Cited by 216Deep Brain Stimulation and Movement DisordersTreatment of Major DepressionObsessive-Compulsive Spectrum Disorders

The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.

Deep Brain Stimulation for Treatment-resistant Depression: Systematic Review of Clinical Outcomes

Open access

Morishita, Takashi, Fayad, Sarah M., Higuchi, Masa-aki, Nestor, Kelsey A., Foote, Kelly D.·2014·Neurotherapeutics

DOI 10.1007/s13311-014-0282-1PMC PMC4121451

Open this paper in CoChat — free account Open PDF

Abstract

Major depressive disorder (MDD) is a widespread, severe, debilitating disorder that markedly diminishes quality of life. Medication is commonly effective, but 20-30 % of patients are refractory to medical therapy. The surgical treatment of psychiatric disorders has a negative stigma associated with it owing to historical abuses. Various ablative surgeries for MDD have been attempted with marginal success, but these studies lacked standardized outcome measures. The recent development of neuromodulation therapy, especially deep brain stimulation (DBS), has enabled controlled studies with sham stimulation and presents a potential therapeutic option that is both reversible and adjustable. We performed a systematic review of the literature pertaining to DBS for treatment-resistant depression to evaluate the safety and efficacy of this procedure. We included only studies using validated outcome measures. Our review identified 22 clinical research papers with 5 unique DBS approaches using different targets, including nucleus accumbens, ventral striatum/ventral capsule, subgenual cingulate cortex, lateral habenula, inferior thalamic nucleus, and medial forebrain bundle. Among the 22 published studies, only 3 were controlled trials, and 2, as yet unpublished, multicenter, randomized, controlled trials evaluating the efficacy of subgenual cingulate cortex and ventral striatum/ventral capsule DBS were recently discontinued owing to inefficacy based on futility analyses. Overall, the published response rate to DBS therapy, defined as the percentage of patients with > 50 % improvement on the Hamilton Depression Rating Scale, is reported to be 40-70 %, and outcomes were comparable across studies. We conclude that DBS for MDD shows promise, but remains experimental and further accumulation of data is warranted.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s13311-014-0282-1

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988
Selective Cortical Undercutting As a Means of Modifying and Studying Frontal Lobe Function in Man
Scoville, W. B. (1949) · Journal of neurosurgery · doi:10.3171/jns.1949.6.1.0065 · Cited by 7,374
Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585
Diagnosis and definition of treatment-resistant depression
Fava, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00231-2 · Cited by 1,380
Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response
Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115
Cingulate function in depression: a potential predictor of treatment response
Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., Silva, J. A., McGinnis, S., Glass, T. G., Martin, C. C., et al. (1997) · NeuroReport · doi:10.1097/00001756-199703030-00048 · Cited by 1,029

