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Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects
Abstract
A variety of hypotheses have been proposed to explain the premenstrual syndromes. These hypotheses serve as rationales for an equally diverse range of proposed treatments. To investigate these hypotheses, we obtained multiple blood samples across the menstrual cycle in women with well-characterized menstrually related mood disorder and in control subjects. No diagnosis-related differences were observed in the levels or patterns of secretion of progesterone, estradiol, follicle-stimulating hormone, luteinizing hormone, testosterone-estradiol-binding globulin, dehydroepiandrosterone sulfate, dihydrotestosterone, prolactin, or cortisol. Our data suggest that premenstrual syndrome does not represent a simple hormonal deficiency and that the cited rationales for several of the proposed treatments are of questionable merit.
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“Three other studies failed to detect any significant differences between cortisol patterns in healthy controls and PMS/PMDD patients [57, 66, 106].”
From Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (2010) · cites this paper as [106]
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Metadata
- Authors
- Rubinow, D. R., Hoban, M. C., Grover, G. N., Galloway, D. S., Roy-Byrne, P., Andersen, R., & Merriam, G. R.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Rubinow, David R.
- ORCID
- Rubinow, David R.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 158
- Issue
- 1
- Pages
- 5-11
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2012067598
- Cited by
- 235
- References
- 18
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 7 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 9 · 2012: 15
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- premenstrual syndrome, menstrual cycle, plasma hormones, premenstrual dysphoric disorder, progesterone, estradiol, luteinizing hormone, follicle-stimulating hormone, testosterone, dehydroepiandrosterone sulfate, prolactin, cortisol, dihydrotestosterone
- MeSH terms
- Dehydroepiandrosterone, Estradiol, Female, Follicle Stimulating Hormone, Hormones, Humans, Hydrocortisone, Luteinizing Hormone, Menstrual Cycle, Premenstrual Syndrome, Prolactin, Sex Hormone-Binding Globulin, Dihydrotestosterone, Testosterone, Dehydroepiandrosterone Sulfate, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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