Cited by 118Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates

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Monosov, Ilya E., Haber, Suzanne N., Leuthardt, Eric C., Jezzini, Ahmad·2020·Current Biology

Abstract

The brain mechanism for controlling continuous behavior in dynamic contexts must mediate action selection and learning across many timescales, responding differentially to the level of environmental uncertainty and volatility. In this review, we argue that a part of the frontal cortex known as the anterior cingulate cortex (ACC) is particularly well suited for this function. First, the ACC is interconnected with prefrontal, parietal, and subcortical regions involved in valuation and action selection. Second, the ACC integrates diverse, behaviorally relevant information across multiple timescales, producing output signals that temporally encapsulate decision and learning processes and encode high-dimensional information about the value and uncertainty of future outcomes and subsequent behaviors. Third, the ACC signals behaviorally relevant information flexibly, displaying the capacity to represent information about current and future states in a valence-, context-, task- and action-specific manner. Fourth, the ACC dynamically controls instrumental- and non-instrumental information seeking behaviors to resolve uncertainty about future outcomes. We review electrophysiological and circuit disruption studies in primates to develop this point, discuss its relationship to novel therapeutics for neuropsychiatric disorders in humans, and conclude by relating ongoing research in primates to studies of medial frontal cortical regions in rodents.

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  1. [9]Sutton RS, and Barto AG (1998). Reinforcement learning: An introduction, Volume 1, (MIT press Cambridge).
  2. [20]Paxinos G, Huang XF, and Toga AW (2000). The rhesus monkey in stereotaxic coordinates, (San Diego: Academic Press).
  3. [39]Stephens DW, and Krebs JR (1986). Foraging theory, Volume 1, (Princeton University Press).

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Authors
Monosov, I. E., Haber, S. N., Leuthardt, E. C., & Jezzini, A.
Affiliations
  • Washington University in St. Louis (US)
  • Harvard University (US)
Corresponding author
Monosov, Ilya E.
Venue
Current Biology
Publisher
Elsevier BV
Published
2020-12
Volume
30
Issue
23
Pages
R1442-R1454
ISSN
0960-9822 (ISSN-L)
OpenAlex
W3110978274
Cited by
118
References
143
Citations by year
2026: 22 · 2025: 26 · 2024: 28 · 2023: 16 · 2022: 17 · 2021: 8 · 2020: 1
FWCI
1.42
Type
journal article
Language
en
Open access
Locations
  • Current Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • McKnight Foundation (R01CA203861, MH045573)
  • National Institute of Mental Health (R01CA203861, R01MH110594, R01MH116937, MH106435)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
anterior cingulate cortex, action selection, uncertainty, outcome valuation, information seeking, operant conditioning, decision-making, frontal cortex, neuropsychiatric disorders, medial frontal cortex, rodents
MeSH terms
Cortical Excitability, Animals, Behavior, Animal, Central Nervous System Diseases, Choice Behavior, Disease Models, Animal, Drug Evaluation, Preclinical, Frontal Lobe, Gyrus Cinguli, Humans, Learning, Macaca mulatta, Neurons, Reward, Uncertainty, Information Seeking Behavior

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