Cited by 100Menstrual Health and DisordersHypothalamic control of reproductive hormonesOvarian function and disorders

Pituitary–adrenal hormones and testosterone across the menstrual cycle in women with premenstrual syndrome and controls

Bloch, Miki, Schmidt, Peter J, Su, Tung-Ping, Tobin, Marie B, Rubinow, David R·1998·Biological Psychiatry

Abstract

Background Premenstrual syndrome (PMS) is a cyclic mood disorder, widely believed, yet not conclusively shown, to be of endocrine etiology. This study examines basal levels of several hormones reported, albeit inconsistently, to differ in women with PMS compared with controls.Methods Subjects (10 PMS patients and 10 controls) had their blood drawn for one full menstrual cycle. Subjects' mood and behavioral symptoms were assessed by daily self-ratings and objective ratings. Plasma was assayed for total and free testosterone (T), beta-endorphin (beta-EP), adrenocorticotropic hormone (ACTH), and cortisol.Results No differences were observed between the PMS and control groups for beta-EP, ACTH, or cortisol. PMS subjects had significantly lower total and free T plasma levels with a blunting of the normal periovulatory peak, a finding that may be epiphenomenal to age.Conclusions This study does not confirm previous reports of abnormalities in plasma levels of either ACTH or beta-EP in women with PMS; it also fails to replicate a previous observation of high free T levels in women with PMS. These results are not supportive of a primary endocrine abnormality in PMS patients.

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Crossref · 10.1016/s0006-3223(98)00403-x

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Authors
Bloch, M., Schmidt, P. J., Su, T.-P., Tobin, M. B., & Rubinow, D. R.
Affiliations
National Institute of Mental Health (US)
Corresponding author
Rubinow, David R
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1998-06
Volume
43
Issue
12
Pages
897-903
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2021662699
Cited by
100
References
32
Citations by year
2026: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 6
FWCI
4.75
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
premenstrual syndrome, menstrual cycle, testosterone, free testosterone, beta-endorphin, ACTH, cortisol, pituitary-adrenal axis, endocrine etiology, mood symptoms
MeSH terms
Adrenal Cortex Hormones, Adrenocorticotropic Hormone, Adult, beta-Endorphin, Female, Humans, Hydrocortisone, Menstrual Cycle, Pituitary Hormones, Premenstrual Syndrome, Testosterone

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