Cited by 219Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age

Ingham, C.A., Hood, S.H., Arbuthnott, G.W.·1989·Brain Research

Abstract

Golgi-impregnated medium-size spiny neurones were studied in the rat neostriatum at various times after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle. At both short (12-26 days) and long (7-12 months) survival times, the density of spines was significantly lower (13%) on neostriatal neurones ipsilateral to the 6-hydroxydopamine injection. At longer times the density of spines was lower on neurones both ipsilateral and contralateral to the lesion when compared to neurones taken from short-term animals (23%).

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Crossref · 10.1016/0006-8993(89)91686-7

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38 of 38 references verified0 citation errors · 0 not checkable

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  • These morphological changes reflect loss of synapses and reduction in neurotransmission in Parkinson's disease and a wide spectrum of brain disorders including Alzheimer's disease and Fragile-X syndrome.

    “These morphological changes reflect the loss of synapses and hence reduction in neurotransmission not only in PD but a wide spectrum of brain disorders including Alzheimer’s disease and Fragile-X syndrome 91.”

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Authors
Ingham, C. A., Hood, S. H., & Arbuthnott, G. W.
Affiliations
University of Edinburgh (GB)
Corresponding author
Ingham, C.A.
Venue
Brain Research
Publisher
Elsevier BV
Published
1989-12
Volume
503
Issue
2
Pages
334-338
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2074379320
Cited by
219
References
38
Citations by year
2025: 4 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 10 · 2018: 3 · 2017: 8 · 2016: 8 · 2015: 14 · 2014: 6 · 2013: 13 · 2012: 7
FWCI
1.37
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
dendritic spine density, neostriatum, 6-hydroxydopamine lesion, medial forebrain bundle, striatal neurons, age-related changes, ipsilateral and contralateral effects, dopaminergic neurotoxicity, Golgi impregnation
MeSH terms
Aging, Animals, Corpus Striatum, Dendrites, Hydroxydopamines, Male, Medial Forebrain Bundle, Rats, Inbred Strains, Oxidopamine, Rats

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