Show all 80 references

Sorted by citations

Deep brain stimulation: current challenges and future directions
Lozano, A. M., Lipsman, N., Bergman, H., Brown, P., Chabardès, S., Chang, J. W., Matthews, K., McIntyre, C. C., Schlaepfer, T. E., Schulder, M., et al. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0128-2 · Cited by 1,475
Building better biomarkers: brain models in translational neuroimaging
Woo, C.-W., Chang, L. J., Lindquist, M. A., & Wager, T. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4478 · Cited by 1,056
Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Malhi, G. S., Bassett, D., Boyce, P., Bryant, R., Fitzgerald, P. B., Fritz, K., Hopwood, M., Lyndon, B., Mulder, R., Murray, G., et al. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415617657 · Cited by 842
“However, two recent industry sponsored trials have been terminated early due to the lack of positive interim results (Dougherty et al., 2014; Morishita et al., 2014).”
Background
Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines
Cleare, A., Pariante, C., Young, A., Anderson, I., Christmas, D., Cowen, P., Dickens, C., Ferrier, I., Geddes, J., Gilbody, S., et al. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115581093 · Cited by 759
Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment
Peters, S. K., Dunlop, K., & Downar, J. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00104 · Cited by 611
“In MDD, for example, targeting the subgenual cingulate cortex (sgCC) may have modulatory downstream effects on the dACC by propagating stimulation effects through the rostral cingulate cortex (Morishita et al., 2014).”
Background
Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases
Fox, M. D., Buckner, R. L., Liu, H., Chakravarty, M. M., Lozano, A. M., & Pascual-Leone, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405003111 · Cited by 617
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 4. Neurostimulation Treatments
Milev, R. V., Giacobbe, P., Kennedy, S. H., Blumberger, D. M., Daskalakis, Z. J., Downar, J., Modirrousta, M., Patry, S., Vila-Rodriguez, F., Lam, R. W., et al. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716660033 · Cited by 586
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder
Parikh, S. V., Quilty, L. C., Ravitz, P., Rosenbluth, M., Pavlova, B., Grigoriadis, S., Velyvis, V., Kennedy, S. H., Lam, R. W., MacQueen, G. M., et al. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716659418 · Cited by 562
Emerging technologies for improved deep brain stimulation
Cagnan, H., Denison, T., McIntyre, C. C., & Brown, P. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0244-6 · Cited by 274
Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications
Dandekar, M. P., Fenoy, A. J., Carvalho, A. F., Soares, J. C., & Quevedo, J. (2018) · Molecular Psychiatry · doi:10.1038/mp.2018.2 · Cited by 265
Pragmatic randomized controlled trial of long‐term psychoanalytic psychotherapy for treatment‐resistant depression: the Tavistock Adult Depression Study (TADS)
Fonagy, P., Rost, F., Carlyle, J., McPherson, S., Thomas, R., Pasco Fearon, R. M., Goldberg, D., & Taylor, D. (2015) · World Psychiatry · doi:10.1002/wps.20267 · Cited by 237
Rapid Precision Functional Mapping of Individuals Using Multi-Echo fMRI
Lynch, C. J., Power, J. D., Scult, M. A., Dubin, M. J., Gunning, F. M., & Liston, C. M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108540 · Cited by 192
Personalized connectivity‐guided DLPFC‐TMS for depression: Advancing computational feasibility, precision and reproducibility
Cash, R. F. H., Cocchi, L., Lv, J., Wu, Y., Fitzgerald, P. B., & Zalesky, A. (2021) · Human Brain Mapping · doi:10.1002/hbm.25330 · Cited by 211
Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial
Coenen, V. A., Bewernick, B. H., Kayser, S., Kilian, H., Boström, J., Greschus, S., Hurlemann, R., Klein, M. E., Spanier, S., Sajonz, B., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0369-9 · Cited by 176
Personalizing the Treatment of Substance Use Disorders
Volkow, N. D. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19121284 · Cited by 172
A systematic review and meta-analysis of deep brain stimulation for depression
Kisely, S., Li, A., Warren, N., & Siskind, D. (2018) · Depression and Anxiety · doi:10.1002/da.22746 · Cited by 165
Translating the habenula-from rodents to humans
Boulos, L.-J., Darcq, E., & Kieffer, B. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.003 · Cited by 164
Deep brain stimulation targets for treating depression
Drobisz, D., & Damborská, A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.004 · Cited by 164
Deep brain stimulation to the medial forebrain bundle for depression- long-term outcomes and a novel data analysis strategy
Bewernick, B. H., Kayser, S., Gippert, S. M., Switala, C., Coenen, V. A., & Schlaepfer, T. E. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.01.581 · Cited by 156
