Effect of prolactin on plasma DHEA(S) levels
Abstract
Plasma DHEA and DHEA-S levels were significantly higher (P less than 0.001) in women with elevated prolactin levels, due either to chronic treatment with psychotropic drugs or to a prolactinoma, than in untreated controls. This increase was also observed in 3 male patients with prolactinoma. It is suggested that this increase is the consequence of a direct effect of prolactin on the adrenal cortex and that prolactin might be responsible for the ACTH independent andrenocortical androgen secretion.
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In vivo studies show that PRL has a selective stimulatory effect on adrenal androgen production.
“These data are also consistent with the in vivo studies cited before showing that PRL has a selective stimulatory effect on adrenal androgen production 12,23-29 .”
From ACTH and prolactin synergistically and selectively regulate CYP17 expression and adrenal androgen production in human foetal adrenal organ cultures (2023) · cites this paper as [25]
A number of studies have described an association of hyperprolactinemia with increased adrenal androgen levels and an increased adrenocortical response to ACTH in patients with high circulating PRL levels.
“A number of studies have described the association of hyperprolactinemia with increased adrenal androgen levels and an increased adrenocortical response to ACTH in patients with high circulating PRL levels 12,23-29 .”
From ACTH and prolactin synergistically and selectively regulate CYP17 expression and adrenal androgen production in human foetal adrenal organ cultures (2023) · cites this paper as [25]
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STUDIES ON ESTROGEN IN HUMAN MALE PLASMA
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Prof. Em. Dr. med. Alex Vermeulen (1927–2023)—A Giant in Endocrinology
Crée, C. D. (2025) · Endocrines · doi:10.3390/endocrines6010007
Becker, H. (1988) · Springer eBooks · doi:10.1007/978-3-642-73609-4_5
- Authors
- Vermeulen, A., Suy, E., & Rubens, R.
- Affiliations
- Ghent University (BE)
- ORCID
- Vermeulen, Alex
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1977-06
- Volume
- 44
- Issue
- 6
- Pages
- 1222-1225
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2073158788
- Cited by
- 97
- References
- 14
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2018: 1 · 2014: 1
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- prolactin, dehydroepiandrosterone, DHEA sulfate, prolactinoma, psychotropic drugs, adrenal cortex, plasma steroid levels
- MeSH terms
- Adult, Aged, Antidepressive Agents, Dehydroepiandrosterone, Dementia, Depression, Estrogens, Female, Gonadotropins, Pituitary, Humans, Male, Menopause, Prolactin, Sulfates, Sulpiride
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