Changes in hypothalamic corticotropin-releasing hormone, neuropeptide Y, and proopiomelanocortin gene expression during chronic rapid eye movement sleep deprivation of rats
Abstract
Chronic rapid eye movement (paradoxical) sleep deprivation (REM-SD) of rats leads to two conspicuous pathologies: hyperphagia coincident with body weight loss, prompted by elevated metabolism. Our goals were to test the hypotheses that 1) as a stressor, REM-SD would increase CRH gene expression in the hypothalamus and that 2) to account for hyperphagia, hypothalamic gene expression of the orexigen neuropeptide Y (NPY) would increase, but expression of the anorexigen proopiomelanocortin (POMC) would decrease. Enforcement of REM-SD of adult male rats for 20 d with the platform (flowerpot) method led to progressive hyperphagia, increasing to approximately 300% of baseline; body weight steadily declined by approximately 25%. Consistent with changes in food intake patterns, NPY expression rapidly increased in the hypothalamic arcuate nucleus by d 5 of REM-SD, peaking at d 20; by contrast, POMC expression decreased progressively during REM-SD. CRH expression was increased by d 5, both in mRNA and ability to detect neuronal perikaryal staining in paraventricular nucleus with immunocytochemistry, and it remained elevated thereafter with modest declines. Taken together, these data indicate that changes in hypothalamic neuropeptides regulating food intake are altered in a manner consistent with the hyperphagia seen with REM-SD. Changes in CRH, although indicative of REM-SD as a stressor, suggest that the anorexigenic actions of CRH are ineffective (or disabled). Furthermore, changes in NPY and POMC agree with current models of food intake behavior, but they are opposite to their acute effects on peripheral energy metabolism and thermogenesis.
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The mechanisms by which sleep loss activates ACTH release are likely to involve increased brain CRH levels rather than increased pituitary sensitivity to CRH.
“The mechanisms by which sleep loss activates ACTH release are likely to involve increased brain CRH levels rather than increased pituitary sensitivity to CRH, because rodents studies have reported enhanced brain synthesis and release of CRH (32–34) but also reduced CRH binding in the pituitary (32) after acute and chronic sleep restriction.”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [34]
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MethodSleep and circadian rhythms: key components in the regulation of energy metabolism
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“nocortin (POMC), an anorectic neuropeptide, in the hypothalamus [22,23].”
BackgroundYang, D., Huang, W.-C., Wu, C. W., Huang, C., Yang, Y. S. H., & Tung, Y. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127292 · Cited by 221 · see citing works
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“Also experimental studies in rats showed that sleep deprivation can induce up-regulation of orexigenic peptides and down-regulation of anorexigenic peptides leading to hyperphagia (61,62).”
BackgroundConnecting insufficient sleep and insomnia with metabolic dysfunction
Duan, D., Kim, L. J., Jun, J. C., & Polotsky, V. Y. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14926 · Cited by 110 · see citing works
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Short sleep duration and its association with energy metabolism
Klingenberg, L., Sjödin, A., Holmbäck, U., Astrup, A., & Chaput, J. ‐. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.00991.x · Cited by 94 · see citing works
“The idea of thermoregulatory-driven increased EE is also supported by the fact that studies have shown increased orexinergic activation, leading to increased neuropeptide Y (NPY) expression in the arcuate nucleus of the hypothalamus (24,25).”
BackgroundShechter, A., O'Keeffe, M., Roberts, A. L., Zammit, G. K., RoyChoudhury, A., & St-Onge, M.-P. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00222.2012 · Cited by 92 · see citing works
Markov, D. D., & Novosadova, E. V. (2022) · Biology · doi:10.3390/biology11111621 · Cited by 95 · see citing works
“The effect of rapid eye movement (REM) sleep deprivation on HPAA activation [19] was confirmed by an increase in the level of ACTH and corticosterone in the blood [20,21], an increase in corticotropin-releasing hormone (CRH) expression [22] and an increase in adrenal weight [23].”
