Corticotropin-releasing hormone-induced adrenocorticotropin and cortisol secretion depends on sleep and wakefulness
Abstract
Twenty-four-hour profiles of pituitary-adrenocortical secretory activity in humans are characterized by a distinct decrease in hormone secretion after sleep onset and a strong increase during the early morning hours. It is a widely accepted notion that this pattern of hormone secretion is driven by intrinsic circadian oscillators, and the contributions of sleep and wakefulness have been greatly neglected. Here, we examined whether there is a sleep-dependent inhibition of stimulated ACTH and cortisol release during early nocturnal sleep, which is dominated by slow wave sleep (SWS). We administered human CRH (hCRH; 50 micrograms), the main corticotropin secretagogue, to 14 healthy men during the first SWS period after sleep onset and another time in the same night during a period of stage 2 sleep in the second half of sleeping time. To discriminate possible circadian influences from influences of sleep, on a second night another two injections of hCRH were administered at identical points during the night to the same subject, who was kept awake. Exclusively during sleep, but only during SWS in the beginning of sleep time, ACTH and cortisol responses to hCRH were blunted. The results demonstrate an inhibiting influence of sleep on stimulated ACTH and cortisol secretion, with this effect restricted to the early part of sleep.
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Sleep, specifically SWS, contributes to the generation of this unique endocrine pattern in concert with circadian mechanisms.
“Sleep, specifically SWS, contributes to the generation of this unique endocrine pattern in concert with circadian mechanisms (91,1125,1126,1129).”
From About Sleep's Role in Memory (2013) · cites this paper as [1126]
The response of ACTH and cortisol to CRH administration, alone or with vasopressin, is blunted if the test is performed during nighttime sleep, especially during SWS, compared with nighttime wakefulness.
“Furthermore, the response of ACTH and cortisol to a stimulus (CRH administration, alone or in association with vasopressin) has been shown to be blunted if the test was performed during nighttime sleep, and in particular during SWS, compared with nighttime wakefulness [44, 45].”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [44]
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- Authors
- Spath-Schwalbe, E.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1993-11-01
- Volume
- 77
- Issue
- 5
- Pages
- 1170-1173
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W1983680482
- Cited by
- 86
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- corticotropin-releasing factor, adrenocorticotropin secretion, cortisol secretion, sleep, slow-wave sleep, wakefulness, circadian rhythm, pituitary-adrenal axis, stage 2 sleep
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Arginine Vasopressin, Corticotropin-Releasing Hormone, Humans, Hydrocortisone, Injections, Intravenous, Male, Sleep, Wakefulness
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