Cited by 239Diet and metabolism studiesDietary Effects on HealthDiabetes Management and Research

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Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome

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Gershuni, Victoria M., Yan, Stephanie L., Medici, Valentina·2018·Current Nutrition Reports

DOI 10.1007/s13668-018-0235-0PMC PMC6472268

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Abstract

Purpose of review The goal of this paper is to review current literature on nutritional ketosis within the context of weight management and metabolic syndrome, namely, insulin resistance, lipid profile, cardiovascular disease risk, and development of non-alcoholic fatty liver disease. We provide background on the mechanism of ketogenesis and describe nutritional ketosis.Recent findings Nutritional ketosis has been found to improve metabolic and inflammatory markers, including lipids, HbA1c, high-sensitivity CRP, fasting insulin and glucose levels, and aid in weight management. We discuss these findings and elaborate on potential mechanisms of ketones for promoting weight loss, decreasing hunger, and increasing satiety. Humans have evolved with the capacity for metabolic flexibility and the ability to use ketones for fuel. During states of low dietary carbohydrate intake, insulin levels remain low and ketogenesis takes place. These conditions promote breakdown of excess fat stores, sparing of lean muscle, and improvement in insulin sensitivity.

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Authors: Gershuni, V. M., Yan, S. L., & Medici, V.
Affiliations: Hospital of the University of Pennsylvania (US)
University of California, Davis (US)
Corresponding author: Gershuni, Victoria M.
ORCID: Gershuni, Victoria M.
Yan, Stephanie L.
Medici, Valentina
Venue: Current Nutrition Reports
Publisher: Springer Science and Business Media LLC
Published: 2018-08-20
Volume: 7
Issue: 3
Pages: 97-106
ISSN: 2161-3311 (ISSN-L)
DOI: 10.1007/s13668-018-0235-0
PMC: PMC6472268
OpenAlex: W2888188466
Cited by: 239
References: 78
Citations by year: 2026: 15 · 2025: 37 · 2024: 40 · 2023: 40 · 2022: 33 · 2021: 34 · 2020: 32 · 2019: 8
FWCI: 2.43
Type: journal article
Language: en
Update notices: correction (2025-03-03)
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Current Nutrition Reports (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (TL1TR001880)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: nutritional ketosis, weight management, weight loss, metabolic syndrome, insulin resistance, ketogenesis, lipid profile, cardiovascular risk, non-alcoholic fatty liver disease, HbA1c, C-reactive protein, satiety, hunger, metabolic flexibility, low-carbohydrate diet, fat oxidation
MeSH terms: Humans, Obesity, Weight Loss, Metabolic Syndrome, Diet, Ketogenic

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Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome

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