Cited by 122Regulation of Appetite and ObesityEating Disorders and BehaviorsStress Responses and Cortisol

The anorectic effects of CRH and restraint stress decrease with repeated exposures

Open access
Krahn, Dean D., Gosnell, Blake A., Majchrzak, Mark J.·1990·Biological Psychiatry

Abstract

Intracerebroventricular (icv) administration of corticotropin-releasing hormone (CRH) or exposure to a restraint stressor causes acute anorexia in rats. However, the effects on food intake of repeated injections of CRH or repeated exposures to restraint stress have not been previously reported. As the effects of these more chronic CRH and stress treatments may be of greater relevance to emerging hypotheses of the pathogenesis of human eating and affective disorders, we measured the changes in food intake and body weight of rats after repeated central injections of CRH. In two experiments using two different daily dosages of CRH and two different schedules of administration, we found that the anorectic effect of CRH decreased over repeated injections. Weight gain was slowed significantly only in the high-dose experiment. Rats may become tolerant to the anorectic effects of CRH delivered by repeated icv injections. These findings have important implications for hypothesized mechanisms of anorexia nervosa and/or depression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/0006-3223(90)90046-5

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Procedural acclimatisation immediately before a procedure allows stabilisation of the animals' responses after unaccustomed handling, novel environments, and previous procedures, which otherwise can induce behavioural and physiological changes.

    “Procedural acclimatisation immediately before a procedure allows stabilisation of the animals’ responses after unaccustomed handling, novel environments, and previous procedures, which otherwise can induce behavioural and physiological changes [140,141].”

    From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [140]

    Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Lei A, Ahlers ST, WojniclO FHE, Harrod C, Barrett IE (1988): Effects of central administration of corticotropin-releasing factor (CRF) on schedule-controlled responding and central mono- aminergic metabolites in pigeons (Abstract 7393). Fed Proc.
  2. D.D. Krahn et al. 1990;27:1094-1102

Cited by

Sorted by citations

Authors
Krahn, D. D., Gosnell, B. A., & Majchrzak, M. J.
Affiliations
University of Michigan (US)
Corresponding author
Krahn, Dean D.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1990-05
Volume
27
Issue
10
Pages
1094-1102
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2022798217
Cited by
122
References
27
Citations by year
2025: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 12 · 2013: 7 · 2012: 3
FWCI
1.29
Type
journal article
Language
en
Open access
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
  • University of Michigan
  • National Institutes of Health (2s07rr005383-30, 7r01da005471-09)
  • Medical School, University of Michigan
  • National Institute on Drug Abuse (DA05471)
  • National Center for Research Resources (2S07RR05383)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
corticotropin-releasing factor, restraint stress, anorexia, dietary intake, body weight, tolerance (pharmacology and immunology), repeated administration, intracerebroventricular administration, anorexia nervosa, depression
MeSH terms
Animals, Appetite, Arousal, Body Weight, Brain, Corticotropin-Releasing Hormone, Dose-Response Relationship, Drug, Eating, Habituation, Psychophysiologic, Injections, Intraventricular, Male, Rats, Inbred Strains, Restraint, Physical, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review