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Cited by 84Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsSleep and related disorders

Buying time: a rationale for examining the use of circadian rhythm and sleep interventions to delay progression of mild cognitive impairment to Alzheimer’s disease

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Landry, Glenn J., Liu-Ambrose, Teresa·2014·Frontiers in Aging Neuroscience
DOI 10.3389/fnagi.2014.00325PMC PMC4259166
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Abstract

As of 2010, the worldwide economic impact of dementia was estimated at $604 billion USD; and without discovery of a cure or effective interventions to delay disease progression, dementia's annual global economic impact is expected to surpass $1 trillion USD as early as 2030. Alzheimer's disease (AD) is the leading cause of dementia accounting for over 75% of all cases. Toxic accumulation of amyloid beta (Aβ), either by overproduction or some clearance failure, is thought to be an underlying mechanism of the neuronal cell death characteristic of AD-though this amyloid hypothesis has been increasingly challenged in recent years. A compelling alternative hypothesis points to chronic neuroinflammation as a common root in late-life degenerative diseases including AD. Apolipoprotein-E (APOE) genotype is the strongest genetic risk factor for AD: APOE-ε4 is proinflammatory and individuals with this genotype accumulate more Aβ, are at high risk of developing AD, and almost half of all AD patients have at least one ε4 allele. Recent studies suggest a bidirectional relationship exists between sleep and AD pathology. Sleep may play an important role in Aβ clearance, and getting good quality sleep vs. poor quality sleep might reduce the AD risk associated with neuroinflammation and the ε4 allele. Taken together, these findings are particularly important given the sleep disruptions commonly associated with AD and the increased burden disrupted sleep poses for AD caregivers. The current review aims to: (1) identify individuals at high risk for dementia who may benefit most from sleep interventions; (2) explore the role poor sleep quality plays in exacerbating AD type dementia; (3) examine the science of sleep interventions to date; and (4) provide a road map in pursuit of comprehensive sleep interventions, specifically targeted to promote cognitive function and delay progression of dementia.

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  • Some older adults with MCI struggle with reduced awareness of their circadian rhythms, placing additional stress on their ability to adhere to routines.

    “Some older adults with MCI also struggle with reduced awareness of their circadian rhythms, placing additional stress on their ability to adhere to routines [8,22].”

    From A Collaborative Approach to Support Medication Management in Older Adults with Mild Cognitive Impairment Using Conversational Assistants (CAs) (2022) · cites this paper as [22]

    The 'Mild cognitive impairment: circadian rhythms and sleep' section (page unavailable) reports altered circadian timing and disrupted sleep in adults with MCI. It does not report reduced awareness of circadian rhythms or say that such awareness places stress on adherence to routines. (LLM, conf=0.82)

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Authors
Landry, G. J., & Liu-Ambrose, T.
Affiliations
University of British Columbia (CA)
Corresponding author
Liu-Ambrose, Teresa
ORCID
Venue
Frontiers in Aging Neuroscience
Publisher
Frontiers Media SA
Published
2014-12-08
Volume
6
Pages
325-325
ISSN
1663-4365 (ISSN-L)
DOI
10.3389/fnagi.2014.00325
PMC
PMC4259166
OpenAlex
W2118478089
Cited by
84
References
260
Citations by year
2026: 3 · 2025: 1 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 13
FWCI
1.06
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Aging Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Fondation pour la Recherche sur Alzheimer
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
Alzheimer's disease, mild cognitive impairment, circadian rhythm, sleep interventions, sleep quality, amyloid-beta clearance, neuroinflammation, APOE ε4, dementia risk, cognitive function

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