Topical Hypochlorous Acid (HOCl) as a Potential Treatment of Pruritus
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HOCl-based therapeutics optimized for topical delivery are now serving as pharmaceutical formulations for wound management, scar prevention, diabetic ulcers, atopic dermatitis, pruritus, psoriasis, and seborrheic dermatitis.
“Importantly, HOCl-based therapeutics optimized for topical delivery are now serving as pharmaceutical formulations for wound management, scar prevention, diabetic ulcers, atopic dermatitis, pruritus, psoriasis, and seborrheic dermatitis (84, 168, 173, 174).”
From Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer (2022) · cites this paper as [84]
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Myeloperoxidase: friend and foe
Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282 · see citing works
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,199 · see citing works
Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing
Hampton, M. B., Kettle, A. J., & Winterbourn, C. C. (1998) · Blood · doi:10.1182/blood.v92.9.3007.421k47_3007_3017 · Cited by 1,640 · see citing works
Katzung, B. G. (2018) · Cited by 1,383 · see citing works
A subpopulation of nociceptors specifically linked to itch
Han, L., Ma, C., Liu, Q., Weng, H.-J., Cui, Y., Tang, Z., Kim, Y., Nie, H., Qu, L., Patel, K., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3289 · Cited by 614 · see citing works
The Henderson-Hasselbalch Equation: Its History and Limitations
Po, H. N., & Senozan, N. M. (2001) · Journal of Chemical Education · doi:10.1021/ed078p1499 · Cited by 515 · see citing works
Redox Reactions and Microbial Killing in the Neutrophil Phagosome
Winterbourn, C. C., & Kettle, A. J. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4827 · Cited by 468 · see citing works
Albrich, J. M., McCarthy, C. A., & Hurst, J. K. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.1.210 · Cited by 442 · see citing works
Itch: scratching more than the surface
Twycross, R. (2003) · QJM · doi:10.1093/qjmed/hcg002 · Cited by 412 · see citing works
Awad, S., Allison, S. P., & Lobo, D. N. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.01.008 · Cited by 295 · see citing works
Reddy, V. B., Iuga, A. O., Shimada, S. G., LaMotte, R. H., & Lerner, E. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0716-08.2008 · Cited by 255 · see citing works
Wang, L., Bassiri, M., Najafi, R., Najafi, K. H. B. R. M. A. N. R., Yang, J., Khosrovi, B., Hwong, W., Barati, E., Belisle, B., Celeri, C., et al. (2007) · PubMed Central · Cited by 237 · see citing works
Fitzpatrick's Color Atlas & Synopsis of Clinical Dermatology
Wolff, K. D., & Johnson, R. A. (2005) · Medical Entomology and Zoology · Cited by 196 · see citing works
Harris, D. C. (1996) · Medical Entomology and Zoology · Cited by 192 · see citing works
IL-31 Expression by Inflammatory Cells is Preferentially Elevated in Atopic Dermatitis
Hofbauer, G. F. L., Nobbe, S., Dziunycz, P., Mühleisen, B., Bilsborough, J., Dillon, S. R., & French, L. E. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1191 · Cited by 157 · see citing works
What causes itch in atopic dermatitis?