Functional connectivity of the left DLPFC to striatum predicts treatment response of depression to TMS
Avissar, M., Powell, F., Ilieva, I. P., Respino, M., Gunning, F. M., Liston, C. M., & Dubin, M. J. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.07.002 · Cited by 162
Brain-computer interface-based control of closed-loop brain stimulation: attitudes and ethical considerations
Klein, E. P., Goering, S., Gagne, J., Shea, C. V., Franklin, R., Zorowitz, S., Dougherty, D. D., & Widge, A. S. (2016) · Brain-Computer Interfaces · doi:10.1080/2326263x.2016.1207497 · Cited by 142
Freedom of Thought and Mental Integrity: The Moral Requirements for Any Neural Prosthesis
Lavazza, A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00082 · Cited by 164
Visualization of the medial forebrain bundle using diffusion tensor imaging
Hana, A., Hana, A., Dooms, G., Boecher-Schwarz, H., & Hertel, F. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00139 · Cited by 137
Intrinsic network architecture predicts the effects elicited by intracranial electrical stimulation of the human brain
Fox, K. C. R., Shi, L., Baek, S., Raccah, O., Foster, B. L., Saha, S., Margulies, D. S., Kucyi, A., & Parvizi, J. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-0910-1 · Cited by 133
Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis
Yun, S., Reynolds, R. P., Masiulis, I., & Eisch, A. J. (2016) · Nature Medicine · doi:10.1038/nm.4218 · Cited by 136
Staying in the Loop: Relational Agency and Identity in Next-Generation DBS for Psychiatry
Goering, S., Klein, E. P., Dougherty, D. D., & Widge, A. S. (2017) · AJOB Neuroscience · doi:10.1080/21507740.2017.1320320 · Cited by 130
Treating refractory mental illness with closed-loop brain stimulation: Progress towards a patient-specific transdiagnostic approach
Widge, A. S., Ellard, K. K., Paulk, A. C., Basu, I., Yousefi, A., Zorowitz, S., Gilmour, A., Afzal, A., Deckersbach, T., Cash, S. S., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.021 · Cited by 118
Closed-loop neuromodulation systems: next-generation treatments for psychiatric illness
Lo, M.-C., & Widge, A. S. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1282438 · Cited by 125
Transcranial focused ultrasound: a new tool for non-invasive neuromodulation
Fini, M. E., & Tyler, W. J. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1302924 · Cited by 121
Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates
Monosov, I. E., Haber, S. N., Leuthardt, E. C., & Jezzini, A. (2020) · Current Biology · doi:10.1016/j.cub.2020.10.009 · Cited by 118
The application of deep brain stimulation in the treatment of psychiatric disorders
Graat, I., Figee, M., & Denys, D. A. J. P. (2017) · International Review of Psychiatry · doi:10.1080/09540261.2017.1282439 · Cited by 107
Does the Prefrontal Cortex Play an Essential Role in Consciousness? Insights from Intracranial Electrical Stimulation of the Human Brain
Raccah, O., Block, N., & Fox, K. C. R. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.1141-20.2020 · Cited by 96
A systematic review and meta-analysis of deep brain stimulation in treatment-resistant depression
Zhou, C., Zhang, H., Qin, Y., Tian, T., Xu, B., Chen, J., Zhou, X., Zeng, L., Fang, L., Qi, X., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.012 · Cited by 100
Intracranial Electrophysiology of the Human Default Network
Fox, K. C. R., Foster, B. L., Kucyi, A., Daitch, A. L., & Parvizi, J. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.02.002 · Cited by 96
The habenula in psychiatric disorders: More than three decades of translational investigation
Fakhoury, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.010 · Cited by 92
A control-theoretic system identification framework and a real-time closed-loop clinical simulation testbed for electrical brain stimulation
Yang, Y., Connolly, A. T., & Shanechi, M. M. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aad1a8 · Cited by 90
Deep brain stimulation of the subcallosal cingulate gyrus in patients with treatment-resistant depression: A double-blinded randomized controlled study and long-term follow-up in eight patients
Merkl, A., Aust, S., Schneider, G., Visser-Vandewalle, V. E. R. M., Horn, A., Kühn, A. A., Kuhn, J., & Bajbouj, M. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.024 · Cited by 88
Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors
Shrestha, P., Mousa, A., & Heintz, N. (2015) · eLife · doi:10.7554/elife.08752 · Cited by 84
Deep Brain Stimulation in Treatment-Resistant Depression: A Systematic Review and Meta-Analysis on Efficacy and Safety
Wu, Y., Mo, J., Sui, L., Zhang, J., Hu, W., Zhang, C., Wang, Y., Liu, C., Zhao, B., Xiu, W., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.655412 · Cited by 84
Charting the road forward in psychiatric neurosurgery: proceedings of the 2016 American Society for Stereotactic and Functional Neurosurgery workshop on neuromodulation for psychiatric disorders
