The DOI matches its Crossref record; 77 of the 78 references it cites were found in a registry or an index.
Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome
Open accessAbstract
Purpose of review The goal of this paper is to review current literature on nutritional ketosis within the context of weight management and metabolic syndrome, namely, insulin resistance, lipid profile, cardiovascular disease risk, and development of non-alcoholic fatty liver disease. We provide background on the mechanism of ketogenesis and describe nutritional ketosis.Recent findings Nutritional ketosis has been found to improve metabolic and inflammatory markers, including lipids, HbA1c, high-sensitivity CRP, fasting insulin and glucose levels, and aid in weight management. We discuss these findings and elaborate on potential mechanisms of ketones for promoting weight loss, decreasing hunger, and increasing satiety. Humans have evolved with the capacity for metabolic flexibility and the ability to use ketones for fuel. During states of low dietary carbohydrate intake, insulin levels remain low and ketogenesis takes place. These conditions promote breakdown of excess fat stores, sparing of lean muscle, and improvement in insulin sensitivity.
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“Its mechanism for weight loss is mainly associated with reducing insulin levels, which promotes redirecting lipid metabolism from synthesis and storage toward breakdown and oxidation, consequently inducing nutritional ketosis, mimicking metabolic starvation in the body to utilize ketone bodies as alternative energy sources [15].”
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“Humans can survive and arguably thrive on low-carbohydrate ketogenic diets”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [39]
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Cited by
Sorted by citations
Insulin resistance and cardiovascular disease
Kosmas, C. E., Bousvarou, M. D., Kostara, C. E., Papakonstantinou, E. J., Salamou, E., & Guzman, E. (2023) · Journal of International Medical Research · doi:10.1177/03000605231164548 · Cited by 434
Ketone bodies: from enemy to friend and guardian angel
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Yuan, X., Wang, J., Yang, S., Gao, M., Cao, L., Li, X., Hong, D., Tian, S., & Sun, C. (2020) · Nutrition & Diabetes · doi:10.1038/s41387-020-00142-z · Cited by 240
Metadata
- Authors
- Gershuni, V. M., Yan, S. L., & Medici, V.
- Affiliations
- Hospital of the University of Pennsylvania (US)
- University of California, Davis (US)
- Corresponding author
- Gershuni, Victoria M.
- Venue
- Current Nutrition Reports
- Published
- 2018-08-20
- Volume
- 7
- Issue
- 3
- Pages
- 97-106
- ISSN
- 2161-3311 (ISSN-L)
- PMC
- PMC6472268
- OpenAlex
- W2888188466
- Cited by
- 239
- References
- 78
- Citations by year
- 2026: 15 · 2025: 37 · 2024: 40 · 2023: 40 · 2022: 33 · 2021: 34 · 2020: 32 · 2019: 8
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-03-03)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Current Nutrition Reports (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (TL1TR001880)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- nutritional ketosis, weight management, weight loss, metabolic syndrome, insulin resistance, ketogenesis, lipid profile, cardiovascular risk, non-alcoholic fatty liver disease, HbA1c, C-reactive protein, satiety, hunger, metabolic flexibility, low-carbohydrate diet, fat oxidation
- MeSH terms
- Humans, Obesity, Weight Loss, Metabolic Syndrome, Diet, Ketogenic
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