Effects of omega-3 fatty acids on cognitive performance: a meta-analysis
Abstract
Background Higher intake of omega-3 fatty acids (n-3 FAs) is associated with a reduced risk of Alzheimer's disease (AD) and milder forms of cognitive impairment (e.g. cognitive impairment no dementia [CIND]); however, findings from interventional trials are inconsistent. This meta-analysis examined the neuropsychological benefit of n-3 FAs in randomized double-blind placebo-controlled studies (RCTs) including healthy, CIND, or AD subjects.Methods Literature was searched using Medline, Embase, PsycInfo, Cochrane Library, Allied and Complementary Medicine Database (AMED), and Cumulative Index to Nursing and Allied Health Literature (CINAHL) up to September 2011. Treatment effects were summarized across cognitive subdomains, and effect sizes were estimated using Hedge's g and random effects modeling.Results Ten RCTs were combined quantitatively. There was no effect of n-3 FAs on composite memory (g = 0.04 [95% CI: -0.06-0.14], N = 934/812, p = 0.452). When examined by domain, no overall benefit for immediate recall (0.04 [-0.05-0.13], N = 934/812, p = 0.358) was detected; however, an effect in CIND subjects (0.16 [0.01-0.31], N = 349/327, p = 0.034) was found. A benefit for attention and processing speed was also detected in CIND (0.30 [0.02-0.57], N = 107/86, p = 0.035), but not healthy subjects. Benefits for delayed recall, recognition memory, or working memory and executive function were not observed. Treatment did not benefit AD patients as measured by the Mini-Mental State Examination (MMSE) or Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog). No differences in adverse events (AE), dropout, or dropout due to AE between groups were observed.Conclusions These results suggest an effect of n-3 FAs within specific cognitive domains in CIND, but not in healthy or AD subjects.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
For people with mild cognitive impairment, n-3 LCPUFA may improve certain aspects of cognitive function, including attention, processing speed, and immediate recall.
“However, for people with mild cognitive impairment, n-3 LCPUFA may improve certain aspects of cognitive function, including attention, processing speed, and immediate recall [89].”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [89]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Reliability of the PEDro Scale for Rating Quality of Randomized Controlled Trials
Maher, C. G., Sherrington, C., Herbert, R. D., Moseley, A. M., & Elkins, M. (2003) · Physical Therapy · doi:10.1093/ptj/83.8.713 · Cited by 4,808 · see citing works
The Neuropsychological Assessment
Ogden, J. A. (2005) · Oxford University Press eBooks · doi:10.1093/oso/9780195171358.003.0002 · Cited by 4,382 · see citing works
A new rating scale for Alzheimer's disease
(1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.11.1356 · Cited by 4,175 · see citing works
Gauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 3,920 · see citing works
Neuropsychological assessment, 4th ed.
Lezak, M. D., Howieson, D. B., Loring, D. W., Hannay, H. J., & Fischer, J. S. (2004) · Cited by 1,934 · see citing works
Smith, P. J., Blumenthal, J. A., Hoffman, B. M., Cooper, H., Strauman, T. A., Welsh-Bohmer, K., Browndyke, J. N., & Sherwood, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d14633 · Cited by 1,714 · see citing works
Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease
Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.940 · Cited by 1,135 · see citing works
Lauritzen, L. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00017-5 · Cited by 1,066 · see citing works
Metan: fixed- and random-effects meta-analysis
Harris, R. J., Deeks, J. J., Altman, D. G., Bradburn, M. J., Harbord, R. M., & Sterne, J. A. C. (2008) · The Stata Journal: Promoting communications on statistics and Stata · doi:10.1177/1536867x0800800102 · Cited by 1,027 · see citing works
Linking lipids to Alzheimer's disease: cholesterol and beyond
Di Paolo, G., & Kim, T.-W. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3012 · Cited by 972 · see citing works
Prevalence of Cognitive Impairment without Dementia in the United States
Plassman, B. L., Langa, K. M., Fisher, G. G., Heeringa, S. G., Weir, D. R., Ofstedal, M. B., Burke, J. R., Hurd, M. D., Potter, G. G., Rodgers, W. L., et al. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-6-200803180-00005 · Cited by 927 · see citing works