BackgroundMartins, P. J. F., Marques, M. S., Tufik, S., & D’Almeida, V. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00660.2009 · Cited by 87 · see citing works
“(20) have shown that sleep deprivation increased the expression of the most potent orexigenic peptide, NPY, and reduced the anorexigenic peptide POMC in the hypothalamus of rats.”
BackgroundResultInfluentialStern, J. H., Grant, A. S., Thomson, C. A., Tinker, L., Hale, L., Brennan, K. M., Woods, N. F., & Chen, Z. (2014) · Obesity · doi:10.1002/oby.20683 · Cited by 86 · see citing works
“While the association between sleep duration, energy intake, energy expenditure, and hormones that regulate intake and expenditure has been described (7-10), there are sparse data describing the association between sleep and diet quality.”
BackgroundSleep-deprivation reduces NK cell number and function mediated by β-adrenergic signalling
De Lorenzo, B. H. P., de Oliveira Marchioro, L., Greco, C. R., & Suchecki, D. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.04.006 · Cited by 85 · see citing works
Galvão, M. D. O. L., Sinigaglia‐Coimbra, R., Kawakami, S. E., Tufik, S., & Suchecki, D. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.003 · Cited by 83 · see citing works
“, 2008) and hypothalamic—pituitary—adrenal (HPA) axis activity (Fadda and Fratta, 1997; Koban et al., 2006; Suchecki et al., 1998; Suchecki et al., 2002), increasing catabolic hormones such as corticosterone and adrenaline.”
BackgroundInfluentialHusse, J., Hintze, S. C., Gregor Eichele, C., Lehnert, H., & Oster, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052983 · Cited by 82 · see citing works
“As reported before [44,45,46] mice did not gain body weight during the week of TSR.”
Glucocorticoids Are Not Responsible for Paradoxical Sleep Deprivation-Induced Memory Impairments
Tiba, P. A., Oliveira, M. G. D. M., Rossi, V. C., Tufik, S., & Suchecki, D. (2008) · SLEEP · doi:10.1093/sleep/31.4.505 · Cited by 80 · see citing works
Barf, R. P., Van Dijk, G., Scheurink, A. J. W., Hoffmann, K., Novati, A., Hulshof, H. J., Fuchs, E., & Meerlo, P. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.09.005 · Cited by 77 · see citing works
“Some sleep deprivation studies in literature show hyperphagia together with increased neuropeptide Y mRNA levels and orexin/hypocretins mRNA levels in the hypothalamus [21,52,53].”
BackgroundSleep Deprivation of Rats: The Hyperphagic Response Is Real
Koban, M., Sita, L. V., Le, W. W., & Hoffman, G. E. (2008) · SLEEP · doi:10.5665/sleep/31.7.927 · Cited by 74 · see citing works
Ovarian Abnormalities in a Mouse Model of Fragile X Primary Ovarian Insufficiency
Hoffman, G. E., Le, W. W., Entezam, A., Otsuka, N., Tong, Z., Nelson, L. M., Flaws, J. A., McDonald, J. H., Jafar, S., & Usdin, K. (2012) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155412441002 · Cited by 73 · see citing works
“Hybridization to sections of mouse ovary was carried out as described previously (Berghorn et al. 2001; Koban et al. 2006; Carlson et al. 2009).”
MethodNitric oxide in the regulation of the sleep-wake states
Cespuglio, R., Amrouni, D., Meiller, A., Buguet, A., & Gautier-Sauvigné, S. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.01.006 · Cited by 73 · see citing works
Energy Expenditure is Affected by Rate of Accumulation of Sleep Deficit in Rats
Caron, A. M., & Stephenson, R. (2010) · SLEEP · doi:10.1093/sleep/33.9.1226 · Cited by 65 · see citing works
Prefrontal cortex to accumbens projections in sleep regulation of reward
Liu, Z., Wang, Y., Cai, L., Li, Y., Chen, B., Dong, Y., & Huang, Y. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0347-16.2016 · Cited by 66 · see citing works
“Indeed, similar paradoxical changes have been observed in chronic REM sleep-deprived rats—their overall daily consumption of food is increased, but their motivation for food is decreased (Bhanot et al., 1989; Kushida et al., 1989; Hanlon et al., 2005, 2010; Koban et al., 2006).”
