE Shaw NS Dong D Noy N Ligand selectivity of the peroxisome proliferator-activated receptor alpha Biochemistry (Mosc). 5 38 1999 185 190 10.1021/bi9816094 9890897 · DOI · Paper page
  25. [27]Simopoulos AP Omega-3 fatty acids in inflammation and autoimmune diseases J Am Coll Nutr. 21 6 2002 495 505 PubMed PMID: 12480795 10.1080/07315724.2002.10719248 12480795 · DOI
  26. [28]McGeer PL McGeer EG The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy Acta Neuropathol (Berl). 126 4 2013 479 497 10.1007/s00401-013-1177-7 24052108 · DOI · Paper page

Cited by

Sorted by citations

Authors
Hooper, C., de Souto Barreto, P., Coley, N., Cantet, C., Cesari, M., Andrieu, S., & Vellas, B.
Affiliations
  • Centre Hospitalier Universitaire de Toulouse (FR)
  • Université Toulouse III - Paul Sabatier (FR)
Corresponding author
Hooper, Claudie
ORCID
Venue
The Journal of nutrition, health and aging
Publisher
Elsevier BV
Published
2017-11
Volume
21
Issue
9
Pages
988-993
ISSN
1279-7707 (ISSN-L)
DOI
10.1007/s12603-017-0957-5
PMC
PMC12879888
OpenAlex
W2749299089
Cited by
69
References
2
Citations by year
2026: 7 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 8
FWCI
5.69
Type
journal article
Language
en
Open access
Licence
Locations
  • The journal of nutrition health & aging (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
Funders
Agence Nationale de la Recherche (ANR-11-LABX-0018)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
omega-3 polyunsaturated fatty acids, n-3 PUFA supplementation, omega-3 index, cognitive decline, executive function, subjective memory complaints, older adults, dementia prevention, docosahexaenoic acid, EPA, Controlled Oral Word Association Test
MeSH terms
Aged, Cognition, Female, Humans, Male, Fatty Acids, Omega-3, Executive Function

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