Links between circadian rhythms and psychiatric disease
Open accessAbstract
Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will hopefully lead to the discovery of treatments to either prevent or alleviate the suffering caused by these diseases. One roadblock to attaining this goal is the realization that neuropsychiatric diseases are rarely due to a single gene polymorphism, environmental exposure, or developmental insult. Rather, it is a complex interaction between these various influences that likely leads to the development of clinically relevant syndromes. Our lab is exploring the links between environmental exposures and neurobehavioral function by investigating how disruption of the circadian (daily) clock alters the structure and function of neural circuits, with the hypothesis that disrupting this crucial homeostatic system can directly contribute to altered vulnerability of the organism to other factors that interact to produce psychiatric illness. This review explores some historical and more recent findings that link disrupted circadian clocks to neuropsychiatric disorders, particularly depression, mania, and schizophrenia. We take a comparative approach by exploring the effects observed in human populations, as well as some experimental models used in the laboratory to unravel mechanistic and causal relationships between disruption of the circadian clock and behavioral abnormalities. This is a rich area of research that we predict will contribute greatly to our understanding of how genes, environment, and development interact to modulate an individual's vulnerability to psychiatric disorders.
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Psychiatric illness, including depression, involves circadian disruption of body temperature, mood, and sleep.
“There is wide agreement that psychiatric illness, including depression, involves CD of body temperature, mood, and sleep.50,51”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [51]
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Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works
Circadian rhythms from multiple oscillators: lessons from diverse organisms
Bell‐Pedersen, D., Cassone, V. M., Earnest, D. J., Golden, S. S., Hardin, P. E., Thomas, T. L., & Zoran, M. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1633 · Cited by 1,481 · see citing works
A clockwork web: circadian timing in brain and periphery, in health and disease
Hastings, M. H., Reddy, A. B., & Maywood, E. S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1177 · Cited by 1,189 · see citing works
Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators
Buhr, E. D., Yoo, S.-H., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195262 · Cited by 917 · see citing works
Mania-like behavior induced by disruption of <i>CLOCK</i>
Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803 · see citing works
Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
Cheng, M. Y., Bullock, C. M., Li, C., Lee, A. G., Bermak, J. C., Belluzzi, J., Weaver, D. R., Leslie, F. M., & Zhou, Q.-Y. (2002) · Nature · doi:10.1038/417405a · Cited by 715 · see citing works
Circadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666 · see citing works
Agomelatine, the first melatonergic antidepressant: discovery, characterization and development
de Bodinat, C., Lemaître, B. J., Mocaër, E., Renard, P., Muñoz, C., & Millan, M. J. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3140 · Cited by 595 · see citing works
Disruption of circadian clocks has ramifications for metabolism, brain, and behavior
Karatsoreos, I. N., Bhagat, S., Bloss, E. B., Morrison, J. H., & McEwen, B. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018375108 · Cited by 547 · see citing works
Self-citationHow might circadian rhythms control mood? Let me count the ways
McClung, C. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.019 · Cited by 507 · see citing works
Psychobiological allostasis: resistance, resilience and vulnerability
Karatsoreos, I. N., & McEwen, B. S. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.10.005 · Cited by 458 · see citing works
Self-citationSleep and circadian rhythm disruption in schizophrenia
Wulff, K., Dijk, D.-J., Middleton, B., Foster, R. G., & Joyce, E. M. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.096321 · Cited by 426 · see citing works
A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock
Iitaka, C., Miyazaki, K., Akaike, T., & Ishida, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503526200 · Cited by 373 · see citing works
Sleep in children with autistic spectrum disorder
Cortesi, F., Giannotti, F., Ivanenko, A., & Johnson, K. (2010) · Sleep Medicine · doi:10.1016/j.sleep.2010.01.010 · Cited by 355 · see citing works
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia
Vacic, V., McCarthy, S., Malhotra, D., Murray, F., Chou, H.-H., Peoples, A., Makarov, V., Yoon, S., Bhandari, A., Corominas, R., et al. (2011) · Nature · doi:10.1038/nature09884 · Cited by 337 · see citing works