Bari, A., Mikell, C. B., Abosch, A., Ben‐Haim, S., Buchanan, R. J., Burton, A. W., Carcieri, S., Cosgrove, G. R., D’Haese, P.-F., Daskalakis, Z. J., et al. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317082 · Cited by 72
Deep brain stimulation of the posterior gyrus rectus region for treatment resistant depression
Accolla, E. A., Aust, S., Merkl, A., Schneider, G.-H., Kühn, A. A., Bajbouj, M., & Draganski, B. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.01.022 · Cited by 72
Combinatorial Inputs to the Ventral Striatum from the Temporal Cortex, Frontal Cortex, and Amygdala: Implications for Segmenting the Striatum
Choi, E. Y., Ding, S., & Haber, S. N. (2017) · eNeuro · doi:10.1523/eneuro.0392-17.2017 · Cited by 70
Reward systems and cognitions in Major Depressive Disorder
Cléry-Melin, M.-L., Jollant, F., & Gorwood, P. A. P. M. (2018) · CNS Spectrums · doi:10.1017/s1092852918001335 · Cited by 73
The Self and its Disorders
Gallagher, S. (2023) · doi:10.1093/oso/9780198873068.001.0001 · Cited by 72
A systematic review of psychiatric indications for deep brain stimulation, with focus on major depressive and obsessive-compulsive disorder
Naesström, M., Blomstedt, P. C., & Bodlund, O. (2016) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2016.1162846 · Cited by 64
Neuromodulation Therapies for Geriatric Depression
Gálvez, V., Ho, K.-A., Alonzo, A., Martin, D. M., George, D., & Loo, C. K. A. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0592-y · Cited by 66
The Clinical Applicability of Functional Connectivity in Depression: Pathways Toward More Targeted Intervention
Fischer, A. S., Keller, C. J., & Etkin, A. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.02.004 · Cited by 65
Multi-Watt Near-Infrared Phototherapy for the Treatment of Comorbid Depression: An Open-Label Single-Arm Study
Henderson, T. A., & Morries, L. D. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00187 · Cited by 60
Habenula
Benarroch, E. E. (2015) · Neurology · doi:10.1212/wnl.0000000000001937 · Cited by 61
Behavioral, neurochemical and molecular changes after acute deep brain stimulation of the infralimbic prefrontal cortex
Jiménez-Sánchez, L., Linge, R., Campa, L., Valdizán, E. M., Pazos, Á., Díaz, Á., & Adell, A. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.020 · Cited by 61
Medial Forebrain Bundle Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Importance of BDNF and Inflammatory Cytokines
Dandekar, M. P., Saxena, A., Scaini, G., Shin, J. H., Migut, A., Giridharan, V. V., Zhou, Y., Barichello, T., Soares, J. C., Quevedo, J., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1381-5 · Cited by 58
Deep Brain Stimulation for Treatment-Resistant Depression: Towards a More Personalized Treatment Approach
Roet, M., Boonstra, J. T., Şahin, E., Mulders, A. E. P., Leentjens, A. F. G., & Jahanshahi, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092729 · Cited by 56
Alterations of Intrinsic Brain Connectivity Patterns in Depression and Bipolar Disorders: A Critical Assessment of Magnetoencephalography-Based Evidence
Alamian, G., Hincapié, A.-S., Combrisson, E., Thiery, T., Martel, V., Altukhov, D., & Jerbi, K. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00041 · Cited by 55
Mechanisms of action and clinical efficacy of NMDA receptor modulators in mood disorders
Ghasemi, M., Phillips, C., Fahimi, A., McNerney, M. W., & Salehi, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.002 · Cited by 53
Therapeutic potential of brain stimulation techniques in the treatment of mental, psychiatric, and cognitive disorders
Conde, J. A. C., Gonzalez‐Bermudez, M. D. R., Carretero‐Rey, M., & Khan, Z. U. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13971 · Cited by 49
Deep brain stimulation in mental health: Review of evidence for clinical efficacy
Fitzgerald, P. B., & Segrave, R. A. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415598011 · Cited by 48
High Frequency Electrical Stimulation of Lateral Habenula Reduces Voluntary Ethanol Consumption in Rats
Li, J., Zuo, W., Fu, R., Xie, G., Kaur, A., Bekker, A., & Ye, J. H. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw050 · Cited by 45
Five-Year Follow-Up of Bilateral Epidural Prefrontal Cortical Stimulation for Treatment-Resistant Depression
Williams, N., Short, E. B., Hopkins, T., Bentzley, B. S., Sahlem, G. L., Pannu, J., Schmidt, M., Borckardt, J. J., Korte, J. E., George, M. S., et al. (2016) · Brain stimulation · doi:10.1016/j.brs.2016.06.054 · Cited by 46
Intensity of affective experience is modulated by magnitude of intracranial electrical stimulation in human orbitofrontal, cingulate and insular cortices
Yih, J., Beam, D. E., Fox, K. C. R., & Parvizi, J. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz015 · Cited by 43
Treating brain disorders with neuromodulation
Temel, Y., & Jahanshahi, A. (2015) · Science · doi:10.1126/science.aaa9610 · Cited by 43
