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Circulating MicroRNAs in Drug Safety Assessment for Hepatic and Cardiovascular Toxicity: The Latest Biomarker Frontier?
Abstract
Drug-induced liver and cardiovascular injuries are important aspects of safety evaluations of numerous drugs in development. Therefore, reliable and predictive biomarkers to allow detection of early signs of drug-induced liver and cardiovascular injuries are required in clinical and preclinical pharmaceutical evaluation. MicroRNAs (miRNAs) are reported to be present in body fluids (blood, urine, etc.), and these 'circulating miRNAs' have been proposed as toxicological biomarkers of drug-induced tissue injury in preclinical and clinical practice. To be used as biomarkers of drug toxicity, such miRNAs need to show rapid and injured-tissue-specific upregulation in body fluids after injury, be more sensitive than existing protein markers such as alanine aminotransferase (ALT) and troponins, and be able to identify the toxicants responsible, if possible. In this article, we focus on the current knowledge of circulating miRNAs, which have potential for use in assessment of drug-induced liver and cardiovascular injuries. In addition, we discuss an important question regarding normalization of the expression levels of certain circulating miRNAs in body fluids.
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“Therefore, circulating miRNAs could be utilized as novel liquid biopsy biomarkers [14,15,16,17,18,19,20].”
From Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets (2015) · cites this paper as [19]
Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., et al. (2008) · Cell Research · doi:10.1038/cr.2008.282 · Cited by 4,560
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1065062 · Cited by 3,345
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., & Remaley, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2210 · Cited by 2,741
The MicroRNA Spectrum in 12 Body Fluids
Weber, J. A., Baxter, D. H., Zhang, S., Huang, D. Y., How Huang, K., Jen Lee, M., Galas, D. J., & Wang, K. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.147405 · Cited by 2,477
Characterization of extracellular circulating microRNA
Turchinovich, A., Weiz, L., Langheinz, A., & Burwinkel, B. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr254 · Cited by 1,941
Identification of hundreds of conserved and nonconserved human microRNAs
Bentwich, I., Avniel, A., Karov, Y., Aharonov, R., Gilad, S., Barad, O., Barzilai, A., Einat, P., Einav, U., Meiri, E., et al. (2005) · Nature Genetics · doi:10.1038/ng1590 · Cited by 1,841
Lawrie, C. H., Gal, S., Dunlop, H. M., Pushkaran, B., Liggins, A. P., Pulford, K., Banham, A. H., Pezzella, F., Boultwood, J., Wainscoat, J. S., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07077.x · Cited by 1,735
Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
Wolfers, J., Lozier, A., Raposo, G., Regnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,640
Small non-coding RNAs in animal development
Stefani, G., & Slack, F. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2347 · Cited by 1,368
Serum MicroRNAs Are Promising Novel Biomarkers
Gilad, S., Meiri, E., Yogev, Y., Benjamin, S., Lebanony, D., Yerushalmi, N., Benjamin, H., Kushnir, M., Cholakh, H., Melamed, N., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003148 · Cited by 1,347
Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection
Zernecke, A., Bidzhekov, K., Noels, H., Shagdarsuren, E., Gan, L., Denecke, B., Hristov, M., Köppel, T., Jahantigh, M. N., Lutgens, E., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000610 · Cited by 1,334