Harbord, R. M., & Higgins, J. P. T. (2008) · The Stata Journal: Promoting communications on statistics and Stata · doi:10.1177/1536867x0800800403 · Cited by 897 · see citing works
Scales to Assess the Quality of Randomized Controlled Trials: A Systematic Review
Olivo, S. A., Macedo, L. G., Gadotti, I. C., Fuentes, J., Stanton, T., & Magee, D. J. (2008) · Physical Therapy · doi:10.2522/ptj.20070147 · Cited by 829 · see citing works
Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Trial
Quinn, J. F., Raman, R., Thomas, R. G., Yurko-Mauro, K., Nelson, E. B., Van Dyck, C., Galvin, J. E., Emond, J., Jack, C. R., Weiner, M., et al. (2010) · JAMA · doi:10.1001/jama.2010.1510 · Cited by 764 · see citing works
Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751 · see citing works
Schaefer, E. J., Bongard, V., Beiser, A. S., Lamon-Fava, S., Robins, S. J., Au, R., Tucker, K. L., Kyle, D. J., Wilson, P. W. F., & Wolf, P. A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.11.1545 · Cited by 686 · see citing works
Whitwell, J. L., Przybelski, S. A., Weigand, S. D., Knopman, D. S., Boeve, B. F., Petersen, R. C., & Jack, C. R. (2007) · Brain · doi:10.1093/brain/awm112 · Cited by 607 · see citing works
Beneficial effects of docosahexaenoic acid on cognition in age‐related cognitive decline
Yurko‐Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A. D., Salem, N., Stedman, M., & MIDAS Investigators (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.01.013 · Cited by 584 · see citing works
World Alzheimer Report 2010: The global economic impact of dementia
Wimo, A. B., & Prince, M. J. (2010) · Cited by 559 · see citing works
Disclosure of <i>APOE</i> Genotype for Risk of Alzheimer's Disease
Green, R. C., Roberts, J. S., Cupples, L. A., Relkin, N. R., Whitehouse, P. J., Brown, T., Eckert, S. L., Butson, M., Sadovnick, A. D., Quaid, K. A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0809578 · Cited by 554 · see citing works
Dietary intake of fatty acids and fish in relation to cognitive performance at middle age
Kalmijn, S., van Boxtel, M. P. J., Ocké, M., Verschuren, W. M. M., Kromhout, D., & Launer, L. J. (2004) · Neurology · doi:10.1212/01.wnl.0000103860.75218.a5 · Cited by 524 · see citing works
Conquer, J. A., Tierney, M. C., Zecevic, J., Bettger, W. J., & Fisher, R. H. (2000) · Lipids · doi:10.1007/s11745-000-0646-3 · Cited by 523 · see citing works
PEDro. A database of randomized trials and systematic reviews in physiotherapy
Sherrington, C., Herbert, R. D., Maher, C. G., & Moseley, A. M. (2000) · Manual Therapy · doi:10.1054/math.2000.0372 · Cited by 508 · see citing works
Chiu, C.-C., Su, K., Cheng, T., Liu, H., Chang, C.-J., Dewey, M. E., Stewart, R. J., & Huang, S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.05.015 · Cited by 407 · see citing works
Effect of fish oil on cognitive performance in older subjects
van de Rest, O., Geleijnse, J. M., Kok, F. J., van Staveren, W. A., Dullemeijer, C., Olde-Rikkert, M. G. M., Beekman, A. T. F., & de Groot, C. P. G. M. (2008) · Neurology · doi:10.1212/01.wnl.0000324268.45138.86 · Cited by 380 · see citing works
Cognition-based interventions for healthy older people and people with mild cognitive impairment
Martin, M., Clare, L., Altgassen, A. M., Cameron, M. H., & Zehnder, F. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006220.pub2 · Cited by 350 · see citing works
van Gelder, B. M., Tijhuis, M., Kalmijn, S., & Kromhout, D. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1142 · Cited by 346 · see citing works
Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
Kotani, S., Sakaguchi, E., Warashina, S., Matsukawa, N., Ishikura, Y., Kiso, Y., Sakakibara, M., Yoshimoto, T., Guo, J., & Yamashima, T. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.06.010 · Cited by 321 · see citing works
Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study
Tully, A.-M., Roche, H. M., Doyle, R., Fallon, C., Bruce, I., LAWLOR, B. A., Coakley, D., & Gibney, M. J. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2002804 · Cited by 309 · see citing works
Sinn, N., Milte, C. M., Street, S. J., Buckley, J. D., Coates, A. M., Petkov, J., & Howe, P. R. C. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511004788 · Cited by 297 · see citing works
Dangour, A. D., Allen, E., Elbourne, D., Fasey, N., Fletcher, A. E., Hardy, P., Holder, G. E., Knight, R., Letley, L., Richards, M., et al. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29121 · Cited by 296 · see citing works