Invasive and Non-invasive Neurostimulation for OCD
Bergfeld, I. O., Dijkstra, E., Graat, I., de Koning, P. P., van den Boom, B. J. G., Arbab, T., Vulink, N. C. C., Denys, D. A. J. P., Willuhn, I., & Mocking, R. J. T. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_206 · Cited by 46
Lateral habenula perturbation reduces default-mode network connectivity in a rat model of depression
Clemm von Hohenberg, C., Weber-Fahr, W., Lebhardt, P., Ravi, N., Braun, U., Gass, N., Becker, R., Sack, M., Cosa Linan, A., Gerchen, M. F., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0121-y · Cited by 39
Deep Brain Stimulation for Major Depression—Steps on a Long and Winding Road
Schlaepfer, T. E. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.020 · Cited by 41
Evaluation of White Matter Injury Patterns Underlying Neuropsychiatric Symptoms after Mild Traumatic Brain Injury
Alhilali, L. M., Delic, J. A., Gümüş, S., & Fakhran, S. (2015) · Radiology · doi:10.1148/radiol.2015142974 · Cited by 44
Deep brain stimulation for movement disorders: update on recent discoveries and outlook on future developments
Mahlknecht, P., Limousin, P. D., & Foltynie, T. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7790-8 · Cited by 41
Neuromodulation Treatments for Geriatric Mood and Cognitive Disorders
McDonald, W. M. (2016) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.08.014 · Cited by 40
Deep Brain Stimulation, Self and Relational Autonomy
Gallagher, S. (2018) · Neuroethics · doi:10.1007/s12152-018-9355-x · Cited by 40
Neurofeedback Control in Parkinsonian Patients Using Electrocorticography Signals Accessed Wirelessly With a Chronic, Fully Implanted Device
Khanna, P., Swann, N. C., de Hemptinne, C., Miocinovic, S., Miller, A. M., Starr, P. A., & Carmena, J. M. (2016) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2016.2597243 · Cited by 38
Neural Prosthetics: A Review of Empirical vs. Systems Engineering Strategies
Loeb, G. E. (2018) · Applied Bionics and Biomechanics · doi:10.1155/2018/1435030 · Cited by 38
Using probabilistic tractography to target the subcallosal cingulate cortex in patients with treatment resistant depression
Tsolaki, E. C., Espinoza, R. T., & Pouratian, N. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.01.006 · Cited by 38
Neurocognitive Predictors of Response in Treatment Resistant Depression to Subcallosal Cingulate Gyrus Deep Brain Stimulation
McInerney, S. J., McNeely, H. E., Geraci, J., Giacobbe, P., Rizvi, S. J., Ceniti, A. K., Cyriac, A., Mayberg, H. S., Lozano, A. M., & Kennedy, S. H. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00074 · Cited by 37
The Predictive Validity of Machine Learning Models in the Classification and Treatment of Major Depressive Disorder: State of the Art and Future Directions
Ermers, N. J., Hagoort, K., & Scheepers, F. E. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00472 · Cited by 41
Neuromodulation for treatment-resistant depression: Functional network targets contributing to antidepressive outcomes
Idlett-Ali, S., Salazar, C. A., Bell, M. S., Short, E. B., & Rowland, N. C. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1125074 · Cited by 44
Clinical Improvement in a Treatment-Resistant Patient With Schizophrenia Treated With Deep Brain Stimulation
Corripio, I., Sarró, S., McKenna, P. J., Molet, J., Álvarez, E., Pomarol‐Clotet, E., & Portella, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.03.1049 · Cited by 36
Cellular and molecular mechanisms triggered by Deep Brain Stimulation in depression: A preclinical and clinical approach
Torres-Sánchez, S., Pérez-Caballero, L., & Berrocoso, E. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.09.005 · Cited by 39
Rivaling paradigms in psychiatric neurosurgery: adjustability versus quick fix versus minimal-invasiveness
ller, S. M. ⁄., Riedmüller, R., & van Oosterhout, A. (2015) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00027 · Cited by 35
Testing different paradigms to optimize antidepressant deep brain stimulation in different rat models of depression
Rummel, J., Voget, M., Hadar, R., Ewing, S. G., Sohr, R., Klein, J., Sartorius, A., Heinz, A., Mathé, A. A., Vollmayr, B., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.06.016 · Cited by 38
Deep Brain Stimulation for Treatment-Refractory Mood and Obsessive-Compulsive Disorders
Widge, A. S., & Dougherty, D. D. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0049-y · Cited by 32
State of the Art: Novel Applications for Cortical Stimulation
Ridder, D. D., Perera, S., & Vanneste, S. (2017) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12593 · Cited by 32
DTI-based deterministic fibre tracking of the medial forebrain bundle
Anthofer, J., Steib, K., Fellner, C., Lange, M., Brawanski, A. T., & Schlaier, J. R. (2015) · Acta Neurochirurgica · doi:10.1007/s00701-014-2335-y · Cited by 31
Closed-Loop Stimulation in Emotional Circuits for Neuro-Psychiatric Disorders