Yosipovitch, G., & Papoiu, A. D. P. (2008) · Current Allergy and Asthma Reports · doi:10.1007/s11882-008-0049-z · Cited by 150 · see citing works
Neuropeptides and their receptors in psoriatic skin in relation to pruritus
Chang, S.-E., Han, S.-S., Jung, H.-J., & Choi, J. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.07935.x · Cited by 140 · see citing works
Patel, T. S., & Yosipovitch, G. (2010) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2010.484420 · Cited by 137 · see citing works
Seeliger, S., Derian, C. K., Vergnolle, N., Bunnett, N. W., Nawroth, R., Schmelz, M., von der Weid, P., Buddenkotte, J., Sunderkötter, C. H., Metze, D., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-1112com · Cited by 125 · see citing works
Wakelin, S. H. (2001) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2001.00780.x · Cited by 123 · see citing works
Mirtazapine and gabapentin for reducing pruritus in cutaneous T-cell lymphoma
Demierre, M., & Taverna, J. A. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.04.025 · Cited by 121 · see citing works
Racioppi, F., Daskaleros, P. A., Besbelli, N., Borges, A., Deraemaeker, C., Magalini, S. I., Arrifta, R. M., Pulce, C., Ml, R., & Vlachos, P. (1994) · Food and Chemical Toxicology · doi:10.1016/0278-6915(94)90162-7 · Cited by 115 · see citing works
Johansson, O., Liang, Y., & Emtestam, L. (2002) · Archives of Dermatological Research · doi:10.1007/s00403-001-0285-8 · Cited by 106 · see citing works
Tatsumi, T., & Fliss, H. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.4.h1597 · Cited by 92 · see citing works
Miller, J. H. (2004) · Journal for Cultural Research · doi:10.1080/1479758042000229136 · Cited by 88 · see citing works
Reaction of hemoglobin with HOCl: Mechanism of heme destruction and free iron release
Maitra, D., Byun, J., Andreana, P. R., Abdulhamid, I. B., Diamond, M. P., Saed, G. M., Pennathur, S., & Abu‐Soud, H. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.011 · Cited by 84 · see citing works
Hypochlorous Acid and Taurine-N-Monochloramine in Periodontal Diseases
Mainnemare, A., Mégarbane, B., Soueidan, A., Daniel, A., & Chapple, I. L. C. (2004) · Journal of Dental Research · doi:10.1177/154405910408301101 · Cited by 76 · see citing works
Human skin buffering capacity: an overview
Levin, J., & Maibach, H. I. (2007) · Skin Research and Technology · doi:10.1111/j.1600-0846.2007.00271.x · Cited by 74 · see citing works
Understanding the pathophysiology of itch
Garibyan, L., Rheingold, C. G., & Lerner, E. A. (2013) · Dermatologic Therapy · doi:10.1111/dth.12025 · Cited by 74 · see citing works
Fitzpatrick's color atlas and synopsis of clinical dermatology
Wolff, K., Johnson, R. A., Suurmond, D., & Fitzpatrick, T. B. (2005) · Cited by 71 · see citing works
Use of bleach baths for the treatment of infected atopic eczema
Barnes, T. M., & Greive, K. A. (2013) · Australasian Journal of Dermatology · doi:10.1111/ajd.12015 · Cited by 69 · see citing works
Clarys, P., Barel, A., & Gabard, B. (1999) · Skin Research and Technology · doi:10.1111/j.1600-0846.1999.tb00198.x · Cited by 63 · see citing works
Hypochlorite sensitivity in man
Hostynek, J. J., Patrick, E., Younger, B., & Maibach, H. I. (1989) · Contact Dermatitis · doi:10.1111/j.1600-0536.1989.tb03092.x · Cited by 55 · see citing works
Pathogenesis and Treatment of Pruritus
Greaves, M. W. (2010) · Current Allergy and Asthma Reports · doi:10.1007/s11882-010-0117-z · Cited by 54 · see citing works
Leukotriene B4 Mediates Sphingosylphosphorylcholine-Induced Itch-Associated Responses in Mouse Skin
Andoh, T., Saito, A., & Kuraishi, Y. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.155 · Cited by 50 · see citing works