Resolvins and protectins: mediating solutions to inflammation
Kohli, P., & Levy, B. D. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00290.x · Cited by 293 · see citing works
Johnson, E. J., McDonald, K. Q., Caldarella, S. M., Chung, H.-Y., Troen, A. M., & Snodderly, D. M. (2008) · Nutritional Neuroscience · doi:10.1179/147683008x301450 · Cited by 292 · see citing works
He, C., Qu, X., Cui, L., Wang, J., & Kang, J. X. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904835106 · Cited by 233 · see citing works
Dissociable Human Perirhinal, Hippocampal, and Parahippocampal Roles during Verbal Encoding
Strange, B. A., Otten, L. J., Josephs, O., Rugg, M. D., & Dolan, R. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00523.2002 · Cited by 229 · see citing works
Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk
Devore, E. E., Grodstein, F., van Rooij, F. J., Hofman, A., Rosner, B., Stampfer, M. J., Witteman, J. C., & Breteler, M. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27037 · Cited by 205 · see citing works
Hippocampal Head Size Associated with Verbal Memory Performance in Nondemented Elderly
Hackert, V., den Heijer, T., Oudkerk, M., Koudstaal, P. J., Albert Hofman, D., & Breteler, M. M. B. (2002) · NeuroImage · doi:10.1006/nimg.2002.1248 · Cited by 195 · see citing works
Whalley, L. J., Deary, I. J., Starr, J. M., Wahle, K. W. J., Rance, K. A., Bourne, V. J., & Fox, H. C. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.449 · Cited by 180 · see citing works
Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease
Jicha, G. A. (2010) · Clinical Interventions in Aging · doi:10.2147/cia.s5231 · Cited by 153 · see citing works
Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study
Nurk, E., Drevon, C. A., Refsum, H., Solvoll, K., Vollset, S. E., Nygard, O. K., Nygaard, H. A., Engedal, K., Tell, G. S., & Smith, A. D. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1470 · Cited by 147 · see citing works
Diagnosis and biomarkers of predementia in Alzheimer's disease
Forlenza, O. V., Diniz, B. S., & Gattaz, W. F. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-89 · Cited by 145 · see citing works
Essential Fatty Acids Preparation (Sr-3) Improves Alzheimer's Patients Quality of Life
Yehuda, S., Rabinovtz, S., Carasso, R. L., & Mostofsky, D. I. (1996) · International Journal of Neuroscience · doi:10.3109/00207459609070833 · Cited by 142 · see citing works
Omega 3 fatty acid for the prevention of dementia
Lim, W. S., Gammack, J. K., van Niekerk, J. K., & Dangour, A. D. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005379.pub2 · Cited by 134 · see citing works
Hippocampal region-specific contributions to memory performance in normal elderly
Chen, K. H. M., Chuah, L. Y. M., Sim, S. K. Y., & Chee, M. W. L. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2009.11.007 · Cited by 124 · see citing works
Whalley, L. J., Fox, H. C., Wahle, K. W. J., Starr, J. M., & Deary, I. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1650 · Cited by 116 · see citing works
Plourde, M., Vohl, M., Vandal, M., Couture, P., Lemieux, S., & Cunnane, S. C. (2009) · British Journal Of Nutrition · doi:10.1017/s000711450938215x · Cited by 107 · see citing works
Vakhapova, V., Cohen, T., Richter, Y., Herzog, Y., & Korczyn, A. D. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000310330 · Cited by 101 · see citing works
Ethyl-EPA in Alzheimer's disease—a pilot study
Boston, P. F., Bennett, A., Horrobin, D. F., & Bennett, C. N. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.07.001 · Cited by 94 · see citing works
Huang, T. L. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-090934 · Cited by 88 · see citing works
The feeding of sledge dogs on Antarctic expeditions
Orr, N. W. M. (1966) · British Journal Of Nutrition · doi:10.1079/bjn19660003 · Cited by 87 · see citing works
Dietary fatty acids and the aging brain
Cole, G. M., Ma, Q., & Frautschy, S. A. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00345.x · Cited by 79 · see citing works
A review comparing the safety and tolerability of memantine with the acetylcholinesterase inhibitors
Jones, R. W. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2384 · Cited by 75 · see citing works
Screening for Dementia: Comparison of Three Commonly Used Instruments
van Gorp, W. G., Marcotte, T. D., Sultzer, D. L., et al. (1999) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.21.1.29.939 · Cited by 70 · see citing works
