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Targeting neuroinflammation in Alzheimer’s disease

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Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology

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Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases

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Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection

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Plant alkaloids as drug leads for Alzheimer's disease

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Expression of interleukin-18 is increased in the brains of Alzheimer’s disease patients

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The roles of TNF in brain dysfunction and disease

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Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

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TREM2 and the neuroimmunology of Alzheimer's disease

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Role of chronic neuroinflammation in neuroplasticity and cognitive function: A hypothesis

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Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

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Neuronal Apoptosis in Neurodegeneration

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Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks

Domingues, C., Silva, O. A. B. D. C. E., & Henriques, A. G. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170317113606 · Cited by 212 · see citing works

Role of p38/MAPKs in Alzheimer's Disease: Implications for Amyloid Beta Toxicity Targeted Therapy

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IFN-γ Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid β Precursor Protein Transgenic Mice

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Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

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CSF amyloid β42 and tau levels correlate with AIDS dementia complex

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Tumor necrosis factor α Inhibition for Alzheimer’s Disease

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Anesthetic Sevoflurane Causes Neurotoxicity Differently in Neonatal Naïve and Alzheimer Disease Transgenic Mice

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Neuroinflammation and neurogenesis in Alzheimer's disease and potential therapeutic approaches

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Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

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Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

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Ligand-Dependent Cleavage of the P75 Neurotrophin Receptor Is Necessary for NRIF Nuclear Translocation and Apoptosis in Sympathetic Neurons

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JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

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(−)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency

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Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production

Hoey, S. E., Williams, R. J., & Perkinton, M. S. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.6017-08.2009 · Cited by 178 · see citing works

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism

Hong, W., Mo, F., Zhang, Z., Huang, M., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00246 · Cited by 179 · see citing works

Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection

Bazan, N. G. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.024 · Cited by 171 · see citing works

Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase

Shen, C., Chen, Y., Liu, H., Zhang, K., Zhang, T., Lin, A., & Jing, N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800013200 · Cited by 168 · see citing works

(Peri)vascular production and action of pro-inflammatory cytokines in brain pathology

Konsman, J. P., Drukarch, B., & van Dam, A. (2006) · Clinical Science · doi:10.1042/cs20060043 · Cited by 168 · see citing works

Stigmasterol attenuates inflammatory response of microglia via NF-κB and NLRP3 signaling by AMPK activation

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Ocular changes in TgF344-AD rat model of Alzheimer's disease

Tsai, Y., Lu, B., Ljubimov, A. V., Girman, S., Ross-Cisneros, F. N., Sadun, A. A., Svendsen, C. N., Cohen, R. M., & Wang, S. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-12888 · Cited by 153 · see citing works

Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

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Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease

Yao, Z., Yang, W., Gao, Z., & Jia, P. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.03.027 · Cited by 140 · see citing works

Reduced Reelin Expression Accelerates Amyloid-  Plaque Formation and Tau Pathology in Transgenic Alzheimer's Disease Mice

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The role of microglia in human disease: therapeutic tool or target?

Cartier, N., Lewis, C. B., Zhang, R., & Rossi, F. M. V. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1330-y · Cited by 135 · see citing works

RAC1 Inhibition Targets Amyloid Precursor Protein Processing by γ-Secretase and Decreases Aβ Production in Vitro and in Vivo

Désiré, L., Bourdin, J., Loiseau, N., Peillon, H., Picard, V., Oliveira, C. D., Bachelot, F., Leblond, B., Taverne, T., Beausoleil, E., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507913200 · Cited by 134 · see citing works

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice

McManus, R. M., Higgins, S. C., Mills, K. H. G., & Lynch, M. A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.025 · Cited by 132 · see citing works

p75 Neurotrophin Receptor-mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up-regulation of Tumor Necrosis Factor-α-converting Enzyme/ADAM17

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Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels/Metabolism

Alasmari, F., Alshammari, M. A., Alasmari, A. F., Alanazi, W. A., & Alhazzani, K. (2018) · BioMed Research International · doi:10.1155/2018/3087475 · Cited by 125 · see citing works

Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairment

Buchhave, P., Zetterberg, H., Blennow, K., Minthon, L., Janciauskiene, S. M., & Hansson, O. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.10.012 · Cited by 120 · see citing works

The Comorbidity of HIV-Associated Neurocognitive Disorders and Alzheimer’s Disease: A Foreseeable Medical Challenge in Post-HAART Era

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The Many Faces of Astrocytes in Alzheimer's Disease

Monterey, M. D., Wei, H., Wu, X., & Wu, J. Q. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.619626 · Cited by 117 · see citing works