Spectrum of Sodium Hypochlorite Toxicity in Man-Also a Concern for Nephrologists
Peck, B., Workeneh, B., Kadikoy, H., Patel, S. J., & Abdellatif, A. (2011) · Clinical Kidney Journal · doi:10.1093/ndtplus/sfr053 · Cited by 48 · see citing works
Irritation factors of sodium hypochlorite solutions in human skin
Hostynek, J. J., Kp, W., Cua, A., & Maibach, H. I. (1990) · Contact Dermatitis · doi:10.1111/j.1600-0536.1990.tb05165.x · Cited by 34 · see citing works
Sodium Hypochlorite, Bleaching Agents, and the Stratum Corneum
Goffin, V., Pierard, G., Henry, F., Letawe, C., & Maibach, H. I. (1997) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.1997.1537 · Cited by 27 · see citing works
Mak, R. K. H., O'Gorman-Lalor, O., Croom, A., & Wakelin, S. H. (2005) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2004.01708.x · Cited by 21 · see citing works
Sterilization of Wounds, Treatment of Suppurating Wounds and Osteomyelitis (Carrel Method)
SHERMAN, W. O. (1917) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591571701002001 · Cited by 3 · see citing works
New Section Editors, One-Year Experience of Open Access and Now Also Apps for iPad and iPhone
Vahlquist, A., & Andersson, A. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1298 · Cited by 1 · see citing works
Flagged first, then by citations
2 of the 43 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- • Friedman AJ, Cash K, Berman B. Hypochlorous Acid is Anti- inflammatory and Immunomodulatory. Poster. Presented at the Winter Clinical Dermatology Conference, Kauai, HI, January 18, 2013. This poster gives an overview of the anti-inflammatory effects of HOCl and suggests that they may serve as a mechanism by which HOCl could reduce pruritus.
- Katzung BG, Masters SB, Trevor AJ. Basic & Clinical Pharmacol- ogy. 12th ed. New York: McGraw Hill Medical; 2012:24 -26, 275, 277 -278, 307, 319, 546, 643 -644, 988, 1076.
Cited by
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Gold, M. H., Andriessen, A., Bhatia, A. C., Bitter, P., Chilukuri, S., Cohen, J. L., & Robb, C. W. (2020) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13280 · Cited by 84 · see citing works
El-Houseiny, W., Mansour, M. F., Mohamed, W. A. M., Al-Gabri, N. A., El‐Sayed, A. A., Altohamy, D. E., & Ibrahim, R. E. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736430 · Cited by 60 · see citing works
New therapies for atopic dermatitis: Additional treatment classes
Vakharia, P. P., & Silverberg, J. I. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.12.024 · Cited by 50 · see citing works
Snell, J. A., Jandova, J., & Wondrak, G. T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.887220 · Cited by 37 · see citing works
Topical agents for the treatment of atopic dermatitis
Diaz, A., & Guttman‐Yassky, E. (2018) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2019.1564038 · Cited by 32 · see citing works
Wound cleansing: benefits of hypochlorous acid
Dissemond, J. (2020) · Journal of Wound Care · doi:10.12968/jowc.2020.29.sup10a.s4 · Cited by 28 · see citing works
Finger, P. T., Fam, A., Tomar, A., Garg, G., & Chin, K. J. (2020) · Indian Journal of Ophthalmology · doi:10.4103/ijo.ijo_2001_20 · Cited by 17 · see citing works
dianty, R., Hirano, J., Anzai, I., Kanai, Y., Hayashi, T., Morimoto, M., Kataoka-Nakamura, C., Kobayashi, S., Uemura, K., Ono, C., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1284274 · Cited by 15 · see citing works
Modifications of IL-6 by Hypochlorous Acids: Effects on Receptor Binding
Robins, L. I., Keim, E. K., Robins, D. B., Edgar, J. S., Meschke, J. S., Gafken, P. R., & Williams, J. F. (2021) · ACS Omega · doi:10.1021/acsomega.1c05297 · Cited by 12 · see citing works
