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Cited by 13

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

Circulating MicroRNAs in Drug Safety Assessment for Hepatic and Cardiovascular Toxicity: The Latest Biomarker Frontier?

Osaki, Mitsuhiko, Kosaka, Nobuyoshi, Okada, Futoshi, Ochiya, Takahiro·2014·Molecular Diagnosis & Therapy

Abstract

Drug-induced liver and cardiovascular injuries are important aspects of safety evaluations of numerous drugs in development. Therefore, reliable and predictive biomarkers to allow detection of early signs of drug-induced liver and cardiovascular injuries are required in clinical and preclinical pharmaceutical evaluation. MicroRNAs (miRNAs) are reported to be present in body fluids (blood, urine, etc.), and these 'circulating miRNAs' have been proposed as toxicological biomarkers of drug-induced tissue injury in preclinical and clinical practice. To be used as biomarkers of drug toxicity, such miRNAs need to show rapid and injured-tissue-specific upregulation in body fluids after injury, be more sensitive than existing protein markers such as alanine aminotransferase (ALT) and troponins, and be able to identify the toxicants responsible, if possible. In this article, we focus on the current knowledge of circulating miRNAs, which have potential for use in assessment of drug-induced liver and cardiovascular injuries. In addition, we discuss an important question regarding normalization of the expression levels of certain circulating miRNAs in body fluids.

Overview

Integrity signals

Registry

Crossref · 10.1007/s40291-013-0065-0

Cites

68 of 68 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 1

  1. Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 2008;105:10513–8. · DOI · Paper page

Cited by

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Metadata

Authors
Osaki, M., Kosaka, N., Okada, F., & Ochiya, T.
Venue
Molecular Diagnosis & Therapy
Published
2013-11-06
Volume
18
Issue
2
Pages
121-126
ISSN
  • 1177-1062
  • 1179-2000
Cited by
13
References
68
Language
en
Licence
www.springer.com/tdm (tdm)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.