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Cited by 93Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

Effects of lesions in the hypothalamic paraventricular, supraoptic and suprachiasmatic nuclei on vasopressin and oxytocin in rat-brain and spinal-cord

Hawthorn, Janet, Ang, Vincent T.Y., Jenkins, John S.·1985·Brain Research
DOI 10.1016/0006-8993(85)91093-5
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Abstract

The content of arginine vasopressin and oxytocin in various extrahypothalamic sites of the rat brain and spinal cord was determined by specific radioimmunoassays after lesions had been made in either the paraventricular (PVN), supraoptic (SON) or suprachiasmatic nuclei (SCN). In some animals all 3 nuclei were destroyed together. The PVN provided a considerable amount of the vasopressin innervation of the solitary tract nucleus, and most of that in the spinal cord. Oxytocin was removed from some areas after lesions of the PVN and, again, most of this peptide was lost from the spinal cord. Lesions of the SCN did not appear to be followed by significant quantitative changes in either hormone in any of the areas studied. Lesions of the SON resulted in loss of oxytocin, particularly in the periventricular grey and some other areas, suggesting that extrahypothalamic projections from this nucleus may be more important than was previously assumed. Lesions of all 3 nuclei which included destruction of accessory hypothalamic nuclei resulted in a much more widespread loss of vasopressin and oxytocin, but there was preservation of both peptides in the dorsal raphe nucleus and much of those present in the locus coeruleus. It is concluded that the contribution of the classical hypothalamic nuclei to the extrahypothalamic content of vasopressin and oxytocin in rat brain is less than was originally believed, and that there are areas of the brain such as the locus coeruleus and dorsal raphe nucleus in which the source of these peptides may be outside the hypothalamus.

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  • Prairie voles have significantly higher densities of oxytocin receptors in the nucleus accumbens than non-monogamous meadow and montane voles.

    “Prairie voles have significantly higher densities of OTR in the NAcc than non-monogamous meadow and montane voles [57] (Figure 3A,B).”

    From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [57]

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Authors
Hawthorn, J., Ang, V. T. Y., & Jenkins, J. S.
Affiliations
St George's, University of London (GB)
Corresponding author
Hawthorn, Janet
Venue
Brain Research
Publisher
Elsevier BV
Published
1985-10
Volume
346
Issue
1
Pages
51-57
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(85)91093-5
OpenAlex
W1969205984
Cited by
93
References
32
Citations by year
2026: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 3 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2012: 1
FWCI
7.01
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
vasopressin, oxytocin, hypothalamic paraventricular nucleus, supraoptic nucleus, suprachiasmatic nucleus, spinal cord, solitary tract nucleus, dorsal raphe nucleus, locus coeruleus, hypothalamic lesions, rat brain
MeSH terms
Animals, Arginine Vasopressin, Brain Mapping, Central Nervous System, Hypothalamus, Male, Oxytocin, Paraventricular Hypothalamic Nucleus, Rats, Inbred Strains, Suprachiasmatic Nucleus, Supraoptic Nucleus, Rats

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