Haralović, V., Mokos, M., Špoljar, S., Dolački, L., Šitum, M., & Lugović‐Mihić, L. (2025) · Biomedicines · doi:10.3390/biomedicines13122921 · Cited by 11 · see citing works
Hypochlorous Acid for Wound Healing in Diabetic Rats: Effect on MMP-9 and Histology
Irawan, D. M., Lesmana, R., & Sahiratmadja, E. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s468494 · Cited by 10 · see citing works
Kabanda, M. M., & Bahadur, I. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2021.118191 · Cited by 3 · see citing works
Howard, M. D., Hall, A., & Ramsay, D. (2016) · Australasian Journal of Dermatology · doi:10.1111/ajd.12451 · Cited by 2 · see citing works
Pharmacological evaluation and preclinical studies of hypochlorous acid solution
Brezvyn, O. M., Kotsiumbas, I. Y., Velichenko, A. B., Shmychkova, O. B., Luk’yanenko, T. V., Girenko, D., & Dmitrikova, L. V. (2023) · Ukrainian Journal of Veterinary and Agricultural Sciences · doi:10.32718/ujvas6-2.02 · Cited by 2 · see citing works
Brezvyn, O. M., Kotsiumbas, I. Y., Girenko, D., Лук'яненко, Т. В., Shmychkova, O. B., Dmitrikova, L. V., & Velichenko, A. B. (2023) · Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького · doi:10.32718/nvlvet11107 · Cited by 2 · see citing works
Rapid inactivation of aerosolised influenza virus using low-concentration gaseous hypochlorous acid
Narihata, K., Minamiguchi, M., Hata, M., Ueda, M., Yoshida, S., & Sakoda, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-19020-8 · Cited by 1 · see citing works
Brezvyn, O. M., Kotsiumbas, I. Y., Hyrenko, D. V., Luk’yanenko, T. V., Shmychkova, O. B., Dmitrikova, L. V., & Velichenko, A. B. (2024) · Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького · doi:10.32718/nvlvet11418 · Cited by 1 · see citing works
Silvani, L. (2021) · Open Access Journal of Ophthalmology · doi:10.23880/oajo-16000232 · Cited by 1 · see citing works
Robins, L. I., Keim, E. K., Robins, D. B., Edgar, S., Meschke, J. S., Gafken, P. R., & Williams, J. F. (2021) · doi:10.33774/chemrxiv-2021-s68cw · Cited by 1 · see citing works
Silvani, L., Bedei, A., Castellini, L., grazia, G. D., & Remiddi, S. (2021) · Research Square · doi:10.21203/rs.3.rs-1013812/v1 · Cited by 1 · see citing works
Sharma, A. K., Shukla, S. K., Kalonia, A., Shaw, P., Khanna, K., Yashavarddhan, M. H., Gupta, R., & Bhatnagar, A. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210311140922
Feng, K., Liu, H., Ghai, A., Li, J., Luo, H., Lee, W.-I., Mueller, S., Cymerman, J. J., Simon, M., & Rafailovich, M. H. (2023) · Hygiene and Environmental Health Advances · doi:10.1016/j.heha.2023.100077
Smith, W. K., Oledinma, U. A., Neary, S., & Martini, L. G. A. (2023) · doi:10.22541/au.169443912.23329396/v1
Tavirimirwa, B., Siziba, S., Dera, P., Matekenya, T. D., Sisito, G., Zhakata, X., & Ngulube, B. (2025) · doi:10.38124/ijisrt/25aug282
- Authors
- Pelgrift, R. Y., & Friedman, A. J.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Friedman, Adam J.
- ORCID
- Friedman, Adam J.
- Venue
- Current Dermatology Reports
- Published
- 2013-07-03
- Volume
- 2
- Issue
- 3
- Pages
- 181-190
- ISSN
- 2162-4933 (ISSN-L)
- OpenAlex
- W2087134134
- Cited by
- 24
- References
- 43
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 7 · 2020: 3 · 2018: 1 · 2017: 1 · 2016: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Dermatology Reports (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Dermatology › Medicine and Dermatology Studies History
- Keywords
- pruritus, atopic dermatitis, Staphylococcus aureus, anti-inflammatory activity, histamine, leukotriene B4, interleukin-2, nerve growth factor, irritant contact dermatitis, allergic contact dermatitis, pruritus pathophysiology
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