The Role of TNF-α in Alzheimer’s Disease: A Narrative Review

Plantone, D., Pardini, M., Righi, D., Manco, C., Colombo, B. M., & Stefano, N. D. (2023) · Cells · doi:10.3390/cells13010054 · Cited by 119 · see citing works

Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms

Wei, Z.-H., Koya, J., & Reznik, S. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.687157 · Cited by 121 · see citing works

When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease

Avila-Muñoz, E., & Arias, C. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.07.004 · Cited by 114 · see citing works

Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease

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1,8-Cineole (Eucalyptol) Mitigates Inflammation in Amyloid Beta Toxicated PC12 Cells: Relevance to Alzheimer’s Disease

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Inducible Nitric Oxide Synthase Up-Regulates Notch-1 in Mouse Cholangiocytes: Implications for Carcinogenesis

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Inflammation and Alzheimer’s Disease: Mechanisms and Therapeutic Implications by Natural Products

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The effect of insomnia on development of Alzheimer’s disease

Sadeghmousavi, S., Eskian, M., Rahmani, F., & Rezaei, N. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01960-9 · Cited by 113 · see citing works

T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers

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Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice

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Metformin Facilitates Amyloid-β Generation by β- and γ -Secretases via Autophagy Activation

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Metformin loaded phosphatidylserine nanoliposomes improve memory deficit and reduce neuroinflammation in streptozotocin-induced Alzheimer's disease model

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Inhibition of ??-Secretase as a Therapeutic Intervention for Alzheimer???s Disease

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Inhibition of c‐ J un N ‐terminal kinase activation reverses A lzheimer disease phenotypes in APP swe/ PS 1dE 9 mice

Zhou, Q., Wang, M., Du, Y., Zhang, W., Bai, M., Zhang, Z., Li, Z., & Miao, J. (2015) · Annals of Neurology · doi:10.1002/ana.24361 · Cited by 105 · see citing works

Brain injury, neuroinflammation and Alzheimer's disease

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Notch and Wnt signaling mediated rod photoreceptor regeneration by Müller cells in adult mammalian retina

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Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

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Neurobiology of HIV

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Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease

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New Therapeutic Strategies and Drug Candidates for Neurodegenerative Diseases: p53 and TNF‐α Inhibitors, and GLP‐1 Receptor Agonists

Greig, N. H., Mattson, M. P., Perry, T., Chan, S. L., Giordano, T., Sambamurti, K., Rogers, J. T., Ovadia, H., & Lahiri, D. K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.018 · Cited by 98 · see citing works

RAGE is a key cellular target for A -induced perturbation in Alzheimer s disease

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Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy

Ou, W., Yang, J., Simanauskaite, J., Choi, M. K., Castellanos, D. M., Chang, R., Sun, J., Jagadeesan, N., Parfitt, K. D., Cribbs, D. H., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02332-7 · Cited by 98 · see citing works

Interleukins, Inflammation, and Mechanisms of Alzheimer's Disease

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ERK1/2 is an endogenous negative regulator of the γsecretase activity

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Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models

Vasciaveo, V., Iadarola, A., Casile, A., Dante, D., Morello, G., Minotta, L., Tamagno, E., Cicolin, A., & Guglielmotto, M. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01498-2 · Cited by 96 · see citing works

TNF-α經由活化JNK MAPK pathway增強γ-secretase活性分子機制之研究

郭嵐忻 (2006) · doi:10.6342/ntu.2006.02771

P1-295 γ-secretase-mediated cleavage of amyloid precursor protein is stimulated by the cytokine-elicited activation of a JNK-dependent MAPK pathway

Liao, Y.-F., Wang, B., Cheng, H.-T., Kuo, L.-H., & Wolfe, M. S. (2004) · Neurobiology of Aging · doi:10.1016/s0197-4580(04)80608-0 · Cited by 1 · see citing works

Interferon-γ and Tumor Necrosis Factor-α Regulate Amyloid-β Plaque Deposition and β-Secretase Expression in Swedish Mutant APP Transgenic Mice

Yamamoto, M., Kiyota, T., Horiba, M., Buescher, J. L., Walsh, S. M., Gendelman, H. E., & Ikezu, T. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060378 · Cited by 367 · see citing works

TNF-alpha-elicited stimulation of gamma-secretase is mediated by JNK-dependent phosphorylation of presenilin and nicastrin

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P4‐194: Presenilin‐dependent gamma‐secretase proteolysis of cytokine receptors

McCarthy, J. V., Elzinga, B. M., Twomey, C., Harte, F. M., Powell, J. C., & Wujek, P. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.2261