Widge, A. S., & Moritz, C. T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802452-2.00017-2 · Cited by 29
Acute and chronic changes in brain activity with deep brain stimulation for refractory depression
Conen, S., Matthews, J. C., Patel, N. K., Anton‐Rodriguez, J., & Talbot, P. S. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117742668 · Cited by 30
A Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression
Khairuddin, S., Ngo, F. Y., Lim, W. L., Aquili, L., Khan, N. A., Fung, M.-L., Chan, Y., Temel, Y., & Lim, L. W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103260 · Cited by 29
Cellular mechanisms of deep brain stimulation: activity-dependent focal circuit reprogramming?
Veerakumar, A., & Berton, O. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.02.004 · Cited by 27
Should DBS for Psychiatric Disorders be Considered a Form of Psychosurgery? Ethical and Legal Considerations
Stahl, D. J., Cabrera, L. Y., & Gibb, T. S. (2017) · Science and Engineering Ethics · doi:10.1007/s11948-017-9934-y · Cited by 28
A neural mass model to predict electrical stimulation evoked responses in human and non-human primate brain
Basu, I., Crocker, B., Farnes, K., Robertson, M. M., Paulk, A. C., Vallejo-Lopez, D. I., Dougherty, D. D., Cash, S. S., Eskandar, E. N., Kramer, M., et al. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aae136 · Cited by 25
Selective Mapping of Deep Brain Stimulation Lead Currents Using Acoustoelectric Imaging
Preston, C., Kasoff, W. S., & Witte, R. S. (2018) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2018.06.021 · Cited by 27
Deep brain stimulation and recordings: Insights into the contributions of subthalamic nucleus in cognition
Drummond, N. M., & Chen, R. E. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117300 · Cited by 26
Mitochondrial Metabolism in Major Depressive Disorder: From Early Diagnosis to Emerging Treatment Options
Larrea, A., Sánchez-Sánchez, L., Díez-Martín, E., Elexpe, A., Torrecilla, M., Astigarraga, E., & Barreda‐Gómez, G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13061727 · Cited by 28
Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation
Moore, S. R., Halldorsdottir, T., Martins, J., Lucae, S., Müller‐Myhsok, B., Müller, N. S., Piechaczek, C., Feldmann, L., Freisleder, F. J., Greimel, E., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01756-2 · Cited by 25
Closed-Loop Rehabilitation of Age-Related Cognitive Disorders
Mishra, J., & Gazzaley, A. H. (2014) · Seminars in Neurology · doi:10.1055/s-0034-1396011 · Cited by 25
Surgical Approaches in Psychiatry: A Survey of the World Literature on Psychosurgery
Neumaier, F., Paterno, M., Alpdogan, S., Tevoufouet, E. E., Schneider, T., Hescheler, J., & Albanna, W. (2016) · World Neurosurgery · doi:10.1016/j.wneu.2016.10.008 · Cited by 26
State of the Art: Novel Applications for Deep Brain Stimulation
Roy, H., Green, A. L., & Aziz, T. Z. (2017) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12604 · Cited by 23
Neurobiological correlates of emotional processing in Parkinson's disease: A systematic review of experimental studies
Moonen, A. J. H., Wijers, A. A., Dujardin, K., & Leentjens, A. F. G. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.07.009 · Cited by 23
Patients’ Beliefs About Deep Brain Stimulation for Treatment-Resistant Depression
Lawrence, R. E., Kaufmann, C. R., DeSilva, R. B., & Appelbaum, P. S. (2018) · AJOB Neuroscience · doi:10.1080/21507740.2018.1553897 · Cited by 23
Stimulation of subgenual cingulate area decreases limbic top-down effect on ventral visual stream: A DBS-EEG pilot study
Kibleur, A., Polosan, M., Favre, P., Rudrauf, D., Bougerol, T., Chabardès, S., & Olivier David, A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.10.018 · Cited by 23
Clinical Perspectives on Psychiatric Neurosurgery
Cabrera, L. Y., Courchesne, C., Kiss, Z. H. T., & Illes, J. (2019) · Stereotactic and Functional Neurosurgery · doi:10.1159/000505080 · Cited by 20
Deep brain stimulation for treatment-resistant depression: a safe and effective option
Torre, D. L., Torre, A. D., Chirchiglia, D., Volpentesta, G., Guzzi, G., & Lavano, A. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1749049 · Cited by 20
Acute deep brain stimulation in the thalamic reticular nucleus protects against acute stress and modulates initial events of adult hippocampal neurogenesis
Magdaleno-Madrigal, V. M., Pantoja-Jiménez, C. R., Bazaldúa, A., Fernández‐Mas, R., Almazán‐Alvarado, S., Bolaños-Alejos, F., Ortíz‐López, L., & Ramírez-Rodríguez, G. B. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.022 · Cited by 18
Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex
Lehto, L. J., Filip, P., Laakso, H., Sierra, A., Slopsema, J. P., Johnson, M. D., Eberly, L. E., Low, W. C., Gröhn, O. H. J., Tanila, H., et al. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00899 · Cited by 18

