Impact of endogenous and exogenous progesterone exposure on stress biomarkers: a systematic review
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Stress activates the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal axis (HPAA). Based on a systematic literature review of the impact of endogenous and exogenous exposure with natural progesterone on the stress response in healthy premenopausal and postmenopausal women, the following conclusions can be drawn: the HPAA activity was not relevantly affected by endogenous progesterone exposure across the menstrual cycle, but might be reduced by exogenous micronized progesterone application; in contrast, the ANS has a sympathetic predominance in the (progesterone-dominated) luteal phase of the menstrual cycle. Future studies should assess various stress biomarkers under various hormonal conditions to, for example, allow for cardiovascular risk stratification in hormone users.
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Available data indicate that weak correlations are observed for circadian or follicular-to-luteal fluctuations of the HPG and HPA axes, while significant negative correlations are found for wider fluctuations under stress conditions, perimenstrual, pregnancy, or pharmacological treatments.
“Available data indicate that weak correlations are observed for circadian or follicular-to-luteal fluctuations of these axes, while significant negative correlations are found for wider fluctuations under stress conditions, perimenstrual, pregnancy, or pharmacological treatments [71].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [71]
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Hormonal Contraceptive Use, Stress Disorders, and Cardiovascular and Thrombotic Risk in Women
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- Authors
- Stadler, A., Weidlinger, S., & Stute, P.
- Affiliations
- University Hospital of Bern (CH)
- Corresponding author
- Stute, P.
- Venue
- Climacteric
- Publisher
- Informa UK Limited
- Published
- 2019-07-03
- Volume
- 22
- Issue
- 5
- Pages
- 435-441
- ISSN
- 1369-7137 (ISSN-L)
- 1473-0804
- OpenAlex
- W2955264885
- Cited by
- 23
- References
- 85
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Climacteric (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion, cc-by-nc-nd)
- Funders
- Inselspital, Universitätsspital Bern
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- progesterone, endogenous progesterone, exogenous progesterone, micronized progesterone, stress biomarkers, hypothalamic-pituitary-adrenal axis, autonomic nervous system, sympathetic nervous system, menstrual cycle, luteal phase, premenopausal women, postmenopausal women, hormone replacement therapy, cardiovascular risk
- MeSH terms
- Autonomic Nervous System, Female, Humans, Hydrocortisone, Menstrual Cycle, Progesterone, Stress, Physiological, Biomarkers, Premenopause, Postmenopause
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