BackgroundSleep deprivation and energy metabolism: to sleep, perchance to eat?
Penev, P. D. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282be9093 · Cited by 65 · see citing works
Central administration of neuropeptide Y induces wakefulness in rats
Szentirmai, É., & Krueger, J. M. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00919.2005 · Cited by 62 · see citing works
Distinct effects of acute and chronic sleep loss on DNA damage in rats
Andersen, M. L., Ribeiro, D. A., Bergamaschi, C. T., Alvarenga, T. A., Silva, A., Zager, A., Campos, R. R., & Tufik, S. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.02.014 · Cited by 60 · see citing works
“Although different protocols of long-term SR could be employed (Koban et al., 2006), most likely they would produce the same results, as both induce suppression of paradoxical sleep.”
BackgroundMaternal Sleep Quality and Diurnal Cortisol Regulation Over Pregnancy
Bublitz, M. H., Bourjeily, G. R., D’Angelo, C. M., & Stroud, L. R. (2016) · Behavioral Sleep Medicine · doi:10.1080/15402002.2016.1210147 · Cited by 59 · see citing works
Mavanji, V., Teske, J. A., Billington, C. J., & Kotz, C. M. (2013) · Obesity · doi:10.1002/oby.20182 · Cited by 57 · see citing works
“The ability of this method of PSD to induce weight gain is in contrast to effects on weight in other animal sleep deprivation models and is likely due to the less severe method used to disrupt sleep (11-13,26,28).”
BackgroundMethodResultInfluentialChronic sleep deprivation and seasonality: implications for the obesity epidemic.
Cizza, G., Requena, M., Galli, G., & de Jonge, L. (2011) · PubMed · doi:10.3275/7808 · Cited by 55 · see citing works
“Selective REM sleep deprivation caused an increase in the expression of neuropeptide Y, a strong appetite stimulant, in the arcuate nucleus; the expression of the stress neuropeptide CRH was also increased in the paraventricular nucleus, but its anorexic effect was lost in sleep deprivation (31).”
Wiater, M. F., Mukherjee, S., Li, A.-J., Dinh, T. T. N., Rooney, E., Simasko, S. M., & Ritter, S. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00168.2011 · Cited by 55 · see citing works
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Social jet-lag potentiates obesity and metabolic syndrome when combined with cafeteria diet in rats
Espítia‐Bautista, E., Velasco-Ramos, M., Osnaya-Ramírez, I., Castellanos, A., Buijs, R. M., & Escobar, C. (2017) · Metabolism · doi:10.1016/j.metabol.2017.04.006 · Cited by 49 · see citing works
Barf, R. P., Desprez, T., Meerlo, P., & Scheurink, A. J. W. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00326.2011 · Cited by 48 · see citing works
“Indeed, REM sleep deprivation leads to significant increases in neuropeptide Y mRNA levels (15, 16).”
