A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia
Open accessAbstract
Chronic stress causes dysregulations of mood and energy homeostasis, but the neurocircuitry underlying these alterations remain to be fully elucidated. Here we demonstrate that chronic restraint stress in mice results in hyperactivity of pro-opiomelanocortin neurons in the arcuate nucleus of the hypothalamus (POMC ARH neurons) associated with decreased neural activities of dopamine neurons in the ventral tegmental area (DA VTA neurons). We further revealed that POMC ARH neurons project to the VTA and provide an inhibitory tone to DA VTA neurons via both direct and indirect neurotransmissions. Finally, we show that photoinhibition of the POMC ARH→VTA circuit in mice increases body weight and food intake, and reduces depression-like behaviors and anhedonia in mice exposed to chronic restraint stress. Thus, our results identified a novel neurocircuitry regulating feeding and mood in response to stress.
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A recent study failed to show a change in AgRP neuron activity after repeated restraint stress.
“However, a recent study failed to show a change in AgRP neuron activity after repeated restraint stress [29].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [29]
A recent study using repeated restraint stress in a predictable fashion failed to show any changes in AgRP neuron activity.
“a recent study using repeated restraint stress in a predictable fashion failed to show any changes in AgRP neuron activity [29].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [29]
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Fang, X., Jiang, S., Wang, J., Bai, Y., Kim, C. S., Blake, D., Weintraub, N. L., Lei, Y., & Lu, X.-Y. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-01004-x · Cited by 95 · see citing works
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- Authors
- Qu, N., He, Y., Wang, C., Xu, P., Yang, Y., Cai, X., Liu, H., Yu, K., Pei, Z., Hyseni, I., Sun, Z., Fukuda, M., Li, Y., Tian, Q., & Xu, Y.
- Affiliations
- Baylor College of Medicine (US)
- China University of Geosciences (CN)
- Huazhong University of Science and Technology (CN)
- Corresponding author
- Xu, Yong
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 2019-09-05
- Volume
- 25
- Issue
- 5
- Pages
- 1006-1021
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC7056580
- OpenAlex
- W2971724322
- Cited by
- 122
- References
- 80
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 26 · 2023: 18 · 2022: 21 · 2021: 16 · 2020: 10 · 2019: 1
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Civil War Book Review (submittedVersion)
- Funders
- National Natural Science Foundation of China (81400886)
- Hubei Provincial Population and Family Planning Commission (WX14B34)
- American Diabetes Association (1-17-PDF-138)
- American Heart Association (16POST27260254, 16GRNT30970064)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- proopiomelanocortin neurons, arcuate nucleus, ventral tegmental area, dopaminergic neurons, chronic restraint stress, depression, anhedonia, neural circuits, photoinhibition, feeding behavior, energy homeostasis, mood regulation
- MeSH terms
- Animals, Feeding and Eating Disorders, Arcuate Nucleus of Hypothalamus, Depression, Female, Male, Mice, Inbred C57BL, Neural Pathways, Pro-Opiomelanocortin, Stress, Psychological, Ventral Tegmental Area, Mice, Anhedonia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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