Quantitative real-time RT-PCR – a perspective
Bustin, S. A., Benes, V, Nolan, T., & Pfaffl, M. W. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01755 · Cited by 1,321
Wang, G., Zhu, J., Zhang, J., Li, Q., Li, Y., He, J., Qin, Y., & Jing, Q. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq013 · Cited by 1,190
Ng, E. K. O., Chong, W. W. S., Jin, H., Lam, E. K. Y., Shin, V. Y., Yu, J., Poon, T. C. W., Ng, S. S. M., & Sung, J. J. Y. (2009) · Gut · doi:10.1136/gut.2008.167817 · Cited by 1,151
Circulating microRNAs, potential biomarkers for drug-induced liver injury
Wang, K., Zhang, S., Marzolf, B., Troisch, P., Brightman, A., Hu, Z., Hood, L. E., & Galas, D. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813371106 · Cited by 1,149
Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis
Kosaka, N., Iguchi, H., & Ochiya, T. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01650.x · Cited by 1,147
Self-citationNew microRNAs from mouse and human
LAGOS-QUINTANA, M., RAUHUT, R., MEYER, J., BORKHARDT, A., & TUSCHL, T. (2003) · RNA · doi:10.1261/rna.2146903 · Cited by 909
Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease†
Kim, W. R., Flamm, S. L., Bisceglie, A. M. D., & Bodenheimer, H. C. (2008) · Hepatology · doi:10.1002/hep.22109 · Cited by 858
Detection and Characterization of Placental MicroRNAs in Maternal Plasma
Chim, S. S. C., Shing, T. K. F., Hung, E. C. W., Leung, T.-Y., Lau, T.-K., Chiu, R. W. K., & Dennis Lo, Y. M. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097972 · Cited by 850
Peltier, H. J., & Latham, G. J. (2008) · RNA · doi:10.1261/rna.939908 · Cited by 820
Hu, Z., Chen, X., Zhao, Y., Tian, T., Jin, G., Shu, Y., Chen, Y., Xu, L., Zen, K., Zhang, C., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.9342 · Cited by 798
Circulating microRNAs are new and sensitive biomarkers of myocardial infarction
D'Alessandra, Y., Devanna, P., Limana, F., Straino, S., Di Carlo, A., Brambilla, P. G., Rubino, M., Carena, M. C., Spazzafumo, L., De Simone, M., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq167 · Cited by 797
Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease
Corsten, M. F., Dennert, R., Jochems, S., Kuznetsova, T., Devaux, Y., Hofstra, L., Wagner, D. R., Staessen, J. A., Heymans, S., & Schroen, B. (2010) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.110.957415 · Cited by 794
Bala, S., Petrasek, J., Mundkur, S., Catalano, D., Levin, I., Ward, J., Alao, H., Kodys, K., & Szabo, G. (2012) · Hepatology · doi:10.1002/hep.25873 · Cited by 631
Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury
Laterza, O. F., Lim, L., Garrett-Engele, P. W., Vlasakova, K., Muniappa, N., Tanaka, W. K., Johnson, J. M., Sina, J. F., Fare, T. L., Sistare, F. D., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.131797 · Cited by 619
Guenin, S., Mauriat, M., Pelloux, J., Van Wuytswinkel, O., Bellini, C., & Gutierrez, L. (2009) · Journal of Experimental Botany · doi:10.1093/jxb/ern305 · Cited by 596
Kuwabara, Y., Ono, K., Horie, T., Nishi, H., Nagao, K., Kinoshita, M., Watanabe, S., Baba, O., Kojima, Y., Shizuta, S., et al. (2011) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.110.958975 · Cited by 592
Xu, J., Wu, C., Che, X., Wang, L., Yu, D., Zhang, T., Huang, L., Li, H., Tan, W., Wang, C., et al. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20712 · Cited by 567
Circulating MicroRNAs in Patients with Chronic Hepatitis C and Non-Alcoholic Fatty Liver Disease
Cermelli, S., Ruggieri, A., Marrero, J. A., Ioannou, G. N., & Beretta, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023937 · Cited by 564
Circulating microRNAs as potential markers of human drug-induced liver injury