Soto-Rodríguez, S., López-Armas, G. D. C., Luquı́n, S., Ramos-Zúñiga, R., Jáuregui-Huerta, F., González-Pérez, Ó., & González-Castañeda, R. E. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00132 · Cited by 46 · see citing works
Miyazaki, K., Itoh, N., Ohyama, S., Kadota, K., & Oishi, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055452 · Cited by 40 · see citing works
Martelli, D., Luppi, M., Cerri, M., Tupone, D., Mastrotto, M., Perez, E., Zamboni, G., & Amici, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087793 · Cited by 39 · see citing works
“The possibility that this process is a local expression of an activity of repair or recovery carried out during sleep on some nervous structures [29] is supported by the observations that a forced longterm deprivation of REMS induces in the rat: i) a life-threatening syndrome characterized by an increase in energy exp…”
BackgroundPlasticity of circadian clocks and consequences for metabolism
Coomans, C. P., Lucassen, E. A., Kooijman, S., Fifel, K., Deboer, T., Rensen, P. C. N., Michel, S. H., & Meijer, J. H. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12513 · Cited by 37 · see citing works
“Consistent with the change in food intake, the expression of neuropeptide Y, a peptide that potently stimulates food intake and reduces energy expenditure, rapidly increased in the arcuate nucleus (ARC) in the hypothalamus; in contrast, the expression of pro-opiomelanocortin, a peptide that decreases food intake and i…”
BackgroundEffects of Insufficient Sleep on Pituitary–Adrenocortical Response to CRH Stimulation in Healthy Men
Guyon, A., Morselli, L. L., Balbo, M. L., Tasali, E., Leproult, R., L’Hermite-Balériaux, M., Van Cauter, E., & Spiegel, K. (2017) · SLEEP · doi:10.1093/sleep/zsx064 · Cited by 35 · see citing works
Inverse relationship of food and alcohol intake to sleep measures in obesity
Galli, G., Piaggi, P., Mattingly, M. S., de Jonge, L., Courville, A. B., Pinchera, A., Santini, F., Csako, G., Cizza, G., & for the Sleep Extension Study Group (2013) · Nutrition & Diabetes · doi:10.1038/nutd.2012.33 · Cited by 36 · see citing works
Carlson, D. E., Chiu, W. C., Fiedler, S. M., & Hoffman, G. E. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.03.015 · Cited by 35 · see citing works
“During the chronic stress of sleep deprivation, an increase in CRH immunoreactivity in the PVH parallels the upregulation of CRH mRNA (Koban et al., 2006).”
BackgroundSleep restriction acutely impairs glucose tolerance in rats
Jha, P. K., Foppen, E., Kalsbeek, A., & Challet, É. (2016) · Physiological Reports · doi:10.14814/phy2.12839 · Cited by 31 · see citing works
“NPY is another hypothalamic neuropeptide involved in the control of feeding, arousal, and glucose metabolism (Szentirmai and Krueger 2006; Kalsbeek et al. 2010a; Wiater et al. 2011).”
BackgroundInfluentialBrianza-Padilla, M., Bonilla‐Jaime, H., Almanza-Pérez, J. C., López-López, A. L., Sánchez‐Muñoz, F., & Vázquez-Palacios, G. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0337 · Cited by 31 · see citing works
Bhisikar, S. M., Kokare, D. M., Nakhate, K. T., Chopde, C. T., & Subhedar, N. K. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.10.007 · Cited by 30 · see citing works
“It is implicated in the regulation of food intake (Clark et al. 1998), sleep–wake cycle (Fuxe et al. 1983; Sorensen et al. 2004; Koban et al. 2006), anxiety (Britton et al. 1997; Kokare et al. 2005) or epilepsy (Vezzani et al. 1999) and also in ethanol consumption (Kelley et al. 2001).”
BackgroundHanlon, E. C., Benca, R. M., Baldo, B. A., & Kelley, A. E. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.06.012 · Cited by 28 · see citing works
Nooshinfar, E., Baghban, A. A., & Meisami, E. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.243 · Cited by 26 · see citing works
Hermanstyne, T. O., Subedi, K., Le, W. W., Hoffman, G. E., Meredith, A. L., Mong, J. A., & Misonou, H. (2013) · SLEEP · doi:10.5665/sleep.3212 · Cited by 24 · see citing works
Short Sleep Duration and Erectile Dysfunction: A Review of the Literature
Zhang, F., Xiong, Y., Qin, F., & Yuan, J. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s375571 · Cited by 23 · see citing works
“It is reported that chronic sleep deprivation serving as a stressor significantly increases NPY expression in the hypothalamus, which might mediate the connection between sleep disorders and various diseases.(158) Meanwhile, it is presumed that short sleep duration in humans might be associated with significant differ…”
BackgroundType of diet modulates the metabolic response to sleep deprivation in rats
Martins, P. J. F., Fernandes, L., de Oliveira, A. C., Tufik, S., & D’Almeida, V. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-86 · Cited by 22 · see citing works
Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats
Machado, R. B., Tufik, S., & Suchecki, D. (2010) · International Journal of Endocrinology · doi:10.1155/2010/326151 · Cited by 21 · see citing works
“Additional data demonstrate that sleep deprivation induces increased immunoreactivity [10] and expression of hypothalamic CRH [11].”