Chronic 'jet lag' produces temporal lobe atrophy and spatial cognitive deficits
Cho, K. (2001) · Nature Neuroscience · doi:10.1038/88384 · Cited by 332 · see citing works
Neurogenesis and affective disorders
Samuels, B. A., & Hen, R. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07614.x · Cited by 286 · see citing works
Sleep Disturbance in Bipolar Disorder: Therapeutic Implications
Plante, D. T., & Winkelman, J. W. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08010077 · Cited by 268 · see citing works
Kasper, S. F., Hajak, G., Wulff, K., Hoogendijk, W. J. G., Montejo, A. L., Smeraldi, E., RYBAKOWSKI, J. K., Quera-Salva, M.-A., Wirz‐Justice, A., Picarel-Blanchot, F., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05347blu · Cited by 256 · see citing works
Circadian misalignment in major depressive disorder
Emens, J., Lewy, A., Kinzie, J. M., Arntz, D., & Rough, J. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2009.04.009 · Cited by 253 · see citing works
Mukherjee, S., Coque, L., Cao, J., Kumar, J., Chakravarty, S., Asaithamby, A., Graham, A., Gordon, E., Enwright, J. F., Dileone, R., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.031 · Cited by 249 · see citing works
The clocks that time us. Physiology of the circadian timing system
Aschoff, J. (1983) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(83)90088-3 · Cited by 203 · see citing works
Gibson, E. M., Wang, C., Tjho, S., Khattar, N., & Kriegsfeld, L. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015267 · Cited by 196 · see citing works
Souêtre, E., Salvati, E., Wehr, T. A., Sack, D. A., Krebs, B., & DARCOURT, G. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.9.1133 · Cited by 188 · see citing works
Circadian rhythms and mood regulation: insights from pre-clinical models
McClung, C. A. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.008 · Cited by 169 · see citing works
Asaoka, S., Aritake, S., Komada, Y., Ozaki, A., Odagiri, Y., Inoue, S., Shimomitsu, T., & Inoue, Y. (2013) · Chronobiology International · doi:10.3109/07420528.2012.762010 · Cited by 165 · see citing works
Sleep and circadian rhythm dysregulation in schizophrenia
Monti, J. M., BaHammam, A. S., Pandi-Perumal, S. R., Bromundt, V., Spence, D. W., Cardinali, D. P., & Brown, G. M. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.021 · Cited by 157 · see citing works
Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia
Rao, M. L., Gross, G., Strebel, B., Halaris, A., Huber, G., Bräunig, P., & Marler, M. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91147-9 · Cited by 154 · see citing works
Circadian genes and bipolar disorder
Mansour, H., Monk, T. H., & Nimgaonkar, V. L. (2005) · Annals of Medicine · doi:10.1080/07853890510007377 · Cited by 142 · see citing works
Morley‐Fletcher, S., Mairesse, J., Soumier, A., Banasr, M., Fagioli, F., Gabriel, C., Mocaër, E., Daszuta, A., McEwen, B. S., Nicoletti, F., et al. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2280-x · Cited by 141 · see citing works
Shiftwork as a Risk Factor for Depression: A Pilot Study.
Scott, Monk, T., & Brink, L. (1997) · PubMed · Cited by 129 · see citing works
Disruption of the Circadian Timing Systems
Mendlewicz, J. (2009) · CNS Drugs · doi:10.2165/11318630-000000000-00000 · Cited by 122 · see citing works
Jeans, A. F., Oliver, P. L., Johnson, R., Capogna, M., Vikman, J., Molnár, Z., Babbs, A., Partridge, C. J., Salehi, A. A., Bengtsson, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610222104 · Cited by 121 · see citing works
Expression of prokineticins and their receptors in the adult mouse brain
Cheng, M., Leslie, F. M., & Zhou, Q. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21087 · Cited by 116 · see citing works
From circadian rhythms to clock genes in depression
Turek, F. W. (2007) · International Clinical Psychopharmacology · doi:10.1097/01.yic.0000277956.93777.6a · Cited by 114 · see citing works
Circadian rhythm disturbances in manic-depressive illness.
Wehr, T. A., Sack, D. A., Rosenthal, N. E., Duncan, W. R., & Gillin, J. C. (1983) · PubMed · Cited by 111 · see citing works
Evaluating the links between schizophrenia and sleep and circadian rhythm disruption
Pritchett, D., Wulff, K., Oliver, P. L., Bannerman, D. M., Davies, K. E., Harrison, P. J., Peirson, S. N., & Foster, F. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0817-8 · Cited by 107 · see citing works
Ko, H. W., Kim, E. Y., Chiu, J. C., Vanselow, J. T., Kramer, A., & Edery, I. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1586-10.2010 · Cited by 107 · see citing works
Iwahana, E., Akiyama, M., Miyakawa, K., Uchida, A., Kasahara, J., Fukunaga, K., Hamada, T., & Shibata, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03322.x · Cited by 103 · see citing works
Circadian rhythms and clock genes in psychotic disorders.
