Cited by 23Menopause: Health Impacts and TreatmentsStress Responses and CortisolAdrenal Hormones and Disorders

Impact of endogenous and exogenous progesterone exposure on stress biomarkers: a systematic review

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Stadler, A., Weidlinger, S., Stute, P.·2019·Climacteric

Abstract

Stress activates the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal axis (HPAA). Based on a systematic literature review of the impact of endogenous and exogenous exposure with natural progesterone on the stress response in healthy premenopausal and postmenopausal women, the following conclusions can be drawn: the HPAA activity was not relevantly affected by endogenous progesterone exposure across the menstrual cycle, but might be reduced by exogenous micronized progesterone application; in contrast, the ANS has a sympathetic predominance in the (progesterone-dominated) luteal phase of the menstrual cycle. Future studies should assess various stress biomarkers under various hormonal conditions to, for example, allow for cardiovascular risk stratification in hormone users.

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Crossref · 10.1080/13697137.2019.1622085

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  • Available data indicate that weak correlations are observed for circadian or follicular-to-luteal fluctuations of the HPG and HPA axes, while significant negative correlations are found for wider fluctuations under stress conditions, perimenstrual, pregnancy, or pharmacological treatments.

    “Available data indicate that weak correlations are observed for circadian or follicular-to-luteal fluctuations of these axes, while significant negative correlations are found for wider fluctuations under stress conditions, perimenstrual, pregnancy, or pharmacological treatments [71].”

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Authors
Stadler, A., Weidlinger, S., & Stute, P.
Affiliations
University Hospital of Bern (CH)
Corresponding author
Stute, P.
Venue
Climacteric
Published
2019-07-03
Volume
22
Issue
5
Pages
435-441
ISSN
  • 1369-7137 (ISSN-L)
  • 1473-0804
OpenAlex
W2955264885
Cited by
23
References
85
Citations by year
2026: 2 · 2025: 7 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3
FWCI
0.35
Type
journal article
Language
en
Open access
Locations
  • Climacteric (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • BORIS (University Library Bern) (submittedVersion, cc-by-nc-nd)
Funders
Inselspital, Universitätsspital Bern
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
progesterone, endogenous progesterone, exogenous progesterone, micronized progesterone, stress biomarkers, hypothalamic-pituitary-adrenal axis, autonomic nervous system, sympathetic nervous system, menstrual cycle, luteal phase, premenopausal women, postmenopausal women, hormone replacement therapy, cardiovascular risk
MeSH terms
Autonomic Nervous System, Female, Humans, Hydrocortisone, Menstrual Cycle, Progesterone, Stress, Physiological, Biomarkers, Premenopause, Postmenopause

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