BackgroundMetabolism as an integral cog in the mammalian circadian clockwork
Gamble, K. L., & Young, M. E. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.786672 · Cited by 18 · see citing works
“At the CNS level, sleep deprivation also increases hypothalamic expression of neuropeptide y (orexigenic) and decreases expression of proopiomelanocortin (anorectic; Koban et al., 2006).”
BackgroundSimionato, N. M., Rocha-Lopes, J. D. S., Machado, R. B., & Suchecki, D. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173410 · Cited by 13 · see citing works
Sleep Deprivation Alters the Pituitary Stress Transcriptome in Male and Female Mice
Oyola, M. G., Shupe, E. A., Soltis, A. R., Sukumar, G., Páez-Pereda, M., Larco, D. O., Wilkerson, M. D., Rothwell, S. W., Dalgard, C. L., & Wu, T. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00676 · Cited by 14 · see citing works
de Moraes, D. A., Machado, R. B., Koban, M., Hoffman, G. E., & Suchecki, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.885909 · Cited by 14 · see citing works
Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound
Machado, R. B., & Suchecki, D. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00163 · Cited by 12 · see citing works
“alpha-helical CRH (9-41) on the sleep/waking cycle in rats under normal”
BackgroundInfluentialNeuropeptide Y – Its role in human performance and extreme environments
Kienast, C., Gunga, H., & Steinach, M. (2019) · REACH · doi:10.1016/j.reach.2019.100032 · Cited by 12 · see citing works
Menezes, L., de Moraes, D. A., Silva, N. R., Silva, S. M. A., Suchecki, D., & Luz, J. (2020) · Experimental Physiology · doi:10.1113/ep088474 · Cited by 12 · see citing works
“The hyperphagic response to prolonged, unremitted sleep deprivation canbeattributed toaprogressive increase inneuropeptide Y (NPY) mRNA and reduction in proopiomelanocortin mRNA levels in the hypothalamus (Koban et al., 2006).”
BackgroundUpregulation of Gene Expression in Reward-Modulatory Striatal Opioid Systems by Sleep Loss
Baldo, B. A., Hanlon, E. C., Obermeyer, W. H., Bremer, Q. Z., Paletz, E. M., & Benca, R. M. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.174 · Cited by 11 · see citing works
Siran, R., Ahmad, A. H., Aziz, C. B. A., & Ismail, Z. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0356-x · Cited by 10 · see citing works
“Previous studies have show that REM sleep-deprived rats develop a degree of hyperphagia that is conversely associated with a loss of body weight and this was reproducible in this study [22, 27, 25, 26, 48, 51].”
Carlson, D. E., Le, W., Chiu, W. C., & Hoffman, G. E. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.046 · Cited by 9 · see citing works
“The previously described staining procedure [16] included multiple rinses of the sections in 0.”
BackgroundMethodInfluentialTranslational Models of Sleep and Sleep Disorders
Doran, S. M., Wessel, T. C., Kilduff, T. S., Turek, F. W., & Renger, J. J. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373861-5.00012-6 · Cited by 7 · see citing works
The anorexigenic peptide cocaine-and-amphetamine-regulated transcript modulates rem-sleep in rats
Méndez‐Díaz, M., Domínguez‐Martín, E., Pérez-Morales, M., Ruiz‐Contreras, A. E., Navarro, L., & Prospero-Garcia, O. E. (2009) · Neuropeptides · doi:10.1016/j.npep.2009.08.004 · Cited by 6 · see citing works
Administration of growth hormone ameliorates adverse effects of total sleep deprivation
Arvin, P., Ghafouri, S., Bavarsad, K., Hajipour, S., Khoshnam, S. E., Sarkaki, A., & Farbood, Y. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01192-9 · Cited by 5 · see citing works
Parrino, L., Rausa, F., Balella, G., Bottignole, D., Rosenzweig, I., & Mutti, C. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14342 · Cited by 5 · see citing works
“…of REM sleep deprivation is demonstrated by the activation of the hypothalamic – pituitary – adrenal axis, with increased synthesis of the corticotrophin-releasing hormone, and increased adrenocorticotrophic hormone and corticosterone plasma levels (de Galv ˜ ao et al., 2009; Koban et al., 2006).”
Anatomical Markers of Activity in Hypothalamic Neurons
Hoffman, G. E. (2020) · Comprehensive physiology · doi:10.1002/cphy.c170021 · Cited by 4 · see citing works
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Hypothalamic L-Histidine Decarboxylase Is Up-Regulated During Chronic REM Sleep Deprivation of Rats
Hoffman, G. E., & Koban, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152252 · Cited by 3 · see citing works
Participation of agouti-related peptide in the regulation of the wakefulness-sleep cycle
Romanova, I. V., & Михрина, А. Л. (2013) · Human Physiology · doi:10.1134/s0362119713060108 · Cited by 3 · see citing works
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Neuroprotective Effects of Caffeine in Sleep Deprivation
Alkadhi, K. A., Zagaar, M. A., Alhaider, I. A., & Alzoubi, K. H. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849734752-00287
wakefulness in rats Central administration of neuropeptide Y induces
Szentirmai, É., & Krueger, J. M. (2006)
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Neurological Modulations of Sleep
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“Paradoxical sleep deprivation triggers the production of some anabolic hormones, but at the same time induces the synthesis of catabolic hormones, such as corticosterone and adrenaline (Koban and Swinson 2005; Koban et al .”
Neuroprotective Effects of Caffeine in Sleep Deprivation
Alkadhi, K. A., Zagaar, M. A., Alhaider, I. A., & Alzoubi, K. H. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849733670-00287
Anatomical Markers of Activity in Hypothalamic Neurons
Hoffman, G. E. (2020) · Comprehensive physiology · doi:10.1002/j.2040-4603.2020.tb00114.x
Sleep deprivation and its impact on circadian rhythms and glucose metabolism
Jha, P. K. (2016) · theses.fr (ABES) · doi:10.70675/090a1809z3e96z4876zbbcez4a3609e56272
Manque de sommeil et maladies métaboliques
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- Authors
- Koban, M., Le, W. W., & Hoffman, G. E.
- Affiliations
- Morgan State University (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Hoffman, Gloria E.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2006-01-01
- Volume
- 147
- Issue
- 1
- Pages
- 421-431
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2069250032
- Cited by
- 85
- References
- 97
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 6 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 7 · 2015: 3 · 2014: 3 · 2013: 10 · 2012: 9
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (S06GM051971, 2-SO6-GM-51971-04)
- National Institute of Neurological Disorders and Stroke (NS 43788, R01NS043788)
- National Center for Research Resources (G12-RR-17581-02, G12RR017581)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- REM sleep deprivation, corticotropin-releasing factor, neuropeptide Y, proopiomelanocortin, hypothalamus, hyperphagia, food intake regulation, arcuate nucleus, paraventricular nucleus, stress response, weight loss, energy metabolism, thermogenesis
- MeSH terms
- Animals, Corticotropin-Releasing Hormone, Hypothalamus, Male, Neuropeptide Y, Pro-Opiomelanocortin, Sleep Deprivation, Sleep, REM, Weight Loss, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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