Lewis, P. J. S., Dear, J. W., Platt, V., Simpson, K. J., Craig, D. G. N., Antoine, D. J., French, N. S., Dhaun, N., Webb, D. J., Costello, E., et al. (2011) · Hepatology · doi:10.1002/hep.24538 · Cited by 527
Plasma miR-208 as a Biomarker of Myocardial Injury
Ji, X., Takahashi, R., Hiura, Y., Hirokawa, G., Fukushima, Y., & Iwai, N. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.125310 · Cited by 476
Serum microRNAs as non-invasive biomarkers for cancer
Brase, J. C., Wuttig, D., Kuner, R., & Sültmann, H. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-306 · Cited by 421
Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases
Zhang, Y., Jia, Y., Zheng, R., Guo, Y., Wang, Y., Guo, H., Fei, M., & Sun, S. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.147850 · Cited by 415
Serum alanine aminotransferase in skeletal muscle diseases†
Nathwani, R. A., Pais, S., Reynolds, T. B., & Kaplowitz, N. (2005) · Hepatology · doi:10.1002/hep.20548 · Cited by 398
Fung, M., Thornton, A., Mybeck, K., Wu, J. H.-H., Hornbuckle, K., & Muniz, E. (2001) · Drug Information Journal · doi:10.1177/009286150103500134 · Cited by 384
Plasma MicroRNA 499 as a Biomarker of Acute Myocardial Infarction
Adachi, T., Nakanishi, M., Otsuka, Y., Nishimura, K., Hirokawa, G., Goto, Y., Nonogi, H., & Iwai, N. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.144121 · Cited by 383
Serum miR-146a and miR-223 as potential new biomarkers for sepsis
Wang, J.-F., Yu, M.-L., Yu, G., Bian, J.-J., Deng, X.-M., Wan, X.-J., & Zhu, K.-M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.145 · Cited by 356
A translational study of circulating cell-free microRNA-1 in acute myocardial infarction
Cheng, Y., Tan, N., Yang, J., Liu, X., Cao, X., He, P., Dong, X., Qin, S., & Zhang, C. (2010) · Clinical Science · doi:10.1042/cs20090645 · Cited by 341
Horizontal Transfer of DNA by the Uptake of Apoptotic Bodies
Holmgren, L., Szeles, A., Rajnavölgyi, E., Folkman, J., Klein, G., Ernberg, I., & Falk, K. I. (1999) · Blood · doi:10.1182/blood.v93.11.3956 · Cited by 333
Adams, J. E., Schechtman, K. B., Landt, Y., Ladenson, J. H., & Jaffe, A. S. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.7.1291 · Cited by 321
de Winter, R. J., Koster, R. W., Sturk, A., & Sanders, G. T. (1995) · Circulation · doi:10.1161/01.cir.92.12.3401 · Cited by 317
Song, J., Bai, Z., Han, W., Zhang, J., Meng, H., Bi, J., Ma, X., Han, S., & Zhang, Z. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1981-7 · Cited by 272
Review article: drug hepatotoxicity
CHANG, C. Y., & SCHIANO, T. D. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03307.x · Cited by 264
Lima, L. G., Chammas, R. J., Monteiro, R. Q., Moreira, M. E. C., & Barcinski, M. A. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.03.041 · Cited by 260
Boone, L. I., Meyer, D. J., Cusick, P. K., Ennulat, D., Bolliger, A. P., Everds, N. E., Meador, V., Elliott, G., Honor, D. J., Bounous, D. I., et al. (2005) · Veterinary Clinical Pathology · doi:10.1111/j.1939-165x.2005.tb00041.x · Cited by 235
Ghosh, A. K., Secreto, C. R., Knox, T. R., Ding, W., Mukhopadhyay, D., & Kay, N. E. (2009) · Blood · doi:10.1182/blood-2009-09-242719 · Cited by 235
Antoine, D. J., Williams, D. P., Kipar, A., Jenkins, R. E., Regan, S. L., Sathish, J. G., Kitteringham, N. R., & Park, B. K. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp235 · Cited by 223 · cited 1×
“A number of exploratory biomarkers are currently under investigation, including high-mobility group box 1, cytokeratin 18, glutamate dehydrogenase, sorbitol dehydrogenase, albumin mRNA, a-glutathione S-transferase, and F-protein [39, 40].”