Lamont, E. W., Coutu, D. L., Cermakian, N., & Boivin, D. B. (2010) · PubMed · Cited by 102 · see citing works
Principal pathogenetic components and biological endophenotypes in autism spectrum disorders
Sacco, R., Curatolo, P., Manzi, B., Militerni, R., Bravaccio, C., Frolli, A., Lenti, C., Saccani, M., Elia, M., Reichelt, K.-L., et al. (2010) · Autism Research · doi:10.1002/aur.151 · Cited by 102 · see citing works
Karatsoreos, I. N., & Silver, R. (2007) · Endocrinology · doi:10.1210/en.2007-1083 · Cited by 101 · see citing works
Disrupted Circadian Rhythms in a Mouse Model of Schizophrenia
Oliver, P. L., Sobczyk, M. V., Maywood, E. S., Edwards, B., Lee, S., Livieratos, A., Oster, H., Butler, R., Godinho, S. I. H., Wulff, K., et al. (2012) · Current Biology · doi:10.1016/j.cub.2011.12.051 · Cited by 92 · see citing works
Mairesse, J., Silletti, V., Laloux, C., Zuena, A. R., Giovine, A., Consolazione, M., Camp, G. V., Malagodi, M., Gaetani, S., Cianci, S., et al. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001970 · Cited by 87 · see citing works
Effects of Circadian Disruption on Mental and Physical Health
Karatsoreos, I. N. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0252-0 · Cited by 85 · see citing works
Self-citationResilience and vulnerability: a neurobiological perspective
Karatsoreos, I. N., & McEwen, B. S. (2013) · F1000Prime Reports · doi:10.12703/p5-13 · Cited by 84 · see citing works
Self-citationDepression: A Disorder of Timekeeping?
Cauter, E. V., & Turek, F. W. (1986) · Perspectives in biology and medicine · doi:10.1353/pbm.1986.0033 · Cited by 83 · see citing works
A schizophrenic patient with an arrhythmic circadian rest-activity cycle
Wirz-Justice, A., Cajochen, C., & Nussbaum, P. (1997) · Psychiatry Research · doi:10.1016/s0165-1781(97)00117-0 · Cited by 78 · see citing works
Wulff, K., Joyce, E. M., Middleton, B., Dijk, D., & Foster, F. (2006) · Chronobiology International · doi:10.1080/07420520500545987 · Cited by 66 · see citing works
Glycogen Synthase Kinase 3β as a Likely Target for the Action of Lithium on Circadian Clocks
Padiath, Q. S., Paranjpe, D., Jain, S., & Sharma, V. K. (2004) · Chronobiology International · doi:10.1081/cbi-120027981 · Cited by 64 · see citing works
Minireview: Circadian Control of Metabolism by the Suprachiasmatic Nuclei
Kalsbeek, A., Kreier, F., Fliers, E., Sauerwein, H. P., Romijn, J. A., & Buijs, R. M. (2007) · Endocrinology · doi:10.1210/en.2007-0776 · Cited by 58 · see citing works
Lithium differentially affects clock gene expression in serum-shocked NIH-3T3 cells
Osland, T. M., Fernø, J., Håvik, B., Heuch, I., Ruoff, P., Lærum, O. D., & Steen, V. M. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110379508 · Cited by 56 · see citing works
Wirz‐Justice, A. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.024 · Cited by 51 · see citing works
Goetze, U., & Tölle, R. (2008) · Neuropsychobiology · doi:10.1159/000118414 · Cited by 50 · see citing works
Lithium lengthens the period of circadian rhythms in lesioned hamsters bearing SCN grafts
LeSauter, J., & Silver, R. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90259-g · Cited by 46 · see citing works
Recent Advances in Sleep-Wake Cycle and Biological Rhythms in Bipolar Disorder
Robillard, R., Naismith, S. L., & Hickie, I. B. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0402-3 · Cited by 43 · see citing works
Koresh, O., Kozlovsky, N., Kaplan, Z., Zohar, J., Matar, M. A., & Cohen, H. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.012 · Cited by 40 · see citing works
Antimanic drugs stabilize hamster circadian rhythms
Klemfuss, H., & Kripke, D. F. (1995) · Psychiatry Research · doi:10.1016/0165-1781(95)02687-r · Cited by 35 · see citing works
Jamadar, S. D., O'Neil, K. M., Pearlson, G. D., Ansari, M., Gill, A., Jagannathan, K., & Assaf, M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.027 · Cited by 32 · see citing works
The free-running circadian rhythms of two schizophrenics.
