A complication of coronavirus disease 2019: delirium
Open accessAbstract
COVID-19 is predominantly a respiratory disease. However, some cases exhibit other features including Central Nervous System symptoms. In the older adult, COVID-19 may present with atypical symptoms, including delirium and its complications. The objective of this study is to describe the relationship between the new type of coronavirus infection and delirium. Systematic research (Cochrane Library and PubMed) was carried out (only upper time limit: April 2020). Publications found through this indexed search were reviewed and manually screened to identify relevant studies. Search terms used included "COVID-19, Delirium, Dementia, Intensive Care Unit". We manually added articles identified through other sources (i.e., key journals). Older people are at the greatest risk from COVID-19. If infected, they may present delirium. Moreover, it is not exclusive to older people. Delirium is not inevitable; rather, it is preventable. Delirium prevention programs are even more crucial in the era of COVID-19 and cannot be allowed to wither despite the challenges of integrating delirium prevention with COVID-19 care. An acute change in condition, behaviour, or mental status should prompt a delirium screen. As regards the treatment, it is advisable to use non-pharmacological interventions first where possible. Medication may be needed for patients with agitation where there is intractable distress or high risk to self/others.
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A variety of neuropsychiatric symptoms and delirium have been observed in patients with severe COVID-19 infection, even in the absence of any other symptoms/signs.
“Among the many clinical manifestations a variety of neuropsychiatric symptoms (1) and delirium (2) have been observed in patients with severe COVID-19 infection, even in the absence of any other symptoms/signs.”
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148 · see citing works
La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
Martínez González, M. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,463 · see citing works
Chan, J., Yuan, S.-F., Kok, K.-H., To, K., Chu, H., Yang, J., Xing, F., Liu, J.-L., Yip, C., Poon, R., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30154-9 · Cited by 8,450 · see citing works
Gorbalenya, A. E., Baker, S. C., Baric, R. S., de Groot, R. J., Drosten, C., Gulyaeva, A. A., Haagmans, B. L., Lauber, C., Leontovich, A. M., Neuman, B. W., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0695-z · Cited by 8,436 · see citing works
Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1127 · Cited by 7,166 · see citing works
Devlin, J. W., Skrobik, Y. K., Gélinas, C., Needham, D. M., Slooter, A. J. C., Pandharipande, P. P., Watson, P. L., Weinhouse, G. L., Nunnally, M., Rochwerg, B. N., et al. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003299 · Cited by 4,082 · see citing works
Inouye, S. K., Westendorp, R. G., & Saczynski, J. S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60688-1 · Cited by 3,722 · see citing works
Comorbidity and its impact on 1590 patients with covid-19 in China: a nationwide analysis
Guan, W.-J., Liang, W.-H., Zhao, Y., Liang, H.-R., Chen, Z.-S., Li, Y.-M., Liu, X.-Q., Chen, R.-C., Tang, C.-L., Wang, T., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.00547-2020 · Cited by 3,680 · see citing works
Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle
Lu, H., Stratton, C. W., & Tang, Y. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25678 · Cited by 3,497 · see citing works
Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
Ely, E. W. (2004) · JAMA · doi:10.1001/jama.291.14.1753 · Cited by 3,073 · see citing works
Inouye, S. K. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052321 · Cited by 2,091 · see citing works
Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dubé, M., & Talbot, P. J. (2019) · Viruses · doi:10.3390/v12010014 · Cited by 1,048 · see citing works
Delirium in Older Persons: Advances in Diagnosis and Treatment
Oh, E. S., Fong, T. G., Hshieh, T. T., & Inouye, S. K. (2017) · JAMA · doi:10.1001/jama.2017.12067 · Cited by 926 · see citing works
Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2
Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., & Zuo, W. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202001-0179le · Cited by 916 · see citing works
Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2
Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., & Zuo, W. (2020) · doi:10.1101/2020.01.26.919985 · Cited by 860 · see citing works
Neurologic alterations due to respiratory virus infections
Bohmwald, K., Gálvez, N. M. S., Ríos, M., & Kalergis, A. M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00386 · Cited by 636 · see citing works
Delirium in the intensive care unit
Girard, T. D., Pandharipande, P. P., & Ely, E. W. (2008) · Critical Care · doi:10.1186/cc6149 · Cited by 628 · see citing works
An approach to drug induced delirium in the elderly
Alagiakrishnan, K., & Wiens, C. A. (2004) · Postgraduate Medical Journal · doi:10.1136/pgmj.2003.017236 · Cited by 338 · see citing works
Coronavirus Disease 2019 in Geriatrics and Long‐Term Care: The ABCDs of COVID ‐19
D’Adamo, H., Yoshikawa, T. T., & Ouslander, J. G. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16445 · Cited by 321 · see citing works
Wang, X., Ferro, E., Zhou, G.-H., Hashimoto, D., & Bhatt, D. L. (2020) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2020.12897 · Cited by 305 · see citing works
Foo, J. N., Chew, E. G. Y., Chung, S. J., Peng, R., Blauwendraat, C., Nalls, M. A., Mok, K. Y., Satake, W., Toda, T., Chao, Y., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.0428 · Cited by 250 · see citing works
Laine, C. M., Goldmann, D. R., & Sox, H. C. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-1-200701020-00014 · Cited by 234 · see citing works
Burns, A. S. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.023366 · Cited by 154 · see citing works
Managing the supportive care needs of those affected by COVID-19
Bajwah, S., Wilcock, A., Towers, R. P., Costantini, M., Bausewein, C., Simon, S. T., Bendstrup, E. M., Prentice, W. M., Johnson, M. J., Currow, D. C., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.00815-2020 · Cited by 148 · see citing works
Marcantonio, E. R. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-154-11-201106070-01006 · Cited by 102 · see citing works
Collaborative Delirium Prevention in the Age of COVID ‐19
LaHue, S. C., James, T. C., Newman, J. C., Esmaili, A. M., Ormseth, C. H., & Ely, E. W. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16480 · Cited by 90 · see citing works
Cole, M. G., Bailey, R., Bonnycastle, M., McCusker, J., Fung, S., Ciampi, A., Belzile, É., & Bai, C. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13791 · Cited by 77 · see citing works
McNeil, J. B., Hughes, C. G., Girard, T. D., Ware, L. B., Ely, E. W., Chandrasekhar, R., & Han, J. H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226412 · Cited by 72 · see citing works
The neuropsychology of delirium: advancing the science of delirium assessment
Tieges, Z., Evans, J. J., Neufeld, K. J., & MacLullich, A. M. J. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4711 · Cited by 71 · see citing works
Snapshot of the evolution and mutation patterns of SARS-CoV-2Preprint
Zhao, J., Sun, J., He, W., Ji, X., Gao, Q., Zhai, X., Suchard, M. A., Hong, S. L., Baele, G., Su, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.04.187435 · Cited by 21 · see citing works
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Research works printed but not linked: 1
- [27]National Institute for Health and Care Excellence (2020) COVID-19 rapid guideline: managing symptoms (including at the end of life) in the community (NICE guideline NG163). https://www.nice.org.uk/guidance/ng163 Accessed 3 Apr 2020 33497151
Cited by
Sorted by citations
Manca, R., De Marco, M., & Venneri, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.585540 · Cited by 227 · see citing works
- Authors
- Cipriani, G., Danti, S., Nuti, A., Carlesi, C., Lucetti, C., & Di Fiorino, M.
- Affiliations
- Ospedale Versilia (IT)
- Corresponding author
- Cipriani, Gabriele
- ORCID
- Cipriani, Gabriele
- Venue
- Acta Neurologica Belgica
- Published
- 2020-06-10
- Volume
- 120
- Issue
- 4
- Pages
- 927-932
- ISSN
- 0300-9009 (ISSN-L)
- 2240-2993
- PMC
- PMC7286634
- OpenAlex
- W3033433167
- Cited by
- 65
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 13 · 2021: 22 · 2020: 14
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Acta Neurologica Belgica (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- COVID-19 pandemic, delirium, older adults, central nervous system complications, delirium prevention, delirium screening, non-pharmacological treatment, agitation, intensive care unit, dementia
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Delirium, Humans, Pneumonia, Viral, Coronavirus Infections, Pandemics
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