Polyunsaturated Fatty Acids and Reduced Odds of MCI: The Mayo Clinic Study of Aging
Roberts, R. O., Cerhan, J. R., Geda, Y. E., Knopman, D. S., Cha, R. H., Christianson, T. J. H., Pankratz, V. S., Ivnik, R. J., O’Connor, H. M., & Petersen, R. C. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091597 · Cited by 52 · see citing works
Effect of DHA Oil Supplementation on Intelligence and Visual Acuity in the Elderly
Suzuki, H., Morikawa, Y., & Takahashi, H. (2000) · KARGER eBooks · doi:10.1159/000059767 · Cited by 45 · see citing works
Jacova, C., Peters, K. R., Beattie, B. L., Wong, E. B., Riddehough, A., Foti, D. J., Scheltens, P., Li, D. K. B., & Feldman, H. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000115848 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Deckers, K., van Boxtel, M. P. J., Schiepers, O. J. G., de Vugt, M., Muñoz Sánchez, J. L., Anstey, K. J., Brayne, C., Dartigues, J.-F., Engedal, K., Kivipelto, M., et al. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4245 · Cited by 534 · see citing works
Zhang, Y., Chen, J., Qiu, J., Li, Y., Wang, J., & Jiao, J. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.124081 · Cited by 330 · see citing works
Nutrition for the ageing brain: Towards evidence for an optimal diet
Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.010 · Cited by 241 · see citing works
Omega-3 fatty acids' supplementation in Alzheimer's disease: A systematic review
Canhada, S., Castro, K., Perry, I. S., & Luft, V. C. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1321813 · Cited by 156 · see citing works
Denis, I., Potier, B., Vancassel, S., Heberden, C., & Lavialle, M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.007 · Cited by 150 · see citing works
Van Dael, P. (2021) · Nutrition Research and Practice · doi:10.4162/nrp.2021.15.2.137 · Cited by 138 · see citing works
van Soest, A. P. M., Hermes, G. D. A., Berendsen, A. A. M., van de Rest, O., Zoetendal, E. G., Fuentes, S., Santoro, A., Franceschi, C., de Groot, L. C. P. G. M., & de Vos, W. M. (2020) · Nutrients · doi:10.3390/nu12113471 · Cited by 118 · see citing works
Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets
Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works
Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial
Lindbergh, C. A., Renzi-Hammond, L. M., Hammond, B. R., Terry, D. P., Mewborn, C. M., Puente, A. N., & Miller, L. S. (2018) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000534 · Cited by 94 · see citing works
Effects of cocoa extract and a multivitamin on cognitive function: a randomized clinical trial
Baker, L. D., Manson, J. E., Rapp, S. R., Sesso, H. D., Gaussoin, S. A., Shumaker, S. A., & Espeland, M. A. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.12767 · Cited by 88 · see citing works
Zhu, R.-Z., Chen, M.-Q., Zhang, Z.-W., Wu, T.-Y., & Zhao, W.-H. (2021) · Nutrition · doi:10.1016/j.nut.2021.111355 · Cited by 61 · see citing works
Nonpharmacologic Treatment and Prevention Strategies for Dementia
Yaffe, K., & Hoang, T. (2013) · Continuum · doi:10.1212/01.con.0000429178.14354.67 · Cited by 28 · see citing works
Metabolites Associated with Early Cognitive Changes Implicated in Alzheimer’s Disease
Darst, B. F., Huo, Z., Jonaitis, E. M., Koscik, R. L., Clark, L. R., Lu, Q., Kremen, W. S., Franz, C. E., Rana, B., Lyons, M. J., et al. (2021) · Journal of Alzheimer’s Disease · doi:10.3233/jad-200176 · Cited by 16 · see citing works
- Authors
- Mazereeuw, G., Lanctôt, K. L., Chau, S. A., Swardfager, W., & Herrmann, N.
- Affiliations
- Sunnybrook Health Science Centre (CA)
- Corresponding author
- Herrmann, Nathan
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 33
- Issue
- 7
- Pages
- 1482.e17-1482.e29
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2044850402
- Cited by
- 253
- References
- 61
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 8 · 2023: 13 · 2022: 16 · 2021: 27 · 2020: 23 · 2019: 14 · 2018: 14 · 2017: 30 · 2016: 17 · 2015: 19 · 2014: 26 · 2013: 22 · 2012: 3
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Psychological Association
- Alzheimer Society Research Program
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- omega-3 fatty acids, cognitive performance, Alzheimer's disease, cognitive impairment without dementia, memory, attention and processing speed, dietary supplementation, neuropsychological outcomes
- MeSH terms
- Alzheimer Disease, Cognition Disorders, Humans, Mental Recall, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