Mills, J. N., Morgan, R., Minors, D. S., & Waterhouse, J. M. (1977) · PubMed · Cited by 31 · see citing works
Circadian Regulation of Endocrine Functions
Butler, M. P., Kriegsfeld, L. J., & Silver, R. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00013-9 · Cited by 22 · see citing works
Differential effect of lithium on the circadian oscillator in young and old hamsters
Iwahana, E., Hamada, T., Uchida, A., & Shibata, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.042 · Cited by 17 · see citing works
Morley, S. (1983) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(83)90115-0 · Cited by 8 · see citing works
AN UNDERLYING CIRCANNUAL RHYTHM IN SEASONAL AFFECTIVE DISORDER?
Wirz‐Justice, A., Kräuchi, K., & Graw, P. (2001) · Chronobiology International · doi:10.1081/cbi-100103193 · Cited by 8 · see citing works
Calcium, lithium, and circadian rhythms
Terao, T. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90149-t · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Colten H. R. Altevogt B. M. (eds). (2006). Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem. Washington, DC: The National Academies Press 20669438
Cited by
Sorted by citations
Sleep Deprivation and Circadian Disruption
McEwen, B. S., & Karatsoreos, I. N. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2014.11.007 · Cited by 338 · see citing works
Self-citationPeripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197 · see citing works
Molecular mechanisms underlying alcohol-drinking behaviours
Ron, D., & Barak, S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.85 · Cited by 165 · see citing works
A <i>PERIOD3</i> variant causes a circadian phenotype and is associated with a seasonal mood trait
Zhang, L., Hirano, A., Hsu, P.-K., Jones, C. R., Sakai, N., Okuro, M., McMahon, T., Yamazaki, M., Xu, Y., Saigoh, N., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600039113 · Cited by 169 · see citing works
Altered circadian clock gene expression in patients with schizophrenia
Johansson, A.-S., Owe-Larsson, B., Hetta, J., & Lundkvist, G. B. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.04.029 · Cited by 120 · see citing works
Disrupted sleep and circadian rhythms in schizophrenia and their interaction with dopamine signaling
Ashton, A., & Jagannath, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00636 · Cited by 106 · see citing works
Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95 · see citing works
Gruzdev, S. K., Yakovlev, A. A., Druzhkova, T. A., Guekht, A. B., & Gulyaeva, N. V. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00684-6 · Cited by 75 · see citing works
NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors
Ozburn, A. R., Kern, J., Parekh, P. K., Logan, R. W., Liu, Z., Falcon, E., Becker-Krail, D., Purohit, K., Edgar, N. M., Huang, Y., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00360 · Cited by 49 · see citing works
Logan, R. W., Parekh, P. K., Kaplan, G. N., Becker-Krail, D. D., Williams, W. P., Yamaguchi, S., Yoshino, J., Shelton, M. A., Zhu, X., Zhang, H., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0061-1 · Cited by 48 · see citing works
Using behavioral rhythms and multi-task learning to predict fine-grained symptoms of schizophrenia
Tseng, V. W.-S., Sano, A., Ben-Zeev, D., Brian, R., Campbell, A. T., Hauser, M., Kane, J. M., Scherer, E. A., Wang, R., Wang, W., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-71689-1 · Cited by 44 · see citing works
Familiarity of Brazilian psychologists with basic concepts in sleep science and chronobiology
Marilac Soalheiro, L., de Jesus Brandão, B., Paiva, R. V. N., Dias Carvalho, L., Menezes Paranhos, R. D., Ribeiro Barbosa, P. C., Guerrero-Vargas, N. N., & Tamura, E. K. (2023) · Chronobiology International · doi:10.1080/07420528.2023.2250870 · Cited by 5 · see citing works
- Authors
- Karatsoreos, I. N.
- Affiliations
- Washington State University (US)
- Corresponding author
- Karatsoreos, Ilia N.
- ORCID
- Karatsoreos, Ilia N.
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2014-05-06
- Volume
- 8
- Pages
- 162-162
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC4018537
- OpenAlex
- W2108993317
- Cited by
- 146
- References
- 66
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 11 · 2020: 14 · 2019: 12 · 2018: 15 · 2017: 13 · 2016: 13 · 2015: 19 · 2014: 4
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Brain Research Foundation
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- circadian rhythm, circadian clock disruption, neuropsychiatric disorders, depression, mania, schizophrenia, environmental exposure, gene-environment interaction, psychiatric vulnerability
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