BackgroundOerlemans, M. I. F. J., Mosterd, A., Dekker, M. S., de Vrey, E. A., van Mil, A., Pasterkamp, G., Doevendans, P. A., Hoes, A. W., & Sluijter, J. P. G. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201749 · Cited by 205
Bihrer, V., Friedrich‐Rust, M., Kronenberger, B., Forestier, N., Haupenthal, J., Shi, Y., Peveling‐Oberhag, J., Radeke, H. H., Sarrazin, C., Herrmann, E. M., et al. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.161 · Cited by 199
MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia
Moussay, E., Wang, K., Cho, J., Moer, K. V., Pierson, S., Paggetti, J., Nazarov, P. V., Palissot, V., Hood, L., Berchem, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019557108 · Cited by 178
A translational study of urine miRNAs in acute myocardial infarction
Cheng, Y., Wang, X., Yang, J., Duan, X., Yao, Y., Shi, X., Chen, Z., Fan, Z., Liu, X., Qin, S., et al. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.08.010 · Cited by 175
microRNAs in heart disease: putative novel therapeutic targets?
Condorelli, G., Latronico, M. V. G., & Dorn, G. W. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp573 · Cited by 162
Cancer diagnosis and prognosis decoded by blood-based circulating microRNA signatures
Madhavan, D., Ćuk, K., Burwinkel, B., & Yang, R. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00116 · Cited by 139
Serum miR-210 as a potential biomarker of early clear cell renal cell carcinoma
Iwamoto, H., Kanda, Y., Sejima, T., Osaki, M., Okada, F., & Takenaka, A. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2169 · Cited by 116
Self-citationBiomarkers for drug-induced liver injury
Shi, Q., Hong, H., Senior, J. R., & Tong, W. (2010) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.10.8 · Cited by 91
Fannin, R. D., Russo, M. W., O’Connell, T. M., Gerrish, K., Winnike, J. H., Macdonald, J. M., Newton, J., Malik, S. M., Sieber, S. O., Parker, J. S., et al. (2009) · Hepatology · doi:10.1002/hep.23330 · Cited by 90
Plasma MicroRNA Profiles in Rat Models of Hepatocellular Injury, Cholestasis, and Steatosis
Yamaura, Y., Nakajima, M., Takagi, S., Fukami, T., Tsuneyama, K., & Yokoi, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030250 · Cited by 82
Identification of Urinary microRNA Profiles in Rats That May Diagnose Hepatotoxicity
Yang, X., Greenhaw, J. J., Shi, Q., Su, Z., Qian, F., Davis, K. J., Mendrick, D. L., & Salminen, W. F. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr321 · Cited by 79
miRNA: Small Molecules as Potential Novel Biomarkers in Cancer
Shah, A. A., Leidinger, P., Blin, N., & Meese, E. U. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710794182980 · Cited by 68
Kosaka, N., & Ochiya, T. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2011.00097 · Cited by 63
Self-citationMechanism-based bioanalysis and biomarkers for hepatic chemical stress
Antoine, D. J., Mercer, A. E., Williams, D. P., & Park, B. K. (2009) · Xenobiotica · doi:10.1080/00498250903046993 · Cited by 49
Wang, Y., Tang, N., Hui, T., Wang, S., Zeng, X., Li, H., & Ma, J. (2013) · Journal of Applied Toxicology · doi:10.1002/jat.2864 · Cited by 42
Drug-induced hepatotoxicity in humans.
Marzio, D. H., & Navarro, V. J. (2008) · PubMed · Cited by 26
Research works printed but not linked: 1
- Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 2008;105:10513–8. · DOI · Paper page
Cited by
Bioinformatic Interrogation of 5p-arm and 3p-arm Specific miRNA Expression Using TCGA Datasets
Kuo, W.-T., Su, M.-W., Lee, Y., Chen, C.-H., Wu, C.-W., Fang, W.-L., Huang, K.-H., & Lin, W.-C. (2015) · Journal of Clinical Medicine · doi:10.3390/jcm4091798 · Cited by 30
Metadata
- Authors
- Osaki, M., Kosaka, N., Okada, F., & Ochiya, T.
- Venue
- Molecular Diagnosis & Therapy
- Published
- 2013-11-06
- Volume
- 18
- Issue
- 2
- Pages
- 121-126
- ISSN
- 1177-1062
- 1179-2000
- Cited by
- 13
- References
- 68
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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