The anorectic effects of CRH and restraint stress decrease with repeated exposures
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Intracerebroventricular (icv) administration of corticotropin-releasing hormone (CRH) or exposure to a restraint stressor causes acute anorexia in rats. However, the effects on food intake of repeated injections of CRH or repeated exposures to restraint stress have not been previously reported. As the effects of these more chronic CRH and stress treatments may be of greater relevance to emerging hypotheses of the pathogenesis of human eating and affective disorders, we measured the changes in food intake and body weight of rats after repeated central injections of CRH. In two experiments using two different daily dosages of CRH and two different schedules of administration, we found that the anorectic effect of CRH decreased over repeated injections. Weight gain was slowed significantly only in the high-dose experiment. Rats may become tolerant to the anorectic effects of CRH delivered by repeated icv injections. These findings have important implications for hypothesized mechanisms of anorexia nervosa and/or depression.
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Procedural acclimatisation immediately before a procedure allows stabilisation of the animals' responses after unaccustomed handling, novel environments, and previous procedures, which otherwise can induce behavioural and physiological changes.
“Procedural acclimatisation immediately before a procedure allows stabilisation of the animals’ responses after unaccustomed handling, novel environments, and previous procedures, which otherwise can induce behavioural and physiological changes [140,141].”
From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [140]
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- Authors
- Krahn, D. D., Gosnell, B. A., & Majchrzak, M. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Krahn, Dean D.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 27
- Issue
- 10
- Pages
- 1094-1102
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2022798217
- Cited by
- 122
- References
- 27
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 12 · 2013: 7 · 2012: 3
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- University of Michigan
- National Institutes of Health (2s07rr005383-30, 7r01da005471-09)
- Medical School, University of Michigan
- National Institute on Drug Abuse (DA05471)
- National Center for Research Resources (2S07RR05383)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- corticotropin-releasing factor, restraint stress, anorexia, dietary intake, body weight, tolerance (pharmacology and immunology), repeated administration, intracerebroventricular administration, anorexia nervosa, depression
- MeSH terms
- Animals, Appetite, Arousal, Body Weight, Brain, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Eating, Habituation, Psychophysiologic, Injections, Intraventricular, Male, Rats, Inbred Strains, Restraint, Physical, Rats
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