A fine-grained anatomical analysis of the role of the rat suprachiasmatic nucleus in circadian rhythms of feeding and drinking
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SCN-lesioned rats do not have a rhythm in food intake.
“SCN-lesioned rats, however, do not have a rhythm in food intake either [55].”
From Circadian control of glucose metabolism (2014) · cites this paper as [55]
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“This pattern can be disrupted by lesioning of the nucleus suprachiasmaticus [9] and by VMH lesioning [1,8].”
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The suprachiasmatic hypothalamic nuclei of the rat
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“Importantly, in discussing this study’s findings, the authors point out that the 50% reduction in AVPexpressing SCN cells—observed in adults with AD—matches the lesion magnitude required to disrupt circadian rhythms in rodent studies (Van den Pol and Powley, 1979; Pickard and Turek, 1983).”
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Targeted Microlesions Reveal Novel Organization of the Hamster Suprachiasmatic Nucleus
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“%) of any portion of the SCN is sufficient to support rhythmic function (Rusak, 1977; Van den Pol and Powley, 1979; Davis and Gorski, 1988; Harrington et al., 1993; Welsh et al., 1995).”
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“…in part on the master circadian clock activity in the suprachiasmatic nuclei (SCN), since it is been long known that lesions in this region abolish feeding rhythms (van den Pol and Powley 1979) and alter metabolic variables such as the response to insulin and gluconeogenesis (Rudic et al. 2004).”
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Circadian changes in arginine vasopressin level in the suprachiasmatic nuclei in the rat
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Restoration of Circadian Rhythmicity by Transplants of SCN "Micropunches"
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Effect of suprachiasmatic nucleus lesion on circadian dentin increment in rats
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- Authors
- Van Den Pol, A. N., & Powley, T.
- Affiliations
- Yale University (US)
- ORCID
- Powley, Terry
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1979-01
- Volume
- 160
- Issue
- 2
- Pages
- 307-326
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1981206448
- Cited by
- 216
- References
- 39
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- suprachiasmatic nucleus, circadian rhythm, feeding behavior, drinking behavior, radiofrequency lesions, lesion size, ultradian rhythms, autocorrelation coefficient, light-dark ratio
- MeSH terms
- Animals, Brain Mapping, Circadian Rhythm, Computers, Drinking Behavior, Feeding Behavior, Hypothalamus, Hypothalamus, Middle, Male, Optic Chiasm, Rats, Inbred Strains, Sensory Deprivation, Rats
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