Authors: Morishita, T., Fayad, S. M., Higuchi, M.-A., Nestor, K. A., & Foote, K. D.
Affiliations: UF Health Shands Hospital (US)
Corresponding author: Foote, Kelly D.
ORCID: Morishita, Takashi
Fayad, Sarah M.
Foote, Kelly D.
Venue: Neurotherapeutics
Publisher: Elsevier BV
Published: 2014-07
Volume: 11
Issue: 3
Pages: 475-484
ISSN: 1878-7479 (ISSN-L)
DOI: 10.1007/s13311-014-0282-1
PMC: PMC4121451
OpenAlex: W2025929754
Cited by: 216
References: 80
Citations by year: 2026: 5 · 2025: 5 · 2024: 8 · 2023: 24 · 2022: 7 · 2021: 12 · 2020: 12 · 2019: 12 · 2018: 30 · 2017: 32 · 2016: 37 · 2015: 29 · 2014: 3
FWCI: 4.62
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3334 d)
Locations: Neurotherapeutics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Boston Scientific Corporation
Nakatomi Foundation
Otsuka Pharmaceutical
Topics: Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Keywords: deep brain stimulation, treatment-resistant depression, major depressive disorder, neuromodulation, subgenual anterior cingulate cortex, ventral capsule/ventral striatum, nucleus accumbens, lateral habenula, medial forebrain bundle, DBS targets, response rate, treatment efficacy and safety
MeSH terms: Brain, Major Depressive Disorder, Humans, Treatment Outcome, Deep Brain Stimulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Deep Brain Stimulation for Treatment-resistant Depression: Systematic Review of Clinical Outcomes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks