The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Sleep disruption alters nocturnal ACTH and cortisol secretory patterns
Abstract
Recent studies have provided evidence that nocturnal cortisol secretion is coupled to ultradian rhythms of sleep. The present study was designed to specify how exogenous and sleep-related endogenous factors influence nocturnal adrenocorticotropin (ACTH) and cortisol secretion. We compared the influences of (1) temporary sleep deprivation, (2) arousals continuously induced during sleep and, (3) undisturbed sleep (baseline) on pituitary-adrenocortical activity in 10 healthy men. Sleep deprivation (DS) and continuous arousals during sleep (AS) were introduced at the beginning of the second rapid eye movement (REM) sleep period which is an epoch close to the first significant nocturnal rise in plasma cortisol. Compared with the baseline nights, plasma cortisol significantly increased immediately after continuous arousals were started or the subject was awakened and remained awake. Despite this exogenously provoked first cortisol peak, average cortisol release during DS and AS was no higher than during undisturbed sleep. The arousal-induced cortisol burst was followed by a temporary inhibition of cortisol secretion, suggesting that once the subject is aroused (i.e., in stage 1 sleep or awake), the hypothalamus-pituitary-adrenal (HPA) system becomes highly sensitive to negative feedback inhibition. Spontaneously occurring endogenous cortisol peaks of comparable size during undisturbed sleep did not exhibit such a temporary inhibition of cortisol secretion. We hypothesize that sleep attenuates negative feedback inhibition within the HPA system, whereas wakefulness (or stage 1 sleep) reflects increased feedback sensitivity of this system.
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“awakenings and sleep offset are accompanied by cortisol stimulation”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [38]
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Cortisol Secretion Is Inhibited during Sleep in Normal Man*
WEITZMAN, E. D., ZIMMERMAN, J. C., CZEISLER, C. A., & RONDA, J. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-2-352 · Cited by 265
WEITZMAN, E. D., NOGEIRE, C., PERLOW, M., FUKUSHIMA, D., SASSIN, J., MCGREGOR, P., GALLAGHER, T. F., & HELLMAN, L. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-6-1018 · Cited by 235
The application of EEG sleep for the differential diagnosis of affective disorders
Kupfer, D. J., FOSTER, F. G., Coble, P. A., McPartland, R. J., & Ulrich, R. F. (1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.1.69 · Cited by 227
Born, J. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90021-2 · Cited by 172
Night-time plasma cortisol secretion is associated with specific sleep stages
Jan Born, A., Kern, W., Bieber, K., Fehm‐Wolfsdorf, G., Schiebe, M., & Fehm, H. L. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90333-1 · Cited by 110
Self-citationHodgkinson, S. C., Allolio, B., Landon, J., & Lowry, P. J. (1984) · Biochemical Journal · doi:10.1042/bj2180703 · Cited by 109
Reduced Cortisol Latency in Depressive Illness
Jarrett, D. B. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790050032004 · Cited by 101
Circadian Rhythm of Adrenal Cortical Activity in Depression
Fullerton, D. T. (1968) · Archives of General Psychiatry · doi:10.1001/archpsyc.1968.01740120034005 · Cited by 77
Evidence for Extrapituitary Mechanisms Mediating the Morning Peak of Plasma Cortisol in Man*
Fehm, H. L., Klein, E., Holl, R. W., & Voigt, K. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-3-410 · Cited by 69
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Pruessner, J. C., Wolf, O. T., Hellhammer, D. H., Buske-Kirschbaum, A., von Auer, K., Jobst, S., Kaspers, F., & Kirschbaum, C. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)01008-4 · Cited by 1,450
Buckley, T. M., & Schatzberg, A. F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1056 · Cited by 964
Meerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948
The awakening cortisol response: methodological issues and significance
Clow, A., Thorn, L., Evans, P., & Hucklebridge, F. (2004) · Stress · doi:10.1080/10253890410001667205 · Cited by 856
“The finding that there is a dissociation between ACTH and cortisol at the time of the morning peak (Fehm et al., 1984; Spathschwalbe et al., 1991; Born et al., 1999) lends further support to this idea.”
Sleep Loss Results in an Elevation of Cortisol Levels the Next Evening
(1997) · Sleep · doi:10.1093/sleep/20.10.865 · Cited by 745
Metadata
- Authors
- Späth-Schwalbe, E., Gofferje, M., Kern, W., Born, J., & Fehm, H. L.
- Affiliations
- University of Lübeck (DE)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1991-03
- Volume
- 29
- Issue
- 6
- Pages
- 575-584
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2012118444
- Cited by
- 266
- References
- 20
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 5 · 2022: 7 · 2021: 14 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 9 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 13 · 2012: 15
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep disruption, ACTH secretion, sleep deprivation, sleep arousal, hypothalamic-pituitary-adrenal axis, negative feedback inhibition, REM sleep, ultradian rhythms
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Arousal, Circadian Rhythm, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Reference Values, Sleep Deprivation, Sleep Stages, Sleep, REM
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